Compile Data Set for Download or QSAR
Report error Found 20 Enz. Inhib. hit(s) with all data for entry = 12871
TargetReplicase polyprotein 1ab(2019-nCoV)
Medchemica

WIPO
LigandPNGBDBM736196((4S,4'S)-6-chloro-4,-[(ethylamino)methyl]-1,-(4-is...)
Affinity DataIC50: 1nMAssay Description:The inhibition of the SAR-CoV-2 MPro Enzyme was measured by the method of Mesecar et al.20: The fluorescence of the cleaved FAM peptide (excitation 4...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/28/2025
Entry Details
WIPO WO2025125695

TargetReplicase polyprotein 1ab(2019-nCoV)
Medchemica

WIPO
LigandPNGBDBM736195((4S,4'S)-6-chloro-4,-[(ethylamino)methyl]-1,-(4-is...)
Affinity DataIC50: 1nMAssay Description:The inhibition of the SAR-CoV-2 MPro Enzyme was measured by the method of Mesecar et al.20: The fluorescence of the cleaved FAM peptide (excitation 4...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/28/2025
Entry Details
WIPO WO2025125695

TargetReplicase polyprotein 1ab(2019-nCoV)
Medchemica

WIPO
LigandPNGBDBM736194((4S,4'S)-6-chloro-4,-[(ethylamino)methyl]-1,-(4-is...)
Affinity DataIC50: 1nMAssay Description:The inhibition of the SAR-CoV-2 MPro Enzyme was measured by the method of Mesecar et al.20: The fluorescence of the cleaved FAM peptide (excitation 4...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/28/2025
Entry Details
WIPO WO2025125695

TargetReplicase polyprotein 1ab(SARS-CoV)
Medchemica

WIPO
LigandPNGBDBM736197((4S,4'S)-6-chloro-4,-[(ethylamino)methyl]-1,-(4-is...)
Affinity DataIC50: 2nMAssay Description:The inhibition of the SAR-CoV-2 MPro Enzyme was measured by the method of Mesecar et al.20: The fluorescence of the cleaved FAM peptide (excitation 4...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/28/2025
Entry Details
WIPO WO2025125695

TargetReplicase polyprotein 1ab(2019-nCoV)
Medchemica

WIPO
LigandPNGBDBM736193((4S,4'S)-6-chloro-4'-[(isopropylamino)methyl]-1'-(...)
Affinity DataIC50: 2nMAssay Description:The inhibition of the SAR-CoV-2 MPro Enzyme was measured by the method of Mesecar et al.20: The fluorescence of the cleaved FAM peptide (excitation 4...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/28/2025
Entry Details
WIPO WO2025125695

TargetTransmembrane protease serine 2(Human)
Medchemica

WIPO
LigandPNGBDBM736194((4S,4'S)-6-chloro-4,-[(ethylamino)methyl]-1,-(4-is...)
Affinity DataEC50:  10nMAssay Description:Four thousand HeLa-ACE2 or Vero-TMPRSS2 cells (BPS Bioscience) were seeded into 96-well plates in DMEM (10% FBS) and incubated for 24 hours at 37°C, ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/28/2025
Entry Details
WIPO WO2025125695

TargetAngiotensin-converting enzyme 2(Human)
Medchemica

WIPO
LigandPNGBDBM736194((4S,4'S)-6-chloro-4,-[(ethylamino)methyl]-1,-(4-is...)
Affinity DataEC50:  15nMAssay Description:Four thousand HeLa-ACE2 or Vero-TMPRSS2 cells (BPS Bioscience) were seeded into 96-well plates in DMEM (10% FBS) and incubated for 24 hours at 37°C, ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/28/2025
Entry Details
WIPO WO2025125695

TargetTransmembrane protease serine 2(Human)
Medchemica

WIPO
LigandPNGBDBM736193((4S,4'S)-6-chloro-4'-[(isopropylamino)methyl]-1'-(...)
Affinity DataEC50:  17nMAssay Description:Four thousand HeLa-ACE2 or Vero-TMPRSS2 cells (BPS Bioscience) were seeded into 96-well plates in DMEM (10% FBS) and incubated for 24 hours at 37°C, ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/28/2025
Entry Details
WIPO WO2025125695

TargetAngiotensin-converting enzyme 2(Human)
Medchemica

WIPO
LigandPNGBDBM736195((4S,4'S)-6-chloro-4,-[(ethylamino)methyl]-1,-(4-is...)
Affinity DataEC50:  18nMAssay Description:Four thousand HeLa-ACE2 or Vero-TMPRSS2 cells (BPS Bioscience) were seeded into 96-well plates in DMEM (10% FBS) and incubated for 24 hours at 37°C, ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/28/2025
Entry Details
WIPO WO2025125695

TargetTransmembrane protease serine 2(Human)
Medchemica

WIPO
LigandPNGBDBM736196((4S,4'S)-6-chloro-4,-[(ethylamino)methyl]-1,-(4-is...)
Affinity DataEC50:  19nMAssay Description:Four thousand HeLa-ACE2 or Vero-TMPRSS2 cells (BPS Bioscience) were seeded into 96-well plates in DMEM (10% FBS) and incubated for 24 hours at 37°C, ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/28/2025
Entry Details
WIPO WO2025125695

