Reaction Details Report a problem with these data
Target
Translocator protein
Ligand
BDBM22032
Substrate
n/a
Meas. Tech.
ChEMBL_37218 (CHEMBL651678)
IC50
2.2±n/a nM
Citation
 Cappelli, A; Anzini, M; Vomero, S; De Benedetti, PG; Menziani, MC; Giorgi, G; Manzoni, C Mapping the peripheral benzodiazepine receptor binding site by conformationally restrained derivatives of 1-(2-chlorophenyl)-N-methyl-N-(1-methylpropyl)-3- isoquinolinecarboxamide (PK11195). J Med Chem 40:2910-21 (1997) [PubMed]  Article 
Target
Name:
Translocator protein
Synonyms:
PKBS | Peripheral benzodiazepine receptor (PBR) | PBR | Mitochondrial benzodiazepine receptor | TSPO_RAT | Tspo | Bzrp | Mbr | Benzodiazepine receptors; peripheral & central | Peripheral-Type Benzodiazepine Receptor
Type:
Mitochondrion membrane protein
Mol. Mass.:
18945.84
Organism:
Rat
Description:
Competitive binding experiments were performed on rat kidney mitochondrial membranes.
Residue:
169
Sequence:
MSQSWVPAVGLTLVPSLGGFMGAYFVRGEGLRWYASLQKPSWHPPRWTLAPIWGTLYSAMGYGSYIIWKELGGFTEEAMVPLGLYTGQLALNWAWPPIFFGARQMGWALVDLMLVSGVATATTLAWHRVSPPAARLLYPYLAWLAFATMLNYYVWRDNSGRRGGSRLTE
  
Inhibitor
Name:
BDBM22032
Synonyms:
PK 11195 | PK11195 | RP 52028 | N-(butan-2-yl)-1-(2-chlorophenyl)-N-methylisoquinoline-3-carboxamide | PK-11195 | CHEMBL15313 | 1-(2-chlorophenyl)-N-methyl-N-(1-methylpropyl)isoquinoline-3-carboxamide | [3H]PK 11195
Type:
radiolabeled ligand
Emp. Form.:
C21H21ClN2O
Mol. Mass.:
352.13
SMILES:
CC[C@@H](C)N(C)C(=O)c1cc2ccccc2c(n1)c3ccccc3Cl
Structure:
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