Reaction Details  Report a problem with these data
Cell Reactant:
3-phosphoinositide dependent protein kinase-1
Syringe Reactant:
BDBM50433916
Meas. Tech.:
Enzyme Inhibition
Entry Date.:
2016-11-02
ΔG°:
-8.38±n/a (kcal/mole)
Log10Kb:
4.3
Temperature:
310.0000±0.0000 (K)
ΔH° :
-1.2±0.07 (kJ/mole)
ΔS° :
0.02±0 (kJ/mole-K)
Citation
 Schulze, JO; Saladino, G; Busschots, K; Neimanis, S; Süß, E; Odadzic, D; Zeuzem, S; Hindie, V; Herbrand, AK; Lisa, MN; Alzari, PM; Gervasio, FL; Biondi, RM Bidirectional Allosteric Communication between the ATP-Binding Site and the Regulatory PIF Pocket in PDK1 Protein Kinase. Cell Chem Biol 23:1193-1205 (2016) [PubMed]  Article 
Cell React
Name:
3-phosphoinositide-dependent protein kinase 1
Synonyms:
3-Phosphoinositide-Dependent Protein Kinase 1 (PDK1) | 3-phosphoinositide-dependent protein kinase 1 | 3-phosphoinositide-dependent protein kinase 1 (PDK) | 3-phosphoinositide-dependent protein kinase 1 (PDK-1) | 3-phosphoinositide-dependent protein kinase 1 (PDK1)( 1-50) | Isoform 2 of 3-phosphoinositide-dependent protein kinase 1 | Phosphoinositide-dependent protein kinase 1 (PDK1) | Pyruvate dehydrogenase kinase isoenzyme 1 (PDK1) | hPDK1 | PDPK1_HUMAN | PDPK1 | PDK1 | 3-phosphoinositide dependent protein kinase-1
Type:
Enzyme
Mol. Mass.:
63157.65
Organism:
Human
Description:
O15530
Residue:
556
Sequence:
MARTTSQLYDAVPIQSSVVLCSCPSPSMVRTQTESSTPPGIPGGSRQGPAMDGTAAEPRPGAGSLQHAQPPPQPRKKRPEDFKFGKILGEGSFSTVVLARELATSREYAIKILEKRHIIKENKVPYVTRERDVMSRLDHPFFVKLYFTFQDDEKLYFGLSYAKNGELLKYIRKIGSFDETCTRFYTAEIVSALEYLHGKGIIHRDLKPENILLNEDMHIQITDFGTAKVLSPESKQARANSFVGTAQYVSPELLTEKSACKSSDLWALGCIIYQLVAGLPPFRAGNEYLIFQKIIKLEYDFPEKFFPKARDLVEKLLVLDATKRLGCEEMEGYGPLKAHPFFESVTWENLHQQTPPKLTAYLPAMSEDDEDCYGNYDNLLSQFGCMQVSSSSSSHSLSASDTGLPQRSGSNIEQYIHDLDSNSFELDLQFSEDEKRLLLEKQAGGNPWHQFVENNLILKMGPVDKRKGLFARRRQLLLTEGPHLYYVDPVNKVLKGEIPWSQELRPEAKNFKTFFVHTPNRTYYLMDPSGNAHKWCRKIQEVWRQRYQSHPDAAVQ
  
Syringe React
Name:
BDBM50433916
Synonyms:
SP-600125 | PS653 ('1,6-dihydrodibenzo[c,d,g]indazol-6-one)
Type:
Small organic molecule
Emp. Form.:
TBD
Mol. Mass.:
TBD
SMILES:
TBD
Structure:
Search PDB for entries with ligand similarity: