Compile Data Set for Download or QSAR
Report error Found 29 Enz. Inhib. hit(s) with all data for entry = 183
TargetMitogen-activated protein kinase 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM204807(US9546168, ex 16)
Affinity DataIC50: 0.230nMAssay Description:Activated ERK2 activity was determined in an IMAP-FP assay (Molecular Devices). Using this assay format, the potency (IC.sub.50) of each compound was...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/28/2018
Entry Details
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TargetMitogen-activated protein kinase 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM204806(US9546168, ex 15)
Affinity DataIC50: 0.290nMAssay Description:Activated ERK2 activity was determined in an IMAP-FP assay (Molecular Devices). Using this assay format, the potency (IC.sub.50) of each compound was...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/28/2018
Entry Details
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TargetMitogen-activated protein kinase 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM204804(US9546168, ex 13)
Affinity DataIC50: 0.310nMAssay Description:Activated ERK2 activity was determined in an IMAP-FP assay (Molecular Devices). Using this assay format, the potency (IC.sub.50) of each compound was...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/28/2018
Entry Details
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TargetMitogen-activated protein kinase 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM204788(US9546168, ex 1)
Affinity DataIC50: 0.370nMAssay Description:Activated ERK2 activity was determined in an IMAP-FP assay (Molecular Devices). Using this assay format, the potency (IC.sub.50) of each compound was...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/28/2018
Entry Details
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TargetMitogen-activated protein kinase 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM204791(US9546168, ex 4)
Affinity DataIC50: 0.390nMAssay Description:Activated ERK2 activity was determined in an IMAP-FP assay (Molecular Devices). Using this assay format, the potency (IC.sub.50) of each compound was...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/28/2018
Entry Details
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TargetMitogen-activated protein kinase 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM204805(US9546168, ex 14)
Affinity DataIC50: 0.390nMAssay Description:Activated ERK2 activity was determined in an IMAP-FP assay (Molecular Devices). Using this assay format, the potency (IC.sub.50) of each compound was...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/28/2018
Entry Details
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TargetMitogen-activated protein kinase 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM204802(US9546168, ex 11)
Affinity DataIC50: 0.450nMAssay Description:Activated ERK2 activity was determined in an IMAP-FP assay (Molecular Devices). Using this assay format, the potency (IC.sub.50) of each compound was...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/28/2018
Entry Details
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TargetMitogen-activated protein kinase 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM204821(US9546168, ex 23)
Affinity DataIC50: 0.490nMAssay Description:Activated ERK2 activity was determined in an IMAP-FP assay (Molecular Devices). Using this assay format, the potency (IC.sub.50) of each compound was...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/28/2018
Entry Details
Go to US Patent

TargetMitogen-activated protein kinase 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM204817(US9546168, ex 19)
Affinity DataIC50: 0.530nMAssay Description:Activated ERK2 activity was determined in an IMAP-FP assay (Molecular Devices). Using this assay format, the potency (IC.sub.50) of each compound was...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/28/2018
Entry Details
Go to US Patent

TargetMitogen-activated protein kinase 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM204800(US9546168, ex 10)
Affinity DataIC50: 0.660nMAssay Description:Activated ERK2 activity was determined in an IMAP-FP assay (Molecular Devices). Using this assay format, the potency (IC.sub.50) of each compound was...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/28/2018
Entry Details
Go to US Patent

TargetMitogen-activated protein kinase 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM204792(US9546168, ex 5)
Affinity DataIC50: 0.720nMAssay Description:Activated ERK2 activity was determined in an IMAP-FP assay (Molecular Devices). Using this assay format, the potency (IC.sub.50) of each compound was...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/28/2018
Entry Details
Go to US Patent

TargetMitogen-activated protein kinase 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM204799(US9546168, ex 9)
Affinity DataIC50: 0.75nMAssay Description:Activated ERK2 activity was determined in an IMAP-FP assay (Molecular Devices). Using this assay format, the potency (IC.sub.50) of each compound was...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/28/2018
Entry Details
Go to US Patent

TargetMitogen-activated protein kinase 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM204820(US9546168, ex 22)
Affinity DataIC50: 0.75nMAssay Description:Activated ERK2 activity was determined in an IMAP-FP assay (Molecular Devices). Using this assay format, the potency (IC.sub.50) of each compound was...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/28/2018
Entry Details
Go to US Patent

TargetMitogen-activated protein kinase 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM204796(US9546168, ex 7)
Affinity DataIC50: 0.830nMAssay Description:Activated ERK2 activity was determined in an IMAP-FP assay (Molecular Devices). Using this assay format, the potency (IC.sub.50) of each compound was...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/28/2018
Entry Details
Go to US Patent

TargetMitogen-activated protein kinase 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM204798(US9546168, ex 8)
Affinity DataIC50: 0.910nMAssay Description:Activated ERK2 activity was determined in an IMAP-FP assay (Molecular Devices). Using this assay format, the potency (IC.sub.50) of each compound was...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/28/2018
Entry Details
Go to US Patent

TargetMitogen-activated protein kinase 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM204790(US9546168, ex 3)
Affinity DataIC50: 0.920nMAssay Description:Activated ERK2 activity was determined in an IMAP-FP assay (Molecular Devices). Using this assay format, the potency (IC.sub.50) of each compound was...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/28/2018
Entry Details
Go to US Patent

TargetMitogen-activated protein kinase 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM204818(US9546168, ex 20)
Affinity DataIC50: 1.13nMAssay Description:Activated ERK2 activity was determined in an IMAP-FP assay (Molecular Devices). Using this assay format, the potency (IC.sub.50) of each compound was...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/28/2018
Entry Details
Go to US Patent

TargetMitogen-activated protein kinase 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM204789(US9546168, ex 2)
Affinity DataIC50: 1.24nMAssay Description:Activated ERK2 activity was determined in an IMAP-FP assay (Molecular Devices). Using this assay format, the potency (IC.sub.50) of each compound was...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/28/2018
Entry Details
Go to US Patent

TargetMitogen-activated protein kinase 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM204822(US9546168, ex 24)
Affinity DataIC50: 1.25nMAssay Description:Activated ERK2 activity was determined in an IMAP-FP assay (Molecular Devices). Using this assay format, the potency (IC.sub.50) of each compound was...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/28/2018
Entry Details
Go to US Patent

TargetMitogen-activated protein kinase 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM204803(US9546168, ex 12)
Affinity DataIC50: 1.64nMAssay Description:Activated ERK2 activity was determined in an IMAP-FP assay (Molecular Devices). Using this assay format, the potency (IC.sub.50) of each compound was...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/28/2018
Entry Details
Go to US Patent

TargetMitogen-activated protein kinase 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM204824(US9546168, ex 25)
Affinity DataIC50: 1.85nMAssay Description:Activated ERK2 activity was determined in an IMAP-FP assay (Molecular Devices). Using this assay format, the potency (IC.sub.50) of each compound was...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/28/2018
Entry Details
Go to US Patent

TargetMitogen-activated protein kinase 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM204812(US9546168, ex 18)
Affinity DataIC50: 3.70nMAssay Description:Activated ERK2 activity was determined in an IMAP-FP assay (Molecular Devices). Using this assay format, the potency (IC.sub.50) of each compound was...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/28/2018
Entry Details
Go to US Patent

TargetMitogen-activated protein kinase 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM204795(US9546168, ex 6)
Affinity DataIC50: 4.34nMAssay Description:Activated ERK2 activity was determined in an IMAP-FP assay (Molecular Devices). Using this assay format, the potency (IC.sub.50) of each compound was...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/28/2018
Entry Details
Go to US Patent

TargetMitogen-activated protein kinase 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM204825(US9546168, ex 27 | US9546168, ex 26)
Affinity DataIC50: 5.52nMAssay Description:Activated ERK2 activity was determined in an IMAP-FP assay (Molecular Devices). Using this assay format, the potency (IC.sub.50) of each compound was...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/28/2018
Entry Details
Go to US Patent

TargetMitogen-activated protein kinase 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM204819(US9546168, ex 21)
Affinity DataIC50: 6.10nMAssay Description:Activated ERK2 activity was determined in an IMAP-FP assay (Molecular Devices). Using this assay format, the potency (IC.sub.50) of each compound was...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/28/2018
Entry Details
Go to US Patent

TargetMitogen-activated protein kinase 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM204809(US9546168, ex 17)
Affinity DataIC50: 8.64nMAssay Description:Activated ERK2 activity was determined in an IMAP-FP assay (Molecular Devices). Using this assay format, the potency (IC.sub.50) of each compound was...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/28/2018
Entry Details
Go to US Patent

TargetMitogen-activated protein kinase 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM204825(US9546168, ex 27 | US9546168, ex 26)
Affinity DataIC50: 12.7nMAssay Description:Activated ERK2 activity was determined in an IMAP-FP assay (Molecular Devices). Using this assay format, the potency (IC.sub.50) of each compound was...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/28/2018
Entry Details
Go to US Patent

TargetMitogen-activated protein kinase 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM204925(US9546168, ex 29)
Affinity DataIC50: 13.3nMAssay Description:Activated ERK2 activity was determined in an IMAP-FP assay (Molecular Devices). Using this assay format, the potency (IC.sub.50) of each compound was...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/28/2018
Entry Details
Go to US Patent

TargetMitogen-activated protein kinase 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM204827(US9546168, ex 28)
Affinity DataIC50: 14.1nMAssay Description:Activated ERK2 activity was determined in an IMAP-FP assay (Molecular Devices). Using this assay format, the potency (IC.sub.50) of each compound was...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/28/2018
Entry Details
Go to US Patent