Compile Data Set for Download or QSAR
Report error Found 28 Enz. Inhib. hit(s) for PDB: 9R42
TargetD(3) dopamine receptor(Human)
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Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 84637BDBM84637(NSC_54562 | CHEMBL240773 | QUINPIROLE | CAS_85760-...)
Affinity DataKi:  0.410nMAssay Description:Displacement of [3H]spiroperidol from cloned human dopamine receptor D3 in CHO cell membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetD(3) dopamine receptor(Human)
Università

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 84637BDBM84637(NSC_54562 | CHEMBL240773 | QUINPIROLE | CAS_85760-...)
Affinity DataEC50:  1.40nMAssay Description:Effective concentration in [3H]thymidine uptake assay by CHO dhfr- mutant cells expressing human D3 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetD(3) dopamine receptor(Human)
Università

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 84637BDBM84637(NSC_54562 | CHEMBL240773 | QUINPIROLE | CAS_85760-...)
Affinity DataEC50:  1.40nMAssay Description:Agonist activity at human dopamine D3 receptor expressed in dhfr-deficient CHO cells assessed as [3H]thymidine incorporationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetD(3) dopamine receptor(Human)
Università

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 84637BDBM84637(NSC_54562 | CHEMBL240773 | QUINPIROLE | CAS_85760-...)
Affinity DataEC50:  1.70nMAssay Description:Effective concentration was determined as thymidine uptake in CHO-L6 cells transfected with the rat Dopamine receptor D3 by mitogenesis assay (intrin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/15/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetD(3) dopamine receptor(Human)
Università

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 84637BDBM84637(NSC_54562 | CHEMBL240773 | QUINPIROLE | CAS_85760-...)
Affinity DataEC50:  2.10nMAssay Description:Intrinsic activity at human D3 receptor expressed in CHO dhfr- cells by [3H]thymidine incorporation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetD(3) dopamine receptor(Human)
Università

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 84637BDBM84637(NSC_54562 | CHEMBL240773 | QUINPIROLE | CAS_85760-...)
Affinity DataEC50:  2.60nMAssay Description:Effective concentration to stimulate human Dopamine receptor D3 mediated [3H]-thymidine incorporation into growing cells using mitogenesis assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetD(3) dopamine receptor(Human)
Università

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 84637BDBM84637(NSC_54562 | CHEMBL240773 | QUINPIROLE | CAS_85760-...)
Affinity DataEC50:  2.60nMAssay Description:Effective concentration against dopamine D3 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetD(3) dopamine receptor(Human)
Università

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 84637BDBM84637(NSC_54562 | CHEMBL240773 | QUINPIROLE | CAS_85760-...)
Affinity DataEC50:  2.60nMAssay Description:Intrinsic activity at human D3 receptor expressed in CHO dhfr- cells assessed as rate of [3H]thymidine incorporation by mitogenesis assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetD(3) dopamine receptor(Human)
Università

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 84637BDBM84637(NSC_54562 | CHEMBL240773 | QUINPIROLE | CAS_85760-...)
Affinity DataEC50:  2.90nMAssay Description:Intrinsic activity at human D3 receptor expressed in CHO dhfr- cells assessed as inhibition of forskolin-induced cAMP releaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetD(3) dopamine receptor(Human)
Università

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 84637BDBM84637(NSC_54562 | CHEMBL240773 | QUINPIROLE | CAS_85760-...)
Affinity DataEC50:  3.10nMAssay Description:Intrinsic activity in mitogenesis assay using Dopamine receptor D3 expressing CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetD(3) dopamine receptor(Human)
Università

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 84637BDBM84637(NSC_54562 | CHEMBL240773 | QUINPIROLE | CAS_85760-...)
Affinity DataEC50:  3.40nMAssay Description:Intrinsic activity against dopamine D3 receptor assessed as [3H]thymidine uptake in CHO cells by mitogenesis assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetD(3) dopamine receptor(Human)
Università

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 84637BDBM84637(NSC_54562 | CHEMBL240773 | QUINPIROLE | CAS_85760-...)
Affinity DataEC50:  5.20nMAssay Description:Agonist activity at human dopamine D3 receptor expressed in CHO dhfr mutant cells assessed as stimulation of mitogenesis after 4 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetD(3) dopamine receptor(Human)
Università

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 84637BDBM84637(NSC_54562 | CHEMBL240773 | QUINPIROLE | CAS_85760-...)
Affinity DataEC50:  8.40nMAssay Description:Agonist activity at human dopamine D3 receptor expressed in CHOp cells assessed as stimulation of mitogenesis incubated for 24 hrs by [3H]thymidine i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetD(3) dopamine receptor(Human)
Università

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 84637BDBM84637(NSC_54562 | CHEMBL240773 | QUINPIROLE | CAS_85760-...)
Affinity DataKi:  12.5nMAssay Description:Displacement of [3H]spiroperidol from human cloned dopamine D3 receptor by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetD(3) dopamine receptor(Human)
Università

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 84637BDBM84637(NSC_54562 | CHEMBL240773 | QUINPIROLE | CAS_85760-...)
Affinity DataKi:  15nMAssay Description:Displacement of [3H]spiperone from human dopamine D3 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetD(3) dopamine receptor(Human)
Università

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 84637BDBM84637(NSC_54562 | CHEMBL240773 | QUINPIROLE | CAS_85760-...)
Affinity DataKi:  17nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/3/2012
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetD(3) dopamine receptor(Human)
Università

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 84637BDBM84637(NSC_54562 | CHEMBL240773 | QUINPIROLE | CAS_85760-...)
Affinity DataKi:  24nMAssay Description:In vitro for its ability to displace [3H]- spiperone from cloned human Dopamine receptor D3 expressed in CHO cells; high binding affinityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetD(3) dopamine receptor(Human)
Università

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 84637BDBM84637(NSC_54562 | CHEMBL240773 | QUINPIROLE | CAS_85760-...)
Affinity DataKi:  24nMAssay Description:In vitro binding affinity to displace [3H]spiperone from the cloned human dopamine receptor D3 in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetD(3) dopamine receptor(Human)
Università

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 84637BDBM84637(NSC_54562 | CHEMBL240773 | QUINPIROLE | CAS_85760-...)
Affinity DataKi:  24nMAssay Description:High binding affinity towards human dopamine receptor 3 expressed in Chinese hamster ovary cells using [3H]spiperone (0.5 nM) as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetD(3) dopamine receptor(Human)
Università

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 84637BDBM84637(NSC_54562 | CHEMBL240773 | QUINPIROLE | CAS_85760-...)
Affinity DataKi:  24nMAssay Description:High inhibition constant against [3H]spiperone binding to human Dopamine receptor D3 expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetD(3) dopamine receptor(Human)
Università

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 84637BDBM84637(NSC_54562 | CHEMBL240773 | QUINPIROLE | CAS_85760-...)
Affinity DataKi:  39nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2011
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetD(3) dopamine receptor(Human)
Università

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 84637BDBM84637(NSC_54562 | CHEMBL240773 | QUINPIROLE | CAS_85760-...)
Affinity DataKi:  41.7nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/13/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetD(3) dopamine receptor(Human)
Università

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 84637BDBM84637(NSC_54562 | CHEMBL240773 | QUINPIROLE | CAS_85760-...)
Affinity DataKi:  43nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2012
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetD(3) dopamine receptor(Human)
Università

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 84637BDBM84637(NSC_54562 | CHEMBL240773 | QUINPIROLE | CAS_85760-...)
Affinity DataKi:  43nMAssay Description:Displacement of [3H]YM-09151-2 from human dopamine D3 receptor expressed in CHOp cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetD(3) dopamine receptor(Human)
Università

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 84637BDBM84637(NSC_54562 | CHEMBL240773 | QUINPIROLE | CAS_85760-...)
Affinity DataKi:  49nMAssay Description:Displacement of [3H]spiperone from human cloned dopamine D3 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2010
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetD(3) dopamine receptor(Human)
Università

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 84637BDBM84637(NSC_54562 | CHEMBL240773 | QUINPIROLE | CAS_85760-...)
Affinity DataKi:  420nMAssay Description:Low inhibition constant against [3H]spiperone binding to human Dopamine receptor D3 expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetD(3) dopamine receptor(Human)
Università

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 84637BDBM84637(NSC_54562 | CHEMBL240773 | QUINPIROLE | CAS_85760-...)
Affinity DataKi:  420nMAssay Description:Low binding affinity towards human dopamine receptor 3 expressed in Chinese hamster ovary cells using [3H]spiperone (0.5 nM) as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetD(3) dopamine receptor(Human)
Università

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 84637BDBM84637(NSC_54562 | CHEMBL240773 | QUINPIROLE | CAS_85760-...)
Affinity DataKi:  420nMAssay Description:In vitro for its ability to displace [3H]- spiperoneI from cloned human Dopamine receptor D3 expressed in CHO cells; Low binding affinityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)