Compile Data Set for Download or QSAR
Report error Found 25 Enz. Inhib. hit(s) with all data for entry = 1362
TargetType-2 angiotensin II receptor(Human)
Novartis

US Patent
LigandPNGBDBM318438((2S,4R)-4-((4,4-dimethylpent-2-yn-1-yl)(methyl)ami...)
Affinity DataIC50: 33.9nMAssay Description:120 μL membrane (5 mg protein/well) was incubated with 15 μL of [125I]-CGP42112A and 15 μL of compound at RT for 1.5 hrs.The binding r...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/15/2019
Entry Details
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TargetType-2 angiotensin II receptor(Human)
Novartis

US Patent
LigandPNGBDBM318435(((2S,4R)-1-(2,2-diphenylacetyl)-4-((3-(4-fluorophe...)
Affinity DataIC50: 55.9nMAssay Description:120 μL membrane (5 mg protein/well) was incubated with 15 μL of [125I]-CGP42112A and 15 μL of compound at RT for 1.5 hrs.The binding r...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/15/2019
Entry Details
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TargetType-2 angiotensin II receptor(Human)
Novartis

US Patent
LigandPNGBDBM318414( (2S,4R)-4-benzyloxy-1-(2,2-diphenylacetyl)piperid...)
Affinity DataIC50: 76.7nMAssay Description:120 μL membrane (5 mg protein/well) was incubated with 15 μL of [125I]-CGP42112A and 15 μL of compound at RT for 1.5 hrs.The binding r...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/15/2019
Entry Details
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TargetType-2 angiotensin II receptor(Human)
Novartis

US Patent
LigandPNGBDBM318430((2S,4R)-1-(2,2-diphenylacetyl)-4-((3-phenylpropyl)...)
Affinity DataIC50: 101nMAssay Description:120 μL membrane (5 mg protein/well) was incubated with 15 μL of [125I]-CGP42112A and 15 μL of compound at RT for 1.5 hrs.The binding r...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/15/2019
Entry Details
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TargetType-2 angiotensin II receptor(Human)
Novartis

US Patent
LigandPNGBDBM318426((2S,4S)-1-(2,2-diphenylacetyl)-4-(methyl(3-pheneth...)
Affinity DataIC50: 101nMAssay Description:120 μL membrane (5 mg protein/well) was incubated with 15 μL of [125I]-CGP42112A and 15 μL of compound at RT for 1.5 hrs.The binding r...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/15/2019
Entry Details
Go to US Patent

TargetType-2 angiotensin II receptor(Human)
Novartis

US Patent
LigandPNGBDBM318423((2S,4R)-4-(2,2-diphenylacetyl)-4-(methyl(3-phenylp...)
Affinity DataIC50: 108nMAssay Description:120 μL membrane (5 mg protein/well) was incubated with 15 μL of [125I]-CGP42112A and 15 μL of compound at RT for 1.5 hrs.The binding r...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/15/2019
Entry Details
Go to US Patent

TargetType-2 angiotensin II receptor(Human)
Novartis

US Patent
LigandPNGBDBM318440( (2′S,3R,4′R)-1-(2,2-diphenylacetyl)-3...)
Affinity DataIC50: 111nMAssay Description:120 μL membrane (5 mg protein/well) was incubated with 15 μL of [125I]-CGP42112A and 15 μL of compound at RT for 1.5 hrs.The binding r...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/15/2019
Entry Details
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TargetType-2 angiotensin II receptor(Human)
Novartis

US Patent
LigandPNGBDBM318433((2S,4R)-1-(2,2-diphenylacetyl)-4-((methyl(4-methyl...)
Affinity DataIC50: 153nMAssay Description:120 μL membrane (5 mg protein/well) was incubated with 15 μL of [125I]-CGP42112A and 15 μL of compound at RT for 1.5 hrs.The binding r...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/15/2019
Entry Details
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TargetType-2 angiotensin II receptor(Human)
Novartis

