Compile Data Set for Download or QSAR
Report error Found 6 Enz. Inhib. hit(s) with all data for entry = 197
TargetHistone-lysine N-methyltransferase EZH2(Human)
Glaxosmithkline

US Patent
LigandPNGBDBM227712(US9556157, 3 | n-((5-amino-2,6-dimethyl-4-oxo-1,4-...)
Affinity DataIC50: 16nMpH: 8.0 T: 2°CAssay Description:Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Human PRC2 com...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2018
Entry Details
Go to US Patent

TargetHistone-lysine N-methyltransferase EZH2(Human)
Glaxosmithkline

US Patent
LigandPNGBDBM227711(US9556157, 2 | n-((2,6-dimethyl-4-oxo-1,4-dihydrop...)
Affinity DataIC50: 32nMpH: 8.0 T: 2°CAssay Description:Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Human PRC2 com...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2018
Entry Details
Go to US Patent

TargetHistone-lysine N-methyltransferase EZH2(Human)
Glaxosmithkline

US Patent
LigandPNGBDBM227712(US9556157, 3 | n-((5-amino-2,6-dimethyl-4-oxo-1,4-...)
Affinity DataIC50: 32nMpH: 8.0 T: 2°CAssay Description:Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Human PRC2 com...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2018
Entry Details
Go to US Patent

TargetHistone-lysine N-methyltransferase EZH2(Human)
Glaxosmithkline

US Patent
LigandPNGBDBM227711(US9556157, 2 | n-((2,6-dimethyl-4-oxo-1,4-dihydrop...)
Affinity DataIC50: 100nMpH: 8.0 T: 2°CAssay Description:Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Human PRC2 com...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2018
Entry Details
Go to US Patent

TargetHistone-lysine N-methyltransferase EZH2(Human)
Glaxosmithkline

US Patent
LigandPNGBDBM227713(US9556157, 4 | 2-bromo-n-((2,6-dimethyl-4-oxo-1,4-...)
Affinity DataIC50: 160nMpH: 8.0 T: 2°CAssay Description:Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Human PRC2 com...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2018
Entry Details
Go to US Patent

TargetHistone-lysine N-methyltransferase EZH2(Human)
Glaxosmithkline

US Patent
LigandPNGBDBM227710(US9556157, 1 | N-((2,6-dimethyl-4-oxo-1,4-dihydro...)
Affinity DataIC50: 316nMpH: 8.0 T: 2°CAssay Description:Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Human PRC2 com...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2018
Entry Details
Go to US Patent