Compile Data Set for Download or QSAR
Report error Found 34 Enz. Inhib. hit(s) with all data for entry = 1805
TargetOrexin receptor type 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM341144(US9765057, 11 | US9765057, 16 | US9765057, 12 | me...)
Affinity DataIC50: 5.46nMAssay Description:FLIPR Ca2+ Flux Assay (Okumura et al., Biochem. Biophys. Res. Comm. 280:976-981, 2001). In a typical experiment the OX1 and OX2 receptor antagonistic...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/29/2019
Entry Details
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TargetOrexin receptor type 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM341072(US9765057, 1 | Benzyl trans-5-hydroxy-2-methylpipe...)
Affinity DataIC50: 8.30nMAssay Description:FLIPR Ca2+ Flux Assay (Okumura et al., Biochem. Biophys. Res. Comm. 280:976-981, 2001). In a typical experiment the OX1 and OX2 receptor antagonistic...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/29/2019
Entry Details
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TargetOrexin receptor type 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM341136(US9765057, 3 | methyl 4-(methylsulfanyl)-2- {[(3R,...)
Affinity DataIC50: 10nMAssay Description:FLIPR Ca2+ Flux Assay (Okumura et al., Biochem. Biophys. Res. Comm. 280:976-981, 2001). In a typical experiment the OX1 and OX2 receptor antagonistic...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/29/2019
Entry Details
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TargetOrexin receptor type 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM341135(US9765057, 2 | methyl 4-methy1-2-{[(3R,6R)-6- meth...)
Affinity DataIC50: 17.4nMAssay Description:FLIPR Ca2+ Flux Assay (Okumura et al., Biochem. Biophys. Res. Comm. 280:976-981, 2001). In a typical experiment the OX1 and OX2 receptor antagonistic...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/29/2019
Entry Details
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TargetOrexin receptor type 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM341143(US9765057, 10 | Methyl 4-ethyl-2-{[(3R,6R)-6-methy...)
Affinity DataIC50: 21.1nMAssay Description:FLIPR Ca2+ Flux Assay (Okumura et al., Biochem. Biophys. Res. Comm. 280:976-981, 2001). In a typical experiment the OX1 and OX2 receptor antagonistic...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/29/2019
Entry Details
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TargetOrexin receptor type 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM341137(US9765057, 4)
Affinity DataIC50: 28.3nMAssay Description:FLIPR Ca2+ Flux Assay (Okumura et al., Biochem. Biophys. Res. Comm. 280:976-981, 2001). In a typical experiment the OX1 and OX2 receptor antagonistic...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/29/2019
Entry Details
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TargetOrexin receptor type 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM341139(US9765057, 6 | methyl 2-({(3R,6R)-1-[(4-fluoro-2- ...)
Affinity DataIC50: 31.6nMAssay Description:FLIPR Ca2+ Flux Assay (Okumura et al., Biochem. Biophys. Res. Comm. 280:976-981, 2001). In a typical experiment the OX1 and OX2 receptor antagonistic...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/29/2019
Entry Details
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TargetOrexin receptor type 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM341141(US9765057, 8 | Methyl 4-azetidin-1-yl-2-{[(3R,6R)-...)
Affinity DataIC50: 33nMAssay Description:FLIPR Ca2+ Flux Assay (Okumura et al., Biochem. Biophys. Res. Comm. 280:976-981, 2001). In a typical experiment the OX1 and OX2 receptor antagonistic...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/29/2019
Entry Details
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TargetOrexin receptor type 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM341135(US9765057, 2 | methyl 4-methy1-2-{[(3R,6R)-6- meth...)
Affinity DataIC50: 36.2nMAssay Description:FLIPR Ca2+ Flux Assay (Okumura et al., Biochem. Biophys. Res. Comm. 280:976-981, 2001). In a typical experiment the OX1 and OX2 receptor antagonistic...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/29/2019
Entry Details
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TargetOrexin receptor type 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM341140(US9765057, 7 | methyl 2-({(3R,6R)-1-[(3-fluoro-2- ...)
Affinity DataIC50: 37.8nMAssay Description:FLIPR Ca2+ Flux Assay (Okumura et al., Biochem. Biophys. Res. Comm. 280:976-981, 2001). In a typical experiment the OX1 and OX2 receptor antagonistic...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/29/2019
Entry Details
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TargetOrexin receptor type 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM341150(US9765057, 17 | Ethyl 4-ethyl-2-{[(3R,6R)-6-methyl...)
Affinity DataIC50: 40.4nMAssay Description:FLIPR Ca2+ Flux Assay (Okumura et al., Biochem. Biophys. Res. Comm. 280:976-981, 2001). In a typical experiment the OX1 and OX2 receptor antagonistic...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/29/2019
Entry Details
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TargetOrexin receptor type 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM341144(US9765057, 11 | US9765057, 16 | US9765057, 12 | me...)
Affinity DataIC50: 68.8nMAssay Description:FLIPR Ca2+ Flux Assay (Okumura et al., Biochem. Biophys. Res. Comm. 280:976-981, 2001). In a typical experiment the OX1 and OX2 receptor antagonistic...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/29/2019
Entry Details
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TargetOrexin receptor type 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM341138(US9765057, 5 | methyl 2-({(3R,6R)-1-[(5-fluoro-2- ...)
Affinity DataIC50: 72.9nMAssay Description:FLIPR Ca2+ Flux Assay (Okumura et al., Biochem. Biophys. Res. Comm. 280:976-981, 2001). In a typical experiment the OX1 and OX2 receptor antagonistic...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/29/2019
Entry Details
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TargetOrexin/Hypocretin receptor type 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM341143(US9765057, 10 | Methyl 4-ethyl-2-{[(3R,6R)-6-methy...)
Affinity DataIC50: 74.9nMAssay Description:FLIPR Ca2+ Flux Assay (Okumura et al., Biochem. Biophys. Res. Comm. 280:976-981, 2001). In a typical experiment the OX1 and OX2 receptor antagonistic...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/29/2019
Entry Details
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TargetOrexin/Hypocretin receptor type 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM341072(US9765057, 1 | Benzyl trans-5-hydroxy-2-methylpipe...)
Affinity DataIC50: 79nMAssay Description:FLIPR Ca2+ Flux Assay (Okumura et al., Biochem. Biophys. Res. Comm. 280:976-981, 2001). In a typical experiment the OX1 and OX2 receptor antagonistic...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/29/2019
Entry Details
Go to US Patent

