Compile Data Set for Download or QSAR
Report error Found 146 Enz. Inhib. hit(s) with all data for entry = 2288
TargetOrexin/Hypocretin receptor type 1(Rat)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM360351(US9828368, Example 13 | US9828368, Example 14 | US...)
Affinity DataIC50: 10nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2019
Entry Details
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TargetOrexin receptor type 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM360364(US9828368, Example 25)
Affinity DataIC50: 10.7nMAssay Description:For intracellular calcium measurements, Chinese hamster ovary (CHO) cells expressing the rat orexin-1 receptor or the human orexin-2 receptor, are gr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2019
Entry Details
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TargetOrexin receptor type 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM360376(US9828368, Example 35)
Affinity DataIC50: 11.7nMAssay Description:For intracellular calcium measurements, Chinese hamster ovary (CHO) cells expressing the rat orexin-1 receptor or the human orexin-2 receptor, are gr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2019
Entry Details
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TargetOrexin receptor type 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM360366(US9828368, Example 27)
Affinity DataIC50: 12nMAssay Description:For intracellular calcium measurements, Chinese hamster ovary (CHO) cells expressing the rat orexin-1 receptor or the human orexin-2 receptor, are gr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2019
Entry Details
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TargetOrexin receptor type 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM360351(US9828368, Example 13 | US9828368, Example 14 | US...)
Affinity DataIC50: 12.8nMAssay Description:For intracellular calcium measurements, Chinese hamster ovary (CHO) cells expressing the rat orexin-1 receptor or the human orexin-2 receptor, are gr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2019
Entry Details
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TargetOrexin receptor type 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM50108616(CHEMBL3597957 | US9828368, Example 24)
Affinity DataIC50: 13.5nMAssay Description:For intracellular calcium measurements, Chinese hamster ovary (CHO) cells expressing the rat orexin-1 receptor or the human orexin-2 receptor, are gr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2019
Entry Details
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TargetOrexin receptor type 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM360356(US9828368, Example 18 | US9828368, Example 19)
Affinity DataIC50: 13.9nMAssay Description:For intracellular calcium measurements, Chinese hamster ovary (CHO) cells expressing the rat orexin-1 receptor or the human orexin-2 receptor, are gr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2019
Entry Details
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TargetOrexin receptor type 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM360367(US9828368, Example 28 | ((2R,5R)-5-(4-(2-Hydroxypr...)
Affinity DataIC50: 14.1nMAssay Description:For intracellular calcium measurements, Chinese hamster ovary (CHO) cells expressing the rat orexin-1 receptor or the human orexin-2 receptor, are gr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2019
Entry Details
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TargetOrexin receptor type 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM360382(US9828368, Example 38)
Affinity DataIC50: 14.1nMAssay Description:For intracellular calcium measurements, Chinese hamster ovary (CHO) cells expressing the rat orexin-1 receptor or the human orexin-2 receptor, are gr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2019
Entry Details
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TargetOrexin receptor type 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM360396(US9828368, Example 48 | US9828368, Example 49)
Affinity DataIC50: 15nMAssay Description:For intracellular calcium measurements, Chinese hamster ovary (CHO) cells expressing the rat orexin-1 receptor or the human orexin-2 receptor, are gr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2019
Entry Details
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TargetOrexin receptor type 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM360396(US9828368, Example 48 | US9828368, Example 49)
Affinity DataIC50: 16nMAssay Description:For intracellular calcium measurements, Chinese hamster ovary (CHO) cells expressing the rat orexin-1 receptor or the human orexin-2 receptor, are gr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2019
Entry Details
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TargetOrexin receptor type 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM360845(US9828368, Example 75 | Cyclobutyl (2-(2H-1,2,3-Tr...)
