Reaction Details  Report a problem with these data
Cell Reactant:
HIV-1 Nef
Syringe Reactant:
BDBM22592
Meas. Tech.:
Isothermal Titration Calorimetry
Entry Date.:
2008-06-14
ΔG°:
-33.3000±n/a (kJ/mole)
pH:
7.0000±n/a
Log10Kb:
5.5
Temperature:
298.1500±n/a (K)
ΔHobs :
-2.3000±0.1700 (kJ/mole)
Corrected for ΔHioniz:
no
Stoich. Param.:
1.2000
ΔS° :
0.1040±n/a (kJ/mole-K)
Citation
 Betzi, S; Restouin, A; Opi, S; Arold, ST; Parrot, I; Guerlesquin, F; Morelli, X; Collette, Y Protein protein interaction inhibition (2P2I) combining high throughput and virtual screening: Application to the HIV-1 Nef protein. Proc Natl Acad Sci U S A 104:19256-61 (2007) [PubMed]  Article
Cell React
Source:
The HIV-1 Nef core domain (residues 57-205) was expressed in Escherichia coli as glutathione S-transferase fusion proteins.
Name:
Protein Nef
Synonyms:
Protein Nef | Negative factor | 3ORF | F-protein | NEF_HV1BR | nef | HIV-1 Nef
Type:
C-terminal core protein
Mol. Mass.:
23340.47
Organism:
HIV-1
Description:
P03406
Residue:
206
Sequence:
MGGKWSKSSVVGWPTVRERMRRAEPAADGVGAASRDLEKHGAITSSNTAATNAACAWLEAQEEEEVGFPVTPQVPLRPMTYKAAVDLSHFLKEKGGLEGLIHSQRRQDILDLWIYHTQGYFPDWQNYTPGPGVRYPLTFGWCYKLVPVEPDKVEEANKGENTSLLHPVSLHGMDDPEREVLEWRFDSRLAFHHVARELHPEYFKNC
  
Syringe React
Name:
BDBM22592
Synonyms:
1-carboxy-7-(dimethylamino)-4-hydroxy-3-oxo-3H-phenoxazin-10-ium chloride | gallocyanine | Compound D12
Type:
Coloring Agent, DNA-interacting Compound
Emp. Form.:
TBD
Mol. Mass.:
TBD
SMILES:
TBD
Structure:
Search PDB for entries with ligand similarity: