Compile Data Set for Download or QSAR
Report error Found 18 Enz. Inhib. hit(s) with all data for entry = 6104
TargetLysosomal acid glucosylceramidase(Human)
Amicus Therapeutics

US Patent
LigandPNGBDBM108418(US8604206, 14 | US8604206, 13)
Affinity DataKi:  0.900nM IC50: 17.1nMpH: 7.0Assay Description:The enzyme inhibition assays used monitored the ability of a test compound to bind and prevent the hydrolysis of a fluorogenic substrate in a concent...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/12/2014
Entry Details
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TargetLysosomal acid glucosylceramidase(Human)
Amicus Therapeutics

US Patent
LigandPNGBDBM108417(US8604206, 6)
Affinity DataKi:  3.06nM IC50: 5.80nMpH: 7.0Assay Description:The enzyme inhibition assays used monitored the ability of a test compound to bind and prevent the hydrolysis of a fluorogenic substrate in a concent...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/12/2014
Entry Details
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TargetLysosomal acid glucosylceramidase(Human)
Amicus Therapeutics

US Patent
LigandPNGBDBM108418(US8604206, 14 | US8604206, 13)
Affinity DataKi:  4nM IC50: 7nMpH: 7.0Assay Description:The enzyme inhibition assays used monitored the ability of a test compound to bind and prevent the hydrolysis of a fluorogenic substrate in a concent...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/12/2014
Entry Details
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TargetLysosomal acid glucosylceramidase(Human)
Amicus Therapeutics

US Patent
LigandPNGBDBM108423(US8604206, (3R,4R,5R)-5((S)-hydroxy(phenyl)methyl)...)
Affinity DataKi:  8.90nM IC50: 17nMpH: 7.0Assay Description:The enzyme inhibition assays used monitored the ability of a test compound to bind and prevent the hydrolysis of a fluorogenic substrate in a concent...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/12/2014
Entry Details
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TargetLysosomal acid glucosylceramidase(Human)
Amicus Therapeutics

US Patent
LigandPNGBDBM108419(US8604206, 10 | US8604206, 9)
Affinity DataKi:  10nM IC50: 20nMpH: 7.0Assay Description:The enzyme inhibition assays used monitored the ability of a test compound to bind and prevent the hydrolysis of a fluorogenic substrate in a concent...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/12/2014
Entry Details
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TargetLysosomal acid glucosylceramidase(Human)
Amicus Therapeutics

US Patent
LigandPNGBDBM108417(US8604206, 6)
Affinity DataKi:  13.6nM IC50: 25.9nMpH: 5.2Assay Description:The enzyme inhibition assays used monitored the ability of a test compound to bind and prevent the hydrolysis of a fluorogenic substrate in a concent...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/12/2014
Entry Details
Go to US Patent

TargetLysosomal acid glucosylceramidase(Human)
Amicus Therapeutics

US Patent
LigandPNGBDBM108424(US8604206, (3R,4R,5S)-5(2-hydroxypropan-2-yl)piper...)
Affinity DataKi:  15nM IC50: 29nMpH: 7.0Assay Description:The enzyme inhibition assays used monitored the ability of a test compound to bind and prevent the hydrolysis of a fluorogenic substrate in a concent...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/12/2014
Entry Details
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TargetLysosomal acid glucosylceramidase(Human)
Amicus Therapeutics

US Patent
LigandPNGBDBM108418(US8604206, 14 | US8604206, 13)
Affinity DataKi:  16nM IC50: 38nMpH: 5.2Assay Description:The enzyme inhibition assays used monitored the ability of a test compound to bind and prevent the hydrolysis of a fluorogenic substrate in a concent...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/12/2014
Entry Details
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TargetLysosomal acid glucosylceramidase(Human)
Amicus Therapeutics

US Patent
LigandPNGBDBM47182(US8604206, (3R,4R,5S)-5-((R)-1-fluoropropyl)-piper...)
Affinity DataKi:  31nM IC50: 60nMAssay Description:The enzyme inhibition assays used monitored the ability of a test compound to bind and prevent the hydrolysis of a fluorogenic substrate in a concent...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/12/2014
Entry Details
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TargetLysosomal acid glucosylceramidase(Human)
Amicus Therapeutics

