Compile Data Set for Download or QSAR
Report error Found 709 Enz. Inhib. hit(s) with all data for entry = 803
LigandPNGBDBM291686(US9580437, Example 1 | 8-(1,3-Dimethyl-1H-pyrazol-...)
Affinity DataIC50: 0.900nMAssay Description:Cell lysates were transferred to the wells of a 384-well plate and the final volume was adjusted to 50 μL per well with PBS. The plate was seale...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2019
Entry Details
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LigandPNGBDBM291695(US9580437, Example 10 | 3-(5-(((5-fluoro-2,3-dihyd...)
Affinity DataIC50: 1nMAssay Description:Cell lysates were transferred to the wells of a 384-well plate and the final volume was adjusted to 50 μL per well with PBS. The plate was seale...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2019
Entry Details
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LigandPNGBDBM291815(US9580437, Example 130 | (5-(5-(((5-fluoro-2,3-dih...)
Affinity DataIC50: 1.30nMAssay Description:Cell lysates were transferred to the wells of a 384-well plate and the final volume was adjusted to 50 μL per well with PBS. The plate was seale...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2019
Entry Details
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LigandPNGBDBM291908(US9580437, Example 223 | 8-(6-((dimethylamino)meth...)
Affinity DataIC50: 1.40nMAssay Description:Cell lysates were transferred to the wells of a 384-well plate and the final volume was adjusted to 50 μL per well with PBS. The plate was seale...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2019
Entry Details
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LigandPNGBDBM291925(US9580437, Example 240 | N-((5-fluoro-2,3-dihydrob...)
Affinity DataIC50: 1.40nMAssay Description:Cell lysates were transferred to the wells of a 384-well plate and the final volume was adjusted to 50 μL per well with PBS. The plate was seale...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2019
Entry Details
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LigandPNGBDBM291909(US9580437, Example 224 | 8-(6-ethyl-4-methylpyridi...)
Affinity DataIC50: 1.5nMpH: 8.0Assay Description:To assess the compounds potency in the EED-H3K27Me3 competition binding assay, compounds were serially diluted 3-fold in DMSO to obtain a total of tw...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2019
Entry Details
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LigandPNGBDBM291824(US9580437, Example 139 | N-((5-fluoro-2,3-dihydrob...)
Affinity DataIC50: 1.60nMAssay Description:Cell lysates were transferred to the wells of a 384-well plate and the final volume was adjusted to 50 μL per well with PBS. The plate was seale...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2019
Entry Details
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LigandPNGBDBM291824(US9580437, Example 139 | N-((5-fluoro-2,3-dihydrob...)
Affinity DataIC50: 1.70nMpH: 8.0Assay Description:To assess the compounds potency in the EED-H3K27Me3 competition binding assay, compounds were serially diluted 3-fold in DMSO to obtain a total of tw...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2019
Entry Details
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LigandPNGBDBM291814(US9580437, Example 129 | (5-(5-(((5-fluoro-2,3-dih...)
Affinity DataIC50: 1.90nMAssay Description:Cell lysates were transferred to the wells of a 384-well plate and the final volume was adjusted to 50 μL per well with PBS. The plate was seale...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2019
Entry Details
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LigandPNGBDBM291823(US9580437, Example 138 | 8-(4-chloro-6-methoxypyri...)
Affinity DataIC50: 1.90nMpH: 8.0Assay Description:To assess the compounds potency in the EED-H3K27Me3 competition binding assay, compounds were serially diluted 3-fold in DMSO to obtain a total of tw...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2019
Entry Details
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LigandPNGBDBM291909(US9580437, Example 224 | 8-(6-ethyl-4-methylpyridi...)
Affinity DataIC50: 1.90nMpH: 8.0Assay Description:Representative compounds of the present disclosure were serially and separately diluted 3-fold in DMSO to obtain a total of eight or twelve concentra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2019
Entry Details
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LigandPNGBDBM291853(US9580437, Example 168 | 8-(2-(difluoromethyl)pyri...)
Affinity DataIC50: 2nMAssay Description:Cell lysates were transferred to the wells of a 384-well plate and the final volume was adjusted to 50 μL per well with PBS. The plate was seale...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2019
Entry Details
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LigandPNGBDBM291918(US9580437, Example 233 | N-((5-fluoro-2,3-dihydrob...)
Affinity DataIC50: 2nMAssay Description:Cell lysates were transferred to the wells of a 384-well plate and the final volume was adjusted to 50 μL per well with PBS. The plate was seale...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2019
Entry Details
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LigandPNGBDBM291689(US9580437, Example 4 | N-((5-Fluoro-2,3-dihydroben...)
Affinity DataIC50: 2.10nMAssay Description:Cell lysates were transferred to the wells of a 384-well plate and the final volume was adjusted to 50 μL per well with PBS. The plate was seale...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2019
Entry Details
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LigandPNGBDBM291882(US9580437, Example 197 | 8-(6-(difluoromethoxy)-4-...)
Affinity DataIC50: 2.20nMpH: 8.0Assay Description:To assess the compounds potency in the EED-H3K27Me3 competition binding assay, compounds were serially diluted 3-fold in DMSO to obtain a total of tw...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2019
Entry Details
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LigandPNGBDBM291909(US9580437, Example 224 | 8-(6-ethyl-4-methylpyridi...)
Affinity DataIC50: 2.20nMAssay Description:Cell lysates were transferred to the wells of a 384-well plate and the final volume was adjusted to 50 μL per well with PBS. The plate was seale...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2019
Entry Details
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LigandPNGBDBM291873(US9580437, Example 188 | N-((5-fluoro-2,3-dihydrob...)
Affinity DataIC50: 2.30nMpH: 8.0Assay Description:To assess the compounds potency in the EED-H3K27Me3 competition binding assay, compounds were serially diluted 3-fold in DMSO to obtain a total of tw...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2019
Entry Details
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LigandPNGBDBM291827(US9580437, Example 142 | N-((5-fluoro-2,3-dihydrob...)
Affinity DataIC50: 2.40nMpH: 8.0Assay Description:To assess the compounds potency in the EED-H3K27Me3 competition binding assay, compounds were serially diluted 3-fold in DMSO to obtain a total of tw...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2019
Entry Details
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LigandPNGBDBM291830(US9580437, Example 145 | N-((5-fluoro-2,3-dihydrob...)
Affinity DataIC50: 2.40nMpH: 8.0Assay Description:To assess the compounds potency in the EED-H3K27Me3 competition binding assay, compounds were serially diluted 3-fold in DMSO to obtain a total of tw...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2019
Entry Details
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LigandPNGBDBM291879(US9580437, Example 194 | 8-(2,5-dimethylpyridin-4-...)
Affinity DataIC50: 2.40nMpH: 8.0Assay Description:To assess the compounds potency in the EED-H3K27Me3 competition binding assay, compounds were serially diluted 3-fold in DMSO to obtain a total of tw...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2019
Entry Details
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LigandPNGBDBM291880(US9580437, Example 195 | 8-(1,3-dimethyl-1H-pyrazo...)
Affinity DataIC50: 2.40nMAssay Description:Cell lysates were transferred to the wells of a 384-well plate and the final volume was adjusted to 50 μL per well with PBS. The plate was seale...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2019
Entry Details
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LigandPNGBDBM291867(US9580437, Example 182 | N-((5-fluoro-2,3-dihydrob...)
Affinity DataIC50: 2.5nMAssay Description:Cell lysates were transferred to the wells of a 384-well plate and the final volume was adjusted to 50 μL per well with PBS. The plate was seale...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2019
Entry Details
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LigandPNGBDBM291875(US9580437, Example 190 | 2-(4-(5-(((5-fluoro-2,3-d...)
Affinity DataIC50: 2.5nMAssay Description:Cell lysates were transferred to the wells of a 384-well plate and the final volume was adjusted to 50 μL per well with PBS. The plate was seale...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2019
Entry Details
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LigandPNGBDBM291687(US9580437, Example 2 | N-((5-Fluoro-2,3-dihydroben...)
Affinity DataIC50: 2.60nMAssay Description:Cell lysates were transferred to the wells of a 384-well plate and the final volume was adjusted to 50 μL per well with PBS. The plate was seale...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2019
Entry Details
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LigandPNGBDBM291812(US9580437, Example 127 | N-((5-fluoro-2,3-dihydrob...)
Affinity DataIC50: 2.60nMpH: 8.0Assay Description:To assess the compounds potency in the EED-H3K27Me3 competition binding assay, compounds were serially diluted 3-fold in DMSO to obtain a total of tw...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2019
Entry Details
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LigandPNGBDBM291866(US9580437, Example 181 | 8-(2-(difluoromethyl)-3-m...)
