Compile Data Set for Download or QSAR
Report error Found 35 Enz. Inhib. hit(s) with all data for entry = 7621
TargetKappa-type opioid receptor(Human)
The University of Bath

US Patent
LigandPNGBDBM50090760(US9480684, 30, R = Ph- BU10119 | CHEMBL3581750 | U...)
Affinity DataKi:  0.0400nM ΔG°:  -59.3kJ/molepH: 7.4 T: 2°CAssay Description:As Alt et al., 2002. Membranes (20 ug) are incubated in 50 mM Tris-HCl, pH 7.4 with [3H]diprenorphine or [3H]nociceptin in the absence or presence of...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2016
Entry Details
Go to US Patent

TargetKappa-type opioid receptor(Human)
The University of Bath

US Patent
LigandPNGBDBM50090731(US9480684, 22, R = 3- MePh- BU10112 | CHEMBL358174...)
Affinity DataKi:  0.0400nM ΔG°:  -59.3kJ/molepH: 7.4 T: 2°CAssay Description:As Alt et al., 2002. Membranes (20 ug) are incubated in 50 mM Tris-HCl, pH 7.4 with [3H]diprenorphine or [3H]nociceptin in the absence or presence of...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2016
Entry Details
Go to US Patent

TargetKappa-type opioid receptor(Human)
The University of Bath

US Patent
LigandPNGBDBM50090755(US9480684, 22, R = 4- FPh- BU10120 | CHEMBL3581743...)
Affinity DataKi:  0.0500nM ΔG°:  -58.8kJ/molepH: 7.4 T: 2°CAssay Description:As Alt et al., 2002. Membranes (20 ug) are incubated in 50 mM Tris-HCl, pH 7.4 with [3H]diprenorphine or [3H]nociceptin in the absence or presence of...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2016
Entry Details
Go to US Patent

TargetMu-type opioid receptor(Rat)
The University of Bath

US Patent
LigandPNGBDBM50090694(US9480684, 22, R = Ph- BU128 | CHEMBL3581740 | US9...)
Affinity DataKi:  0.0800nM ΔG°:  -57.6kJ/molepH: 7.4 T: 2°CAssay Description:As Alt et al., 2002. Membranes (20 ug) are incubated in 50 mM Tris-HCl, pH 7.4 with [3H]diprenorphine or [3H]nociceptin in the absence or presence of...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2016
Entry Details
Go to US Patent

TargetKappa-type opioid receptor(Human)
The University of Bath

US Patent
LigandPNGBDBM50090694(US9480684, 22, R = Ph- BU128 | CHEMBL3581740 | US9...)
Affinity DataKi:  0.0800nM ΔG°:  -57.6kJ/molepH: 7.4 T: 2°CAssay Description:As Alt et al., 2002. Membranes (20 ug) are incubated in 50 mM Tris-HCl, pH 7.4 with [3H]diprenorphine or [3H]nociceptin in the absence or presence of...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2016
Entry Details
Go to US Patent

TargetKappa-type opioid receptor(Human)
The University of Bath

US Patent
LigandPNGBDBM50015009(CHEMBL3262367 | US9480684, 7a, R = 3,5- diMePh- BU...)
Affinity DataKi:  0.100nM ΔG°:  -57.1kJ/molepH: 7.4 T: 2°CAssay Description:As Alt et al., 2002. Membranes (20 ug) are incubated in 50 mM Tris-HCl, pH 7.4 with [3H]diprenorphine or [3H]nociceptin in the absence or presence of...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2016
Entry Details
Go to US Patent

TargetMu-type opioid receptor(Rat)
The University of Bath

US Patent
LigandPNGBDBM50090760(US9480684, 30, R = Ph- BU10119 | CHEMBL3581750 | U...)
Affinity DataKi:  0.100nM ΔG°:  -57.1kJ/molepH: 7.4 T: 2°CAssay Description:As Alt et al., 2002. Membranes (20 ug) are incubated in 50 mM Tris-HCl, pH 7.4 with [3H]diprenorphine or [3H]nociceptin in the absence or presence of...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2016
Entry Details
Go to US Patent

TargetKappa-type opioid receptor(Human)
The University of Bath

US Patent
LigandPNGBDBM50015011(CHEMBL3262363 | US9480684, 7a, 2- MePh- BU10101 | ...)
Affinity DataKi:  0.160nM ΔG°:  -55.9kJ/molepH: 7.4 T: 2°CAssay Description:As Alt et al., 2002. Membranes (20 ug) are incubated in 50 mM Tris-HCl, pH 7.4 with [3H]diprenorphine or [3H]nociceptin in the absence or presence of...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2016
Entry Details
Go to US Patent

TargetMu-type opioid receptor(Rat)
The University of Bath

US Patent
LigandPNGBDBM50090755(US9480684, 22, R = 4- FPh- BU10120 | CHEMBL3581743...)
Affinity DataKi:  0.160nM ΔG°:  -55.9kJ/molepH: 7.4 T: 2°CAssay Description:As Alt et al., 2002. Membranes (20 ug) are incubated in 50 mM Tris-HCl, pH 7.4 with [3H]diprenorphine or [3H]nociceptin in the absence or presence of...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2016
Entry Details
Go to US Patent

TargetMu-type opioid receptor(Rat)
The University of Bath

US Patent
LigandPNGBDBM50090731(US9480684, 22, R = 3- MePh- BU10112 | CHEMBL358174...)
Affinity DataKi:  0.170nM ΔG°:  -55.8kJ/molepH: 7.4 T: 2°CAssay Description:As Alt et al., 2002. Membranes (20 ug) are incubated in 50 mM Tris-HCl, pH 7.4 with [3H]diprenorphine or [3H]nociceptin in the absence or presence of...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2016
Entry Details
Go to US Patent

TargetMu-type opioid receptor(Rat)
The University of Bath

US Patent
LigandPNGBDBM50015011(CHEMBL3262363 | US9480684, 7a, 2- MePh- BU10101 | ...)
Affinity DataKi:  0.190nM ΔG°:  -55.5kJ/molepH: 7.4 T: 2°CAssay Description:As Alt et al., 2002. Membranes (20 ug) are incubated in 50 mM Tris-HCl, pH 7.4 with [3H]diprenorphine or [3H]nociceptin in the absence or presence of...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2016
Entry Details
Go to US Patent

TargetDelta-type opioid receptor(Rat)
The University of Bath

US Patent
LigandPNGBDBM50090760(US9480684, 30, R = Ph- BU10119 | CHEMBL3581750 | U...)
Affinity DataKi:  0.25nM ΔG°:  -54.8kJ/molepH: 7.4 T: 2°CAssay Description:As Alt et al., 2002. Membranes (20 ug) are incubated in 50 mM Tris-HCl, pH 7.4 with [3H]diprenorphine or [3H]nociceptin in the absence or presence of...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2016
Entry Details
Go to US Patent

TargetMu-type opioid receptor(Rat)
The University of Bath

US Patent
LigandPNGBDBM50015009(CHEMBL3262367 | US9480684, 7a, R = 3,5- diMePh- BU...)
Affinity DataKi:  0.280nM ΔG°:  -54.5kJ/molepH: 7.4 T: 2°CAssay Description:As Alt et al., 2002. Membranes (20 ug) are incubated in 50 mM Tris-HCl, pH 7.4 with [3H]diprenorphine or [3H]nociceptin in the absence or presence of...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2016
Entry Details
Go to US Patent

TargetDelta-type opioid receptor(Rat)
The University of Bath

US Patent
LigandPNGBDBM50090731(US9480684, 22, R = 3- MePh- BU10112 | CHEMBL358174...)
Affinity DataKi:  0.400nM ΔG°:  -53.6kJ/molepH: 7.4 T: 2°CAssay Description:As Alt et al., 2002. Membranes (20 ug) are incubated in 50 mM Tris-HCl, pH 7.4 with [3H]diprenorphine or [3H]nociceptin in the absence or presence of...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2016
Entry Details
Go to US Patent

