Compile Data Set for Download or QSAR
Report error Found 648 Enz. Inhib. hit(s) with all data for entry = 300
TargetSodium channel protein type 9 subunit alpha(Human)
Genentech

US Patent
LigandPNGBDBM71464(US9694002, 495 | US9546164, 495)
Affinity DataIC50: 0.200nMpH: 7.2Assay Description:Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2018
Entry Details
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TargetSodium channel protein type 5 subunit alpha(Human)
Genentech

US Patent
LigandPNGBDBM71381(US9694002, 440 | US9546164, 440)
Affinity DataIC50: 0.300nMpH: 7.4 T: 2°CAssay Description:Radioligand Binding Studies: Saturation experiments. A representative compound of formula (I) having a methyl group was tritiated. Three tritiums wer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2018
Entry Details
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TargetSodium channel protein type 5 subunit alpha(Human)
Genentech

US Patent
LigandPNGBDBM71340(US9694002, 411 | US9546164, 411)
Affinity DataIC50: 0.800nMpH: 7.4 T: 2°CAssay Description:Radioligand Binding Studies: Saturation experiments. A representative compound of formula (I) having a methyl group was tritiated. Three tritiums wer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2018
Entry Details
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TargetSodium channel protein type 9 subunit alpha(Human)
Genentech

US Patent
LigandPNGBDBM70845(US9694002, 27 | US9546164, 6)
Affinity DataIC50: 0.900nMpH: 7.2Assay Description:Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2018
Entry Details
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TargetSodium channel protein type 9 subunit alpha(Human)
Genentech

US Patent
LigandPNGBDBM71211(US9694002, 312 | US9546164, 312)
Affinity DataIC50: 1nMpH: 7.2Assay Description:Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2018
Entry Details
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TargetSodium channel protein type 5 subunit alpha(Human)
Genentech

US Patent
LigandPNGBDBM71351(US9694002, 422 | US9546164, 422)
Affinity DataIC50: 1.30nMpH: 7.4 T: 2°CAssay Description:Radioligand Binding Studies: Saturation experiments. A representative compound of formula (I) having a methyl group was tritiated. Three tritiums wer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2018
Entry Details
Go to US Patent

TargetSodium channel protein type 5 subunit alpha(Human)
Genentech

US Patent
LigandPNGBDBM71341(US9694002, 412 | US9546164, 412)
Affinity DataIC50: 1.5nMpH: 7.4 T: 2°CAssay Description:Radioligand Binding Studies: Saturation experiments. A representative compound of formula (I) having a methyl group was tritiated. Three tritiums wer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2018
Entry Details
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TargetSodium channel protein type 5 subunit alpha(Human)
Genentech

US Patent
LigandPNGBDBM70878(US9694002, 52 | US9546164, 52)
Affinity DataIC50: 1.60nMpH: 7.4 T: 2°CAssay Description:Radioligand Binding Studies: Saturation experiments. A representative compound of formula (I) having a methyl group was tritiated. Three tritiums wer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2018
Entry Details
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TargetSodium channel protein type 5 subunit alpha(Human)
Genentech

US Patent
LigandPNGBDBM71055(US9694002, 202 | US9546164, 202)
Affinity DataIC50: 1.60nMpH: 7.4 T: 2°CAssay Description:Radioligand Binding Studies: Saturation experiments. A representative compound of formula (I) having a methyl group was tritiated. Three tritiums wer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2018
Entry Details
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TargetSodium channel protein type 5 subunit alpha(Human)
Genentech

US Patent
LigandPNGBDBM71063(US9694002, 208 | US9546164, 208)
Affinity DataIC50: 1.60nMpH: 7.4 T: 2°CAssay Description:Radioligand Binding Studies: Saturation experiments. A representative compound of formula (I) having a methyl group was tritiated. Three tritiums wer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2018
Entry Details
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TargetSodium channel protein type 5 subunit alpha(Human)
Genentech

US Patent
LigandPNGBDBM71101(US9694002, 236 | US9546164, 236)
Affinity DataIC50: 1.60nMpH: 7.4 T: 2°CAssay Description:Radioligand Binding Studies: Saturation experiments. A representative compound of formula (I) having a methyl group was tritiated. Three tritiums wer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2018
Entry Details
Go to US Patent

TargetSodium channel protein type 5 subunit alpha(Human)
Genentech

US Patent
LigandPNGBDBM71193(US9694002, 300 | US9546164, 300)
Affinity DataIC50: 1.60nMpH: 7.4 T: 2°CAssay Description:Radioligand Binding Studies: Saturation experiments. A representative compound of formula (I) having a methyl group was tritiated. Three tritiums wer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2018
Entry Details
Go to US Patent

TargetSodium channel protein type 5 subunit alpha(Human)
Genentech

US Patent
LigandPNGBDBM71065(US9694002, 210 | US9546164, 210)
Affinity DataIC50: 1.70nMpH: 7.4 T: 2°CAssay Description:Radioligand Binding Studies: Saturation experiments. A representative compound of formula (I) having a methyl group was tritiated. Three tritiums wer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2018
Entry Details
Go to US Patent

TargetSodium channel protein type 5 subunit alpha(Human)
Genentech

US Patent
LigandPNGBDBM71137(US9694002, 260 | US9546164, 260)
Affinity DataIC50: 1.70nMpH: 7.4 T: 2°CAssay Description:Radioligand Binding Studies: Saturation experiments. A representative compound of formula (I) having a methyl group was tritiated. Three tritiums wer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2018
Entry Details
Go to US Patent

TargetSodium channel protein type 5 subunit alpha(Human)
Genentech

US Patent
LigandPNGBDBM71062(US9694002, 207 | US9546164, 207)
Affinity DataIC50: 1.70nMpH: 7.4 T: 2°CAssay Description:Radioligand Binding Studies: Saturation experiments. A representative compound of formula (I) having a methyl group was tritiated. Three tritiums wer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2018
Entry Details
Go to US Patent

TargetSodium channel protein type 5 subunit alpha(Human)
Genentech

US Patent
LigandPNGBDBM71064(US9694002, 209 | US9546164, 209)
Affinity DataIC50: 1.70nMpH: 7.4 T: 2°CAssay Description:Radioligand Binding Studies: Saturation experiments. A representative compound of formula (I) having a methyl group was tritiated. Three tritiums wer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2018
Entry Details
Go to US Patent

TargetSodium channel protein type 5 subunit alpha(Human)
Genentech

US Patent
LigandPNGBDBM71067(US9694002, 211 | US9546164, 211)
Affinity DataIC50: 1.70nMpH: 7.4 T: 2°CAssay Description:Radioligand Binding Studies: Saturation experiments. A representative compound of formula (I) having a methyl group was tritiated. Three tritiums wer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2018
Entry Details
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TargetSodium channel protein type 5 subunit alpha(Human)
Genentech

US Patent
LigandPNGBDBM71061(US9694002, 206 | US9546164, 206)
Affinity DataIC50: 1.80nMpH: 7.4 T: 2°CAssay Description:Radioligand Binding Studies: Saturation experiments. A representative compound of formula (I) having a methyl group was tritiated. Three tritiums wer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2018
Entry Details
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TargetSodium channel protein type 9 subunit alpha(Human)
Genentech

US Patent
LigandPNGBDBM263840(5-cyclopropyl-N-(cyclopropylsulfonyl)-4-(((1R,3r,5...)
Affinity DataIC50: 1.80nMpH: 7.2Assay Description:Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2018
Entry Details
Go to US Patent

TargetSodium channel protein type 5 subunit alpha(Human)
Genentech

US Patent
LigandPNGBDBM70982(US9694002, 136 | US9546164, 136)
Affinity DataIC50: 1.88nMpH: 7.4 T: 2°CAssay Description:Radioligand Binding Studies: Saturation experiments. A representative compound of formula (I) having a methyl group was tritiated. Three tritiums wer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2018
Entry Details
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TargetSodium channel protein type 5 subunit alpha(Human)
Genentech

US Patent
LigandPNGBDBM71208(US9694002, 309 | US9546164, 309)
Affinity DataIC50: 1.90nMpH: 7.4 T: 2°CAssay Description:Radioligand Binding Studies: Saturation experiments. A representative compound of formula (I) having a methyl group was tritiated. Three tritiums wer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2018
Entry Details
Go to US Patent

TargetSodium channel protein type 5 subunit alpha(Human)
Genentech

US Patent
LigandPNGBDBM70876(US9694002, 51 | US9694002, 50 | US9546164, 50)
Affinity DataIC50: 1.90nMpH: 7.4 T: 2°CAssay Description:Radioligand Binding Studies: Saturation experiments. A representative compound of formula (I) having a methyl group was tritiated. Three tritiums wer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2018
Entry Details
Go to US Patent

TargetSodium channel protein type 5 subunit alpha(Human)
Genentech

US Patent
LigandPNGBDBM71065(US9694002, 210 | US9546164, 210)
Affinity DataIC50: 1.90nMpH: 7.4 T: 2°CAssay Description:Radioligand Binding Studies: Saturation experiments. A representative compound of formula (I) having a methyl group was tritiated. Three tritiums wer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2018
Entry Details
Go to US Patent

TargetSodium channel protein type 5 subunit alpha(Human)
Genentech

US Patent
LigandPNGBDBM71192(US9694002, 299 | US9546164, 299)
Affinity DataIC50: 1.90nMpH: 7.4 T: 2°CAssay Description:Radioligand Binding Studies: Saturation experiments. A representative compound of formula (I) having a methyl group was tritiated. Three tritiums wer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2018
Entry Details
Go to US Patent

TargetSodium channel protein type 5 subunit alpha(Human)
Genentech

US Patent
LigandPNGBDBM71222(US9694002, 322 | US9546164, 322)
Affinity DataIC50: 1.90nMpH: 7.4 T: 2°CAssay Description:Radioligand Binding Studies: Saturation experiments. A representative compound of formula (I) having a methyl group was tritiated. Three tritiums wer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2018
Entry Details
Go to US Patent

TargetSodium channel protein type 5 subunit alpha(Human)
Genentech

US Patent
LigandPNGBDBM71224(US9694002, 323 | US9546164, 323)
Affinity DataIC50: 1.90nMpH: 7.4 T: 2°CAssay Description:Radioligand Binding Studies: Saturation experiments. A representative compound of formula (I) having a methyl group was tritiated. Three tritiums wer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2018
Entry Details
Go to US Patent

TargetSodium channel protein type 5 subunit alpha(Human)
Genentech

US Patent
LigandPNGBDBM71271(US9694002, 352 | US9546164, 352)
Affinity DataIC50: 2nMpH: 7.4 T: 2°CAssay Description:Radioligand Binding Studies: Saturation experiments. A representative compound of formula (I) having a methyl group was tritiated. Three tritiums wer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2018
Entry Details
Go to US Patent

TargetSodium channel protein type 5 subunit alpha(Human)
Genentech

US Patent
LigandPNGBDBM71285(US9694002, 361 | US9546164, 361)
Affinity DataIC50: 2nMpH: 7.4 T: 2°CAssay Description:Radioligand Binding Studies: Saturation experiments. A representative compound of formula (I) having a methyl group was tritiated. Three tritiums wer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2018
Entry Details
Go to US Patent

TargetSodium channel protein type 5 subunit alpha(Human)
Genentech

US Patent
LigandPNGBDBM71006(US9694002, 155 | US9546164, 155)
Affinity DataIC50: 2.02nMpH: 7.4 T: 2°CAssay Description:Radioligand Binding Studies: Saturation experiments. A representative compound of formula (I) having a methyl group was tritiated. Three tritiums wer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2018
Entry Details
Go to US Patent

TargetSodium channel protein type 5 subunit alpha(Human)
Genentech

US Patent
LigandPNGBDBM70985(US9694002, 137 | US9546164, 137)
Affinity DataIC50: 2.05nMpH: 7.4 T: 2°CAssay Description:Radioligand Binding Studies: Saturation experiments. A representative compound of formula (I) having a methyl group was tritiated. Three tritiums wer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2018
Entry Details
Go to US Patent