TargetAngiotensin-converting enzyme 2(Human)
Medchemica

WIPO
LigandPNGBDBM736196((4S,4'S)-6-chloro-4,-[(ethylamino)methyl]-1,-(4-is...)
Affinity DataEC50:  31nMAssay Description:Four thousand HeLa-ACE2 or Vero-TMPRSS2 cells (BPS Bioscience) were seeded into 96-well plates in DMEM (10% FBS) and incubated for 24 hours at 37°C, ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/28/2025
Entry Details
WIPO WO2025125695

TargetTransmembrane protease serine 2(Human)
Medchemica

WIPO
LigandPNGBDBM736195((4S,4'S)-6-chloro-4,-[(ethylamino)methyl]-1,-(4-is...)
Affinity DataEC50:  32nMAssay Description:Four thousand HeLa-ACE2 or Vero-TMPRSS2 cells (BPS Bioscience) were seeded into 96-well plates in DMEM (10% FBS) and incubated for 24 hours at 37°C, ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/28/2025
Entry Details
WIPO WO2025125695

TargetAngiotensin-converting enzyme 2(Human)
Medchemica

WIPO
LigandPNGBDBM736193((4S,4'S)-6-chloro-4'-[(isopropylamino)methyl]-1'-(...)
Affinity DataEC50:  34nMAssay Description:Four thousand HeLa-ACE2 or Vero-TMPRSS2 cells (BPS Bioscience) were seeded into 96-well plates in DMEM (10% FBS) and incubated for 24 hours at 37°C, ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/28/2025
Entry Details
WIPO WO2025125695

TargetReplicase polyprotein 1ab(SARS-CoV)
Medchemica

WIPO
LigandPNGBDBM736196((4S,4'S)-6-chloro-4,-[(ethylamino)methyl]-1,-(4-is...)
Affinity DataIC50: 51nMAssay Description:The inhibition of the MERS-CoV-2 MPro Enzyme was measured by an analogous method to that of Mesecar et al.20 The fluorescence of the cleaved FAM pept...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/28/2025
Entry Details
WIPO WO2025125695

TargetTransmembrane protease serine 2(Human)
Medchemica

WIPO
LigandPNGBDBM736197((4S,4'S)-6-chloro-4,-[(ethylamino)methyl]-1,-(4-is...)
Affinity DataEC50:  52nMAssay Description:Four thousand HeLa-ACE2 or Vero-TMPRSS2 cells (BPS Bioscience) were seeded into 96-well plates in DMEM (10% FBS) and incubated for 24 hours at 37°C, ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/28/2025
Entry Details
WIPO WO2025125695

TargetReplicase polyprotein 1ab(SARS-CoV)
Medchemica

WIPO
LigandPNGBDBM736194((4S,4'S)-6-chloro-4,-[(ethylamino)methyl]-1,-(4-is...)
Affinity DataIC50: 64nMAssay Description:The inhibition of the MERS-CoV-2 MPro Enzyme was measured by an analogous method to that of Mesecar et al.20 The fluorescence of the cleaved FAM pept...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/28/2025
Entry Details
WIPO WO2025125695

TargetReplicase polyprotein 1ab(SARS-CoV)
Medchemica

WIPO
LigandPNGBDBM736193((4S,4'S)-6-chloro-4'-[(isopropylamino)methyl]-1'-(...)
Affinity DataIC50: 75nMAssay Description:The inhibition of the MERS-CoV-2 MPro Enzyme was measured by an analogous method to that of Mesecar et al.20 The fluorescence of the cleaved FAM pept...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/28/2025
Entry Details
WIPO WO2025125695

TargetAngiotensin-converting enzyme 2(Human)
Medchemica

WIPO
LigandPNGBDBM736197((4S,4'S)-6-chloro-4,-[(ethylamino)methyl]-1,-(4-is...)
Affinity DataEC50:  76nMAssay Description:Four thousand HeLa-ACE2 or Vero-TMPRSS2 cells (BPS Bioscience) were seeded into 96-well plates in DMEM (10% FBS) and incubated for 24 hours at 37°C, ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/28/2025
Entry Details
WIPO WO2025125695

TargetReplicase polyprotein 1ab(SARS-CoV)
Medchemica

WIPO
LigandPNGBDBM736195((4S,4'S)-6-chloro-4,-[(ethylamino)methyl]-1,-(4-is...)
Affinity DataIC50: 109nMAssay Description:The inhibition of the MERS-CoV-2 MPro Enzyme was measured by an analogous method to that of Mesecar et al.20 The fluorescence of the cleaved FAM pept...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/28/2025
Entry Details
WIPO WO2025125695

TargetReplicase polyprotein 1ab(SARS-CoV)
Medchemica

WIPO
LigandPNGBDBM736197((4S,4'S)-6-chloro-4,-[(ethylamino)methyl]-1,-(4-is...)
Affinity DataIC50: 133nMAssay Description:The inhibition of the MERS-CoV-2 MPro Enzyme was measured by an analogous method to that of Mesecar et al.20 The fluorescence of the cleaved FAM pept...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/28/2025
Entry Details
WIPO WO2025125695