Compile Data Set for Download or QSAR
Report error Found 8 Enz. Inhib. hit(s) for PDB: 9W4T
LigandChemical structure of BindingDB Monomer ID 20510BDBM20510(AMG9810 | (2E)-3-(4-tert-butylphenyl)-N-(2,3-dihyd...)
Affinity DataIC50: 25nMAssay Description:Antagonist activity at human TRPV1 expressed in CHO cells assessed as blockade of capsaicin-induced receptor activation by [45Ca2+] uptake assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandChemical structure of BindingDB Monomer ID 20510BDBM20510(AMG9810 | (2E)-3-(4-tert-butylphenyl)-N-(2,3-dihyd...)
Affinity DataIC50: 79nMpH: 7.4 T: 2°CAssay Description:TRPV1 activities were monitored as a function of cellular uptake of radioactive calcium (45Ca2+). The test compounds were preincubated with TRPV1 exp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2008
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandChemical structure of BindingDB Monomer ID 20510BDBM20510(AMG9810 | (2E)-3-(4-tert-butylphenyl)-N-(2,3-dihyd...)
Affinity DataIC50: 86nMAssay Description:Antagonist activity at rat TRPV1 expressed in CHO cells assessed as blockade of capsaicin-induced receptor activation by [45Ca2+] uptake assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandChemical structure of BindingDB Monomer ID 20510BDBM20510(AMG9810 | (2E)-3-(4-tert-butylphenyl)-N-(2,3-dihyd...)
Affinity DataIC50: 93nMAssay Description:Antagonist activity at human TRPV1 expressed in CHO cells assessed as blockade of acid-induced receptor activation by [45Ca2+] uptake assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandChemical structure of BindingDB Monomer ID 20510BDBM20510(AMG9810 | (2E)-3-(4-tert-butylphenyl)-N-(2,3-dihyd...)
Affinity DataIC50: 294nMAssay Description:Antagonist activity at rat TRPV1 expressed in CHO cells assessed as blockade of acid-induced receptor activation by [45Ca2+] uptake assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandChemical structure of BindingDB Monomer ID 20510BDBM20510(AMG9810 | (2E)-3-(4-tert-butylphenyl)-N-(2,3-dihyd...)
Affinity DataIC50: 350nMAssay Description:TRPV1 activities were monitored as a function of cellular uptake of radioactive calcium (45Ca2+). The test compounds were preincubated with TRPV1 exp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2008
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandChemical structure of BindingDB Monomer ID 20510BDBM20510(AMG9810 | (2E)-3-(4-tert-butylphenyl)-N-(2,3-dihyd...)
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibition of capsaicin-induced calcium uptake by transient receptor potential vanilloid type 1 expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandChemical structure of BindingDB Monomer ID 20510BDBM20510(AMG9810 | (2E)-3-(4-tert-butylphenyl)-N-(2,3-dihyd...)
Affinity DataIC50: 3.20E+3nMAssay Description:Inhibition of pH-induced calcium uptake by transient receptor potential vanilloid type 1 expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)