| Assay Method Information | |
| | High throughput fluorescence intensity-based biochemical assay to screen for small molecule inhibitors of Furin:Concentration-response Confirmation Assays |
| Description: | Official Symbol FURIN and Name: furin (paired basic amino acid cleaving enzyme) [Homo sapiens] Other Aliases: FUR, PACE, PCSK3, SPC1 Other Designations: FES upstream region; dibasic processing enzyme; dibasic-processing enzyme; furin; furin, membrane associated receptor protein; paired basic amino acid residue-cleaving enzyme; proprotein convertase subtilisin/kexin type 3 Chromosome: 15; Location: 15q26.1 Annotation: Chromosome 15, NC_000015.9 (91411885..91426687) MIM: 136950 ID: 5045 NCBI Reference Sequence: NM_002569.2 GI:20336193 Extracted from the MH080376 proposal submitted by Dr. Nabil Seidah, IRCM, Montreal, Canada; HTS for targets of proprotein convertases Furin, PC5, SKI-1, and PCSK9 Using Cell-Based Assays Introduction: The mammalian subtilisin-like serine proteases comprise the proprotein convertases (PCs) that are implicated in the limited cellular proteolysis of secretory precursor proteins resulting in a diversity of bioactive products, e.g., through zymogen activat |
| Affinity data for this assay | |
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