Compile Data Set for Download or QSAR
Report error Found 17 Enz. Inhib. hit(s) for PDB: 9WQK
TargetMetabotropic glutamate receptor 5(Human)
University of Perugia

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 17657BDBM17657(L-Glutamic acid | L-Glu | (2S)-2-aminopentanedioic...)
Affinity DataKi:  390nMAssay Description:Binding affinity to mGluR5 receptor expressed in BHK cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMetabotropic glutamate receptor 5(Human)
University of Perugia

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 17657BDBM17657(L-Glutamic acid | L-Glu | (2S)-2-aminopentanedioic...)
Affinity DataKi:  1.16E+3nMAssay Description:Displacement of [3H]Quisqualate from human mGluR5 receptor expressed in BHK cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMetabotropic glutamate receptor 5(Rat)
University of Perugia

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 17657BDBM17657(L-Glutamic acid | L-Glu | (2S)-2-aminopentanedioic...)
Affinity DataEC50:  1.20E+3nMAssay Description:Activity at rat recombinant mGluR5 expressed in CHO cells assessed as intracellular calcium concentrationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMetabotropic glutamate receptor 5(Rat)
University of Perugia

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 17657BDBM17657(L-Glutamic acid | L-Glu | (2S)-2-aminopentanedioic...)
Affinity DataEC50:  1.20E+3nMAssay Description:Activity at rat mGluR5 by measuring intracellular calcium concentration in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMetabotropic glutamate receptor 5(Human)
University of Perugia

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 17657BDBM17657(L-Glutamic acid | L-Glu | (2S)-2-aminopentanedioic...)
Affinity DataKi:  3.00E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMetabotropic glutamate receptor 5(Human)
University of Perugia

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 17657BDBM17657(L-Glutamic acid | L-Glu | (2S)-2-aminopentanedioic...)
Affinity DataEC50:  4.10E+3nMAssay Description:Concentration for half maximal activation of metabotropic glutamate mGluR5a in humanMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/31/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMetabotropic glutamate receptor 5(Rat)
University of Perugia

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 17657BDBM17657(L-Glutamic acid | L-Glu | (2S)-2-aminopentanedioic...)
Affinity DataEC50:  4.68E+3nMAssay Description:Agonist activity at rat mGlu5 receptor expressed in HEK293 cells by intracellular Ca2+ mobilization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2017
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMetabotropic glutamate receptor 5(Rat)
University of Perugia

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 17657BDBM17657(L-Glutamic acid | L-Glu | (2S)-2-aminopentanedioic...)
Affinity DataEC50:  4.70E+3nMAssay Description:Agonist activity at rat mGlu5 receptor expressed in HEK293 cells by intracellular Ca2+ mobilization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2017
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMetabotropic glutamate receptor 5(Rat)
University of Perugia

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 17657BDBM17657(L-Glutamic acid | L-Glu | (2S)-2-aminopentanedioic...)
Affinity DataKi:  6.03E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/25/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMetabotropic glutamate receptor 5(Rat)
University of Perugia

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 17657BDBM17657(L-Glutamic acid | L-Glu | (2S)-2-aminopentanedioic...)
Affinity DataKi:  7.40E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetGlutamate metabotropic receptor 5(Guinea pig)
Cnrs Ccipe

Curated by PDSP Ki Database
LigandChemical structure of BindingDB Monomer ID 17657BDBM17657(L-Glutamic acid | L-Glu | (2S)-2-aminopentanedioic...)
Affinity DataKi:  7.67E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2011
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetMetabotropic glutamate receptor 5(Rat)
University of Perugia

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 17657BDBM17657(L-Glutamic acid | L-Glu | (2S)-2-aminopentanedioic...)
Affinity DataEC50:  8.00E+3nMAssay Description:Concentration for half maximal activation of metabotropic glutamate mGluR5b in ratMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/31/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMetabotropic glutamate receptor 5(Rat)
University of Perugia

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 17657BDBM17657(L-Glutamic acid | L-Glu | (2S)-2-aminopentanedioic...)
Affinity DataEC50:  8.99E+3nMAssay Description:Agonist activity at rat mGlu5 receptor expressed in HEK293 cells assessed as IP1 accumulation by IP-One functional assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2017
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetGlutamate metabotropic receptor 5(Guinea pig)
Cnrs Ccipe

Curated by PDSP Ki Database
LigandChemical structure of BindingDB Monomer ID 17657BDBM17657(L-Glutamic acid | L-Glu | (2S)-2-aminopentanedioic...)
Affinity DataKi:  9.75E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2011
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetMetabotropic glutamate receptor 5(Rat)
University of Perugia

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 17657BDBM17657(L-Glutamic acid | L-Glu | (2S)-2-aminopentanedioic...)
Affinity DataEC50:  1.00E+4nMAssay Description:Concentration for half maximal activation of metabotropic glutamate mGluR5a in ratMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/31/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMetabotropic glutamate receptor 5(Human)
University of Perugia

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 17657BDBM17657(L-Glutamic acid | L-Glu | (2S)-2-aminopentanedioic...)
Affinity DataKi:  1.14E+4nMAssay Description:Agonist potency against cloned metabotropic glutamate receptor 5More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/15/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMetabotropic glutamate receptor 5(Human)
University of Perugia

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 17657BDBM17657(L-Glutamic acid | L-Glu | (2S)-2-aminopentanedioic...)
Affinity DataEC50:  1.60E+4nMAssay Description:Agonist activity at mGlu5 receptor (unknown origin) expressed in CHO cells assessed as increase in Gq-mediated PI hydrolysis after 45 mins by yttrium...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)