Affinity DataIC50: 2.60nMpH: 8.0Assay Description:To assess the compounds potency in the EED-H3K27Me3 competition binding assay, compounds were serially diluted 3-fold in DMSO to obtain a total of tw...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2019
Entry Details
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LigandPNGBDBM291914(US9580437, Example 229 | 8-(6-ethyl-2-methylpyridi...)
Affinity DataIC50: 2.70nMAssay Description:Cell lysates were transferred to the wells of a 384-well plate and the final volume was adjusted to 50 μL per well with PBS. The plate was seale...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2019
Entry Details
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LigandPNGBDBM291690(US9580437, Example 5 | N-((5-Fluoro-2,3-dihydroben...)
Affinity DataIC50: 2.90nMAssay Description:Cell lysates were transferred to the wells of a 384-well plate and the final volume was adjusted to 50 μL per well with PBS. The plate was seale...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2019
Entry Details
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LigandPNGBDBM291693(US9580437, Example 8 | 8-(2-Cyclopropyl-4-methylpy...)
Affinity DataIC50: 2.90nMAssay Description:Cell lysates were transferred to the wells of a 384-well plate and the final volume was adjusted to 50 μL per well with PBS. The plate was seale...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2019
Entry Details
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LigandPNGBDBM291854(US9580437, Example 169 | N-((5-fluoro-2,3-dihydrob...)
Affinity DataIC50: 2.90nMAssay Description:Cell lysates were transferred to the wells of a 384-well plate and the final volume was adjusted to 50 μL per well with PBS. The plate was seale...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2019
Entry Details
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LigandPNGBDBM291885(US9580437, Example 200 | 8-(3-(difluoromethyl)-1-m...)
Affinity DataIC50: 3nMAssay Description:Cell lysates were transferred to the wells of a 384-well plate and the final volume was adjusted to 50 μL per well with PBS. The plate was seale...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2019
Entry Details
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LigandPNGBDBM291867(US9580437, Example 182 | N-((5-fluoro-2,3-dihydrob...)
Affinity DataIC50: 3.10nMpH: 8.0Assay Description:To assess the compounds potency in the EED-H3K27Me3 competition binding assay, compounds were serially diluted 3-fold in DMSO to obtain a total of tw...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2019
Entry Details
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LigandPNGBDBM291922(US9580437, Example 237 | N-((5-fluoro-2,3-dihydrob...)
Affinity DataIC50: 3.10nMpH: 8.0Assay Description:To assess the compounds potency in the EED-H3K27Me3 competition binding assay, compounds were serially diluted 3-fold in DMSO to obtain a total of tw...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2019
Entry Details
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LigandPNGBDBM291689(US9580437, Example 4 | N-((5-Fluoro-2,3-dihydroben...)
Affinity DataIC50: 3.20nMpH: 8.0Assay Description:To assess the compounds potency in the EED-H3K27Me3 competition binding assay, compounds were serially diluted 3-fold in DMSO to obtain a total of tw...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2019
Entry Details
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LigandPNGBDBM291816(US9580437, Example 131 | 5-(5-(((5-fluoro-2,3-dihy...)
Affinity DataIC50: 3.30nMAssay Description:Cell lysates were transferred to the wells of a 384-well plate and the final volume was adjusted to 50 μL per well with PBS. The plate was seale...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2019
Entry Details
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LigandPNGBDBM291852(US9580437, Example 167 | 8-(2,6-dimethylpyridin-3-...)
Affinity DataIC50: 3.30nMpH: 8.0Assay Description:To assess the compounds potency in the EED-H3K27Me3 competition binding assay, compounds were serially diluted 3-fold in DMSO to obtain a total of tw...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2019
Entry Details
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LigandPNGBDBM291688(US9580437, Example 3 | 8-(2,4-Dimethylpyrimidin-5-...)
Affinity DataIC50: 3.40nMAssay Description:Cell lysates were transferred to the wells of a 384-well plate and the final volume was adjusted to 50 μL per well with PBS. The plate was seale...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2019
Entry Details
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LigandPNGBDBM291860(US9580437, Example 175 | N-((5-fluoro-2,3-dihydrob...)
