Reaction Details  Report a problem with these data
Cell Reactant:
v-Src SH2 Domain
Syringe Reactant:
BDBM22596
Meas. Tech.:
Isothermal Titration Calorimetry
Entry Date.:
2008-06-14
ΔG°:
-39.9000±n/a (kJ/mole)
pH:
6.0000±n/a
Log10Kb:
6
Temperature:
298.1500±n/a (K)
ΔHobs :
-34.8000±0.1500 (kJ/mole)
Corrected for ΔHioniz:
no
ΔS° :
0.0171±n/a (kJ/mole-K)
Citation
 Taylor, JD; Gilbert, PJ; Williams, MA; Pitt, WR; Ladbury, JE Identification of novel fragment compounds targeted against the pY pocket of v-Src SH2 by computational and NMR screening and thermodynamic evaluation. Proteins 67:981-90 (2007) [PubMed]  Article
Cell React
Name:
Tyrosine-protein kinase transforming protein Src
Synonyms:
p60-Src | v-Src SH2 Domain | SRC_RSVSA | V-SRC
Type:
SH2 Domain
Mol. Mass.:
58884.32
Organism:
RSV-SR-A
Description:
P00524
Residue:
526
Sequence:
MGSSKSKPKDPSQRRRSLEPPDSTHHGGFPASQTPNKTAAPDTHRTPSRSFGTVATEPKLFGGFNTSDTVTSPQRAGALAGGVTTFVALYDYESWIETDLSFKKGERLQIVNNTEGNWWLAHSLTTGQTGYIPSNYVAPSDSIQAEEWYFGKITRRESERLLLNPENPRGTFLVRESETTKGAYCLSVSDFDNAKGLNVKHYKIRKLDSGGFYITSRTQFSSLQQLVAYYSKHADGLCHRLTNVCPTSKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEEPIYIVIEYMSKGSLLDFLKGEMGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMGNGEVLDRVERGYRMPCPPECPESLHDLMCQCWRRDPEERPTFEYLQAQLLPACVLEVAE
  
Syringe React
Name:
BDBM22596
Synonyms:
(4S)-4-{[(1S)-1-{[(2S)-1-[(2S)-2-{[(1S)-1-carbamoyl-2-methylbutyl]carbamoyl}pyrrolidin-1-yl]-3-methyl-1-oxopentan-2-yl]carbamoyl}-3-carboxypropyl]carbamoyl}-4-[(2S)-2-[(2S)-2-{[(2S)-1-acetylpyrrolidin-2-yl]formamido}pentanediamido]-3-[4-(phosphonooxy)phenyl]propanamido]butanoic acid | Ac-PQpYEEIPI-NH2
Type:
Phosphotyrosyl peptide
Emp. Form.:
TBD
Mol. Mass.:
TBD
SMILES:
TBD
Structure:
Search PDB for entries with ligand similarity: