Compile Data Set for Download or QSAR
Report error Found 32 Enz. Inhib. hit(s) with all data for entry = 2802
TargetEpidermal growth factor receptor(Human)
Shanghai Haiyan Pharmaceutical Technology

US Patent
LigandPNGBDBM50322823((S)-N-(4-(3-chloro-4-fluorophenylamino)-7-(tetrahy...)
Affinity DataIC50: 1nMAssay Description:The inhibitory activities on T790M/L858R double mutant EGFR kinase (Invitrogen, PV4879) and wild-type EGFR kinase (Invitrogen, PV3872) were determine...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/16/2020
Entry Details
Go to US Patent
PDB3D3D Structure (crystal)
TargetEpidermal growth factor receptor [T790M,L858R](Human)
Shanghai Haiyan Pharmaceutical Technology

US Patent
LigandPNGBDBM380786(N-(2-((2-(dimethylamino)ethyl)(methyl)amino)-4-met...)
Affinity DataIC50: 1nMAssay Description:The inhibitory activities on T790M/L858R double mutant EGFR kinase (Invitrogen, PV4879) and wild-type EGFR kinase (Invitrogen, PV3872) were determine...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/16/2020
Entry Details
Go to US Patent

TargetEpidermal growth factor receptor [T790M,L858R](Human)
Shanghai Haiyan Pharmaceutical Technology

US Patent
LigandPNGBDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
Affinity DataIC50: 2nMAssay Description:The inhibitory activities on T790M/L858R double mutant EGFR kinase (Invitrogen, PV4879) and wild-type EGFR kinase (Invitrogen, PV3872) were determine...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/16/2020
Entry Details
Go to US Patent

TargetEpidermal growth factor receptor [T790M,L858R](Human)
Shanghai Haiyan Pharmaceutical Technology

US Patent
LigandPNGBDBM380787(N-(2-((2-(dimethylamino)ethyl)(methyl)amino)-4-met...)
Affinity DataIC50: 3nMAssay Description:The inhibitory activities on T790M/L858R double mutant EGFR kinase (Invitrogen, PV4879) and wild-type EGFR kinase (Invitrogen, PV3872) were determine...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/16/2020
Entry Details
Go to US Patent

TargetEpidermal growth factor receptor(Human)
Shanghai Haiyan Pharmaceutical Technology

US Patent
LigandPNGBDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
Affinity DataIC50: 3nMAssay Description:The inhibitory activities on T790M/L858R double mutant EGFR kinase (Invitrogen, PV4879) and wild-type EGFR kinase (Invitrogen, PV3872) were determine...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/16/2020
Entry Details
Go to US Patent

TargetEpidermal growth factor receptor [T790M,L858R](Human)
Shanghai Haiyan Pharmaceutical Technology

US Patent
LigandPNGBDBM380785(N-(2-((2-(dimethylamino)ethyl)(methyl)amino)-4-met...)
Affinity DataIC50: 5nMAssay Description:The inhibitory activities on T790M/L858R double mutant EGFR kinase (Invitrogen, PV4879) and wild-type EGFR kinase (Invitrogen, PV3872) were determine...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/16/2020
Entry Details
Go to US Patent

TargetEpidermal growth factor receptor [T790M,L858R](Human)
Shanghai Haiyan Pharmaceutical Technology

US Patent
LigandPNGBDBM50322823((S)-N-(4-(3-chloro-4-fluorophenylamino)-7-(tetrahy...)
Affinity DataIC50: 5nMAssay Description:The inhibitory activities on T790M/L858R double mutant EGFR kinase (Invitrogen, PV4879) and wild-type EGFR kinase (Invitrogen, PV3872) were determine...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/16/2020
Entry Details
Go to US Patent
PDB3D3D Structure (crystal)
TargetEpidermal growth factor receptor [T790M,L858R](Human)
Shanghai Haiyan Pharmaceutical Technology

US Patent
LigandPNGBDBM380783(N-(2-((2-(dimethylamino)ethyl)(methyl)amino)-4-met...)
Affinity DataIC50: 10nMAssay Description:The inhibitory activities on T790M/L858R double mutant EGFR kinase (Invitrogen, PV4879) and wild-type EGFR kinase (Invitrogen, PV3872) were determine...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/16/2020
Entry Details
Go to US Patent

TargetEpidermal growth factor receptor [T790M,L858R](Human)
Shanghai Haiyan Pharmaceutical Technology

US Patent
LigandPNGBDBM380788(N-(2-((2-(dimethylamino)ethyl)(methyl)amino)-4-met...)
Affinity DataIC50: 13nMAssay Description:The inhibitory activities on T790M/L858R double mutant EGFR kinase (Invitrogen, PV4879) and wild-type EGFR kinase (Invitrogen, PV3872) were determine...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/16/2020
Entry Details
Go to US Patent

TargetEpidermal growth factor receptor(Human)
Shanghai Haiyan Pharmaceutical Technology

US Patent
LigandPNGBDBM380787(N-(2-((2-(dimethylamino)ethyl)(methyl)amino)-4-met...)
Affinity DataIC50: 15nMAssay Description:The inhibitory activities on T790M/L858R double mutant EGFR kinase (Invitrogen, PV4879) and wild-type EGFR kinase (Invitrogen, PV3872) were determine...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/16/2020
Entry Details
Go to US Patent

TargetEpidermal growth factor receptor [T790M,L858R](Human)
Shanghai Haiyan Pharmaceutical Technology

US Patent
LigandPNGBDBM380789(N-(2-((2-(dimethylamino)ethyl)(methyl)amino)-4-met...)
Affinity DataIC50: 20nMAssay Description:The inhibitory activities on T790M/L858R double mutant EGFR kinase (Invitrogen, PV4879) and wild-type EGFR kinase (Invitrogen, PV3872) were determine...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/16/2020
Entry Details
Go to US Patent

TargetEpidermal growth factor receptor [T790M,L858R](Human)
Shanghai Haiyan Pharmaceutical Technology

US Patent
LigandPNGBDBM380783(N-(2-((2-(dimethylamino)ethyl)(methyl)amino)-4-met...)
Affinity DataIC50: 22nMAssay Description:The inhibitory activities on T790M/L858R double mutant EGFR kinase (Invitrogen, PV4879) and wild-type EGFR kinase (Invitrogen, PV3872) were determine...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/16/2020
Entry Details
Go to US Patent

TargetEpidermal growth factor receptor [T790M,L858R](Human)
Shanghai Haiyan Pharmaceutical Technology

US Patent
LigandPNGBDBM380791(N-(2-(2-(dimethylamino)etboxy)-4-methoxy-5-(4-(1-m...)
Affinity DataIC50: 24nMAssay Description:The inhibitory activities on T790M/L858R double mutant EGFR kinase (Invitrogen, PV4879) and wild-type EGFR kinase (Invitrogen, PV3872) were determine...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/16/2020
Entry Details
Go to US Patent

TargetEpidermal growth factor receptor(Human)
Shanghai Haiyan Pharmaceutical Technology

US Patent
LigandPNGBDBM380786(N-(2-((2-(dimethylamino)ethyl)(methyl)amino)-4-met...)
Affinity DataIC50: 39nMAssay Description:The inhibitory activities on T790M/L858R double mutant EGFR kinase (Invitrogen, PV4879) and wild-type EGFR kinase (Invitrogen, PV3872) were determine...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/16/2020
Entry Details
Go to US Patent

TargetEpidermal growth factor receptor [T790M,L858R](Human)
Shanghai Haiyan Pharmaceutical Technology

US Patent
LigandPNGBDBM380784(N-(2-((2-(dimethylamino)ethyl)(methyl)amino)-4-met...)
Affinity DataIC50: 45nMAssay Description:The inhibitory activities on T790M/L858R double mutant EGFR kinase (Invitrogen, PV4879) and wild-type EGFR kinase (Invitrogen, PV3872) were determine...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/16/2020
Entry Details
Go to US Patent

TargetEpidermal growth factor receptor [T790M,L858R](Human)
Shanghai Haiyan Pharmaceutical Technology

US Patent
LigandPNGBDBM380794(N-(5-(5-chloro-4-(1-methyl-1H-pyrazol-4-yl)-7H-pyr...)
Affinity DataIC50: 51nMAssay Description:The inhibitory activities on T790M/L858R double mutant EGFR kinase (Invitrogen, PV4879) and wild-type EGFR kinase (Invitrogen, PV3872) were determine...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/16/2020
Entry Details
Go to US Patent

TargetEpidermal growth factor receptor(Human)
Shanghai Haiyan Pharmaceutical Technology

US Patent
LigandPNGBDBM380785(N-(2-((2-(dimethylamino)ethyl)(methyl)amino)-4-met...)
Affinity DataIC50: 88nMAssay Description:The inhibitory activities on T790M/L858R double mutant EGFR kinase (Invitrogen, PV4879) and wild-type EGFR kinase (Invitrogen, PV3872) were determine...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/16/2020
Entry Details
Go to US Patent

TargetEpidermal growth factor receptor [T790M,L858R](Human)
Shanghai Haiyan Pharmaceutical Technology

US Patent
LigandPNGBDBM380793(N-(4-methoxy-5-(4-(1-methyl-1H-pyrazol-4-yl)-7H-py...)
Affinity DataIC50: 98nMAssay Description:The inhibitory activities on T790M/L858R double mutant EGFR kinase (Invitrogen, PV4879) and wild-type EGFR kinase (Invitrogen, PV3872) were determine...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/16/2020
Entry Details
Go to US Patent

TargetEpidermal growth factor receptor [T790M,L858R](Human)
Shanghai Haiyan Pharmaceutical Technology

US Patent
LigandPNGBDBM380795(N-(2-(4-(dimethylamino)piperidin-1-yl)-4-methoxy-5...)
Affinity DataIC50: 110nMAssay Description:The inhibitory activities on T790M/L858R double mutant EGFR kinase (Invitrogen, PV4879) and wild-type EGFR kinase (Invitrogen, PV3872) were determine...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/16/2020
Entry Details
Go to US Patent

TargetEpidermal growth factor receptor [T790M,L858R](Human)
Shanghai Haiyan Pharmaceutical Technology

US Patent
LigandPNGBDBM380792(N-(2-(3-(dimethylamino)azetidin-1-yl)-4-methoxy-5-...)
Affinity DataIC50: 197nMAssay Description:The inhibitory activities on T790M/L858R double mutant EGFR kinase (Invitrogen, PV4879) and wild-type EGFR kinase (Invitrogen, PV3872) were determine...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/16/2020
Entry Details
Go to US Patent

TargetEpidermal growth factor receptor(Human)
Shanghai Haiyan Pharmaceutical Technology

US Patent
LigandPNGBDBM380789(N-(2-((2-(dimethylamino)ethyl)(methyl)amino)-4-met...)
Affinity DataIC50: 315nMAssay Description:The inhibitory activities on T790M/L858R double mutant EGFR kinase (Invitrogen, PV4879) and wild-type EGFR kinase (Invitrogen, PV3872) were determine...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/16/2020
Entry Details
Go to US Patent

TargetEpidermal growth factor receptor(Human)
Shanghai Haiyan Pharmaceutical Technology

US Patent
LigandPNGBDBM380788(N-(2-((2-(dimethylamino)ethyl)(methyl)amino)-4-met...)
Affinity DataIC50: 347nMAssay Description:The inhibitory activities on T790M/L858R double mutant EGFR kinase (Invitrogen, PV4879) and wild-type EGFR kinase (Invitrogen, PV3872) were determine...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/16/2020
Entry Details
Go to US Patent

TargetEpidermal growth factor receptor(Human)
Shanghai Haiyan Pharmaceutical Technology

US Patent
LigandPNGBDBM380783(N-(2-((2-(dimethylamino)ethyl)(methyl)amino)-4-met...)
Affinity DataIC50: 393nMAssay Description:The inhibitory activities on T790M/L858R double mutant EGFR kinase (Invitrogen, PV4879) and wild-type EGFR kinase (Invitrogen, PV3872) were determine...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/16/2020
Entry Details
Go to US Patent

TargetEpidermal growth factor receptor(Human)
Shanghai Haiyan Pharmaceutical Technology

US Patent
LigandPNGBDBM380791(N-(2-(2-(dimethylamino)etboxy)-4-methoxy-5-(4-(1-m...)
Affinity DataIC50: 578nMAssay Description:The inhibitory activities on T790M/L858R double mutant EGFR kinase (Invitrogen, PV4879) and wild-type EGFR kinase (Invitrogen, PV3872) were determine...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/16/2020
Entry Details
Go to US Patent

TargetEpidermal growth factor receptor(Human)
Shanghai Haiyan Pharmaceutical Technology

US Patent
LigandPNGBDBM380794(N-(5-(5-chloro-4-(1-methyl-1H-pyrazol-4-yl)-7H-pyr...)
Affinity DataIC50: 1.00E+3nMAssay Description:The inhibitory activities on T790M/L858R double mutant EGFR kinase (Invitrogen, PV4879) and wild-type EGFR kinase (Invitrogen, PV3872) were determine...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/16/2020
Entry Details
Go to US Patent

TargetEpidermal growth factor receptor(Human)
Shanghai Haiyan Pharmaceutical Technology

US Patent
LigandPNGBDBM380793(N-(4-methoxy-5-(4-(1-methyl-1H-pyrazol-4-yl)-7H-py...)
Affinity DataIC50: 1.00E+3nMAssay Description:The inhibitory activities on T790M/L858R double mutant EGFR kinase (Invitrogen, PV4879) and wild-type EGFR kinase (Invitrogen, PV3872) were determine...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/16/2020
Entry Details
Go to US Patent

TargetEpidermal growth factor receptor(Human)
Shanghai Haiyan Pharmaceutical Technology

US Patent
LigandPNGBDBM380795(N-(2-(4-(dimethylamino)piperidin-1-yl)-4-methoxy-5...)
Affinity DataIC50: 1.00E+3nMAssay Description:The inhibitory activities on T790M/L858R double mutant EGFR kinase (Invitrogen, PV4879) and wild-type EGFR kinase (Invitrogen, PV3872) were determine...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/16/2020
Entry Details
Go to US Patent

TargetEpidermal growth factor receptor(Human)
Shanghai Haiyan Pharmaceutical Technology

US Patent
LigandPNGBDBM380792(N-(2-(3-(dimethylamino)azetidin-1-yl)-4-methoxy-5-...)
Affinity DataIC50: 1.00E+3nMAssay Description:The inhibitory activities on T790M/L858R double mutant EGFR kinase (Invitrogen, PV4879) and wild-type EGFR kinase (Invitrogen, PV3872) were determine...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/16/2020
Entry Details
Go to US Patent

TargetEpidermal growth factor receptor(Human)
Shanghai Haiyan Pharmaceutical Technology

US Patent
LigandPNGBDBM380783(N-(2-((2-(dimethylamino)ethyl)(methyl)amino)-4-met...)
Affinity DataIC50: 1.00E+3nMAssay Description:The inhibitory activities on T790M/L858R double mutant EGFR kinase (Invitrogen, PV4879) and wild-type EGFR kinase (Invitrogen, PV3872) were determine...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/16/2020
Entry Details
Go to US Patent

TargetEpidermal growth factor receptor(Human)
Shanghai Haiyan Pharmaceutical Technology

US Patent
LigandPNGBDBM380784(N-(2-((2-(dimethylamino)ethyl)(methyl)amino)-4-met...)
Affinity DataIC50: 1.00E+3nMAssay Description:The inhibitory activities on T790M/L858R double mutant EGFR kinase (Invitrogen, PV4879) and wild-type EGFR kinase (Invitrogen, PV3872) were determine...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/16/2020
Entry Details
Go to US Patent

TargetEpidermal growth factor receptor [T790M,L858R](Human)
Shanghai Haiyan Pharmaceutical Technology

US Patent
LigandPNGBDBM380798(US9890168, Compound Comparative compound 1)
Affinity DataIC50: 1.00E+3nMAssay Description:The inhibitory activities on T790M/L858R double mutant EGFR kinase (Invitrogen, PV4879) and wild-type EGFR kinase (Invitrogen, PV3872) were determine...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/16/2020
Entry Details
Go to US Patent

TargetEpidermal growth factor receptor(Human)
Shanghai Haiyan Pharmaceutical Technology

US Patent
LigandPNGBDBM380798(US9890168, Compound Comparative compound 1)
Affinity DataIC50: 1.00E+4nMAssay Description:The inhibitory activities on T790M/L858R double mutant EGFR kinase (Invitrogen, PV4879) and wild-type EGFR kinase (Invitrogen, PV3872) were determine...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/16/2020
Entry Details
Go to US Patent