US Patent
LigandPNGBDBM108419(US8604206, 10 | US8604206, 9)
Affinity DataKi:  35nM IC50: 66nMpH: 7.0Assay Description:The enzyme inhibition assays used monitored the ability of a test compound to bind and prevent the hydrolysis of a fluorogenic substrate in a concent...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/12/2014
Entry Details
Go to US Patent

TargetLysosomal acid glucosylceramidase(Human)
Amicus Therapeutics

US Patent
LigandPNGBDBM108419(US8604206, 10 | US8604206, 9)
Affinity DataKi:  44nM IC50: 107nMpH: 5.2Assay Description:The enzyme inhibition assays used monitored the ability of a test compound to bind and prevent the hydrolysis of a fluorogenic substrate in a concent...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/12/2014
Entry Details
Go to US Patent

TargetLysosomal acid glucosylceramidase(Human)
Amicus Therapeutics

US Patent
LigandPNGBDBM108418(US8604206, 14 | US8604206, 13)
Affinity DataKi:  49.8nM IC50: 94.6nMpH: 5.2Assay Description:The enzyme inhibition assays used monitored the ability of a test compound to bind and prevent the hydrolysis of a fluorogenic substrate in a concent...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/12/2014
Entry Details
Go to US Patent

TargetLysosomal acid glucosylceramidase(Human)
Amicus Therapeutics

US Patent
LigandPNGBDBM108422(US8604206, (3R,4R,5S)-5-benzyl-piperidine-3,4-diol)
Affinity DataKi:  67nM IC50: 127nMpH: 7.0Assay Description:The enzyme inhibition assays used monitored the ability of a test compound to bind and prevent the hydrolysis of a fluorogenic substrate in a concent...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/12/2014
Entry Details
Go to US Patent

TargetLysosomal acid glucosylceramidase(Human)
Amicus Therapeutics

US Patent
LigandPNGBDBM108424(US8604206, (3R,4R,5S)-5(2-hydroxypropan-2-yl)piper...)
Affinity DataKi:  97nM IC50: 234nMpH: 5.2Assay Description:The enzyme inhibition assays used monitored the ability of a test compound to bind and prevent the hydrolysis of a fluorogenic substrate in a concent...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/12/2014
Entry Details
Go to US Patent

TargetLysosomal acid glucosylceramidase(Human)
Amicus Therapeutics

US Patent
LigandPNGBDBM47182(US8604206, (3R,4R,5S)-5-((R)-1-fluoropropyl)-piper...)
Affinity DataKi:  121nM IC50: 291nMAssay Description:The enzyme inhibition assays used monitored the ability of a test compound to bind and prevent the hydrolysis of a fluorogenic substrate in a concent...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/12/2014
Entry Details
Go to US Patent

TargetLysosomal acid glucosylceramidase(Human)
Amicus Therapeutics

US Patent
LigandPNGBDBM108419(US8604206, 10 | US8604206, 9)
Affinity DataKi:  142nM IC50: 343nMpH: 5.2Assay Description:The enzyme inhibition assays used monitored the ability of a test compound to bind and prevent the hydrolysis of a fluorogenic substrate in a concent...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/12/2014
Entry Details
Go to US Patent

TargetLysosomal acid glucosylceramidase(Human)
Amicus Therapeutics

US Patent
LigandPNGBDBM108422(US8604206, (3R,4R,5S)-5-benzyl-piperidine-3,4-diol)
Affinity DataKi:  273nM IC50: 659nMpH: 5.2Assay Description:The enzyme inhibition assays used monitored the ability of a test compound to bind and prevent the hydrolysis of a fluorogenic substrate in a concent...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/12/2014
Entry Details
Go to US Patent

TargetLysosomal acid glucosylceramidase(Human)
Amicus Therapeutics

US Patent
LigandPNGBDBM108423(US8604206, (3R,4R,5R)-5((S)-hydroxy(phenyl)methyl)...)
Affinity DataKi:  1.36E+3nM IC50: 3.29E+3nMpH: 5.2Assay Description:The enzyme inhibition assays used monitored the ability of a test compound to bind and prevent the hydrolysis of a fluorogenic substrate in a concent...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/12/2014
Entry Details
Go to US Patent