Reaction Details 
Report a problem with these data
Report a problem with these dataCell Reactant:
Trypsin
Syringe Reactant:
BDBM772
Meas. Tech.:
Isothermal Titration Calorimetry
Entry Date.:
2004-06-15
ΔG°:
-6.39±0.07 (kcal/mole)
pH:
8.0000±n/a
Log10Kb:
3.5
Temperature:
310.2500±n/a (K)
ΔH° :
-5.67±0.29 (kJ/mole)
ΔHobs :
-5.67±0.29 (kJ/mole)
Corrected for ΔHioniz:
not known
ΔS° :
0±0 (kJ/mole-K)
Comments:
Data taken from Talhout, R.; Engberts, J. B. F. N. Eur. J. Biochem. 2001, 268, 1554-1560.
Citation
Talhout, R; Villa, A; Mark, AE; Engberts, JB Understanding binding affinity: a combined isothermal titration calorimetry/molecular dynamics study of the binding of a series of hydrophobically modified benzamidinium chloride inhibitors to trypsin. J Am Chem Soc 125:10570-9 (2003) [PubMed] ArticleCell React
Source:
no
Name:
Serine protease 1
Synonyms:
Trypsin | Cationic trypsin | Beta-Trypsin | Trypsin I | TRY1_BOVIN | PRSS1 | TRP1 | TRY1 | TRYP1
Type:
Enzyme
Mol. Mass.:
25790.52
Organism:
Bovine
Description:
P00760
Residue:
246
Sequence:
MKTFIFLALLGAAVAFPVDDDDKIVGGYTCGANTVPYQVSLNSGYHFCGGSLINSQWVVSAAHCYKSGIQVRLGEDNINVVEGNEQFISASKSIVHPSYNSNTLNNDIMLIKLKSAASLNSRVASISLPTSCASAGTQCLISGWGNTKSSGTSYPDVLKCLKAPILSDSSCKSAYPGQITSNMFCAGYLEGGKDSCQGDSGGPVVCSGKLQGIVSWGSGCAQKNKPGVYTKVCNYVSWIKQTIASN
Syringe React
Source:
Synthesized
Name:
BDBM772
Synonyms:
Benzamidine | benzamidine deriv. | [amino(phenyl)methylidene]azanium | CHEMBL79897 | benzamidinium chloride
Type:
n/a
Emp. Form.:
TBD
Mol. Mass.:
TBD
SMILES:
TBD
Structure:
