Compile Data Set for Download or QSAR
Report error Found 135 Enz. Inhib. hit(s) with all data for entry = 1223
TargetBeta-secretase 1(Human)
Pfizer

US Patent
LigandPNGBDBM312935(US9605007, Example 3 | N-{2-[(4aR,6S,8aR)-2-amino-...)
Affinity DataIC50: 0.700nMAssay Description:Beta-secretase (BACE) is one of the enzymes involved in the generation of the amyloid beta peptide found in the amyloid plaques of Alzheimer's Di...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2019
Entry Details
Go to US Patent

TargetBeta-secretase 1(Human)
Pfizer

US Patent
LigandPNGBDBM312938(US9605007, Example 4 | N-{2-[(4aR,6S,8aR)-2-amino-...)
Affinity DataIC50: 0.900nMAssay Description:Beta-secretase (BACE) is one of the enzymes involved in the generation of the amyloid beta peptide found in the amyloid plaques of Alzheimer's Di...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2019
Entry Details
Go to US Patent

TargetBeta-secretase 1(Human)
Pfizer

US Patent
LigandPNGBDBM223358(US9315520, Comparator 7 | US9605007, Comparator 7 ...)
Affinity DataIC50: 1nMAssay Description:The BACE1 and BACE2 binding assays measured beta-site amyloid precursor protein-cleaving enzyme (BACE) binding as a decrease in the counts of radioli...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2019
Entry Details
Go to US Patent

TargetBeta-secretase 1(Human)
Pfizer

US Patent
LigandPNGBDBM223381(US9315520, 96 | US9605007, Example 96 | US9744173,...)
Affinity DataIC50: 2nMAssay Description:Beta-secretase (BACE) is one of the enzymes involved in the generation of the amyloid beta peptide found in the amyloid plaques of Alzheimer's Di...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2019
Entry Details
Go to US Patent

TargetBeta-secretase 1(Human)
Pfizer

US Patent
LigandPNGBDBM312936(US9605007, Comparator 3 | US9744173, Comparator 4)
Affinity DataIC50: 3nMAssay Description:The BACE1 and BACE2 binding assays measured beta-site amyloid precursor protein-cleaving enzyme (BACE) binding as a decrease in the counts of radioli...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2019
Entry Details
Go to US Patent

TargetBeta-secretase 1(Human)
Pfizer

US Patent
LigandPNGBDBM312941(US9605007, Example 6 | N-{2-[(4aR,6S,8aR)-2-amino-...)
Affinity DataIC50: 4nMAssay Description:Beta-secretase (BACE) is one of the enzymes involved in the generation of the amyloid beta peptide found in the amyloid plaques of Alzheimer's Di...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2019
Entry Details
Go to US Patent

TargetBeta-secretase 1(Human)
Pfizer

US Patent
LigandPNGBDBM223413(US9315520, Comparator 6 | US9605007, Comparator 6 ...)
Affinity DataIC50: 6nMAssay Description:The BACE1 and BACE2 binding assays measured beta-site amyloid precursor protein-cleaving enzyme (BACE) binding as a decrease in the counts of radioli...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2019
Entry Details
Go to US Patent

TargetBeta-secretase 1(Human)
Pfizer

US Patent
LigandPNGBDBM312934(US9605007, Example 2 | N-{2-[(4aR,6S,8aR)-2-amino-...)
Affinity DataIC50: 7.30nMAssay Description:Beta-secretase (BACE) is one of the enzymes involved in the generation of the amyloid beta peptide found in the amyloid plaques of Alzheimer's Di...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2019
Entry Details
Go to US Patent

TargetBeta-secretase 1(Human)
Pfizer

US Patent
LigandPNGBDBM223406(US9315520, Comparator 4 | US9605007, Comparator 4)
Affinity DataIC50: 9nMAssay Description:The BACE1 and BACE2 binding assays measured beta-site amyloid precursor protein-cleaving enzyme (BACE) binding as a decrease in the counts of radioli...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2019
Entry Details
Go to US Patent

TargetBeta-secretase 1(Human)
Pfizer

US Patent
LigandPNGBDBM312943(US9605007, Example 8 | N-{2-[(4aR,6S,8aR)-2-amino-...)
Affinity DataIC50: 11nMAssay Description:Beta-secretase (BACE) is one of the enzymes involved in the generation of the amyloid beta peptide found in the amyloid plaques of Alzheimer's Di...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2019
Entry Details
Go to US Patent

TargetBeta-secretase 1(Human)
Pfizer

US Patent
LigandPNGBDBM223387(US9315520, 102 | US9605007, Example 102 | US974417...)
Affinity DataIC50: 12nMAssay Description:Beta-secretase (BACE) is one of the enzymes involved in the generation of the amyloid beta peptide found in the amyloid plaques of Alzheimer's Di...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2019
Entry Details
Go to US Patent

TargetBeta-secretase 1(Human)
Pfizer

US Patent
LigandPNGBDBM223335(US9315520, 22 | US9605007, Example 22 | US9744173,...)
Affinity DataIC50: 13nMAssay Description:Beta-secretase (BACE) is one of the enzymes involved in the generation of the amyloid beta peptide found in the amyloid plaques of Alzheimer's Di...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2019
Entry Details
Go to US Patent

TargetBeta-secretase 1(Human)
Pfizer

US Patent
LigandPNGBDBM223374(US9315520, 89 | US9605007, Example 89 | US9744173,...)
Affinity DataIC50: 17nMAssay Description:Beta-secretase (BACE) is one of the enzymes involved in the generation of the amyloid beta peptide found in the amyloid plaques of Alzheimer's Di...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2019
Entry Details
Go to US Patent

TargetBeta-secretase 1(Human)
Pfizer

US Patent
LigandPNGBDBM223379(US9315520, 94 | US9605007, Example 94 | US9744173,...)
Affinity DataIC50: 18nMAssay Description:Beta-secretase (BACE) is one of the enzymes involved in the generation of the amyloid beta peptide found in the amyloid plaques of Alzheimer's Di...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2019
Entry Details
Go to US Patent

TargetBeta-secretase 1(Human)
Pfizer

US Patent
LigandPNGBDBM312939(US9605007, Comparator 5 | Ex. 64 of US 8198269)
Affinity DataIC50: 19nMAssay Description:The BACE1 and BACE2 binding assays measured beta-site amyloid precursor protein-cleaving enzyme (BACE) binding as a decrease in the counts of radioli...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2019
Entry Details
Go to US Patent

TargetBeta-secretase 1(Human)
Pfizer

US Patent
LigandPNGBDBM223396(US9315520, Example 7 | US9315520, 7 | US9605007, E...)
Affinity DataIC50: 19nMAssay Description:Beta-secretase (BACE) is one of the enzymes involved in the generation of the amyloid beta peptide found in the amyloid plaques of Alzheimer's Di...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2019
Entry Details
Go to US Patent

TargetBeta-secretase 1(Human)
Pfizer

US Patent
LigandPNGBDBM312940(US9605007, Example 5 | N-{2-[(4aR,6S,8aR)-2-amino-...)
Affinity DataIC50: 22nMAssay Description:Beta-secretase (BACE) is one of the enzymes involved in the generation of the amyloid beta peptide found in the amyloid plaques of Alzheimer's Di...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2019
Entry Details
Go to US Patent

TargetBeta-secretase 1(Human)
Pfizer

US Patent
LigandPNGBDBM223400(US9315520, Example 45 | US9315520, 45 | US9605007,...)
Affinity DataIC50: 23nMAssay Description:Beta-secretase (BACE) is one of the enzymes involved in the generation of the amyloid beta peptide found in the amyloid plaques of Alzheimer's Di...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2019
Entry Details
Go to US Patent

TargetBeta-secretase 1(Human)
Pfizer

US Patent
LigandPNGBDBM223384(US9315520, 99 | US9605007, Example 99 | US9744173,...)
Affinity DataIC50: 25nMAssay Description:Beta-secretase (BACE) is one of the enzymes involved in the generation of the amyloid beta peptide found in the amyloid plaques of Alzheimer's Di...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2019
Entry Details
Go to US Patent

TargetCytochrome P450 2D6(Human)
Pfizer

US Patent
LigandPNGBDBM223398(US9315520, Comparator 2 | US9315520, Comparator 3 ...)
Affinity DataIC50: 30nMAssay Description:CYP2D6 inhibition was obtained by measuring inhibition of 5 uM Dextromethorphan in pooled HLM (HL-MIX-102).More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2019
Entry Details
Go to US Patent

TargetCytochrome P450 2D6(Human)
Pfizer

US Patent
LigandPNGBDBM312936(US9605007, Comparator 3 | US9744173, Comparator 4)
Affinity DataIC50: 30nMAssay Description:CYP2D6 inhibition was obtained by measuring inhibition of 5 uM Dextromethorphan in pooled HLM (HL-MIX-102).More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2019
Entry Details
Go to US Patent

TargetCytochrome P450 2D6(Human)
Pfizer

US Patent
LigandPNGBDBM223413(US9315520, Comparator 6 | US9605007, Comparator 6 ...)
Affinity DataIC50: 30nMAssay Description:CYP2D6 inhibition was obtained by measuring inhibition of 5 uM Dextromethorphan in pooled HLM (HL-MIX-102).More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2019
Entry Details
Go to US Patent

TargetCytochrome P450 2D6(Human)
Pfizer

US Patent
LigandPNGBDBM223358(US9315520, Comparator 7 | US9605007, Comparator 7 ...)
Affinity DataIC50: 30nMAssay Description:CYP2D6 inhibition was obtained by measuring inhibition of 5 uM Dextromethorphan in pooled HLM (HL-MIX-102).More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2019
Entry Details
Go to US Patent

TargetBeta-secretase 1(Human)
Pfizer

US Patent
LigandPNGBDBM223395(US9315520, Example 1 | US9315520, Comparator 1 | U...)
Affinity DataIC50: 31nMAssay Description:Beta-secretase (BACE) is one of the enzymes involved in the generation of the amyloid beta peptide found in the amyloid plaques of Alzheimer's Di...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2019
Entry Details
Go to US Patent

TargetBeta-secretase 1(Human)
Pfizer

US Patent
LigandPNGBDBM223396(US9315520, Example 7 | US9315520, 7 | US9605007, E...)
Affinity DataIC50: 33nMAssay Description:Beta-secretase (BACE) is one of the enzymes involved in the generation of the amyloid beta peptide found in the amyloid plaques of Alzheimer's Di...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2019
Entry Details
Go to US Patent

TargetBeta-secretase 1(Human)
Pfizer

US Patent
LigandPNGBDBM223383(US9315520, 98 | US9605007, Example 98 | US9744173,...)
Affinity DataIC50: 33nMAssay Description:Beta-secretase (BACE) is one of the enzymes involved in the generation of the amyloid beta peptide found in the amyloid plaques of Alzheimer's Di...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2019
Entry Details
Go to US Patent

TargetBeta-secretase 1(Human)
Pfizer

US Patent
LigandPNGBDBM223395(US9315520, Example 1 | US9315520, Comparator 1 | U...)
Affinity DataIC50: 41nMAssay Description:Beta-secretase (BACE) is one of the enzymes involved in the generation of the amyloid beta peptide found in the amyloid plaques of Alzheimer's Di...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2019
Entry Details
Go to US Patent

TargetBeta-secretase 1(Human)
Pfizer

US Patent
LigandPNGBDBM223398(US9315520, Comparator 2 | US9315520, Comparator 3 ...)
Affinity DataIC50: 43nMAssay Description:The BACE1 and BACE2 binding assays measured beta-site amyloid precursor protein-cleaving enzyme (BACE) binding as a decrease in the counts of radioli...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2019
Entry Details
Go to US Patent

TargetBeta-secretase 1(Human)
Pfizer

US Patent
LigandPNGBDBM223330(US9315520, 17 | US9605007, Example 17 | US9744173,...)
Affinity DataIC50: 54nMAssay Description:Beta-secretase (BACE) is one of the enzymes involved in the generation of the amyloid beta peptide found in the amyloid plaques of Alzheimer's Di...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2019
Entry Details
Go to US Patent

TargetCytochrome P450 2D6(Human)
Pfizer

US Patent
LigandPNGBDBM223406(US9315520, Comparator 4 | US9605007, Comparator 4)
Affinity DataIC50: 65nMAssay Description:CYP2D6 inhibition was obtained by measuring inhibition of 5 uM Dextromethorphan in pooled HLM (HL-MIX-102).More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2019
Entry Details
Go to US Patent

TargetBeta-secretase 1(Human)
Pfizer

US Patent
LigandPNGBDBM223366(US9315520, 53 | US9605007, Example 53 | US9744173,...)
Affinity DataIC50: 65nMAssay Description:Beta-secretase (BACE) is one of the enzymes involved in the generation of the amyloid beta peptide found in the amyloid plaques of Alzheimer's Di...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2019
Entry Details
Go to US Patent

TargetBeta-secretase 1(Human)
Pfizer

US Patent
LigandPNGBDBM223339(US9315520, 26 | US9605007, Example 26 | US9744173,...)
Affinity DataIC50: 68nMAssay Description:Beta-secretase (BACE) is one of the enzymes involved in the generation of the amyloid beta peptide found in the amyloid plaques of Alzheimer's Di...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2019
Entry Details
Go to US Patent

TargetBeta-secretase 1(Human)
Pfizer

US Patent
LigandPNGBDBM223338(US9315520, 25 | US9605007, Example 25 | US9744173,...)
Affinity DataIC50: 74nMAssay Description:Beta-secretase (BACE) is one of the enzymes involved in the generation of the amyloid beta peptide found in the amyloid plaques of Alzheimer's Di...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2019
Entry Details
Go to US Patent

TargetBeta-secretase 1(Human)
Pfizer

US Patent
LigandPNGBDBM223380(US9315520, 95 | US9605007, Example 95 | US9744173,...)
Affinity DataIC50: 75nMAssay Description:Beta-secretase (BACE) is one of the enzymes involved in the generation of the amyloid beta peptide found in the amyloid plaques of Alzheimer's Di...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2019
Entry Details
Go to US Patent

TargetBeta-secretase 1(Human)
Pfizer

US Patent
LigandPNGBDBM223337(US9315520, 24 | US9605007, Example 24 | US9744173,...)
Affinity DataIC50: 81nMAssay Description:Beta-secretase (BACE) is one of the enzymes involved in the generation of the amyloid beta peptide found in the amyloid plaques of Alzheimer's Di...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2019
Entry Details
Go to US Patent

TargetBeta-secretase 1(Human)
Pfizer

US Patent
LigandPNGBDBM223377(US9315520, 92 | US9605007, Example 92)
Affinity DataIC50: 82nMAssay Description:Beta-secretase (BACE) is one of the enzymes involved in the generation of the amyloid beta peptide found in the amyloid plaques of Alzheimer's Di...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2019
Entry Details
Go to US Patent

TargetBeta-secretase 1(Human)
Pfizer

US Patent
LigandPNGBDBM223390(US9315520, 105 | US9605007, Example 105 | US974417...)
Affinity DataIC50: 85nMAssay Description:Beta-secretase (BACE) is one of the enzymes involved in the generation of the amyloid beta peptide found in the amyloid plaques of Alzheimer's Di...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2019
Entry Details
Go to US Patent

TargetBeta-secretase 1(Human)
Pfizer

US Patent
LigandPNGBDBM223326(US9315520, 13 | US9605007, Example 13 | US9744173,...)
Affinity DataIC50: 90nMAssay Description:Beta-secretase (BACE) is one of the enzymes involved in the generation of the amyloid beta peptide found in the amyloid plaques of Alzheimer's Di...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2019
Entry Details
Go to US Patent

TargetBeta-secretase 1(Human)
Pfizer

US Patent
LigandPNGBDBM223365(US9315520, 52 | US9605007, Example 52 | US9744173,...)
Affinity DataIC50: 91nMAssay Description:Beta-secretase (BACE) is one of the enzymes involved in the generation of the amyloid beta peptide found in the amyloid plaques of Alzheimer's Di...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2019
Entry Details
Go to US Patent

TargetBeta-secretase 1(Human)
Pfizer

US Patent
LigandPNGBDBM313052(US9605007, Example 108 | N-{2-[(4aR,6S,8aR)-2-amin...)
Affinity DataIC50: 94nMAssay Description:Beta-secretase (BACE) is one of the enzymes involved in the generation of the amyloid beta peptide found in the amyloid plaques of Alzheimer's Di...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2019
Entry Details
Go to US Patent

