Compile Data Set for Download or QSAR
Report error Found 53 Enz. Inhib. hit(s) with all data for entry = 1512
Target5-hydroxytryptamine receptor 6(Human)
Sunshine Lake Pharma

US Patent
LigandPNGBDBM328390(US9663498, Example 30 | 3-(difluoromethyl)-6-fluor...)
Affinity DataIC50: 0.0660nMAssay Description:The binding affinity of the compound of this invention to human 5-HT6 receptor expressed in CHO cell was evaluated by radioligand binding assay as fo...More data for this Ligand-Target Pair
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Date in BDB:
6/4/2019
Entry Details
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Target5-hydroxytryptamine receptor 6(Human)
Sunshine Lake Pharma

US Patent
LigandPNGBDBM328384(US9663498, Example 24 | 3-(difluoromethyl)-5-fluor...)
Affinity DataIC50: 0.0740nMAssay Description:The binding affinity of the compound of this invention to human 5-HT6 receptor expressed in CHO cell was evaluated by radioligand binding assay as fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2019
Entry Details
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Target5-hydroxytryptamine receptor 6(Human)
Sunshine Lake Pharma

US Patent
LigandPNGBDBM328391(US9663498, Example 31 | 6-chloro-3-(difluoromethyl...)
Affinity DataIC50: 0.0850nMAssay Description:The binding affinity of the compound of this invention to human 5-HT6 receptor expressed in CHO cell was evaluated by radioligand binding assay as fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2019
Entry Details
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Target5-hydroxytryptamine receptor 6(Human)
Sunshine Lake Pharma

US Patent
LigandPNGBDBM328397(US9663498, Example 40 | 6-chloro-3-(difluoromethyl...)
Affinity DataIC50: 0.0900nMAssay Description:The binding affinity of the compound of this invention to human 5-HT6 receptor expressed in CHO cell was evaluated by radioligand binding assay as fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2019
Entry Details
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Target5-hydroxytryptamine receptor 6(Human)
Sunshine Lake Pharma

US Patent
LigandPNGBDBM328394(US9663498, Example 34 | 3-(difluoromethyl)-6-bromo...)
Affinity DataIC50: 0.0900nMAssay Description:The binding affinity of the compound of this invention to human 5-HT6 receptor expressed in CHO cell was evaluated by radioligand binding assay as fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2019
Entry Details
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Target5-hydroxytryptamine receptor 6(Human)
Sunshine Lake Pharma

US Patent
LigandPNGBDBM328396(US9663498, Example 39 | 6-chloro-1-((3-(4-cyclopro...)
Affinity DataIC50: 0.0920nMAssay Description:The binding affinity of the compound of this invention to human 5-HT6 receptor expressed in CHO cell was evaluated by radioligand binding assay as fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2019
Entry Details
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Target5-hydroxytryptamine receptor 6(Human)
Sunshine Lake Pharma

US Patent
LigandPNGBDBM328392(US9663498, Example 32 | 3-(difluoromethyl)-6-chlor...)
Affinity DataIC50: 0.100nMAssay Description:The binding affinity of the compound of this invention to human 5-HT6 receptor expressed in CHO cell was evaluated by radioligand binding assay as fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2019
Entry Details
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Target5-hydroxytryptamine receptor 6(Human)
Sunshine Lake Pharma

US Patent
LigandPNGBDBM328395(US9663498, Example 37 | 6-chloro-3-(difluoromethyl...)
Affinity DataIC50: 0.130nMAssay Description:The binding affinity of the compound of this invention to human 5-HT6 receptor expressed in CHO cell was evaluated by radioligand binding assay as fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2019
Entry Details
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Target5-hydroxytryptamine receptor 6(Human)
Sunshine Lake Pharma

US Patent
LigandPNGBDBM328380(US9663498, Example 20 | 6-chloro-1-((4-methoxy-3-(...)
Affinity DataIC50: 0.140nMAssay Description:The binding affinity of the compound of this invention to human 5-HT6 receptor expressed in CHO cell was evaluated by radioligand binding assay as fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2019
Entry Details
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Target5-hydroxytryptamine receptor 6(Human)
Sunshine Lake Pharma

US Patent
LigandPNGBDBM328400(US9663498, Example 45 | 3-(difluoromethyl)-1-((4-m...)
Affinity DataIC50: 0.140nMAssay Description:The binding affinity of the compound of this invention to human 5-HT6 receptor expressed in CHO cell was evaluated by radioligand binding assay as fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2019
Entry Details
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Target5-hydroxytryptamine receptor 6(Human)
Sunshine Lake Pharma

US Patent
LigandPNGBDBM328381(US9663498, Example 21 | 6-bromo-1-((4-methoxy-3-(4...)
Affinity DataIC50: 0.170nMAssay Description:The binding affinity of the compound of this invention to human 5-HT6 receptor expressed in CHO cell was evaluated by radioligand binding assay as fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2019
Entry Details
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Target5-hydroxytryptamine receptor 6(Human)
Sunshine Lake Pharma

US Patent
LigandPNGBDBM328388(US9663498, Example 28 | 3-(difluoromethyl)-5-bromo...)
Affinity DataIC50: 0.200nMAssay Description:The binding affinity of the compound of this invention to human 5-HT6 receptor expressed in CHO cell was evaluated by radioligand binding assay as fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2019
Entry Details
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Target5-hydroxytryptamine receptor 6(Human)
Sunshine Lake Pharma

US Patent
LigandPNGBDBM328379(US9663498, Example 19 | 6-chloro-1-((4-methoxy-3-(...)
Affinity DataIC50: 0.210nMAssay Description:The binding affinity of the compound of this invention to human 5-HT6 receptor expressed in CHO cell was evaluated by radioligand binding assay as fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2019
Entry Details
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Target5-hydroxytryptamine receptor 6(Human)
Sunshine Lake Pharma

US Patent
LigandPNGBDBM328386(US9663498, Example 26 | 5-chloro-3-(difluoromethyl...)
Affinity DataIC50: 0.220nMAssay Description:The binding affinity of the compound of this invention to human 5-HT6 receptor expressed in CHO cell was evaluated by radioligand binding assay as fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2019
Entry Details
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Target5-hydroxytryptamine receptor 6(Human)
Sunshine Lake Pharma

US Patent
LigandPNGBDBM328401(US9663498, Example 46 | 3-(difluoromethyl)-1-((3-(...)
Affinity DataIC50: 0.25nMAssay Description:The binding affinity of the compound of this invention to human 5-HT6 receptor expressed in CHO cell was evaluated by radioligand binding assay as fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2019
Entry Details
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Target5-hydroxytryptamine receptor 6(Human)
Sunshine Lake Pharma

US Patent
LigandPNGBDBM328389(US9663498, Example 29 | 3-(difluoromethyl)-6-fluor...)
Affinity DataIC50: 0.260nMAssay Description:The binding affinity of the compound of this invention to human 5-HT6 receptor expressed in CHO cell was evaluated by radioligand binding assay as fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2019
Entry Details
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Target5-hydroxytryptamine receptor 6(Human)
Sunshine Lake Pharma

US Patent
LigandPNGBDBM328393(US9663498, Example 33 | 3-(difluoromethyl)-6-bromo...)
Affinity DataIC50: 0.330nMAssay Description:The binding affinity of the compound of this invention to human 5-HT6 receptor expressed in CHO cell was evaluated by radioligand binding assay as fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2019
Entry Details
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Target5-hydroxytryptamine receptor 6(Human)
Sunshine Lake Pharma

US Patent
LigandPNGBDBM328399(US9663498, Example 44 | 3-(difluoromethyl)-1-((4-m...)
Affinity DataIC50: 0.400nMAssay Description:The binding affinity of the compound of this invention to human 5-HT6 receptor expressed in CHO cell was evaluated by radioligand binding assay as fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2019
Entry Details
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Target5-hydroxytryptamine receptor 6(Human)
Sunshine Lake Pharma

US Patent
LigandPNGBDBM328402(US9663498, Example 47 | 1-((3-(4-cyclopropylpipera...)
Affinity DataIC50: 0.400nMAssay Description:The binding affinity of the compound of this invention to human 5-HT6 receptor expressed in CHO cell was evaluated by radioligand binding assay as fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2019
Entry Details
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Target5-hydroxytryptamine receptor 6(Human)
Sunshine Lake Pharma

US Patent
LigandPNGBDBM328366(US9663498, Example 6 | 4-fluoro-1-((4-methoxy-3-(4...)
Affinity DataIC50: 0.430nMAssay Description:The binding affinity of the compound of this invention to human 5-HT6 receptor expressed in CHO cell was evaluated by radioligand binding assay as fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2019
Entry Details
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Target5-hydroxytryptamine receptor 6(Human)
Sunshine Lake Pharma

US Patent
LigandPNGBDBM328408(US9663498, Example 58 | 5-fluoro-1-((4-methoxy-3-(...)
Affinity DataIC50: 0.430nMAssay Description:The binding affinity of the compound of this invention to human 5-HT6 receptor expressed in CHO cell was evaluated by radioligand binding assay as fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2019
Entry Details
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Target5-hydroxytryptamine receptor 6(Human)
Sunshine Lake Pharma

US Patent
LigandPNGBDBM328412(US9663498, Example 71 | 6-chloro-3-ethyl-1-((4-met...)
Affinity DataIC50: 0.450nMAssay Description:The binding affinity of the compound of this invention to human 5-HT6 receptor expressed in CHO cell was evaluated by radioligand binding assay as fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2019
Entry Details
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Target5-hydroxytryptamine receptor 6(Human)
Sunshine Lake Pharma

US Patent
LigandPNGBDBM328383(US9663498, Example 23 | 3-(difluoromethyl)-5-fluor...)
Affinity DataIC50: 0.460nMAssay Description:The binding affinity of the compound of this invention to human 5-HT6 receptor expressed in CHO cell was evaluated by radioligand binding assay as fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2019
Entry Details
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Target5-hydroxytryptamine receptor 6(Human)
Sunshine Lake Pharma

US Patent
LigandPNGBDBM328398(US9663498, Example 41 | 6-chloro-1-((3-(4-cyclobut...)
Affinity DataIC50: 0.5nMAssay Description:The binding affinity of the compound of this invention to human 5-HT6 receptor expressed in CHO cell was evaluated by radioligand binding assay as fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2019
Entry Details
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Target5-hydroxytryptamine receptor 6(Human)
Sunshine Lake Pharma

US Patent
LigandPNGBDBM328404(US9663498, Example 49 | 5,6-dichloro-3-(difluorome...)
Affinity DataIC50: 0.540nMAssay Description:The binding affinity of the compound of this invention to human 5-HT6 receptor expressed in CHO cell was evaluated by radioligand binding assay as fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2019
Entry Details
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Target5-hydroxytryptamine receptor 6(Human)
Sunshine Lake Pharma

US Patent
LigandPNGBDBM328387(US9663498, Example 27 | 5-bromo-3-(difluoromethyl)...)
Affinity DataIC50: 0.550nMAssay Description:The binding affinity of the compound of this invention to human 5-HT6 receptor expressed in CHO cell was evaluated by radioligand binding assay as fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2019
Entry Details
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Target5-hydroxytryptamine receptor 6(Human)
Sunshine Lake Pharma

US Patent
LigandPNGBDBM328382(US9663498, Example 22 | 7-fluoro-1-((4-methoxy-3-(...)
Affinity DataIC50: 0.570nMAssay Description:The binding affinity of the compound of this invention to human 5-HT6 receptor expressed in CHO cell was evaluated by radioligand binding assay as fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2019
Entry Details
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Target5-hydroxytryptamine receptor 6(Human)
Sunshine Lake Pharma

US Patent
LigandPNGBDBM328407(US9663498, Example 57 | 6-bromo-3-(difluoromethyl)...)
Affinity DataIC50: 0.580nMAssay Description:The binding affinity of the compound of this invention to human 5-HT6 receptor expressed in CHO cell was evaluated by radioligand binding assay as fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2019
Entry Details
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Target5-hydroxytryptamine receptor 6(Human)
Sunshine Lake Pharma

US Patent
LigandPNGBDBM328362(US9663498, Example 2 | 1-((4-methoxy-3-(4-methylpi...)
Affinity DataIC50: 0.590nMAssay Description:The binding affinity of the compound of this invention to human 5-HT6 receptor expressed in CHO cell was evaluated by radioligand binding assay as fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2019
Entry Details
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Target5-hydroxytryptamine receptor 6(Human)
Sunshine Lake Pharma

US Patent
LigandPNGBDBM328413(US9663498, Example 72 | 6-bromo-3-ethyl-1-((4-meth...)
Affinity DataIC50: 0.600nMAssay Description:The binding affinity of the compound of this invention to human 5-HT6 receptor expressed in CHO cell was evaluated by radioligand binding assay as fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2019
Entry Details
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Target5-hydroxytryptamine receptor 6(Human)
Sunshine Lake Pharma

US Patent
LigandPNGBDBM328411(US9663498, Example 70 | 3-ethyl-6-fluoro-1-((4-met...)
Affinity DataIC50: 0.630nMAssay Description:The binding affinity of the compound of this invention to human 5-HT6 receptor expressed in CHO cell was evaluated by radioligand binding assay as fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2019
Entry Details
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Target5-hydroxytryptamine receptor 6(Human)
Sunshine Lake Pharma

US Patent
LigandPNGBDBM328385(US9663498, Example 25 | 5-chloro-3-(difluoromethyl...)
Affinity DataIC50: 0.640nMAssay Description:The binding affinity of the compound of this invention to human 5-HT6 receptor expressed in CHO cell was evaluated by radioligand binding assay as fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2019
Entry Details
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Target5-hydroxytryptamine receptor 6(Human)
Sunshine Lake Pharma

US Patent
LigandPNGBDBM328378(US9663498, Example 18 | 6-fluoro-1-((4-methoxy-3-(...)
Affinity DataIC50: 0.670nMAssay Description:The binding affinity of the compound of this invention to human 5-HT6 receptor expressed in CHO cell was evaluated by radioligand binding assay as fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2019
Entry Details
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Target5-hydroxytryptamine receptor 6(Human)
Sunshine Lake Pharma

US Patent
LigandPNGBDBM328409(US9663498, Example 60 | 5-chloro-1-((4-methoxy-3-(...)
Affinity DataIC50: 0.670nMAssay Description:The binding affinity of the compound of this invention to human 5-HT6 receptor expressed in CHO cell was evaluated by radioligand binding assay as fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2019
Entry Details
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Target5-hydroxytryptamine receptor 6(Human)
Sunshine Lake Pharma

US Patent
LigandPNGBDBM328410(US9663498, Example 62 | 5-bromo-1-((4-methoxy-3-(p...)
Affinity DataIC50: 0.870nMAssay Description:The binding affinity of the compound of this invention to human 5-HT6 receptor expressed in CHO cell was evaluated by radioligand binding assay as fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2019
Entry Details
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Target5-hydroxytryptamine receptor 6(Human)
Sunshine Lake Pharma

US Patent
LigandPNGBDBM328364(US9663498, Example 4 | 1-(1-((4-methoxy-3-(4-methy...)
Affinity DataIC50: 0.870nMAssay Description:The binding affinity of the compound of this invention to human 5-HT6 receptor expressed in CHO cell was evaluated by radioligand binding assay as fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2019
Entry Details
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Target5-hydroxytryptamine receptor 6(Human)
Sunshine Lake Pharma

US Patent
LigandPNGBDBM328363(US9663498, Example 3 | 1-(1-((4-methoxy-3-(piperaz...)
Affinity DataIC50: 0.960nMAssay Description:The binding affinity of the compound of this invention to human 5-HT6 receptor expressed in CHO cell was evaluated by radioligand binding assay as fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2019
Entry Details
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Target5-hydroxytryptamine receptor 6(Human)
Sunshine Lake Pharma

US Patent
LigandPNGBDBM328372(US9663498, Example 12 | 5-chloro-1-((4-methoxy-3-(...)
Affinity DataIC50: 1.10nMAssay Description:The binding affinity of the compound of this invention to human 5-HT6 receptor expressed in CHO cell was evaluated by radioligand binding assay as fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2019
Entry Details
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Target5-hydroxytryptamine receptor 6(Human)
Sunshine Lake Pharma

US Patent
LigandPNGBDBM328406(US9663498, Example 56 | 6-chloro-3-(difluoromethyl...)
Affinity DataIC50: 1.10nMAssay Description:The binding affinity of the compound of this invention to human 5-HT6 receptor expressed in CHO cell was evaluated by radioligand binding assay as fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2019
Entry Details
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Target5-hydroxytryptamine receptor 6(Human)
Sunshine Lake Pharma

US Patent
LigandPNGBDBM328365(US9663498, Example 5 | 4-fluoro-1-((4-methoxy-3-(p...)
Affinity DataIC50: 1.10nMAssay Description:The binding affinity of the compound of this invention to human 5-HT6 receptor expressed in CHO cell was evaluated by radioligand binding assay as fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2019
Entry Details
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Target5-hydroxytryptamine receptor 6(Human)
Sunshine Lake Pharma

