Reaction Details 
Report a problem with these data
Report a problem with these dataCell Reactant:
MAP kinase ERK2
Syringe Reactant:
BDBM103302
Meas. Tech.:
Enzyme Inhibition
Entry Date.:
2014-10-22
ΔG°:
-9.1±n/a (kcal/mole)
pH:
7.5000±0.0000
Temperature:
303.1500±0.0000 (K)
ΔH° :
-30.62±0.48 (kJ/mole)
ΔS° :
-0.07±0 (kJ/mole-K)
Citation
Chaikuad, A; Tacconi, EM; Zimmer, J; Liang, Y; Gray, NS; Tarsounas, M; Knapp, S A unique inhibitor binding site in ER K1/2 is associated with slow binding kinetics Nat Chem Biol 10:853-860 (2014) [PubMed] Article More Info.:
Cell React
Name:
Mitogen-activated protein kinase 1
Synonyms:
ERT1 | Extracellular signal-regulated kinase 2 | Extracellular signal-regulated kinase 2 (ERK-2) | Extracellular signal-regulated kinase 2 (ERK2) | MAP Kinase 2/ERK2 | MAPK 2 | Mitogen activated kinase 1 (ERK-2) | Mitogen-activated protein kinase 1 (ERK-2) | Mitogen-activated protein kinase 1 (ERK2) | Mitogen-activated protein kinase 2 | p42-MAPK | MK01_HUMAN | MAPK1 | ERK2 | PRKM1 | PRKM2
Type:
Ser/Thr Protein Kinase
Mol. Mass.:
41392.76
Organism:
Human
Description:
P28482
Residue:
360
Sequence:
MAAAAAAGAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS
Syringe React
Name:
BDBM103302
Synonyms:
SCH772984 | US8546404, 6
Type:
Small organic molecule
Emp. Form.:
TBD
Mol. Mass.:
TBD
SMILES:
TBD
Structure:
