Compile Data Set for Download or QSAR
Report error Found 33 Enz. Inhib. hit(s) for PDB: 9LL8
Target5-hydroxytryptamine receptor 2A(Human)
Usona Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50081701BDBM50081701(4-hydroxy-N,N-dimethyltryptamine | N,N-dimethyl-4-...)
Affinity DataEC50:  4.30nMAssay Description:Agonist activity at human 5-HT2A receptor expressed in Flp-In T-REx 293 cells assessed as induction of Gq-mediated calcium flux incubated for 1 hr by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
Target5-hydroxytryptamine receptor 2A(Human)
Usona Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50081701BDBM50081701(4-hydroxy-N,N-dimethyltryptamine | N,N-dimethyl-4-...)
Affinity DataEC50:  4.30nMAssay Description:Agonist activity at human 5-HT2A receptor expressed in Flp-In T-REx 293 cells assessed as induction of Gq-mediated calcium flux incubated for 1 hr by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
Target5-hydroxytryptamine receptor 2A(Human)
Usona Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50081701BDBM50081701(4-hydroxy-N,N-dimethyltryptamine | N,N-dimethyl-4-...)
Affinity DataEC50:  6.5nMAssay Description:Agonist activity at 5-HT2A receptor (unknown origin) by calcium flux assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMedPDB3D3D Structure (crystal)
Target5-hydroxytryptamine receptor 2A(Human)
Usona Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50081701BDBM50081701(4-hydroxy-N,N-dimethyltryptamine | N,N-dimethyl-4-...)
Affinity DataEC50:  6.5nMAssay Description:Agonist activity at 5HT2A receptor (unknown origin) expressed in HEK293 cells by FLIPR calcium flux assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
Target5-hydroxytryptamine receptor 2A(Human)
Usona Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50081701BDBM50081701(4-hydroxy-N,N-dimethyltryptamine | N,N-dimethyl-4-...)
Affinity DataIC50: 8.30nMAssay Description:Modulation of human 5HT2A expressed in HEK293T cells co-transfected with Galphaq-RLuc8, Ggamma1-GFP2 and Gbeta1 assessed as dissociation of Galphaq f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMedPDB3D3D Structure (crystal)
Target5-hydroxytryptamine receptor 2A(Mouse)
Usona Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50081701BDBM50081701(4-hydroxy-N,N-dimethyltryptamine | N,N-dimethyl-4-...)
Affinity DataEC50:  9.80nMAssay Description:Agonist activity at mouse 5-HT2A receptor expressed in Flp-In T-REx 293 cells assessed as induction of Gq-mediated calcium flux incubated for 1 hr by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
Target5-hydroxytryptamine receptor 2A(Mouse)
Usona Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50081701BDBM50081701(4-hydroxy-N,N-dimethyltryptamine | N,N-dimethyl-4-...)
Affinity DataEC50:  9.90nMAssay Description:Agonist activity at mouse 5-HT2A receptor expressed in Flp-In T-REx 293 cells assessed as induction of Gq-mediated calcium flux incubated for 1 hr by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
Target5-hydroxytryptamine receptor 2A(Rat)
Stanford University

Curated by PDSP Ki Database
LigandChemical structure of BindingDB Monomer ID 50081701BDBM50081701(4-hydroxy-N,N-dimethyltryptamine | N,N-dimethyl-4-...)
Affinity DataKi:  12nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2011
Entry Details
PubMedPDB3D3D Structure (crystal)
Target5-hydroxytryptamine receptor 2A(Human)
Usona Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50081701BDBM50081701(4-hydroxy-N,N-dimethyltryptamine | N,N-dimethyl-4-...)
Affinity DataEC50:  21nMAssay Description:Data from pone.0009019.s006.doc, supplement tables.More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
Target5-hydroxytryptamine receptor 2A(Human)
Usona Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50081701BDBM50081701(4-hydroxy-N,N-dimethyltryptamine | N,N-dimethyl-4-...)
Affinity DataEC50:  24nMAssay Description:Effective concentration required for accumulation of [3H]inositol phosphate in cells stably expressing human 5-hydroxytryptamine 2A receptor determin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
Target5-hydroxytryptamine receptor 2A(Rat)
Stanford University