TargetOrexin/Hypocretin receptor type 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM341144(US9765057, 11 | US9765057, 16 | US9765057, 12 | me...)
Affinity DataIC50: 80nMAssay Description:FLIPR Ca2+ Flux Assay (Okumura et al., Biochem. Biophys. Res. Comm. 280:976-981, 2001). In a typical experiment the OX1 and OX2 receptor antagonistic...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/29/2019
Entry Details
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TargetOrexin/Hypocretin receptor type 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM341135(US9765057, 2 | methyl 4-methy1-2-{[(3R,6R)-6- meth...)
Affinity DataIC50: 86.2nMAssay Description:FLIPR Ca2+ Flux Assay (Okumura et al., Biochem. Biophys. Res. Comm. 280:976-981, 2001). In a typical experiment the OX1 and OX2 receptor antagonistic...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/29/2019
Entry Details
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TargetOrexin/Hypocretin receptor type 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM341150(US9765057, 17 | Ethyl 4-ethyl-2-{[(3R,6R)-6-methyl...)
Affinity DataIC50: 172nMAssay Description:FLIPR Ca2+ Flux Assay (Okumura et al., Biochem. Biophys. Res. Comm. 280:976-981, 2001). In a typical experiment the OX1 and OX2 receptor antagonistic...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/29/2019
Entry Details
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TargetOrexin receptor type 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM341147(US9765057, 14 | methyl 4-cyclobutyl-2-{[(3R,6R)-6-...)
Affinity DataIC50: 272nMAssay Description:FLIPR Ca2+ Flux Assay (Okumura et al., Biochem. Biophys. Res. Comm. 280:976-981, 2001). In a typical experiment the OX1 and OX2 receptor antagonistic...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/29/2019
Entry Details
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TargetOrexin receptor type 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM341146(US9765057, 13 | methyl 4-cyclopropyl-2-{[(3R,6R)-6...)
Affinity DataIC50: 530nMAssay Description:FLIPR Ca2+ Flux Assay (Okumura et al., Biochem. Biophys. Res. Comm. 280:976-981, 2001). In a typical experiment the OX1 and OX2 receptor antagonistic...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/29/2019
Entry Details
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TargetOrexin/Hypocretin receptor type 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM341137(US9765057, 4)
Affinity DataIC50: 554nMAssay Description:FLIPR Ca2+ Flux Assay (Okumura et al., Biochem. Biophys. Res. Comm. 280:976-981, 2001). In a typical experiment the OX1 and OX2 receptor antagonistic...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/29/2019
Entry Details
Go to US Patent

TargetOrexin/Hypocretin receptor type 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM341136(US9765057, 3 | methyl 4-(methylsulfanyl)-2- {[(3R,...)
Affinity DataIC50: 618nMAssay Description:FLIPR Ca2+ Flux Assay (Okumura et al., Biochem. Biophys. Res. Comm. 280:976-981, 2001). In a typical experiment the OX1 and OX2 receptor antagonistic...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/29/2019
Entry Details
Go to US Patent

TargetOrexin/Hypocretin receptor type 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM341141(US9765057, 8 | Methyl 4-azetidin-1-yl-2-{[(3R,6R)-...)
Affinity DataIC50: 743nMAssay Description:FLIPR Ca2+ Flux Assay (Okumura et al., Biochem. Biophys. Res. Comm. 280:976-981, 2001). In a typical experiment the OX1 and OX2 receptor antagonistic...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/29/2019
Entry Details
Go to US Patent

TargetOrexin/Hypocretin receptor type 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM341146(US9765057, 13 | methyl 4-cyclopropyl-2-{[(3R,6R)-6...)
Affinity DataIC50: 803nMAssay Description:FLIPR Ca2+ Flux Assay (Okumura et al., Biochem. Biophys. Res. Comm. 280:976-981, 2001). In a typical experiment the OX1 and OX2 receptor antagonistic...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/29/2019
Entry Details
Go to US Patent

TargetOrexin/Hypocretin receptor type 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM341138(US9765057, 5 | methyl 2-({(3R,6R)-1-[(5-fluoro-2- ...)
Affinity DataIC50: 880nMAssay Description:FLIPR Ca2+ Flux Assay (Okumura et al., Biochem. Biophys. Res. Comm. 280:976-981, 2001). In a typical experiment the OX1 and OX2 receptor antagonistic...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/29/2019
Entry Details
Go to US Patent

TargetOrexin/Hypocretin receptor type 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM341139(US9765057, 6 | methyl 2-({(3R,6R)-1-[(4-fluoro-2- ...)
Affinity DataIC50: 888nMAssay Description:FLIPR Ca2+ Flux Assay (Okumura et al., Biochem. Biophys. Res. Comm. 280:976-981, 2001). In a typical experiment the OX1 and OX2 receptor antagonistic...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/29/2019
Entry Details
Go to US Patent

TargetOrexin receptor type 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM341144(US9765057, 11 | US9765057, 16 | US9765057, 12 | me...)
Affinity DataIC50: 1.01E+3nMAssay Description:FLIPR Ca2+ Flux Assay (Okumura et al., Biochem. Biophys. Res. Comm. 280:976-981, 2001). In a typical experiment the OX1 and OX2 receptor antagonistic...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/29/2019
Entry Details
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TargetOrexin/Hypocretin receptor type 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM341140(US9765057, 7 | methyl 2-({(3R,6R)-1-[(3-fluoro-2- ...)
Affinity DataIC50: 1.03E+3nMAssay Description:FLIPR Ca2+ Flux Assay (Okumura et al., Biochem. Biophys. Res. Comm. 280:976-981, 2001). In a typical experiment the OX1 and OX2 receptor antagonistic...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/29/2019
Entry Details
Go to US Patent

TargetOrexin/Hypocretin receptor type 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM341144(US9765057, 11 | US9765057, 16 | US9765057, 12 | me...)
Affinity DataIC50: 1.46E+3nMAssay Description:FLIPR Ca2+ Flux Assay (Okumura et al., Biochem. Biophys. Res. Comm. 280:976-981, 2001). In a typical experiment the OX1 and OX2 receptor antagonistic...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/29/2019
Entry Details
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TargetOrexin receptor type 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM341142(US9765057, 9 | methyl 4-(4-methylpiperazin-1-yl)- ...)
Affinity DataIC50: 1.53E+3nMAssay Description:FLIPR Ca2+ Flux Assay (Okumura et al., Biochem. Biophys. Res. Comm. 280:976-981, 2001). In a typical experiment the OX1 and OX2 receptor antagonistic...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/29/2019
Entry Details
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TargetOrexin/Hypocretin receptor type 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM341135(US9765057, 2 | methyl 4-methy1-2-{[(3R,6R)-6- meth...)
Affinity DataIC50: 1.93E+3nMAssay Description:FLIPR Ca2+ Flux Assay (Okumura et al., Biochem. Biophys. Res. Comm. 280:976-981, 2001). In a typical experiment the OX1 and OX2 receptor antagonistic...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/29/2019
Entry Details
Go to US Patent

TargetOrexin/Hypocretin receptor type 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM341144(US9765057, 11 | US9765057, 16 | US9765057, 12 | me...)
Affinity DataIC50: 2.05E+3nMAssay Description:FLIPR Ca2+ Flux Assay (Okumura et al., Biochem. Biophys. Res. Comm. 280:976-981, 2001). In a typical experiment the OX1 and OX2 receptor antagonistic...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/29/2019
Entry Details
Go to US Patent

TargetOrexin/Hypocretin receptor type 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM341147(US9765057, 14 | methyl 4-cyclobutyl-2-{[(3R,6R)-6-...)
Affinity DataIC50: 5.58E+3nMAssay Description:FLIPR Ca2+ Flux Assay (Okumura et al., Biochem. Biophys. Res. Comm. 280:976-981, 2001). In a typical experiment the OX1 and OX2 receptor antagonistic...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/29/2019
Entry Details
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TargetOrexin/Hypocretin receptor type 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM341142(US9765057, 9 | methyl 4-(4-methylpiperazin-1-yl)- ...)
Affinity DataIC50: 1.00E+4nMAssay Description:FLIPR Ca2+ Flux Assay (Okumura et al., Biochem. Biophys. Res. Comm. 280:976-981, 2001). In a typical experiment the OX1 and OX2 receptor antagonistic...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/29/2019
Entry Details
Go to US Patent