Affinity DataIC50: 16nMAssay Description:For intracellular calcium measurements, Chinese hamster ovary (CHO) cells expressing the rat orexin-1 receptor or the human orexin-2 receptor, are gr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2019
Entry Details
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TargetOrexin receptor type 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM360359(US9828368, Example 20)
Affinity DataIC50: 16.6nMAssay Description:For intracellular calcium measurements, Chinese hamster ovary (CHO) cells expressing the rat orexin-1 receptor or the human orexin-2 receptor, are gr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2019
Entry Details
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TargetOrexin receptor type 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM360351(US9828368, Example 13 | US9828368, Example 14 | US...)
Affinity DataIC50: 17nMAssay Description:For intracellular calcium measurements, Chinese hamster ovary (CHO) cells expressing the rat orexin-1 receptor or the human orexin-2 receptor, are gr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2019
Entry Details
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TargetOrexin receptor type 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM360384(US9828368, Example 39 | ((2R,5R)-5-(4-(2-Hydroxypr...)
Affinity DataIC50: 17.5nMAssay Description:For intracellular calcium measurements, Chinese hamster ovary (CHO) cells expressing the rat orexin-1 receptor or the human orexin-2 receptor, are gr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2019
Entry Details
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TargetOrexin receptor type 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM330343(US9725434, 2 | 1-(3-{[(3R,6R)- 1-{[6-methoxy- 2-(2...)
Affinity DataIC50: 18nMAssay Description:For intracellular calcium measurements, Chinese hamster ovary (CHO) cells expressing the rat orexin-1 receptor or the human orexin-2 receptor, are gr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2019
Entry Details
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TargetOrexin receptor type 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM360395(US9828368, Example 47 | (4-(2H-1,2,3-triazol-2-yl)...)
Affinity DataIC50: 18nMAssay Description:For intracellular calcium measurements, Chinese hamster ovary (CHO) cells expressing the rat orexin-1 receptor or the human orexin-2 receptor, are gr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2019
Entry Details
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TargetOrexin receptor type 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM360351(US9828368, Example 13 | US9828368, Example 14 | US...)
Affinity DataIC50: 19nMAssay Description:For intracellular calcium measurements, Chinese hamster ovary (CHO) cells expressing the rat orexin-1 receptor or the human orexin-2 receptor, are gr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2019
Entry Details
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TargetOrexin receptor type 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM360381(US9828368, Example 37)
Affinity DataIC50: 19.1nMAssay Description:For intracellular calcium measurements, Chinese hamster ovary (CHO) cells expressing the rat orexin-1 receptor or the human orexin-2 receptor, are gr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2019
Entry Details
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TargetOrexin receptor type 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM360368(US9828368, Example 29 | ((2R,5R)-5-(4-(2-Hydroxypr...)
Affinity DataIC50: 20.4nMAssay Description:For intracellular calcium measurements, Chinese hamster ovary (CHO) cells expressing the rat orexin-1 receptor or the human orexin-2 receptor, are gr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2019
Entry Details
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TargetOrexin/Hypocretin receptor type 1(Rat)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM360351(US9828368, Example 13 | US9828368, Example 14 | US...)
Affinity DataIC50: 21nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2019
Entry Details
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TargetOrexin receptor type 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM360372(US9828368, Example 33)
Affinity DataIC50: 23nMAssay Description:For intracellular calcium measurements, Chinese hamster ovary (CHO) cells expressing the rat orexin-1 receptor or the human orexin-2 receptor, are gr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2019
Entry Details
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TargetOrexin receptor type 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM360356(US9828368, Example 18 | US9828368, Example 19)
Affinity DataIC50: 24nMAssay Description:For intracellular calcium measurements, Chinese hamster ovary (CHO) cells expressing the rat orexin-1 receptor or the human orexin-2 receptor, are gr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2019
Entry Details
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TargetOrexin receptor type 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM360391(US9828368, Example 44 | US9828368, Example 45)
Affinity DataIC50: 24nMAssay Description:For intracellular calcium measurements, Chinese hamster ovary (CHO) cells expressing the rat orexin-1 receptor or the human orexin-2 receptor, are gr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2019
Entry Details
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TargetOrexin receptor type 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM360369(US9828368, Example 30 | US9828368, Example 31 | ((...)
