Compile Data Set for Download or QSAR
Report error Found 43 Enz. Inhib. hit(s) with all data for entry = 10588
LigandPNGBDBM552755(WO2022104345, Compound 24 | (2S,4R)-1-((S)-2-cyclo...)
Affinity DataIC50: 320nMAssay Description:The VHL NanoBRET Target Engagement Assay analyzes the apparent affinity of test compounds for VHL in cells by competitive displacement of a VHL NanoB...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2022
Entry Details
WIPO WO2022104345

LigandPNGBDBM552772(WO2022104345, Compound 49 | (2S,4R)-1-((S)-2-(4-(5...)
Affinity DataIC50: 570nMAssay Description:The VHL NanoBRET Target Engagement Assay analyzes the apparent affinity of test compounds for VHL in cells by competitive displacement of a VHL NanoB...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2022
Entry Details
WIPO WO2022104345

LigandPNGBDBM552760(WO2022104345, Compound 33 | (2S, 4R)-4-hydroxy-N-m...)
Affinity DataIC50: 590nMAssay Description:The VHL NanoBRET Target Engagement Assay analyzes the apparent affinity of test compounds for VHL in cells by competitive displacement of a VHL NanoB...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2022
Entry Details
WIPO WO2022104345

LigandPNGBDBM552751(WO2022104345, Compound 20 | (2S, 4R)-1-((S)-2-(4-(...)
Affinity DataIC50: 800nMAssay Description:The VHL NanoBRET Target Engagement Assay analyzes the apparent affinity of test compounds for VHL in cells by competitive displacement of a VHL NanoB...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2022
Entry Details
WIPO WO2022104345

LigandPNGBDBM552765(WO2022104345, Compound 41 | (2S,4R)-4-hydroxy-N-me...)
Affinity DataIC50: 900nMAssay Description:The VHL NanoBRET Target Engagement Assay analyzes the apparent affinity of test compounds for VHL in cells by competitive displacement of a VHL NanoB...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2022
Entry Details
WIPO WO2022104345

LigandPNGBDBM552762(WO2022104345, Compound 36 | (2S,4R)-4-hydroxy-N-me...)
Affinity DataIC50: 920nMAssay Description:The VHL NanoBRET Target Engagement Assay analyzes the apparent affinity of test compounds for VHL in cells by competitive displacement of a VHL NanoB...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2022
Entry Details
WIPO WO2022104345

LigandPNGBDBM552758(WO2022104345, Compound 30 | (2S, 4R)-1-((S)-2-(5,6...)
Affinity DataIC50: 1.02E+3nMAssay Description:The VHL NanoBRET Target Engagement Assay analyzes the apparent affinity of test compounds for VHL in cells by competitive displacement of a VHL NanoB...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2022
Entry Details
WIPO WO2022104345

LigandPNGBDBM552763(WO2022104345, Compound 38 | (2S, 4R)-4-hydroxy-N-m...)
Affinity DataIC50: 1.10E+3nMAssay Description:The VHL NanoBRET Target Engagement Assay analyzes the apparent affinity of test compounds for VHL in cells by competitive displacement of a VHL NanoB...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2022
Entry Details
WIPO WO2022104345

LigandPNGBDBM552732((2S,4R)-1-((S)-2-(4-cyclopropyl-1H-1,2,3-triazol-1...)
Affinity DataIC50: 1.17E+3nMAssay Description:The binding of test compounds to the VHL Elongin B/C complex is measured using a fluorescence polarization tracer competition assay. The VHL / Elongi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2022
Entry Details
WIPO WO2022104345

LigandPNGBDBM552752(WO2022104345, Compound 21 | (2S,4R)-4-hydroxy-N-me...)
Affinity DataIC50: 1.21E+3nMAssay Description:The VHL NanoBRET Target Engagement Assay analyzes the apparent affinity of test compounds for VHL in cells by competitive displacement of a VHL NanoB...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2022
Entry Details
WIPO WO2022104345

LigandPNGBDBM552768(WO2022104345, Compound 45 | (2S,4R)-4-hydroxy-N-me...)
Affinity DataIC50: 1.22E+3nMAssay Description:The VHL NanoBRET Target Engagement Assay analyzes the apparent affinity of test compounds for VHL in cells by competitive displacement of a VHL NanoB...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2022
Entry Details
WIPO WO2022104345

LigandPNGBDBM552766(WO2022104345, Compound 43 | (2S,4R)-4-hydroxy-N-me...)
Affinity DataIC50: 1.38E+3nMAssay Description:The VHL NanoBRET Target Engagement Assay analyzes the apparent affinity of test compounds for VHL in cells by competitive displacement of a VHL NanoB...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2022
Entry Details
WIPO WO2022104345

LigandPNGBDBM552734((2S,4R)-1-((S)-2-cyclohexyl-2-(4-cyclopropyl-1H-1,...)
Affinity DataIC50: 1.61E+3nMAssay Description:The VHL NanoBRET Target Engagement Assay analyzes the apparent affinity of test compounds for VHL in cells by competitive displacement of a VHL NanoB...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2022
Entry Details
WIPO WO2022104345

LigandPNGBDBM552771(WO2022104345, Compound 48 | (2S,4R)-4-hydroxy-N-me...)
Affinity DataIC50: 1.69E+3nMAssay Description:The VHL NanoBRET Target Engagement Assay analyzes the apparent affinity of test compounds for VHL in cells by competitive displacement of a VHL NanoB...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2022
Entry Details
WIPO WO2022104345

LigandPNGBDBM552767(WO2022104345, Compound 44 | (2S,4R)-4-hydroxy-N-me...)
Affinity DataIC50: 1.70E+3nMAssay Description:The VHL NanoBRET Target Engagement Assay analyzes the apparent affinity of test compounds for VHL in cells by competitive displacement of a VHL NanoB...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2022
Entry Details
WIPO WO2022104345

LigandPNGBDBM552769(WO2022104345, Compound 46 | (2S,4R)-4-hydroxy-N-me...)
Affinity DataIC50: 1.96E+3nMAssay Description:The VHL NanoBRET Target Engagement Assay analyzes the apparent affinity of test compounds for VHL in cells by competitive displacement of a VHL NanoB...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2022
Entry Details
WIPO WO2022104345

LigandPNGBDBM552732((2S,4R)-1-((S)-2-(4-cyclopropyl-1H-1,2,3-triazol-1...)
Affinity DataIC50: 2.00E+3nMAssay Description:The VHL NanoBRET Target Engagement Assay analyzes the apparent affinity of test compounds for VHL in cells by competitive displacement of a VHL NanoB...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2022
Entry Details
WIPO WO2022104345

LigandPNGBDBM552756(WO2022104345, Compound 26 | (2S,4R)-1-((S)-2-(1H-b...)
Affinity DataIC50: 2.15E+3nMAssay Description:The VHL NanoBRET Target Engagement Assay analyzes the apparent affinity of test compounds for VHL in cells by competitive displacement of a VHL NanoB...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2022
Entry Details
WIPO WO2022104345

LigandPNGBDBM552748(WO2022104345, Compound 17 | (2S,4R)-1-((S)-2-(4-cy...)
Affinity DataIC50: 2.43E+3nMAssay Description:The VHL NanoBRET Target Engagement Assay analyzes the apparent affinity of test compounds for VHL in cells by competitive displacement of a VHL NanoB...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2022
Entry Details
WIPO WO2022104345

LigandPNGBDBM552757(WO2022104345, Compound 28 | (2S,4R)-4-hydroxy-1-((...)
Affinity DataIC50: 2.60E+3nMAssay Description:The VHL NanoBRET Target Engagement Assay analyzes the apparent affinity of test compounds for VHL in cells by competitive displacement of a VHL NanoB...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2022
Entry Details
WIPO WO2022104345

LigandPNGBDBM552761(WO2022104345, Compound 34 | (2S, 4R)-4-hydroxy-N-m...)
Affinity DataIC50: 2.65E+3nMAssay Description:The VHL NanoBRET Target Engagement Assay analyzes the apparent affinity of test compounds for VHL in cells by competitive displacement of a VHL NanoB...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2022
Entry Details
WIPO WO2022104345

LigandPNGBDBM552753(WO2022104345, Compound 22 | (2S,4R)-1-((S)-2-(4-cy...)
Affinity DataIC50: 2.83E+3nMAssay Description:The VHL NanoBRET Target Engagement Assay analyzes the apparent affinity of test compounds for VHL in cells by competitive displacement of a VHL NanoB...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2022
Entry Details
WIPO WO2022104345