TargetBeta-secretase 1(Human)
Pfizer

US Patent
LigandPNGBDBM223364(US9315520, 51 | US9605007, Example 51 | US9744173,...)
Affinity DataIC50: 98nMAssay Description:Beta-secretase (BACE) is one of the enzymes involved in the generation of the amyloid beta peptide found in the amyloid plaques of Alzheimer's Di...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2019
Entry Details
Go to US Patent

TargetBeta-secretase 1(Human)
Pfizer

US Patent
LigandPNGBDBM223360(US9315520, 47 | US9605007, Example 47 | US9744173,...)
Affinity DataIC50: 101nMAssay Description:Beta-secretase (BACE) is one of the enzymes involved in the generation of the amyloid beta peptide found in the amyloid plaques of Alzheimer's Di...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2019
Entry Details
Go to US Patent

TargetBeta-secretase 1(Human)
Pfizer

US Patent
LigandPNGBDBM223362(US9315520, 49 | US9605007, Example 49 | US9744173,...)
Affinity DataIC50: 103nMAssay Description:Beta-secretase (BACE) is one of the enzymes involved in the generation of the amyloid beta peptide found in the amyloid plaques of Alzheimer's Di...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2019
Entry Details
Go to US Patent

TargetBeta-secretase 1(Human)
Pfizer

US Patent
LigandPNGBDBM223334(US9315520, 21 | US9605007, Example 21 | US9744173,...)
Affinity DataIC50: 106nMAssay Description:Beta-secretase (BACE) is one of the enzymes involved in the generation of the amyloid beta peptide found in the amyloid plaques of Alzheimer's Di...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2019
Entry Details
Go to US Patent

TargetBeta-secretase 1(Human)
Pfizer

US Patent
LigandPNGBDBM223333(US9315520, 20 | US9605007, Example 20 | US9744173,...)
Affinity DataIC50: 108nMAssay Description:Beta-secretase (BACE) is one of the enzymes involved in the generation of the amyloid beta peptide found in the amyloid plaques of Alzheimer's Di...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2019
Entry Details
Go to US Patent

TargetBeta-secretase 1(Human)
Pfizer

US Patent
LigandPNGBDBM223353(US9315520, 40 | US9605007, Example 40 | US9744173,...)
Affinity DataIC50: 134nMAssay Description:Beta-secretase (BACE) is one of the enzymes involved in the generation of the amyloid beta peptide found in the amyloid plaques of Alzheimer's Di...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2019
Entry Details
Go to US Patent

TargetBeta-secretase 1(Human)
Pfizer

US Patent
LigandPNGBDBM223328(US9315520, 15 | US9605007, Example 15 | US9744173,...)
Affinity DataIC50: 145nMAssay Description:Beta-secretase (BACE) is one of the enzymes involved in the generation of the amyloid beta peptide found in the amyloid plaques of Alzheimer's Di...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2019
Entry Details
Go to US Patent

TargetBeta-secretase 1(Human)
Pfizer

US Patent
LigandPNGBDBM223351(US9315520, 38 | US9605007, Example 38 | US9744173,...)
Affinity DataIC50: 145nMAssay Description:Beta-secretase (BACE) is one of the enzymes involved in the generation of the amyloid beta peptide found in the amyloid plaques of Alzheimer's Di...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2019
Entry Details
Go to US Patent

TargetBeta-secretase 1(Human)
Pfizer

US Patent
LigandPNGBDBM223331(US9315520, 18 | US9605007, Example 18 | US9744173,...)
Affinity DataIC50: 153nMAssay Description:Beta-secretase (BACE) is one of the enzymes involved in the generation of the amyloid beta peptide found in the amyloid plaques of Alzheimer's Di...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2019
Entry Details
Go to US Patent

TargetBeta-secretase 1(Human)
Pfizer

US Patent
LigandPNGBDBM223367(US9315520, 54 | US9605007, Example 54 | US9744173,...)
Affinity DataIC50: 161nMAssay Description:Beta-secretase (BACE) is one of the enzymes involved in the generation of the amyloid beta peptide found in the amyloid plaques of Alzheimer's Di...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2019
Entry Details
Go to US Patent

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