Affinity DataIC50: 29.4nMAssay Description:For intracellular calcium measurements, Chinese hamster ovary (CHO) cells expressing the rat orexin-1 receptor or the human orexin-2 receptor, are gr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2019
Entry Details
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TargetOrexin receptor type 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM360385(US9828368, Example 40 | ((2R,5R)-5-(4-(2-Hydroxypr...)
Affinity DataIC50: 29.5nMAssay Description:For intracellular calcium measurements, Chinese hamster ovary (CHO) cells expressing the rat orexin-1 receptor or the human orexin-2 receptor, are gr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2019
Entry Details
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TargetOrexin receptor type 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM360340(US9828368, Example 5 | (2-(2H-1,2,3-Triazol-2-yl)p...)
Affinity DataIC50: 30nMAssay Description:For intracellular calcium measurements, Chinese hamster ovary (CHO) cells expressing the rat orexin-1 receptor or the human orexin-2 receptor, are gr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2019
Entry Details
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TargetOrexin receptor type 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM360350(US9828368, Example 12)
Affinity DataIC50: 30nMAssay Description:For intracellular calcium measurements, Chinese hamster ovary (CHO) cells expressing the rat orexin-1 receptor or the human orexin-2 receptor, are gr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2019
Entry Details
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TargetOrexin receptor type 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM360390(US9828368, Example 43)
Affinity DataIC50: 30nMAssay Description:For intracellular calcium measurements, Chinese hamster ovary (CHO) cells expressing the rat orexin-1 receptor or the human orexin-2 receptor, are gr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2019
Entry Details
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TargetOrexin receptor type 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM360432(US9828368, Example 73)
Affinity DataIC50: 30nMAssay Description:For intracellular calcium measurements, Chinese hamster ovary (CHO) cells expressing the rat orexin-1 receptor or the human orexin-2 receptor, are gr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2019
Entry Details
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TargetOrexin receptor type 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM360391(US9828368, Example 44 | US9828368, Example 45)
Affinity DataIC50: 31nMAssay Description:For intracellular calcium measurements, Chinese hamster ovary (CHO) cells expressing the rat orexin-1 receptor or the human orexin-2 receptor, are gr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2019
Entry Details
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TargetOrexin receptor type 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM360419(US9828368, Example 67 | US9828368, Example 70)
Affinity DataIC50: 33nMAssay Description:For intracellular calcium measurements, Chinese hamster ovary (CHO) cells expressing the rat orexin-1 receptor or the human orexin-2 receptor, are gr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2019
Entry Details
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TargetOrexin receptor type 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM360846(US9828368, Example 76 | cyclopropyl (2-(2H-1,2,3-T...)
Affinity DataIC50: 33nMAssay Description:For intracellular calcium measurements, Chinese hamster ovary (CHO) cells expressing the rat orexin-1 receptor or the human orexin-2 receptor, are gr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2019
Entry Details
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TargetOrexin receptor type 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM360394(US9828368, Example 46 | (4-(2H-1,2,3-triazol-2-yl)...)
Affinity DataIC50: 37nMAssay Description:For intracellular calcium measurements, Chinese hamster ovary (CHO) cells expressing the rat orexin-1 receptor or the human orexin-2 receptor, are gr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2019
Entry Details
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TargetOrexin receptor type 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM360355(US9828368, Example 17)
Affinity DataIC50: 38nMAssay Description:For intracellular calcium measurements, Chinese hamster ovary (CHO) cells expressing the rat orexin-1 receptor or the human orexin-2 receptor, are gr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2019
Entry Details
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TargetOrexin/Hypocretin receptor type 1(Rat)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM360419(US9828368, Example 67 | US9828368, Example 70)
Affinity DataIC50: 38nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2019
Entry Details
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TargetOrexin receptor type 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM360365(US9828368, Example 26 | ((2R, 5R)-5-(4-(2-Hydroxyp...)
