| Assay Method Information | |
| | Assay of Cytochrome P450 Induction Activity |
| Description: | Imduction of cytochrome P450 3A4 (CYP3A4) activity in human hepatocytes (male, Caucasian) was assayed by multiple-reaction-montoring LC-MS-MS, using midazolam as CCYP3A4-specific substrate and 1′-hydroxymidazolam as CYP3A4-specific product, essentially as described [Rhodes, S., Otten, J., Hingorani, G., Hartley, D., Franklin, R. (2011) J. Pharmacol. Toxicol. Meths. 63, 223-226]. |
| Affinity data for this assay | |
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