| Assay Method Information | |
| | Late stage assay provider results from the probe development effort to identify inhibitors of plasma platelet activating factor acetylhydrolase (pPAFAH) |
| Description: | Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Center Affiliation: The Scripps Research Institute (TSRI) Assay Providers: Brian Bahnson (Univ. of Delaware); Benjamin Cravatt, (TSRI) Network: Molecular Libraries Probe Production Centers Network (MLPCN) Grant Proposal Number: 1R01HL084366 Grant Proposal PI: Brian Bahnson External Assay ID: pPAFAH_INH_FLUO_GELBASEDABPP_3XIC50_HTSHITS Name: Late stage assay provider results from the probe development effort to identify inhibitors of plasma platelet activating factor acetylhydrolase (pPAFAH): fluorescence-based dose response biochemical gel-based competitive Activity-Based Protein Profiling (ABPP) assay for HTS compounds. Description: This project aims to develop specific inhibitors of plasma platelet activating factor acetylhydrolase (pPAFAH), and three associated members of the serine hydrolase family of enzymes-PAFAH2, PAFAH1b2, and PAFAH1b3. pPAFAH, an enzyme linked to the inflammatory |
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