Compile Data Set for Download or QSAR
Report error Found 29 Enz. Inhib. hit(s) with all data for entry = 684
TargetInterleukin-1 receptor-associated kinase 4(Human)
Merck Patent

US Patent
LigandPNGBDBM286259(3-[3-(6-Amino-pyridin-3-yl)-6-oxo-6H-pyridazin-1-y...)
Affinity DataIC50: 100nMAssay Description:IRAK4 hydrolyses ATP, autophosphorylates and phosphorylates a Serine/Threonine generic peptidic substrate (STK: 61ST1BLC from CisBio International ba...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/14/2019
Entry Details
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TargetInterleukin-1 receptor-associated kinase 4(Human)
Merck Patent

US Patent
LigandPNGBDBM286326(US9567320, Example 17**:)
Affinity DataIC50: 100nMAssay Description:IRAK4 hydrolyses ATP, autophosphorylates and phosphorylates a Serine/Threonine generic peptidic substrate (STK: 61ST1BLC from CisBio International ba...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/14/2019
Entry Details
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TargetInterleukin-1 receptor-associated kinase 1(Human)
Merck Patent

US Patent
LigandPNGBDBM286326(US9567320, Example 17**:)
Affinity DataIC50: 100nMAssay Description:IRAK1 is a human purified recombinant enzyme (His-TEV-IRAK1 (194-712)) In this assay, IRAK-1 hydrolyses ATP and autophosphorylates.Measurement of IRA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/14/2019
Entry Details
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TargetInterleukin-1 receptor-associated kinase 1(Human)
Merck Patent

US Patent
LigandPNGBDBM286325(N-(5-methoxy-1H-benzo[d]imidazol-2-yl)-3-((6-oxo-3...)
Affinity DataIC50: 100nMAssay Description:IRAK1 is a human purified recombinant enzyme (His-TEV-IRAK1 (194-712)) In this assay, IRAK-1 hydrolyses ATP and autophosphorylates.Measurement of IRA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/14/2019
Entry Details
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TargetInterleukin-1 receptor-associated kinase 4(Human)
Merck Patent

US Patent
LigandPNGBDBM286321(N-(5,6-dimethoxy-1H-benzo[d]imidazol-2-yl)-3-((6-o...)
Affinity DataIC50: 100nMAssay Description:IRAK4 hydrolyses ATP, autophosphorylates and phosphorylates a Serine/Threonine generic peptidic substrate (STK: 61ST1BLC from CisBio International ba...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/14/2019
Entry Details
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TargetInterleukin-1 receptor-associated kinase 1(Human)
Merck Patent

US Patent
LigandPNGBDBM286276(N-(1H-benzo[d]imidazol-2-yl)-3-((3-(4-methylpyridi...)
Affinity DataIC50: 100nMAssay Description:IRAK1 is a human purified recombinant enzyme (His-TEV-IRAK1 (194-712)) In this assay, IRAK-1 hydrolyses ATP and autophosphorylates.Measurement of IRA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/14/2019
Entry Details
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TargetInterleukin-1 receptor-associated kinase 1(Human)
Merck Patent

US Patent
LigandPNGBDBM286259(3-[3-(6-Amino-pyridin-3-yl)-6-oxo-6H-pyridazin-1-y...)
Affinity DataIC50: 100nMAssay Description:IRAK1 is a human purified recombinant enzyme (His-TEV-IRAK1 (194-712)) In this assay, IRAK-1 hydrolyses ATP and autophosphorylates.Measurement of IRA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/14/2019
Entry Details
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TargetInterleukin-1 receptor-associated kinase 4(Human)
Merck Patent

US Patent
LigandPNGBDBM286249(N-(1H-Benzoimidazol-2-yl)-3-[3-(6-hydroxymethyl-py...)
Affinity DataIC50: 100nMAssay Description:IRAK4 hydrolyses ATP, autophosphorylates and phosphorylates a Serine/Threonine generic peptidic substrate (STK: 61ST1BLC from CisBio International ba...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/14/2019
Entry Details
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TargetInterleukin-1 receptor-associated kinase 4(Human)
Merck Patent

US Patent
LigandPNGBDBM286247(N-(5-Dimethylcarbamoylmethyl-1H-benzoimidazol-2-yl...)
Affinity DataIC50: 100nMAssay Description:IRAK4 hydrolyses ATP, autophosphorylates and phosphorylates a Serine/Threonine generic peptidic substrate (STK: 61ST1BLC from CisBio International ba...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/14/2019
Entry Details
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TargetInterleukin-1 receptor-associated kinase 4(Human)
Merck Patent

US Patent
LigandPNGBDBM286238(N-(5-Hydroxymethyl-1H-benzoimidazol-2-yl)-3-(6-oxo...)
Affinity DataIC50: 100nMAssay Description:IRAK4 hydrolyses ATP, autophosphorylates and phosphorylates a Serine/Threonine generic peptidic substrate (STK: 61ST1BLC from CisBio International ba...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/14/2019
Entry Details
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TargetInterleukin-1 receptor-associated kinase 4(Human)
Merck Patent