LigandPNGBDBM552733((2S,4R)-1-((S)-2-(4-cyclopropyl-1H-1,2,3-triazol-1...)
Affinity DataIC50: 2.99E+3nMAssay Description:The VHL NanoBRET Target Engagement Assay analyzes the apparent affinity of test compounds for VHL in cells by competitive displacement of a VHL NanoB...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2022
Entry Details
WIPO WO2022104345

LigandPNGBDBM552742(WO2022104345, Compound 11 | WO2022104345, Example ...)
Affinity DataIC50: 3.00E+3nMAssay Description:The VHL NanoBRET Target Engagement Assay analyzes the apparent affinity of test compounds for VHL in cells by competitive displacement of a VHL NanoB...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2022
Entry Details
WIPO WO2022104345

LigandPNGBDBM552764(WO2022104345, Compound 40 | (2S, 4R)-4-hydroxy-N-m...)
Affinity DataIC50: 3.20E+3nMAssay Description:The VHL NanoBRET Target Engagement Assay analyzes the apparent affinity of test compounds for VHL in cells by competitive displacement of a VHL NanoB...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2022
Entry Details
WIPO WO2022104345

LigandPNGBDBM552754(WO2022104345, Compound 23 | (2S, 4R)-1-[(2S)-2-(4-...)
Affinity DataIC50: 3.21E+3nMAssay Description:The VHL NanoBRET Target Engagement Assay analyzes the apparent affinity of test compounds for VHL in cells by competitive displacement of a VHL NanoB...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2022
Entry Details
WIPO WO2022104345

LigandPNGBDBM552749(WO2022104345, Compound 18 | (2S,4R)-1-((S)-2-(4-cy...)
Affinity DataIC50: 4.15E+3nMAssay Description:The VHL NanoBRET Target Engagement Assay analyzes the apparent affinity of test compounds for VHL in cells by competitive displacement of a VHL NanoB...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2022
Entry Details
WIPO WO2022104345

LigandPNGBDBM552759(WO2022104345, Compound 32 | (2S, 4R)-1-[2-(4-cyclo...)
Affinity DataIC50: 4.75E+3nMAssay Description:The VHL NanoBRET Target Engagement Assay analyzes the apparent affinity of test compounds for VHL in cells by competitive displacement of a VHL NanoB...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2022
Entry Details
WIPO WO2022104345

LigandPNGBDBM552750(WO2022104345, Compound 19 | (2S, 4R)-1-((S)-2-(4-c...)
Affinity DataIC50: 4.99E+3nMAssay Description:The VHL NanoBRET Target Engagement Assay analyzes the apparent affinity of test compounds for VHL in cells by competitive displacement of a VHL NanoB...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2022
Entry Details
WIPO WO2022104345

LigandPNGBDBM552746(WO2022104345, Compound 15 | (2S,4R)-1-((S)-2-(4-cy...)
Affinity DataIC50: 6.55E+3nMAssay Description:The VHL NanoBRET Target Engagement Assay analyzes the apparent affinity of test compounds for VHL in cells by competitive displacement of a VHL NanoB...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2022
Entry Details
WIPO WO2022104345

LigandPNGBDBM552737((2S,4R)-1-((S)-2-(4-cyclopropyl-1H-1,2,3-triazol-1...)
Affinity DataIC50: 8.04E+3nMAssay Description:The VHL NanoBRET Target Engagement Assay analyzes the apparent affinity of test compounds for VHL in cells by competitive displacement of a VHL NanoB...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2022
Entry Details
WIPO WO2022104345

LigandPNGBDBM552747(WO2022104345, Compound 16 | (2S,4R)-1-((S)-2-(4-cy...)
Affinity DataIC50: 9.09E+3nMAssay Description:The VHL NanoBRET Target Engagement Assay analyzes the apparent affinity of test compounds for VHL in cells by competitive displacement of a VHL NanoB...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2022
Entry Details
WIPO WO2022104345