Curated by PDSP Ki Database
LigandChemical structure of BindingDB Monomer ID 50081701BDBM50081701(4-hydroxy-N,N-dimethyltryptamine | N,N-dimethyl-4-...)
Affinity DataKi:  25nMAssay Description:In vitro binding to 5-hydroxytryptamine 2A receptor using [125 I]-DOIMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
Target5-hydroxytryptamine receptor 2A(Human)
Usona Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50081701BDBM50081701(4-hydroxy-N,N-dimethyltryptamine | N,N-dimethyl-4-...)
Affinity DataEC50:  25.5nMAssay Description:Data from pone.0009019.s006.doc, supplement tables.More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
Target5-hydroxytryptamine receptor 2A(Human)
Usona Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50081701BDBM50081701(4-hydroxy-N,N-dimethyltryptamine | N,N-dimethyl-4-...)
Affinity DataKi:  58.6nMAssay Description:5-HT2A Receptor Radioligand Binding. Affinity of the test compounds for the 5-HT2A receptor was determined in radioligand binding experiments with [3...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2024
Entry Details
US Patent
PDB3D3D Structure (crystal)
Target5-hydroxytryptamine receptor 2A(Human)
Usona Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50081701BDBM50081701(4-hydroxy-N,N-dimethyltryptamine | N,N-dimethyl-4-...)
Affinity DataEC50:  75nMAssay Description:Displacement of [3H]-ketanserin from human 5-HT2A receptor incubated for 90 mins by scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
Target5-hydroxytryptamine receptor 2A(Human)
Usona Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50081701BDBM50081701(4-hydroxy-N,N-dimethyltryptamine | N,N-dimethyl-4-...)
Affinity DataEC50:  75nMAssay Description:Displacement of [3H]-ketanserin from human 5-HT2A receptor incubated for 90 mins by scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
Target5-hydroxytryptamine receptor 2A(Human)
Usona Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50081701BDBM50081701(4-hydroxy-N,N-dimethyltryptamine | N,N-dimethyl-4-...)
Affinity DataKi:  107nMAssay Description:Inhibition of 5-HT2AR (unknown origin ) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
Target5-hydroxytryptamine receptor 2A(Human)
Usona Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50081701BDBM50081701(4-hydroxy-N,N-dimethyltryptamine | N,N-dimethyl-4-...)
Affinity DataIC50: 112nMAssay Description:1. Culture the cells in cell culture medium (DMEM containing 10% FBS 1× penicillin-streptomycin 300 μg/ml G418 and 100 μg/ml hygromycin B) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/14/2023
Entry Details
US Patent
PDB3D3D Structure (crystal)
Target5-hydroxytryptamine receptor 2A(Human)
Usona Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50081701BDBM50081701(4-hydroxy-N,N-dimethyltryptamine | N,N-dimethyl-4-...)
Affinity DataEC50:  162nMAssay Description:Data from pone.0009019.s006.doc, supplement tables.More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
Target5-hydroxytryptamine receptor 2A(Rat)
Stanford University

Curated by PDSP Ki Database
LigandChemical structure of BindingDB Monomer ID 50081701BDBM50081701(4-hydroxy-N,N-dimethyltryptamine | N,N-dimethyl-4-...)
Affinity DataKi:  323nMAssay Description:Displacement of [3H]MDL100907 from 5HT2A receptor in Sprague-Dawley rat brain by liquid scintillation spectroscopyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMedPDB3D3D Structure (crystal)
Target5-hydroxytryptamine receptor 2A(Human)
Usona Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50081701BDBM50081701(4-hydroxy-N,N-dimethyltryptamine | N,N-dimethyl-4-...)
Affinity DataKi:  340nMAssay Description:Table S2 shows raw Ki data for the current study combined with data collected from the literature for the ten additional compounds.More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
Target5-hydroxytryptamine receptor 2A(Human)
Usona Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50081701BDBM50081701(4-hydroxy-N,N-dimethyltryptamine | N,N-dimethyl-4-...)
Affinity DataKi:  340nMAssay Description:The binding affinities shown in table 5 of psilocin and compound 8 at various monoaminergic receptors were determined in radioligand competition bind...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2023
Entry Details
US Patent
PDB3D3D Structure (crystal)
Target5-hydroxytryptamine receptor 2A(Human)
Usona Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50081701BDBM50081701(4-hydroxy-N,N-dimethyltryptamine | N,N-dimethyl-4-...)
Affinity DataIC50: 352nMAssay Description:1. Culture the cells in cell culture medium (DMEM containing 10% FBS 1× penicillin-streptomycin 300 μg/ml G418 and 100 μg/ml hygromycin B) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/14/2023
Entry Details
US Patent
PDB3D3D Structure (crystal)
Target5-hydroxytryptamine receptor 2A(Rat)
Stanford University