US Patent
LigandPNGBDBM286212(2,2-Dimethyl-propionic acid 2-[3-(6-oxo-3-pyridin-...)
Affinity DataIC50: 100nMAssay Description:IRAK4 hydrolyses ATP, autophosphorylates and phosphorylates a Serine/Threonine generic peptidic substrate (STK: 61ST1BLC from CisBio International ba...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/14/2019
Entry Details
Go to US Patent

TargetInterleukin-1 receptor-associated kinase 1(Human)
Merck Patent

US Patent
LigandPNGBDBM286217(N-(1H-Benzoimidazol-2-yl)-3-(6-oxo-3-pyridin-3-yl-...)
Affinity DataIC50: 100nMAssay Description:IRAK1 is a human purified recombinant enzyme (His-TEV-IRAK1 (194-712)) In this assay, IRAK-1 hydrolyses ATP and autophosphorylates.Measurement of IRA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/14/2019
Entry Details
Go to US Patent

TargetInterleukin-1 receptor-associated kinase 1(Human)
Merck Patent

US Patent
LigandPNGBDBM286238(N-(5-Hydroxymethyl-1H-benzoimidazol-2-yl)-3-(6-oxo...)
Affinity DataIC50: 100nMAssay Description:IRAK1 is a human purified recombinant enzyme (His-TEV-IRAK1 (194-712)) In this assay, IRAK-1 hydrolyses ATP and autophosphorylates.Measurement of IRA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/14/2019
Entry Details
Go to US Patent

TargetInterleukin-1 receptor-associated kinase 1(Human)
Merck Patent

US Patent
LigandPNGBDBM286247(N-(5-Dimethylcarbamoylmethyl-1H-benzoimidazol-2-yl...)
Affinity DataIC50: 100nMAssay Description:IRAK1 is a human purified recombinant enzyme (His-TEV-IRAK1 (194-712)) In this assay, IRAK-1 hydrolyses ATP and autophosphorylates.Measurement of IRA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/14/2019
Entry Details
Go to US Patent

TargetInterleukin-1 receptor-associated kinase 4(Human)
Merck Patent

US Patent
LigandPNGBDBM286250(N-(1H-Benzoimidazol-2-yl)-3-(6-oxo-3-pyrimidin-5-y...)
Affinity DataIC50: 550nMAssay Description:IRAK4 hydrolyses ATP, autophosphorylates and phosphorylates a Serine/Threonine generic peptidic substrate (STK: 61ST1BLC from CisBio International ba...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/14/2019
Entry Details
Go to US Patent

TargetInterleukin-1 receptor-associated kinase 1(Human)
Merck Patent

US Patent
LigandPNGBDBM286212(2,2-Dimethyl-propionic acid 2-[3-(6-oxo-3-pyridin-...)
Affinity DataIC50: 550nMAssay Description:IRAK1 is a human purified recombinant enzyme (His-TEV-IRAK1 (194-712)) In this assay, IRAK-1 hydrolyses ATP and autophosphorylates.Measurement of IRA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/14/2019
Entry Details
Go to US Patent

TargetInterleukin-1 receptor-associated kinase 1(Human)
Merck Patent

US Patent
LigandPNGBDBM286262(N-(1H-benzo[d]imidazol-2-yl)-3-(2-cyano-5-(pyridin...)
Affinity DataIC50: 550nMAssay Description:IRAK1 is a human purified recombinant enzyme (His-TEV-IRAK1 (194-712)) In this assay, IRAK-1 hydrolyses ATP and autophosphorylates.Measurement of IRA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/14/2019
Entry Details
Go to US Patent

TargetInterleukin-1 receptor-associated kinase 4(Human)
Merck Patent

US Patent
LigandPNGBDBM286276(N-(1H-benzo[d]imidazol-2-yl)-3-((3-(4-methylpyridi...)
Affinity DataIC50: 550nMAssay Description:IRAK4 hydrolyses ATP, autophosphorylates and phosphorylates a Serine/Threonine generic peptidic substrate (STK: 61ST1BLC from CisBio International ba...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/14/2019
Entry Details
Go to US Patent

TargetInterleukin-1 receptor-associated kinase 1(Human)
Merck Patent

US Patent
LigandPNGBDBM286306(N-(1H-benzo[d]imidazol-2-yl)-3-((3-(6-methylpyrida...)
Affinity DataIC50: 550nMAssay Description:IRAK1 is a human purified recombinant enzyme (His-TEV-IRAK1 (194-712)) In this assay, IRAK-1 hydrolyses ATP and autophosphorylates.Measurement of IRA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/14/2019
Entry Details
Go to US Patent

TargetInterleukin-1 receptor-associated kinase 4(Human)
Merck Patent

US Patent
LigandPNGBDBM286306(N-(1H-benzo[d]imidazol-2-yl)-3-((3-(6-methylpyrida...)
Affinity DataIC50: 550nMAssay Description:IRAK4 hydrolyses ATP, autophosphorylates and phosphorylates a Serine/Threonine generic peptidic substrate (STK: 61ST1BLC from CisBio International ba...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/14/2019
Entry Details
Go to US Patent

TargetInterleukin-1 receptor-associated kinase 1(Human)
Merck Patent

US Patent
LigandPNGBDBM286321(N-(5,6-dimethoxy-1H-benzo[d]imidazol-2-yl)-3-((6-o...)
Affinity DataIC50: 550nMAssay Description:IRAK1 is a human purified recombinant enzyme (His-TEV-IRAK1 (194-712)) In this assay, IRAK-1 hydrolyses ATP and autophosphorylates.Measurement of IRA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/14/2019
Entry Details
Go to US Patent

TargetInterleukin-1 receptor-associated kinase 4(Human)
Merck Patent

US Patent
LigandPNGBDBM286217(N-(1H-Benzoimidazol-2-yl)-3-(6-oxo-3-pyridin-3-yl-...)
Affinity DataIC50: 550nMAssay Description:IRAK4 hydrolyses ATP, autophosphorylates and phosphorylates a Serine/Threonine generic peptidic substrate (STK: 61ST1BLC from CisBio International ba...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/14/2019
Entry Details
Go to US Patent

TargetInterleukin-1 receptor-associated kinase 4(Human)
Merck Patent

US Patent
LigandPNGBDBM286325(N-(5-methoxy-1H-benzo[d]imidazol-2-yl)-3-((6-oxo-3...)
Affinity DataIC50: 550nMAssay Description:IRAK4 hydrolyses ATP, autophosphorylates and phosphorylates a Serine/Threonine generic peptidic substrate (STK: 61ST1BLC from CisBio International ba...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/14/2019
Entry Details
Go to US Patent

TargetInterleukin-1 receptor-associated kinase 1(Human)
Merck Patent

US Patent
LigandPNGBDBM286250(N-(1H-Benzoimidazol-2-yl)-3-(6-oxo-3-pyrimidin-5-y...)
Affinity DataIC50: 550nMAssay Description:IRAK1 is a human purified recombinant enzyme (His-TEV-IRAK1 (194-712)) In this assay, IRAK-1 hydrolyses ATP and autophosphorylates.Measurement of IRA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/14/2019
Entry Details
Go to US Patent

TargetInterleukin-1 receptor-associated kinase 1(Human)
Merck Patent

US Patent
LigandPNGBDBM286268(N-(1H-benzo[d]imidazol-2-yl)-3-((3-(6-((dimethylam...)
Affinity DataIC50: 3.00E+3nMAssay Description:IRAK1 is a human purified recombinant enzyme (His-TEV-IRAK1 (194-712)) In this assay, IRAK-1 hydrolyses ATP and autophosphorylates.Measurement of IRA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/14/2019
Entry Details
Go to US Patent

TargetInterleukin-1 receptor-associated kinase 4(Human)
Merck Patent

US Patent
LigandPNGBDBM286268(N-(1H-benzo[d]imidazol-2-yl)-3-((3-(6-((dimethylam...)
Affinity DataIC50: 3.00E+3nMAssay Description:IRAK4 hydrolyses ATP, autophosphorylates and phosphorylates a Serine/Threonine generic peptidic substrate (STK: 61ST1BLC from CisBio International ba...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/14/2019
Entry Details
Go to US Patent

TargetInterleukin-1 receptor-associated kinase 4(Human)
Merck Patent

US Patent
LigandPNGBDBM286233(2-[3-(6-Oxo-3-pyridin-3-yl-6H-pyridazin-1-ylmethyl...)
Affinity DataIC50: 3.00E+3nMAssay Description:IRAK4 hydrolyses ATP, autophosphorylates and phosphorylates a Serine/Threonine generic peptidic substrate (STK: 61ST1BLC from CisBio International ba...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/14/2019
Entry Details
Go to US Patent

TargetInterleukin-1 receptor-associated kinase 4(Human)
Merck Patent

US Patent
LigandPNGBDBM286319(N-(1H-benzo[d]imidazol-2-yl)-3-((3-(5-((dimethylam...)
Affinity DataIC50: 3.00E+3nMAssay Description:IRAK4 hydrolyses ATP, autophosphorylates and phosphorylates a Serine/Threonine generic peptidic substrate (STK: 61ST1BLC from CisBio International ba...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/14/2019
Entry Details
Go to US Patent

TargetInterleukin-1 receptor-associated kinase 4(Human)
Merck Patent

US Patent
LigandPNGBDBM286229(N-(1-Methyl-1H-benzoimidazol-2-yl)-3-(6-oxo-3-pyri...)
Affinity DataIC50: 3.00E+3nMAssay Description:IRAK4 hydrolyses ATP, autophosphorylates and phosphorylates a Serine/Threonine generic peptidic substrate (STK: 61ST1BLC from CisBio International ba...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/14/2019
Entry Details
Go to US Patent