Compile Data Set for Download or QSAR
Report error Found 367 Enz. Inhib. hit(s) with all data for entry = 6723
TargetBeta-secretase 1(Human)
Comentis

US Patent
LigandPNGBDBM149937(US8975415, 219 | US9242973, 219)
Affinity DataIC50: 41.8nMAssay Description:Potency of compounds were also measured using another fluorogenic substrate, TruPoint BACE1 Substrate Eu-CEVNLDAEFK-QSY 7 (SEQ ID NO:3) (AD0258, Perk...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/10/2015
Entry Details
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TargetBeta-secretase 1(Human)
Comentis

US Patent
LigandPNGBDBM149772(US8975415, RP111 | US8975415, RP52a | US9242973, R...)
Affinity DataIC50: 161nMAssay Description:Potency of test compounds were determined by measurement of their inhibition of BACE1 activity toward a fluorescent substrate. Experiments were perfo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/10/2015
Entry Details
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TargetBeta-secretase 1(Human)
Comentis

US Patent
LigandPNGBDBM149892(US8975415, RP173 | US9242973, RP173)
Affinity DataIC50: 239nMAssay Description:Potency of compounds were also measured using another fluorogenic substrate, TruPoint BACE1 Substrate Eu-CEVNLDAEFK-QSY 7 (SEQ ID NO:3) (AD0258, Perk...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/10/2015
Entry Details
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TargetBeta-secretase 1(Human)
Comentis

US Patent
LigandPNGBDBM149873(US8975415, RP154 | US9242973, RP154)
Affinity DataIC50: 313nMAssay Description:Potency of compounds were also measured using another fluorogenic substrate, TruPoint BACE1 Substrate Eu-CEVNLDAEFK-QSY 7 (SEQ ID NO:3) (AD0258, Perk...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/10/2015
Entry Details
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TargetBeta-secretase 1(Human)
Comentis

US Patent
LigandPNGBDBM149773(US8975415, RP108 | US8975415, RP53b | US9242973, R...)
Affinity DataIC50: 316nMAssay Description:Potency of compounds were also measured using another fluorogenic substrate, TruPoint BACE1 Substrate Eu-CEVNLDAEFK-QSY 7 (SEQ ID NO:3) (AD0258, Perk...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/10/2015
Entry Details
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TargetBeta-secretase 1(Human)
Comentis

US Patent
LigandPNGBDBM149804(US8975415, RP85 | US9242973, RP85)
Affinity DataIC50: 319nMAssay Description:Potency of test compounds were determined by measurement of their inhibition of BACE1 activity toward a fluorescent substrate. Experiments were perfo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/10/2015
Entry Details
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TargetBeta-secretase 1(Human)
Comentis

US Patent
LigandPNGBDBM149787(US8975415, RP68 | US9242973, RP68)
Affinity DataIC50: 345nMAssay Description:Potency of test compounds were determined by measurement of their inhibition of BACE1 activity toward a fluorescent substrate. Experiments were perfo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/10/2015
Entry Details
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TargetBeta-secretase 1(Human)
Comentis

US Patent
LigandPNGBDBM149801(US8975415, RP82 | US9242973, RP82)
Affinity DataIC50: 348nMAssay Description:Potency of test compounds were determined by measurement of their inhibition of BACE1 activity toward a fluorescent substrate. Experiments were perfo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/10/2015
Entry Details
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TargetBeta-secretase 1(Human)
Comentis

US Patent
LigandPNGBDBM149923(US8975415, RP207 | US8975415, RP204 | US9242973, R...)
Affinity DataIC50: 388nMAssay Description:Potency of test compounds were determined by measurement of their inhibition of BACE1 activity toward a fluorescent substrate. Experiments were perfo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/10/2015
Entry Details
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TargetBeta-secretase 1(Human)
Comentis

US Patent
LigandPNGBDBM149784(US8975415, RP65 | US9242973, RP65)
Affinity DataIC50: 388nMAssay Description:Potency of compounds were also measured using another fluorogenic substrate, TruPoint BACE1 Substrate Eu-CEVNLDAEFK-QSY 7 (SEQ ID NO:3) (AD0258, Perk...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/10/2015
Entry Details
Go to US Patent

TargetBeta-secretase 1(Human)
Comentis

US Patent
LigandPNGBDBM149859(US8975415, RP140 | US9242973, RP140)
Affinity DataIC50: 389nMAssay Description:Potency of test compounds were determined by measurement of their inhibition of BACE1 activity toward a fluorescent substrate. Experiments were perfo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/10/2015
Entry Details
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TargetBeta-secretase 1(Human)
Comentis

US Patent
LigandPNGBDBM149770(US8975415, RP69 | US8975415, RP51b | US8975415, RP...)
Affinity DataIC50: 397nMAssay Description:Potency of test compounds were determined by measurement of their inhibition of BACE1 activity toward a fluorescent substrate. Experiments were perfo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/10/2015
Entry Details
Go to US Patent

TargetBeta-secretase 1(Human)
Comentis

US Patent
LigandPNGBDBM149831(US8975415, RP112 | US9242973, RP112)
Affinity DataIC50: 400nMAssay Description:Potency of test compounds were determined by measurement of their inhibition of BACE1 activity toward a fluorescent substrate. Experiments were perfo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/10/2015
Entry Details
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TargetBeta-secretase 1(Human)
Comentis

US Patent
LigandPNGBDBM149861(US8975415, RP142 | US9242973, RP142)
Affinity DataIC50: 401nMAssay Description:Potency of test compounds were determined by measurement of their inhibition of BACE1 activity toward a fluorescent substrate. Experiments were perfo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/10/2015
Entry Details
Go to US Patent

TargetBeta-secretase 1(Human)
Comentis

US Patent
LigandPNGBDBM149892(US8975415, RP173 | US9242973, RP173)
Affinity DataIC50: 401nMAssay Description:Potency of test compounds were determined by measurement of their inhibition of BACE1 activity toward a fluorescent substrate. Experiments were perfo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/10/2015
Entry Details
Go to US Patent

TargetBeta-secretase 1(Human)
Comentis

US Patent
LigandPNGBDBM149774(US8975415, RP54 | US9242973, RP54)
Affinity DataIC50: 406nMAssay Description:Potency of test compounds were determined by measurement of their inhibition of BACE1 activity toward a fluorescent substrate. Experiments were perfo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/10/2015
Entry Details
Go to US Patent

TargetBeta-secretase 1(Human)
Comentis

US Patent
LigandPNGBDBM149923(US8975415, RP207 | US8975415, RP204 | US9242973, R...)
Affinity DataIC50: 460nMAssay Description:Potency of test compounds were determined by measurement of their inhibition of BACE1 activity toward a fluorescent substrate. Experiments were perfo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/10/2015
Entry Details
Go to US Patent

TargetBeta-secretase 1(Human)
Comentis

US Patent
LigandPNGBDBM149745(US8975415, RP23 | US9242973, RP23)
Affinity DataIC50: 519nMAssay Description:Potency of test compounds were determined by measurement of their inhibition of BACE1 activity toward a fluorescent substrate. Experiments were perfo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/10/2015
Entry Details
Go to US Patent

TargetBeta-secretase 1(Human)
Comentis

US Patent
LigandPNGBDBM149889(US8975415, RP170 | US9242973, RP170)
Affinity DataIC50: 588nMAssay Description:Potency of compounds were also measured using another fluorogenic substrate, TruPoint BACE1 Substrate Eu-CEVNLDAEFK-QSY 7 (SEQ ID NO:3) (AD0258, Perk...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/10/2015
Entry Details
Go to US Patent

TargetBeta-secretase 1(Human)
Comentis

US Patent
LigandPNGBDBM149765(US8975415, RP44 | US9242973, RP44)
Affinity DataIC50: 602nMAssay Description:Potency of test compounds were determined by measurement of their inhibition of BACE1 activity toward a fluorescent substrate. Experiments were perfo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/10/2015
Entry Details
Go to US Patent

TargetBeta-secretase 1(Human)
Comentis

US Patent
LigandPNGBDBM149867(US8975415, RP148 | US9242973, RP148)
Affinity DataIC50: 614nMAssay Description:Potency of test compounds were determined by measurement of their inhibition of BACE1 activity toward a fluorescent substrate. Experiments were perfo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/10/2015
Entry Details
Go to US Patent

TargetBeta-secretase 1(Human)
Comentis

US Patent
LigandPNGBDBM149866(US8975415, RP147 | US9242973, RP147)
Affinity DataIC50: 621nMAssay Description:Potency of test compounds were determined by measurement of their inhibition of BACE1 activity toward a fluorescent substrate. Experiments were perfo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/10/2015
Entry Details
Go to US Patent

TargetBeta-secretase 1(Human)
Comentis

US Patent
LigandPNGBDBM149809(US8975415, RP93 | US8975415, RP90 | US9242973, RP9...)
Affinity DataIC50: 629nMAssay Description:Potency of test compounds were determined by measurement of their inhibition of BACE1 activity toward a fluorescent substrate. Experiments were perfo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/10/2015
Entry Details
Go to US Patent

TargetBeta-secretase 1(Human)
Comentis

US Patent
LigandPNGBDBM149855(US8975415, RP136 | US9242973, RP136)
Affinity DataIC50: 635nMAssay Description:Potency of test compounds were determined by measurement of their inhibition of BACE1 activity toward a fluorescent substrate. Experiments were perfo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/10/2015
Entry Details
Go to US Patent

TargetBeta-secretase 1(Human)
Comentis

US Patent
LigandPNGBDBM149810(US8975415, RP94 | US8975415, RP91 | US9242973, RP9...)
Affinity DataIC50: 656nMAssay Description:Potency of test compounds were determined by measurement of their inhibition of BACE1 activity toward a fluorescent substrate. Experiments were perfo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/10/2015
Entry Details
Go to US Patent

TargetBeta-secretase 1(Human)
Comentis

US Patent
LigandPNGBDBM149871(US8975415, RP152 | US9242973, RP152)
Affinity DataIC50: 688nMAssay Description:Potency of test compounds were determined by measurement of their inhibition of BACE1 activity toward a fluorescent substrate. Experiments were perfo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/10/2015
Entry Details
Go to US Patent

TargetBeta-secretase 1(Human)
Comentis

US Patent
LigandPNGBDBM149845(US8975415, RP126 | US9242973, RP126)
Affinity DataIC50: 696nMAssay Description:Potency of test compounds were determined by measurement of their inhibition of BACE1 activity toward a fluorescent substrate. Experiments were perfo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/10/2015
Entry Details
Go to US Patent

TargetBeta-secretase 1(Human)
Comentis

US Patent
LigandPNGBDBM149803(US8975415, RP87 | US8975415, RP84 | US9242973, RP8...)
Affinity DataIC50: 735nMAssay Description:Potency of test compounds were determined by measurement of their inhibition of BACE1 activity toward a fluorescent substrate. Experiments were perfo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/10/2015
Entry Details
Go to US Patent

TargetBeta-secretase 1(Human)
Comentis

US Patent
LigandPNGBDBM149918(US8975415, RP199 | US9242973, RP199)
Affinity DataIC50: 736nMAssay Description:Potency of test compounds were determined by measurement of their inhibition of BACE1 activity toward a fluorescent substrate. Experiments were perfo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/10/2015
Entry Details
Go to US Patent

TargetBeta-secretase 1(Human)
Comentis

US Patent
LigandPNGBDBM149814(US8975415, RP95)
Affinity DataIC50: 740nMAssay Description:Potency of test compounds were determined by measurement of their inhibition of BACE1 activity toward a fluorescent substrate. Experiments were perfo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/10/2015
Entry Details
Go to US Patent

TargetBeta-secretase 1(Human)
Comentis

US Patent
LigandPNGBDBM149897(US8975415, RP178 | US9242973, RP178)
Affinity DataIC50: 747nMAssay Description:Potency of compounds were also measured using another fluorogenic substrate, TruPoint BACE1 Substrate Eu-CEVNLDAEFK-QSY 7 (SEQ ID NO:3) (AD0258, Perk...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/10/2015
Entry Details
Go to US Patent

TargetBeta-secretase 1(Human)
Comentis

US Patent
LigandPNGBDBM149869(US8975415, RP150 | US9242973, RP150)
Affinity DataIC50: 759nMAssay Description:Potency of compounds were also measured using another fluorogenic substrate, TruPoint BACE1 Substrate Eu-CEVNLDAEFK-QSY 7 (SEQ ID NO:3) (AD0258, Perk...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/10/2015
Entry Details
Go to US Patent

TargetBeta-secretase 1(Human)
Comentis

US Patent
LigandPNGBDBM149884(US8975415, RP165 | US9242973, RP165)
Affinity DataIC50: 760nMAssay Description:Potency of test compounds were determined by measurement of their inhibition of BACE1 activity toward a fluorescent substrate. Experiments were perfo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/10/2015
Entry Details
Go to US Patent

TargetBeta-secretase 1(Human)
Comentis

US Patent
LigandPNGBDBM149887(US8975415, RP168 | US9242973, RP168)
Affinity DataIC50: 760nMAssay Description:Potency of compounds were also measured using another fluorogenic substrate, TruPoint BACE1 Substrate Eu-CEVNLDAEFK-QSY 7 (SEQ ID NO:3) (AD0258, Perk...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/10/2015
Entry Details
Go to US Patent

TargetBeta-secretase 1(Human)
Comentis

US Patent
LigandPNGBDBM149856(US8975415, RP137 | US9242973, RP137)
Affinity DataIC50: 773nMAssay Description:Potency of test compounds were determined by measurement of their inhibition of BACE1 activity toward a fluorescent substrate. Experiments were perfo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/10/2015
Entry Details
Go to US Patent

TargetBeta-secretase 1(Human)
Comentis

US Patent
LigandPNGBDBM149874(US8975415, RP155 | US9242973, RP155)
Affinity DataIC50: 786nMAssay Description:Potency of compounds were also measured using another fluorogenic substrate, TruPoint BACE1 Substrate Eu-CEVNLDAEFK-QSY 7 (SEQ ID NO:3) (AD0258, Perk...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/10/2015
Entry Details
Go to US Patent

TargetBeta-secretase 1(Human)
Comentis

US Patent
LigandPNGBDBM149791(US8975415, RP72 | US9242973, RP72)
Affinity DataIC50: 817nMAssay Description:Potency of test compounds were determined by measurement of their inhibition of BACE1 activity toward a fluorescent substrate. Experiments were perfo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/10/2015
Entry Details
Go to US Patent

TargetBeta-secretase 1(Human)
Comentis

US Patent
LigandPNGBDBM149792(US8975415, RP73 | US9242973, RP73)
Affinity DataIC50: 827nMAssay Description:Potency of test compounds were determined by measurement of their inhibition of BACE1 activity toward a fluorescent substrate. Experiments were perfo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/10/2015
Entry Details
Go to US Patent

TargetBeta-secretase 1(Human)
Comentis

US Patent
LigandPNGBDBM149888(US8975415, RP169 | US9242973, RP169)
Affinity DataIC50: 859nMAssay Description:Potency of compounds were also measured using another fluorogenic substrate, TruPoint BACE1 Substrate Eu-CEVNLDAEFK-QSY 7 (SEQ ID NO:3) (AD0258, Perk...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/10/2015
Entry Details
Go to US Patent

TargetBeta-secretase 1(Human)
Comentis

US Patent
LigandPNGBDBM149810(US8975415, RP94 | US8975415, RP91 | US9242973, RP9...)
Affinity DataIC50: 862nMAssay Description:Potency of test compounds were determined by measurement of their inhibition of BACE1 activity toward a fluorescent substrate. Experiments were perfo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/10/2015
Entry Details
Go to US Patent