TargetSodium channel protein type 5 subunit alpha(Human)
Genentech

US Patent
LigandPNGBDBM263408(US9546164, 42 | (R)-5-cyclopropyl-N-(cyclopropylsu...)
Affinity DataIC50: 2.10nMpH: 7.4 T: 2°CAssay Description:Radioligand Binding Studies: Saturation experiments. A representative compound of formula (I) having a methyl group was tritiated. Three tritiums wer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2018
Entry Details
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TargetSodium channel protein type 5 subunit alpha(Human)
Genentech

US Patent
LigandPNGBDBM263417((5-cyclopropyl-4-(((R)-1-((R)-1-(3,5-dichloropheny...)
Affinity DataIC50: 2.10nMpH: 7.4 T: 2°CAssay Description:Radioligand Binding Studies: Saturation experiments. A representative compound of formula (I) having a methyl group was tritiated. Three tritiums wer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2018
Entry Details
Go to US Patent

TargetSodium channel protein type 5 subunit alpha(Human)
Genentech

US Patent
LigandPNGBDBM70946(US9694002, 107 | US9546164, 107)
Affinity DataIC50: 2.10nMpH: 7.4 T: 2°CAssay Description:Radioligand Binding Studies: Saturation experiments. A representative compound of formula (I) having a methyl group was tritiated. Three tritiums wer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2018
Entry Details
Go to US Patent

TargetSodium channel protein type 5 subunit alpha(Human)
Genentech

US Patent
LigandPNGBDBM71328(US9694002, 400 | US9546164, 400)
Affinity DataIC50: 2.10nMpH: 7.4 T: 2°CAssay Description:Radioligand Binding Studies: Saturation experiments. A representative compound of formula (I) having a methyl group was tritiated. Three tritiums wer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2018
Entry Details
Go to US Patent

TargetSodium channel protein type 5 subunit alpha(Human)
Genentech

US Patent
LigandPNGBDBM71352(US9694002, 423 | US9546164, 423)
Affinity DataIC50: 2.10nMpH: 7.4 T: 2°CAssay Description:Radioligand Binding Studies: Saturation experiments. A representative compound of formula (I) having a methyl group was tritiated. Three tritiums wer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2018
Entry Details
Go to US Patent

TargetSodium channel protein type 5 subunit alpha(Human)
Genentech

US Patent
LigandPNGBDBM71546(US9694002, 556 | US9546164, 556)
Affinity DataIC50: 2.10nMpH: 7.4 T: 2°CAssay Description:Radioligand Binding Studies: Saturation experiments. A representative compound of formula (I) having a methyl group was tritiated. Three tritiums wer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2018
Entry Details
Go to US Patent

TargetSodium channel protein type 5 subunit alpha(Human)
Genentech

US Patent
LigandPNGBDBM71107(US9694002, 238 | US9546164, 238)
Affinity DataIC50: 2.20nMpH: 7.4 T: 2°CAssay Description:Radioligand Binding Studies: Saturation experiments. A representative compound of formula (I) having a methyl group was tritiated. Three tritiums wer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2018
Entry Details
Go to US Patent

TargetSodium channel protein type 5 subunit alpha(Human)
Genentech

US Patent
LigandPNGBDBM71136(US9694002, 259 | US9546164, 259)
Affinity DataIC50: 2.20nMpH: 7.4 T: 2°CAssay Description:Radioligand Binding Studies: Saturation experiments. A representative compound of formula (I) having a methyl group was tritiated. Three tritiums wer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2018
Entry Details
Go to US Patent

TargetSodium channel protein type 5 subunit alpha(Human)
Genentech

US Patent
LigandPNGBDBM71211(US9694002, 312 | US9546164, 312)
Affinity DataIC50: 2.20nMpH: 7.4 T: 2°CAssay Description:Radioligand Binding Studies: Saturation experiments. A representative compound of formula (I) having a methyl group was tritiated. Three tritiums wer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2018
Entry Details
Go to US Patent

TargetSodium channel protein type 9 subunit alpha(Human)
Genentech

US Patent
LigandPNGBDBM71258(US9694002, 346 | US9546164, 346)
Affinity DataIC50: 2.20nMpH: 7.2Assay Description:Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2018
Entry Details
Go to US Patent

