| Assay Method Information | |
| | 5HT2B Competitive Binding Assay |
| Description: | Competitive binding assay was performed (Eurofins Cerep) using human recombinant 5-HT1A transfected to CHO cells, 1251-DOJ (0.2 nM) and the test compound from Example 1 was tested at 8 concentrations ranging from 0.01 mM to 30 mM, (Choi D S et al. FEBS Letters 1994, 352, 393). The analysis was performed using software developed at Cerep (Hill software) and validated by comparison with data generated by the commercial software SigmaPlot 4.0 for Windows ( 1997 by SPSS Inc). |
| Affinity data for this assay | |
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