TargetDelta-type opioid receptor(Rat)
The University of Bath

US Patent
LigandPNGBDBM50090755(US9480684, 22, R = 4- FPh- BU10120 | CHEMBL3581743...)
Affinity DataKi:  0.470nM ΔG°:  -53.2kJ/molepH: 7.4 T: 2°CAssay Description:As Alt et al., 2002. Membranes (20 ug) are incubated in 50 mM Tris-HCl, pH 7.4 with [3H]diprenorphine or [3H]nociceptin in the absence or presence of...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2016
Entry Details
Go to US Patent

TargetDelta-type opioid receptor(Rat)
The University of Bath

US Patent
LigandPNGBDBM50090694(US9480684, 22, R = Ph- BU128 | CHEMBL3581740 | US9...)
Affinity DataKi:  0.480nM ΔG°:  -53.2kJ/molepH: 7.4 T: 2°CAssay Description:As Alt et al., 2002. Membranes (20 ug) are incubated in 50 mM Tris-HCl, pH 7.4 with [3H]diprenorphine or [3H]nociceptin in the absence or presence of...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2016
Entry Details
Go to US Patent

TargetKappa-type opioid receptor(Human)
The University of Bath

US Patent
LigandPNGBDBM50015003(CHEMBL3262089 | US9480684, 7a, R = Ph- BU127 | US9...)
Affinity DataKi:  0.490nM ΔG°:  -53.1kJ/molepH: 7.4 T: 2°CAssay Description:As Alt et al., 2002. Membranes (20 ug) are incubated in 50 mM Tris-HCl, pH 7.4 with [3H]diprenorphine or [3H]nociceptin in the absence or presence of...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2016
Entry Details
Go to US Patent

TargetMu-type opioid receptor(Rat)
The University of Bath

US Patent
LigandPNGBDBM50015004(CHEMBL3262372 | US9480684, 7a, R = 2- thienyl- BU0...)
Affinity DataKi:  0.600nM ΔG°:  -52.6kJ/molepH: 7.4 T: 2°CAssay Description:As Alt et al., 2002. Membranes (20 ug) are incubated in 50 mM Tris-HCl, pH 7.4 with [3H]diprenorphine or [3H]nociceptin in the absence or presence of...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2016
Entry Details
Go to US Patent

TargetMu-type opioid receptor(Rat)
The University of Bath

US Patent
LigandPNGBDBM206331(US9480684, 23, R = Ph- BU129 | US9259422, 23, R = ...)
Affinity DataKi:  0.600nM ΔG°:  -52.6kJ/molepH: 7.4 T: 2°CAssay Description:As Alt et al., 2002. Membranes (20 ug) are incubated in 50 mM Tris-HCl, pH 7.4 with [3H]diprenorphine or [3H]nociceptin in the absence or presence of...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2016
Entry Details
Go to US Patent

TargetMu-type opioid receptor(Rat)
The University of Bath

US Patent
LigandPNGBDBM50015003(CHEMBL3262089 | US9480684, 7a, R = Ph- BU127 | US9...)
Affinity DataKi:  0.710nM ΔG°:  -52.2kJ/molepH: 7.4 T: 2°CAssay Description:As Alt et al., 2002. Membranes (20 ug) are incubated in 50 mM Tris-HCl, pH 7.4 with [3H]diprenorphine or [3H]nociceptin in the absence or presence of...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2016
Entry Details
Go to US Patent

TargetDelta-type opioid receptor(Rat)
The University of Bath

US Patent
LigandPNGBDBM206331(US9480684, 23, R = Ph- BU129 | US9259422, 23, R = ...)
Affinity DataKi:  1.08nM ΔG°:  -51.2kJ/molepH: 7.4 T: 2°CAssay Description:As Alt et al., 2002. Membranes (20 ug) are incubated in 50 mM Tris-HCl, pH 7.4 with [3H]diprenorphine or [3H]nociceptin in the absence or presence of...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2016
Entry Details
Go to US Patent