TargetSodium channel protein type 5 subunit alpha(Human)
Genentech

US Patent
LigandPNGBDBM263861(4-(((1R,3r,5S)-3-(3-chloro-5-(trifluoromethoxy)phe...)
Affinity DataIC50: 2.20nMpH: 7.4 T: 2°CAssay Description:Radioligand Binding Studies: Saturation experiments. A representative compound of formula (I) having a methyl group was tritiated. Three tritiums wer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2018
Entry Details
Go to US Patent

TargetSodium channel protein type 5 subunit alpha(Human)
Genentech

US Patent
LigandPNGBDBM71512(US9694002, 531 | US9546164, 531)
Affinity DataIC50: 2.20nMpH: 7.4 T: 2°CAssay Description:Radioligand Binding Studies: Saturation experiments. A representative compound of formula (I) having a methyl group was tritiated. Three tritiums wer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2018
Entry Details
Go to US Patent

TargetSodium channel protein type 5 subunit alpha(Human)
Genentech

US Patent
LigandPNGBDBM71017(US9694002, 165 | US9546164, 165)
Affinity DataIC50: 2.30nMpH: 7.4 T: 2°CAssay Description:Radioligand Binding Studies: Saturation experiments. A representative compound of formula (I) having a methyl group was tritiated. Three tritiums wer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2018
Entry Details
Go to US Patent

TargetSodium channel protein type 5 subunit alpha(Human)
Genentech

US Patent
LigandPNGBDBM71186(US9694002, 295 | US9546164, 295)
Affinity DataIC50: 2.30nMpH: 7.4 T: 2°CAssay Description:Radioligand Binding Studies: Saturation experiments. A representative compound of formula (I) having a methyl group was tritiated. Three tritiums wer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2018
Entry Details
Go to US Patent

TargetSodium channel protein type 5 subunit alpha(Human)
Genentech

US Patent
LigandPNGBDBM71209(US9694002, 310 | US9546164, 310)
Affinity DataIC50: 2.30nMpH: 7.4 T: 2°CAssay Description:Radioligand Binding Studies: Saturation experiments. A representative compound of formula (I) having a methyl group was tritiated. Three tritiums wer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2018
Entry Details
Go to US Patent

TargetSodium channel protein type 5 subunit alpha(Human)
Genentech

US Patent
LigandPNGBDBM71510(US9694002, 530 | US9694002, 529 | US9546164, 530)
Affinity DataIC50: 2.30nMpH: 7.4 T: 2°CAssay Description:Radioligand Binding Studies: Saturation experiments. A representative compound of formula (I) having a methyl group was tritiated. Three tritiums wer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2018
Entry Details
Go to US Patent

TargetSodium channel protein type 5 subunit alpha(Human)
Genentech

US Patent
LigandPNGBDBM71209(US9694002, 310 | US9546164, 310)
Affinity DataIC50: 2.40nMpH: 7.4 T: 2°CAssay Description:Radioligand Binding Studies: Saturation experiments. A representative compound of formula (I) having a methyl group was tritiated. Three tritiums wer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2018
Entry Details
Go to US Patent

TargetSodium channel protein type 5 subunit alpha(Human)
Genentech

US Patent
LigandPNGBDBM70967(US9694002, 122 | US9546164, 122)
Affinity DataIC50: 2.40nMpH: 7.4 T: 2°CAssay Description:Radioligand Binding Studies: Saturation experiments. A representative compound of formula (I) having a methyl group was tritiated. Three tritiums wer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2018
Entry Details
Go to US Patent

TargetSodium channel protein type 9 subunit alpha(Human)
Genentech

US Patent
LigandPNGBDBM71017(US9694002, 165 | US9546164, 165)
Affinity DataIC50: 2.40nMpH: 7.2Assay Description:Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2018
Entry Details
Go to US Patent

TargetSodium channel protein type 5 subunit alpha(Human)
Genentech

US Patent
LigandPNGBDBM71111(US9694002, 240 | US9546164, 240)
Affinity DataIC50: 2.40nMpH: 7.4 T: 2°CAssay Description:Radioligand Binding Studies: Saturation experiments. A representative compound of formula (I) having a methyl group was tritiated. Three tritiums wer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2018
Entry Details
Go to US Patent

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