Affinity DataIC50: 42nMAssay Description:For intracellular calcium measurements, Chinese hamster ovary (CHO) cells expressing the rat orexin-1 receptor or the human orexin-2 receptor, are gr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2019
Entry Details
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TargetOrexin receptor type 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM360401(US9828368, Example 54)
Affinity DataIC50: 42nMAssay Description:For intracellular calcium measurements, Chinese hamster ovary (CHO) cells expressing the rat orexin-1 receptor or the human orexin-2 receptor, are gr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2019
Entry Details
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TargetOrexin receptor type 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM360400(US9828368, Example 53)
Affinity DataIC50: 43nMAssay Description:For intracellular calcium measurements, Chinese hamster ovary (CHO) cells expressing the rat orexin-1 receptor or the human orexin-2 receptor, are gr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2019
Entry Details
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TargetOrexin/Hypocretin receptor type 1(Rat)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM360340(US9828368, Example 5 | (2-(2H-1,2,3-Triazol-2-yl)p...)
Affinity DataIC50: 46nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2019
Entry Details
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TargetOrexin receptor type 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM360339(US9828368, Example 4 | (2-(2H-1,2,3-Triazol-2-yl)p...)
Affinity DataIC50: 47nMAssay Description:For intracellular calcium measurements, Chinese hamster ovary (CHO) cells expressing the rat orexin-1 receptor or the human orexin-2 receptor, are gr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2019
Entry Details
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TargetOrexin receptor type 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM360336(US9828368, Example 2)
Affinity DataIC50: 49nMAssay Description:For intracellular calcium measurements, Chinese hamster ovary (CHO) cells expressing the rat orexin-1 receptor or the human orexin-2 receptor, are gr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2019
Entry Details
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TargetOrexin/Hypocretin receptor type 1(Rat)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM360844(US9828368, Example 74 | Phenyl (2-(2H-1,2,3-Triazo...)
Affinity DataIC50: 55nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2019
Entry Details
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TargetOrexin receptor type 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM360373(US9828368, Example 34)
Affinity DataIC50: 56nMAssay Description:For intracellular calcium measurements, Chinese hamster ovary (CHO) cells expressing the rat orexin-1 receptor or the human orexin-2 receptor, are gr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2019
Entry Details
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TargetOrexin receptor type 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM360380(US9828368, Example 36)
Affinity DataIC50: 56nMAssay Description:For intracellular calcium measurements, Chinese hamster ovary (CHO) cells expressing the rat orexin-1 receptor or the human orexin-2 receptor, are gr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2019
Entry Details
Go to US Patent

TargetOrexin receptor type 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM360387(US9828368, Example 41)
Affinity DataIC50: 57nMAssay Description:For intracellular calcium measurements, Chinese hamster ovary (CHO) cells expressing the rat orexin-1 receptor or the human orexin-2 receptor, are gr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2019
Entry Details
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TargetOrexin receptor type 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM360347(US9828368, Example 10)
Affinity DataIC50: 59nMAssay Description:For intracellular calcium measurements, Chinese hamster ovary (CHO) cells expressing the rat orexin-1 receptor or the human orexin-2 receptor, are gr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2019
Entry Details
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TargetOrexin receptor type 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM360419(US9828368, Example 67 | US9828368, Example 70)
Affinity DataIC50: 59nMAssay Description:For intracellular calcium measurements, Chinese hamster ovary (CHO) cells expressing the rat orexin-1 receptor or the human orexin-2 receptor, are gr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2019
Entry Details
Go to US Patent

TargetOrexin/Hypocretin receptor type 1(Rat)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM360845(US9828368, Example 75 | Cyclobutyl (2-(2H-1,2,3-Tr...)
Affinity DataIC50: 59nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2019
Entry Details
Go to US Patent

TargetOrexin receptor type 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM360354(US9828368, Example 16)
Affinity DataIC50: 60nMAssay Description:For intracellular calcium measurements, Chinese hamster ovary (CHO) cells expressing the rat orexin-1 receptor or the human orexin-2 receptor, are gr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2019
Entry Details
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