TargetMu-type opioid receptor(Rat)
The University of Bath

US Patent
LigandPNGBDBM50014995(CHEMBL3262090 | US9480684, 13a, R = Ph- BU126 | US...)
Affinity DataKi:  1.25nM ΔG°:  -50.8kJ/molepH: 7.4 T: 2°CAssay Description:As Alt et al., 2002. Membranes (20 ug) are incubated in 50 mM Tris-HCl, pH 7.4 with [3H]diprenorphine or [3H]nociceptin in the absence or presence of...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2016
Entry Details
Go to US Patent

TargetDelta-type opioid receptor(Rat)
The University of Bath

US Patent
LigandPNGBDBM50015003(CHEMBL3262089 | US9480684, 7a, R = Ph- BU127 | US9...)
Affinity DataKi:  1.91nM ΔG°:  -49.8kJ/molepH: 7.4 T: 2°CAssay Description:As Alt et al., 2002. Membranes (20 ug) are incubated in 50 mM Tris-HCl, pH 7.4 with [3H]diprenorphine or [3H]nociceptin in the absence or presence of...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2016
Entry Details
Go to US Patent

TargetDelta-type opioid receptor(Rat)
The University of Bath

US Patent
LigandPNGBDBM50014995(CHEMBL3262090 | US9480684, 13a, R = Ph- BU126 | US...)
Affinity DataKi:  2.55nM ΔG°:  -49.0kJ/molepH: 7.4 T: 2°CAssay Description:As Alt et al., 2002. Membranes (20 ug) are incubated in 50 mM Tris-HCl, pH 7.4 with [3H]diprenorphine or [3H]nociceptin in the absence or presence of...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2016
Entry Details
Go to US Patent

TargetKappa-type opioid receptor(Human)
The University of Bath

US Patent
LigandPNGBDBM206331(US9480684, 23, R = Ph- BU129 | US9259422, 23, R = ...)
Affinity DataKi:  3.02nM ΔG°:  -48.6kJ/molepH: 7.4 T: 2°CAssay Description:As Alt et al., 2002. Membranes (20 ug) are incubated in 50 mM Tris-HCl, pH 7.4 with [3H]diprenorphine or [3H]nociceptin in the absence or presence of...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2016
Entry Details
Go to US Patent

TargetDelta-type opioid receptor(Rat)
The University of Bath

US Patent
LigandPNGBDBM50015005(CHEMBL3262093 | US9480684, 13b, R = Ph- BU125 | US...)
Affinity DataKi:  3.21nM ΔG°:  -48.5kJ/molepH: 7.4 T: 2°CAssay Description:As Alt et al., 2002. Membranes (20 ug) are incubated in 50 mM Tris-HCl, pH 7.4 with [3H]diprenorphine or [3H]nociceptin in the absence or presence of...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2016
Entry Details
Go to US Patent

TargetKappa-type opioid receptor(Human)
The University of Bath

US Patent
LigandPNGBDBM50015005(CHEMBL3262093 | US9480684, 13b, R = Ph- BU125 | US...)
Affinity DataKi:  3.84nM ΔG°:  -48.0kJ/molepH: 7.4 T: 2°CAssay Description:As Alt et al., 2002. Membranes (20 ug) are incubated in 50 mM Tris-HCl, pH 7.4 with [3H]diprenorphine or [3H]nociceptin in the absence or presence of...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2016
Entry Details
Go to US Patent

TargetMu-type opioid receptor(Rat)
The University of Bath

US Patent
LigandPNGBDBM50015005(CHEMBL3262093 | US9480684, 13b, R = Ph- BU125 | US...)
Affinity DataKi:  4.03nM ΔG°:  -47.9kJ/molepH: 7.4 T: 2°CAssay Description:As Alt et al., 2002. Membranes (20 ug) are incubated in 50 mM Tris-HCl, pH 7.4 with [3H]diprenorphine or [3H]nociceptin in the absence or presence of...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2016
Entry Details
Go to US Patent