LigandPNGBDBM552745(WO2022104345, Compound 14 | (2S,4R)-N-cyclopropyl-...)
Affinity DataIC50: 9.68E+3nMAssay Description:The VHL NanoBRET Target Engagement Assay analyzes the apparent affinity of test compounds for VHL in cells by competitive displacement of a VHL NanoB...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2022
Entry Details
WIPO WO2022104345

LigandPNGBDBM552741((2S,4R)-1-((S)-2-(4-cyclopropyl-1H-1,2,3-triazol-1...)
Affinity DataIC50: 1.00E+4nMAssay Description:The VHL NanoBRET Target Engagement Assay analyzes the apparent affinity of test compounds for VHL in cells by competitive displacement of a VHL NanoB...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2022
Entry Details
WIPO WO2022104345

LigandPNGBDBM552736((2S,4R)-1-[2-(4-cyclopropyltriazol-1-yl)-2-(1-meth...)
Affinity DataIC50: 1.05E+4nMAssay Description:The VHL NanoBRET Target Engagement Assay analyzes the apparent affinity of test compounds for VHL in cells by competitive displacement of a VHL NanoB...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2022
Entry Details
WIPO WO2022104345

LigandPNGBDBM552770(WO2022104345, Compound 47 | (2S,4R)-4-hydroxy-N-me...)
Affinity DataIC50: 1.38E+4nMAssay Description:The VHL NanoBRET Target Engagement Assay analyzes the apparent affinity of test compounds for VHL in cells by competitive displacement of a VHL NanoB...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2022
Entry Details
WIPO WO2022104345

LigandPNGBDBM552735((2S,4R)-1-((S)-3,3-dimethyl-2-(1H-1,2,3-triazol-1-...)
Affinity DataIC50: 1.52E+4nMAssay Description:The VHL NanoBRET Target Engagement Assay analyzes the apparent affinity of test compounds for VHL in cells by competitive displacement of a VHL NanoB...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2022
Entry Details
WIPO WO2022104345

LigandPNGBDBM552773(WO2022104345, Compound 50 | (2S,4R)-1-((S)-2-(4-cy...)
Affinity DataIC50: 4.99E+4nMAssay Description:The VHL NanoBRET Target Engagement Assay analyzes the apparent affinity of test compounds for VHL in cells by competitive displacement of a VHL NanoB...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2022
Entry Details
WIPO WO2022104345

LigandPNGBDBM552744(WO2022104345, Compound 13 | (3R,5S)-1-((S)-2-(4-cy...)
Affinity DataIC50: 6.28E+4nMAssay Description:The VHL NanoBRET Target Engagement Assay analyzes the apparent affinity of test compounds for VHL in cells by competitive displacement of a VHL NanoB...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2022
Entry Details
WIPO WO2022104345

LigandPNGBDBM552740((2S,4R)-1-((S)-2-(1-acetylpiperidin-4-yl)-2-(4-cyc...)
Affinity DataIC50: 6.95E+4nMAssay Description:The VHL NanoBRET Target Engagement Assay analyzes the apparent affinity of test compounds for VHL in cells by competitive displacement of a VHL NanoB...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2022
Entry Details
WIPO WO2022104345

LigandPNGBDBM552739((2S,4R)-1-((S)-2-(4-cyclopropyl-1H-1,2,3-triazol-1...)
Affinity DataIC50: 1.00E+5nMAssay Description:The VHL NanoBRET Target Engagement Assay analyzes the apparent affinity of test compounds for VHL in cells by competitive displacement of a VHL NanoB...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2022
Entry Details
WIPO WO2022104345

LigandPNGBDBM552738((2S,4R)-1-((S)-2-(4-cyclopropyl-1H-1,2,3-triazol-1...)
Affinity DataIC50: 1.00E+5nMAssay Description:The VHL NanoBRET Target Engagement Assay analyzes the apparent affinity of test compounds for VHL in cells by competitive displacement of a VHL NanoB...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2022
Entry Details
WIPO WO2022104345

LigandPNGBDBM552743(WO2022104345, Compound 12 | WO2022104345, Example ...)
Affinity DataIC50: 1.00E+5nMAssay Description:The VHL NanoBRET Target Engagement Assay analyzes the apparent affinity of test compounds for VHL in cells by competitive displacement of a VHL NanoB...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2022
Entry Details
WIPO WO2022104345