Compile Data Set for Download or QSAR
Report error Found 28 Enz. Inhib. hit(s) with all data for entry = 5863
TargetNociceptin receptor(Human)
Purdue Pharma

US Patent
LigandPNGBDBM97714(US8476271, 405)
Affinity DataKi:  1.10nM ΔG°:  -51.1kJ/molepH: 7.4 T: 2°CAssay Description:Radioligand binding assays (screening and dose-displacement) used 0.1 nM [3H]-nociceptin (NEN; 87.7 Ci/mmole) with 10-20 μg membrane protein in a ...More data for this Ligand-Target Pair
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Date in BDB:
8/5/2013
Entry Details
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TargetNociceptin receptor(Human)
Purdue Pharma

US Patent
LigandPNGBDBM97710(US8476271, 16 | US9145408, 362)
Affinity DataKi:  2.40nM ΔG°:  -49.2kJ/molepH: 7.4 T: 2°CAssay Description:Radioligand binding assays (screening and dose-displacement) used 0.1 nM [3H]-nociceptin (NEN; 87.7 Ci/mmole) with 10-20 μg membrane protein in a ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/5/2013
Entry Details
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TargetNociceptin receptor(Human)
Purdue Pharma

US Patent
LigandPNGBDBM97711(US8846929, 361 | US8846929, 360 | US8476271, 17 | ...)
Affinity DataKi:  5.70nM ΔG°:  -47.1kJ/molepH: 7.4 T: 2°CAssay Description:Radioligand binding assays (screening and dose-displacement) used 0.1 nM [3H]-nociceptin (NEN; 87.7 Ci/mmole) with 10-20 μg membrane protein in a ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/5/2013
Entry Details
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TargetNociceptin receptor(Human)
Purdue Pharma

US Patent
LigandPNGBDBM97712(US8846929, 358 | US8476271, 18 | US9145408, 358)
Affinity DataKi:  9nM ΔG°:  -45.9kJ/molepH: 7.4 T: 2°CAssay Description:Radioligand binding assays (screening and dose-displacement) used 0.1 nM [3H]-nociceptin (NEN; 87.7 Ci/mmole) with 10-20 μg membrane protein in a ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/5/2013
Entry Details
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TargetNociceptin receptor(Human)
Purdue Pharma

US Patent
LigandPNGBDBM97715(US8846929, 356 | US8476271, 96 | US9145408, 356)
Affinity DataKi:  43.1nM ΔG°:  -42.0kJ/molepH: 7.4 T: 2°CAssay Description:Radioligand binding assays (screening and dose-displacement) used 0.1 nM [3H]-nociceptin (NEN; 87.7 Ci/mmole) with 10-20 μg membrane protein in a ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/5/2013
Entry Details
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TargetMu-type opioid receptor(Human)
Purdue Pharma

US Patent
LigandPNGBDBM97714(US8476271, 405)
Affinity DataKi:  61.6nM ΔG°:  -41.2kJ/molepH: 7.4 T: 2°CAssay Description:Radioligand dose displacement assays used 0.4-0.8 nM [3H]-U69,593 (NEN; 40 Ci/mmole) with 10-20 μg membrane protein (recombinant kappa opioid rece...More data for this Ligand-Target Pair
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Date in BDB:
8/5/2013
Entry Details
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TargetKappa-type opioid receptor(Human)
Purdue Pharma

US Patent
LigandPNGBDBM97714(US8476271, 405)
Affinity DataKi:  75.4nM ΔG°:  -40.7kJ/molepH: 7.4 T: 2°CAssay Description:Radioligand dose-displacement binding assays for μ-opioid receptors used 0.2 nM[3H]-diprenorphine (NEN, Boston, Mass.), with 5-20 mg membrane prot...More data for this Ligand-Target Pair
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Date in BDB:
8/5/2013
Entry Details
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TargetKappa-type opioid receptor(Human)
Purdue Pharma

US Patent
LigandPNGBDBM97715(US8846929, 356 | US8476271, 96 | US9145408, 356)
Affinity DataKi:  76nM ΔG°:  -40.6kJ/molepH: 7.4 T: 2°CAssay Description:Radioligand dose-displacement binding assays for μ-opioid receptors used 0.2 nM[3H]-diprenorphine (NEN, Boston, Mass.), with 5-20 mg membrane prot...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/5/2013
Entry Details
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TargetNociceptin receptor(Human)
Purdue Pharma

US Patent
LigandPNGBDBM97713(US8846929, 222 | US8476271, 19)
Affinity DataKi:  178nM ΔG°:  -38.5kJ/molepH: 7.4 T: 2°CAssay Description:Radioligand binding assays (screening and dose-displacement) used 0.1 nM [3H]-nociceptin (NEN; 87.7 Ci/mmole) with 10-20 μg membrane protein in a ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/5/2013
Entry Details
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TargetNociceptin receptor(Human)
Purdue Pharma

US Patent
LigandPNGBDBM97716(US8476271, 97)
Affinity DataKi:  203nM ΔG°:  -38.2kJ/molepH: 7.4 T: 2°CAssay Description:Radioligand binding assays (screening and dose-displacement) used 0.1 nM [3H]-nociceptin (NEN; 87.7 Ci/mmole) with 10-20 μg membrane protein in a ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/5/2013
Entry Details
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TargetKappa-type opioid receptor(Human)
Purdue Pharma

US Patent
LigandPNGBDBM97712(US8846929, 358 | US8476271, 18 | US9145408, 358)
Affinity DataKi:  640nM ΔG°:  -35.4kJ/molepH: 7.4 T: 2°CAssay Description:Radioligand dose-displacement binding assays for μ-opioid receptors used 0.2 nM[3H]-diprenorphine (NEN, Boston, Mass.), with 5-20 mg membrane prot...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/5/2013
Entry Details
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TargetKappa-type opioid receptor(Human)
Purdue Pharma

US Patent
LigandPNGBDBM97714(US8476271, 405)
Affinity DataKi:  691nM ΔG°:  -35.2kJ/molepH: 7.4 T: 2°CAssay Description:Radioligand dose-displacement binding assays for μ-opioid receptors used 0.2 nM[3H]-diprenorphine (NEN, Boston, Mass.), with 5-20 mg membrane prot...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/5/2013
Entry Details
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TargetMu-type opioid receptor(Human)
Purdue Pharma

US Patent
LigandPNGBDBM97715(US8846929, 356 | US8476271, 96 | US9145408, 356)
Affinity DataKi:  1.44E+3nM ΔG°:  -33.3kJ/molepH: 7.4 T: 2°CAssay Description:Radioligand dose displacement assays used 0.4-0.8 nM [3H]-U69,593 (NEN; 40 Ci/mmole) with 10-20 μg membrane protein (recombinant kappa opioid rece...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/5/2013
Entry Details
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TargetMu-type opioid receptor(Human)
Purdue Pharma

US Patent
LigandPNGBDBM97712(US8846929, 358 | US8476271, 18 | US9145408, 358)
Affinity DataKi:  1.60E+3nM ΔG°:  -33.1kJ/molepH: 7.4 T: 2°CAssay Description:