Compile Data Set for Download or QSAR
Report error Found 5 Enz. Inhib. hit(s) for PDB: 9S18
TargetBifunctional 3'-5' exonuclease/ATP-dependent helicase WRN(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 646442BDBM646442(US11878973, Example 123)
Affinity DataIC50: 30nMAssay Description:Inhibition of N-terminal GST-tagged WRN (500 to 946 residues) (unknown origin) expressed in Escherichia coli BL21 cells preincubated with compound fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetBifunctional 3'-5' exonuclease/ATP-dependent helicase WRN(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 646442BDBM646442(US11878973, Example 123)
Affinity DataIC50: 31nMAssay Description:Inhibition of N-terminal GST-tagged WRN (500 to 946 residues) (unknown origin) expressed in Escherichia coli BL21 cells preincubated with compound fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetBifunctional 3'-5' exonuclease/ATP-dependent helicase WRN(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 646442BDBM646442(US11878973, Example 123)
Affinity DataIC50: 88nMAssay Description:Inhibition of N-terminal FLAG-tagged human full length WRN expressed in baculovirus-infected Sf9 cells assessed as inhibition of ATPase activity usin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMedPDB3D3D Structure (crystal)
LigandChemical structure of BindingDB Monomer ID 646442BDBM646442(US11878973, Example 123)
Affinity DataIC50: 100nMAssay Description:The core helicase motif of the WRN protein (aa N517-P1238) was produced for this assay (protein production as described above). A 45 oligonucleotide ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/14/2024
Entry Details
US Patent
PDB3D3D Structure (crystal)
TargetBifunctional 3'-5' exonuclease/ATP-dependent helicase WRN(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 646442BDBM646442(US11878973, Example 123)
Affinity DataIC50: 100nMAssay Description:Inhibition of N-terminal Hexa-histidine-tagged human recombinant WRN helicase domain (517 to 945 residues) extracted from Baculovirus infected Sf9 ce...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMedPDB3D3D Structure (crystal)