TargetBeta-secretase 1(Human)
Comentis

US Patent
LigandPNGBDBM149886(US8975415, RP167 | US9242973, RP167)
Affinity DataIC50: 869nMAssay Description:Potency of test compounds were determined by measurement of their inhibition of BACE1 activity toward a fluorescent substrate. Experiments were perfo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/10/2015
Entry Details
Go to US Patent

TargetBeta-secretase 1(Human)
Comentis

US Patent
LigandPNGBDBM149863(US8975415, RP144 | US9242973, RP144)
Affinity DataIC50: 879nMAssay Description:Potency of test compounds were determined by measurement of their inhibition of BACE1 activity toward a fluorescent substrate. Experiments were perfo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/10/2015
Entry Details
Go to US Patent

TargetBeta-secretase 1(Human)
Comentis

US Patent
LigandPNGBDBM149902(US8975415, RP183 | US9242973, RP183)
Affinity DataIC50: 880nMAssay Description:Potency of compounds were also measured using another fluorogenic substrate, TruPoint BACE1 Substrate Eu-CEVNLDAEFK-QSY 7 (SEQ ID NO:3) (AD0258, Perk...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/10/2015
Entry Details
Go to US Patent

TargetBeta-secretase 1(Human)
Comentis

US Patent
LigandPNGBDBM149809(US8975415, RP93 | US8975415, RP90 | US9242973, RP9...)
Affinity DataIC50: 901nMAssay Description:Potency of test compounds were determined by measurement of their inhibition of BACE1 activity toward a fluorescent substrate. Experiments were perfo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/10/2015
Entry Details
Go to US Patent

TargetBeta-secretase 1(Human)
Comentis

US Patent
LigandPNGBDBM149860(US8975415, RP141 | US9242973, RP141)
Affinity DataIC50: 903nMAssay Description:Potency of test compounds were determined by measurement of their inhibition of BACE1 activity toward a fluorescent substrate. Experiments were perfo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/10/2015
Entry Details
Go to US Patent

TargetBeta-secretase 1(Human)
Comentis

US Patent
LigandPNGBDBM149877(US8975415, RP158 | US9242973, RP158)
Affinity DataIC50: 930nMAssay Description:Potency of test compounds were determined by measurement of their inhibition of BACE1 activity toward a fluorescent substrate. Experiments were perfo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/10/2015
Entry Details
Go to US Patent

TargetBeta-secretase 1(Human)
Comentis

US Patent
LigandPNGBDBM149864(US8975415, RP145 | US9242973, RP145)
Affinity DataIC50: 933nMAssay Description:Potency of test compounds were determined by measurement of their inhibition of BACE1 activity toward a fluorescent substrate. Experiments were perfo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/10/2015
Entry Details
Go to US Patent

TargetBeta-secretase 1(Human)
Comentis

US Patent
LigandPNGBDBM149879(US8975415, RP160 | US9242973, RP160)
Affinity DataIC50: 981nMAssay Description:Potency of test compounds were determined by measurement of their inhibition of BACE1 activity toward a fluorescent substrate. Experiments were perfo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/10/2015
Entry Details
Go to US Patent

TargetBeta-secretase 1(Human)
Comentis

US Patent
LigandPNGBDBM149895(US8975415, RP176 | US9242973, RP176)
Affinity DataIC50: 994nMAssay Description:Potency of compounds were also measured using another fluorogenic substrate, TruPoint BACE1 Substrate Eu-CEVNLDAEFK-QSY 7 (SEQ ID NO:3) (AD0258, Perk...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/10/2015
Entry Details
Go to US Patent

TargetBeta-secretase 1(Human)
Comentis

US Patent
LigandPNGBDBM149889(US8975415, RP170 | US9242973, RP170)
Affinity DataIC50: 1.00E+3nMAssay Description:Potency of test compounds were determined by measurement of their inhibition of BACE1 activity toward a fluorescent substrate. Experiments were perfo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/10/2015
Entry Details
Go to US Patent

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