Reaction Details  Report a problem with these data
Cell Reactant:
cAMP-activated global transcriptional regulator CRP
Syringe Reactant:
BDBM10851
Meas. Tech.:
Enzyme Inhibition
Entry Date.:
2013-12-12
ΔG°:
-6.82±0 (kcal/mole)
pH:
7.8000±0.0000
Temperature:
298.1500±0.0000 (K)
ΔH° :
-2.89±0.1 (kJ/mole)
ΔS° :
0.01±0 (kJ/mole-K)
Comments:
CAP H160L first cAMP binding site
Citation
 Rodgers, TL; Townsend, PD; Burnell, D; Jones, ML; Richards, SA; McLeish, TC; Pohl, E; Wilson, MR; Cann, MJ Modulation of global low-frequency motions underlies allosteric regulation: demonstration in CRP/FNR family transcription factors. PLoS Biol 11:1-15 (2013) [PubMed]  Article
Cell React
Name:
cAMP-activated global transcriptional regulator CRP
Synonyms:
n/a
Type:
n/a
Mol. Mass.:
23514.00
Organism:
Escherichia coli
Description:
n/a
Residue:
209
Sequence:
VLGKPQTDPTLEWFLSHCHIHKYPSKSTLIHQGEKAETLYYIVKGSVAVLIKDEEGKEMILSYLNQGDFIGELGLFEEGQERSAWVRAKTACEVAEISYKKFRQLIQVNPDILMRLSAQMARRLQVTSEKVGNLAFLDVTGRIAQTLLNLAKQPDAMTHPDGMQIKITRQEIGQIVGCSRETVGRILKMLEDQNLISAHGKTIVVYGTR
  
Syringe React
Name:
BDBM10851
Synonyms:
(4aR,6R,7R,7aS)-6-(6-amino-9H-purin-9-yl)tetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinine-2,7-diol 2-oxide | cid_23902375 | Cyclic adenosine monophosphate | (4aR,6R,7R,7aS)-6-(6-amino-9H-purin-9-yl)-2,7-dihydroxy-hexahydro-1,3,5,2-furo[3,2-d][1,3,2]dioxaphosphinin-2-one | ADENOSINE-3 ,5 -CYCLIC-MONOPHOSPHATE | cAMP
Type:
Small organic molecule
Emp. Form.:
TBD
Mol. Mass.:
TBD
SMILES:
TBD
Structure:
Search PDB for entries with ligand similarity: