Reaction Details Report a problem with these data
Target
Bcl-2-related protein A1
Ligand
BDBM32262
Substrate
FITC-conjugated-Bim BH3 Peptide
Meas. Tech.
Multiplexed dose response screen for small molecule regulators of Bcl-2 family protein interactions, specifically Bim-Bfl-1.
pH
7.4000±n/a
Temperature
277.1500±n/a K
EC50
22730±n/a nM
Citation
 PubChem, PC Multiplexed dose response screen for small molecule regulators of Bcl-2 family protein interactions, specifically Bim-Bfl-1. PubChem Bioassay (2008)[AID] 
Target
Name:
Bcl-2-related protein A1
Synonyms:
Protein BFL-1 | Bcl-2-like protein 5 | Protein GRS | Hemopoietic-specific early response protein | B2LA1_HUMAN | BCL2A1 | BCL2L5 | BFL1 | GRS | HBPA1
Type:
Apoptosis regulator protein
Mol. Mass.:
20130.01
Organism:
Human
Description:
n/a
Residue:
175
Sequence:
MTDCEFGYIYRLAQDYLQCVLQIPQPGSGPSKTSRVLQNVAFSVQKEVEKNLKSCLDNVNVVSVDTARTLFNQVMEKEFEDGIINWGRIVTIFAFEGILIKKLLRQQIAPDVDTYKEISYFVAEFIMNNTGEWIRQNGGWENGFVKKFEPKSGWMTFLEVTGKICEMLSLLKQYC
  
Inhibitor
Name:
BDBM32262
Synonyms:
SMR000046397 | 8-methyl-3-methylsulfanyl-5-(phenylmethyl)-[1,2,4]triazino[5,6-b]indole | 5-benzyl-8-methyl-3-methylsulfanyl-[1,2,4]triazino[5,6-b]indole | 8-methyl-3-(methylthio)-5-(phenylmethyl)-[1,2,4]triazino[5,6-b]indole | MLS000042505 | cid_6400963 | 5-benzyl-8-methyl-3-(methylthio)-[1,2,4]triazin[5,6-b]indole
Type:
Small organic molecule
Emp. Form.:
C18H16N4S
Mol. Mass.:
320.11
SMILES:
CSc1nnc2c3cc(C)ccc3n(Cc3ccccc3)c2n1
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
FITC-conjugated-Bim BH3 Peptide
Synonyms:
FITC-Ahx-DMRPEIWIAQELRRIGDEFNAYYAR-OH
Type:
FITC-labeled Peptide
Mol. Mass.:
3112.46
Organism:
n/a
Description:
n/a
Residue:
25
Sequence:
DMRPEIWIAQELRRIGDEFNAYYAR