TargetKappa-type opioid receptor(Human)
The University of Bath

US Patent
LigandPNGBDBM50014995(CHEMBL3262090 | US9480684, 13a, R = Ph- BU126 | US...)
Affinity DataKi:  4.40nM ΔG°:  -47.7kJ/molepH: 7.4 T: 2°CAssay Description:As Alt et al., 2002. Membranes (20 ug) are incubated in 50 mM Tris-HCl, pH 7.4 with [3H]diprenorphine or [3H]nociceptin in the absence or presence of...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2016
Entry Details
Go to US Patent

TargetNociceptin receptor(Human)
The University of Bath

US Patent
LigandPNGBDBM50090755(US9480684, 22, R = 4- FPh- BU10120 | CHEMBL3581743...)
Affinity DataKi:  34nM ΔG°:  -42.6kJ/molepH: 7.4 T: 2°CAssay Description:As Alt et al., 2002. Membranes (20 ug) are incubated in 50 mM Tris-HCl, pH 7.4 with [3H]diprenorphine or [3H]nociceptin in the absence or presence of...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2016
Entry Details
Go to US Patent

TargetNociceptin receptor(Human)
The University of Bath

US Patent
LigandPNGBDBM50015004(CHEMBL3262372 | US9480684, 7a, R = 2- thienyl- BU0...)
Affinity DataKi:  34.5nM ΔG°:  -42.6kJ/molepH: 7.4 T: 2°CAssay Description:As Alt et al., 2002. Membranes (20 ug) are incubated in 50 mM Tris-HCl, pH 7.4 with [3H]diprenorphine or [3H]nociceptin in the absence or presence of...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2016
Entry Details
Go to US Patent

TargetNociceptin receptor(Human)
The University of Bath

US Patent
LigandPNGBDBM50015003(CHEMBL3262089 | US9480684, 7a, R = Ph- BU127 | US9...)
Affinity DataKi:  43.2nM ΔG°:  -42.0kJ/molepH: 7.4 T: 2°CAssay Description:As Alt et al., 2002. Membranes (20 ug) are incubated in 50 mM Tris-HCl, pH 7.4 with [3H]diprenorphine or [3H]nociceptin in the absence or presence of...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2016
Entry Details
Go to US Patent

TargetNociceptin receptor(Human)
The University of Bath

US Patent
LigandPNGBDBM50090731(US9480684, 22, R = 3- MePh- BU10112 | CHEMBL358174...)
Affinity DataKi:  79nM ΔG°:  -40.5kJ/molepH: 7.4 T: 2°CAssay Description:As Alt et al., 2002. Membranes (20 ug) are incubated in 50 mM Tris-HCl, pH 7.4 with [3H]diprenorphine or [3H]nociceptin in the absence or presence of...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2016
Entry Details
Go to US Patent

TargetNociceptin receptor(Human)
The University of Bath

US Patent
LigandPNGBDBM50090760(US9480684, 30, R = Ph- BU10119 | CHEMBL3581750 | U...)
Affinity DataKi:  80nM ΔG°:  -40.5kJ/molepH: 7.4 T: 2°CAssay Description:As Alt et al., 2002. Membranes (20 ug) are incubated in 50 mM Tris-HCl, pH 7.4 with [3H]diprenorphine or [3H]nociceptin in the absence or presence of...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2016
Entry Details
Go to US Patent

TargetNociceptin receptor(Human)
The University of Bath

US Patent
LigandPNGBDBM50090694(US9480684, 22, R = Ph- BU128 | CHEMBL3581740 | US9...)
Affinity DataKi:  97nM ΔG°:  -40.0kJ/molepH: 7.4 T: 2°CAssay Description:As Alt et al., 2002. Membranes (20 ug) are incubated in 50 mM Tris-HCl, pH 7.4 with [3H]diprenorphine or [3H]nociceptin in the absence or presence of...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2016
Entry Details
Go to US Patent