US Patent
LigandPNGBDBM318049(US9624234, 9 | (S)-3-(2,2-diphenylacetyl)-1,2,3,4...)
Affinity DataIC50: 159nMAssay Description:120 μL membrane (5 mg protein/well) was incubated with 15 μL of [125I]-CGP42112A and 15 μL of compound at RT for 1.5 hrs.The binding r...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/15/2019
Entry Details
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TargetType-2 angiotensin II receptor(Human)
Novartis

US Patent
LigandPNGBDBM318442( (2′S,3S,4′S)-1′-(2,2-diphenylac...)
Affinity DataIC50: 170nMAssay Description:120 μL membrane (5 mg protein/well) was incubated with 15 μL of [125I]-CGP42112A and 15 μL of compound at RT for 1.5 hrs.The binding r...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/15/2019
Entry Details
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TargetType-2 angiotensin II receptor(Human)
Novartis

US Patent
LigandPNGBDBM318046(US9624234, 1 | (S)-5-benzyl-2-(2,2-diphenylacetyl...)
Affinity DataIC50: 210nMAssay Description:120 μL membrane (5 mg protein/well) was incubated with 15 μL of [125I]-CGP42112A and 15 μL of compound at RT for 1.5 hrs.The binding r...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/15/2019
Entry Details
Go to US Patent

TargetType-2 angiotensin II receptor(Human)
Novartis

US Patent
LigandPNGBDBM318050(US9624234, 26 | (2S)-4-(benzyloxy)-1-(2,2-diphenyl...)
Affinity DataIC50: 218nMAssay Description:120 μL membrane (5 mg protein/well) was incubated with 15 μL of [125I]-CGP42112A and 15 μL of compound at RT for 1.5 hrs.The binding r...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/15/2019
Entry Details
Go to US Patent

TargetType-2 angiotensin II receptor(Human)
Novartis

US Patent
LigandPNGBDBM318429((2S,4R)-1-(2,2-diphenylacetyl)-4-((3-phenylprop-2-...)
Affinity DataIC50: 228nMAssay Description:120 μL membrane (5 mg protein/well) was incubated with 15 μL of [125I]-CGP42112A and 15 μL of compound at RT for 1.5 hrs.The binding r...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/15/2019
Entry Details
Go to US Patent

TargetType-2 angiotensin II receptor(Human)
Novartis

US Patent
LigandPNGBDBM318437((2S,4R)-1-(2,2-diphenylacetyl)-4-((3-(4-fluorophen...)
Affinity DataIC50: 228nMAssay Description:120 μL membrane (5 mg protein/well) was incubated with 15 μL of [125I]-CGP42112A and 15 μL of compound at RT for 1.5 hrs.The binding r...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/15/2019
Entry Details
Go to US Patent

TargetType-2 angiotensin II receptor(Human)
Novartis

US Patent
LigandPNGBDBM318439((2′S,3R,4′R)-1′-(2,2-diphenylace...)
Affinity DataIC50: 294nMAssay Description:120 μL membrane (5 mg protein/well) was incubated with 15 μL of [125I]-CGP42112A and 15 μL of compound at RT for 1.5 hrs.The binding r...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/15/2019
Entry Details
Go to US Patent

TargetType-2 angiotensin II receptor(Human)
Novartis

US Patent
LigandPNGBDBM318434((2S,4S)-1-(2,2-diphenylacetyl)-4-((methyl(4-methyl...)
Affinity DataIC50: 354nMAssay Description:120 μL membrane (5 mg protein/well) was incubated with 15 μL of [125I]-CGP42112A and 15 μL of compound at RT for 1.5 hrs.The binding r...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/15/2019
Entry Details
Go to US Patent

TargetType-2 angiotensin II receptor(Human)
Novartis

US Patent
LigandPNGBDBM318428( (2S,4S)-4-(benzyl(methyl)amino)-1-(2,2-diphenylac...)
Affinity DataIC50: 648nMAssay Description:120 μL membrane (5 mg protein/well) was incubated with 15 μL of [125I]-CGP42112A and 15 μL of compound at RT for 1.5 hrs.The binding r...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/15/2019
Entry Details
Go to US Patent