US Patent
LigandPNGBDBM328377(US9663498, Example 17 | 6-fluoro-1-((4-methoxy-3-(...)
Affinity DataIC50: 1.30nMAssay Description:The binding affinity of the compound of this invention to human 5-HT6 receptor expressed in CHO cell was evaluated by radioligand binding assay as fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2019
Entry Details
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Target5-hydroxytryptamine receptor 6(Human)
Sunshine Lake Pharma

US Patent
LigandPNGBDBM328403(US9663498, Example 48 | 3-(difluoromethyl)-5,6-dif...)
Affinity DataIC50: 1.40nMAssay Description:The binding affinity of the compound of this invention to human 5-HT6 receptor expressed in CHO cell was evaluated by radioligand binding assay as fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2019
Entry Details
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Target5-hydroxytryptamine receptor 6(Human)
Sunshine Lake Pharma

US Patent
LigandPNGBDBM328371(US9663498, Example 11 | 5-chloro-1-((4-methoxy-3-(...)
Affinity DataIC50: 1.40nMAssay Description:The binding affinity of the compound of this invention to human 5-HT6 receptor expressed in CHO cell was evaluated by radioligand binding assay as fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2019
Entry Details
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Target5-hydroxytryptamine receptor 6(Human)
Sunshine Lake Pharma

US Patent
LigandPNGBDBM328374(US9663498, Example 14 | 5-bromo-1-((4-methoxy-3-(4...)
Affinity DataIC50: 1.5nMAssay Description:The binding affinity of the compound of this invention to human 5-HT6 receptor expressed in CHO cell was evaluated by radioligand binding assay as fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2019
Entry Details
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Target5-hydroxytryptamine receptor 6(Human)
Sunshine Lake Pharma

US Patent
LigandPNGBDBM328361(US9663498, Example 1 | 1-((4-methoxy-3-(piperazin-...)
Affinity DataIC50: 1.70nMAssay Description:The binding affinity of the compound of this invention to human 5-HT6 receptor expressed in CHO cell was evaluated by radioligand binding assay as fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2019
Entry Details
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Target5-hydroxytryptamine receptor 6(Human)
Sunshine Lake Pharma

US Patent
LigandPNGBDBM328368(US9663498, Example 8 | 1-((4-methoxy-3-(4-methylpi...)
Affinity DataIC50: 2nMAssay Description:The binding affinity of the compound of this invention to human 5-HT6 receptor expressed in CHO cell was evaluated by radioligand binding assay as fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2019
Entry Details
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Target5-hydroxytryptamine receptor 6(Human)
Sunshine Lake Pharma

US Patent
LigandPNGBDBM328370(US9663498, Example 10 | 5-fluoro-1-((4-methoxy-3-(...)
Affinity DataIC50: 2.10nMAssay Description:The binding affinity of the compound of this invention to human 5-HT6 receptor expressed in CHO cell was evaluated by radioligand binding assay as fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2019
Entry Details
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Target5-hydroxytryptamine receptor 6(Human)
Sunshine Lake Pharma

US Patent
LigandPNGBDBM328373(US9663498, Example 13 | 5-bromo-1-((4-methoxy-3-(p...)
Affinity DataIC50: 2.10nMAssay Description:The binding affinity of the compound of this invention to human 5-HT6 receptor expressed in CHO cell was evaluated by radioligand binding assay as fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2019
Entry Details
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Target5-hydroxytryptamine receptor 6(Human)
Sunshine Lake Pharma

US Patent
LigandPNGBDBM328375(US9663498, Example 15 | 1-((4-methoxy-3-(piperazin...)
Affinity DataIC50: 3.20nMAssay Description:The binding affinity of the compound of this invention to human 5-HT6 receptor expressed in CHO cell was evaluated by radioligand binding assay as fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2019
Entry Details
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Target5-hydroxytryptamine receptor 6(Human)
Sunshine Lake Pharma

US Patent
LigandPNGBDBM328405(US9663498, Example 55 | 3-(difluoromethyl)-6-fluor...)
Affinity DataIC50: 3.5nMAssay Description:The binding affinity of the compound of this invention to human 5-HT6 receptor expressed in CHO cell was evaluated by radioligand binding assay as fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2019
Entry Details
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