Affinity DataIC50: 3.40nMAssay Description:Cell lysates were transferred to the wells of a 384-well plate and the final volume was adjusted to 50 μL per well with PBS. The plate was seale...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2019
Entry Details
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LigandPNGBDBM291694(US9580437, Example 9 | N-((5-fluoro-2,3-dihydroben...)
Affinity DataIC50: 3.5nMAssay Description:Cell lysates were transferred to the wells of a 384-well plate and the final volume was adjusted to 50 μL per well with PBS. The plate was seale...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2019
Entry Details
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LigandPNGBDBM291871(US9580437, Example 186 | (2R)-1-(4-(5-(((5-fluoro-...)
Affinity DataIC50: 3.5nMpH: 8.0Assay Description:To assess the compounds potency in the EED-H3K27Me3 competition binding assay, compounds were serially diluted 3-fold in DMSO to obtain a total of tw...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2019
Entry Details
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LigandPNGBDBM291877(US9580437, Example 192 | 8-(1-cyclopropyl-1H-pyraz...)
Affinity DataIC50: 3.5nMpH: 8.0Assay Description:To assess the compounds potency in the EED-H3K27Me3 competition binding assay, compounds were serially diluted 3-fold in DMSO to obtain a total of tw...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2019
Entry Details
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LigandPNGBDBM291832(US9580437, Example 147 | N-((5-fluoro-2,3-dihydrob...)
Affinity DataIC50: 3.60nMpH: 8.0Assay Description:To assess the compounds potency in the EED-H3K27Me3 competition binding assay, compounds were serially diluted 3-fold in DMSO to obtain a total of tw...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2019
Entry Details
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LigandPNGBDBM291846(US9580437, Example 161 | N-((5-fluoro-2,3-dihydrob...)
Affinity DataIC50: 3.60nMpH: 8.0Assay Description:To assess the compounds potency in the EED-H3K27Me3 competition binding assay, compounds were serially diluted 3-fold in DMSO to obtain a total of tw...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2019
Entry Details
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LigandPNGBDBM291873(US9580437, Example 188 | N-((5-fluoro-2,3-dihydrob...)
Affinity DataIC50: 3.60nMAssay Description:Cell lysates were transferred to the wells of a 384-well plate and the final volume was adjusted to 50 μL per well with PBS. The plate was seale...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2019
Entry Details
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LigandPNGBDBM291881(US9580437, Example 196 | 8-(6-ethoxy-4-methylpyrid...)
Affinity DataIC50: 3.60nMpH: 8.0Assay Description:To assess the compounds potency in the EED-H3K27Me3 competition binding assay, compounds were serially diluted 3-fold in DMSO to obtain a total of tw...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2019
Entry Details
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LigandPNGBDBM291886(US9580437, Example 201 | 8-(2-(difluoromethyl)-6-m...)
Affinity DataIC50: 3.60nMAssay Description:Cell lysates were transferred to the wells of a 384-well plate and the final volume was adjusted to 50 μL per well with PBS. The plate was seale...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2019
Entry Details
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LigandPNGBDBM291892(US9580437, Example 207 | N-((5-Fluorobenzofuran-4-...)
Affinity DataIC50: 3.60nMAssay Description:Cell lysates were transferred to the wells of a 384-well plate and the final volume was adjusted to 50 μL per well with PBS. The plate was seale...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2019
Entry Details
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LigandPNGBDBM291765(US9580437, Example 80 | (5-(5-(((2,3-dihydrobenzof...)
Affinity DataIC50: 3.70nMpH: 8.0Assay Description:To assess the compounds potency in the EED-H3K27Me3 competition binding assay, compounds were serially diluted 3-fold in DMSO to obtain a total of tw...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2019
Entry Details
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LigandPNGBDBM291813(US9580437, Example 128 | N-((5-fluoro-2,3-dihydrob...)
Affinity DataIC50: 3.70nMAssay Description:Cell lysates were transferred to the wells of a 384-well plate and the final volume was adjusted to 50 μL per well with PBS. The plate was seale...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2019
Entry Details
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LigandPNGBDBM291688(US9580437, Example 3 | 8-(2,4-Dimethylpyrimidin-5-...)
Affinity DataIC50: 3.80nMpH: 8.0Assay Description:To assess the compounds potency in the EED-H3K27Me3 competition binding assay, compounds were serially diluted 3-fold in DMSO to obtain a total of tw...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2019
Entry Details
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