Curated by PDSP Ki Database
LigandChemical structure of BindingDB Monomer ID 50081701BDBM50081701(4-hydroxy-N,N-dimethyltryptamine | N,N-dimethyl-4-...)
Affinity DataKi:  390nMAssay Description:Compound was tested for binding affinity using [3H]MDL-100,907 at 5-hydroxytryptamine 2A receptor sites in rat cortical homogenate.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
Target5-hydroxytryptamine receptor 2A(Human)
Usona Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50081701BDBM50081701(4-hydroxy-N,N-dimethyltryptamine | N,N-dimethyl-4-...)
Affinity DataIC50: 500nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2023
Entry Details
US Patent
PDB3D3D Structure (crystal)
Target5-hydroxytryptamine receptor 2A(Human)
Usona Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50081701BDBM50081701(4-hydroxy-N,N-dimethyltryptamine | N,N-dimethyl-4-...)
Affinity DataIC50: 500nMAssay Description:i. Prepare the assay buffer following the table below;Reagent ConcentrationTris 50 mMCaCl2  4 mMBSA 0.1% (w/v)Adjust pH to 7.4 followed by 0.2 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2022
Entry Details
US Patent
PDB3D3D Structure (crystal)
Target5-hydroxytryptamine receptor 2A(Human)
Usona Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50081701BDBM50081701(4-hydroxy-N,N-dimethyltryptamine | N,N-dimethyl-4-...)
Affinity DataIC50: 500nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2023
Entry Details
US Patent
PDB3D3D Structure (crystal)
Target5-hydroxytryptamine receptor 2A(Human)
Usona Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50081701BDBM50081701(4-hydroxy-N,N-dimethyltryptamine | N,N-dimethyl-4-...)
Affinity DataIC50: 500nMAssay Description:Table 2: i. Prepare the assay buffer following the table below;Reagent ConcentrationTris 50 mMCaCl2  4 mMBSA 0.1% (w/v)Adjust pH to 7.4 followe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2022
Entry Details
US Patent
PDB3D3D Structure (crystal)
Target5-hydroxytryptamine receptor 2A(Human)
Usona Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50081701BDBM50081701(4-hydroxy-N,N-dimethyltryptamine | N,N-dimethyl-4-...)
Affinity DataIC50: 500nMAssay Description:Table 2: i. Prepare the assay buffer following the table below;Reagent ConcentrationTris 50 mMCaCl2  4 mMBSA 0.1% (w/v)Adjust pH to 7.4 followe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2022
Entry Details
US Patent
PDB3D3D Structure (crystal)
Target5-hydroxytryptamine receptor 2A(Human)
Usona Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50081701BDBM50081701(4-hydroxy-N,N-dimethyltryptamine | N,N-dimethyl-4-...)
Affinity DataEC50: <1.00E+3nMAssay Description:Agonist activity at human 5-HT2A receptor expressed in cells assessed as increase in calcium mobilization by Calcium-6 dye based FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
Target5-hydroxytryptamine receptor 2A(Human)
Usona Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50081701BDBM50081701(4-hydroxy-N,N-dimethyltryptamine | N,N-dimethyl-4-...)
Affinity DataIC50: 1.00E+3nMAssay Description:Adjust pH to 7.4 followed by 0.2 μM sterile filtration ii. 8 doses of reference and exemplary test compounds were prepared starting from 10 mM s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2024
Entry Details
US Patent
PDB3D3D Structure (crystal)
Target5-hydroxytryptamine receptor 2A(Human)
Usona Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50081701BDBM50081701(4-hydroxy-N,N-dimethyltryptamine | N,N-dimethyl-4-...)
Affinity DataEC50: <1.00E+3nMAssay Description:Agonist activity at human 5-HT2A receptor assessed as activation of calcium mobilization incubated for 2 mins by Calcium-6 dye based FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
Target5-hydroxytryptamine receptor 2A(Human)
Usona Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50081701BDBM50081701(4-hydroxy-N,N-dimethyltryptamine | N,N-dimethyl-4-...)
Affinity DataEC50: <1.00E+3nMAssay Description:i. Prepare the assay buffer following the table below;Reagent ConcentrationTris 50 mMCaCl2  4 mMBSA 0.1% (w/v)Adjust pH to 7.4 followed by 0.2 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2022
Entry Details
US Patent
PDB3D3D Structure (crystal)
Target5-hydroxytryptamine receptor 2A(Rat)
Stanford University

Curated by PDSP Ki Database
LigandChemical structure of BindingDB Monomer ID 50081701BDBM50081701(4-hydroxy-N,N-dimethyltryptamine | N,N-dimethyl-4-...)
Affinity DataEC50:  2.30E+3nMAssay Description:Tested for its ability to activate phospholipase C by quantification of IP3 at cloned rat 5-hydroxytryptamine 2A receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)