TargetType-2 angiotensin II receptor(Human)
Novartis

US Patent
LigandPNGBDBM318431((2S,4R)-4-((but-2-yn-1-yl)methyl)amino)-1-(2,2-dip...)
Affinity DataIC50: 852nMAssay Description:120 μL membrane (5 mg protein/well) was incubated with 15 μL of [125I]-CGP42112A and 15 μL of compound at RT for 1.5 hrs.The binding r...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/15/2019
Entry Details
Go to US Patent

TargetType-2 angiotensin II receptor(Human)
Novartis

US Patent
LigandPNGBDBM318427((2S,4R)-4-(benzyl(methyl)amino)-1-(2,2-diphenylace...)
Affinity DataIC50: 854nMAssay Description:120 μL membrane (5 mg protein/well) was incubated with 15 μL of [125I]-CGP42112A and 15 μL of compound at RT for 1.5 hrs.The binding r...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/15/2019
Entry Details
Go to US Patent

TargetType-2 angiotensin II receptor(Human)
Novartis

US Patent
LigandPNGBDBM318422(US9624234, 31 | US9624234, 34 | (2S,4R)-1-(2,2-di...)
Affinity DataIC50: 918nMAssay Description:120 μL membrane (5 mg protein/well) was incubated with 15 μL of [125I]-CGP42112A and 15 μL of compound at RT for 1.5 hrs.The binding r...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/15/2019
Entry Details
Go to US Patent

TargetType-2 angiotensin II receptor(Human)
Novartis

US Patent
LigandPNGBDBM318436((2S,4S)-1-(2,2-diphenylacetyl)-4-((3-(4-fluorophen...)
Affinity DataIC50: 1.04E+3nMAssay Description:120 μL membrane (5 mg protein/well) was incubated with 15 μL of [125I]-CGP42112A and 15 μL of compound at RT for 1.5 hrs.The binding r...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/15/2019
Entry Details
Go to US Patent

TargetType-2 angiotensin II receptor(Human)
Novartis

US Patent
LigandPNGBDBM318441((2′S,3S,4′R)-1′-(2,2-diphenylace...)
Affinity DataIC50: 1.44E+3nMAssay Description:120 μL membrane (5 mg protein/well) was incubated with 15 μL of [125I]-CGP42112A and 15 μL of compound at RT for 1.5 hrs.The binding r...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/15/2019
Entry Details
Go to US Patent

TargetType-2 angiotensin II receptor(Human)
Novartis

US Patent
LigandPNGBDBM318432((2S,4S)-4-((but-2-yn-1-yl)methyl)amino)-1-(2,2-dip...)
Affinity DataIC50: 2.05E+3nMAssay Description:120 μL membrane (5 mg protein/well) was incubated with 15 μL of [125I]-CGP42112A and 15 μL of compound at RT for 1.5 hrs.The binding r...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/15/2019
Entry Details
Go to US Patent

TargetType-2 angiotensin II receptor(Human)
Novartis

US Patent
LigandPNGBDBM318424((2S,4S)-1-(2,2-diphenylacetyl)-4-(methyl(3-phenylp...)
Affinity DataIC50: 2.71E+3nMAssay Description:120 μL membrane (5 mg protein/well) was incubated with 15 μL of [125I]-CGP42112A and 15 μL of compound at RT for 1.5 hrs.The binding r...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/15/2019
Entry Details
Go to US Patent

TargetType-2 angiotensin II receptor(Human)
Novartis

US Patent
LigandPNGBDBM318422(US9624234, 31 | US9624234, 34 | (2S,4R)-1-(2,2-di...)
Affinity DataIC50: 5.09E+3nMAssay Description:120 μL membrane (5 mg protein/well) was incubated with 15 μL of [125I]-CGP42112A and 15 μL of compound at RT for 1.5 hrs.The binding r...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/15/2019
Entry Details
Go to US Patent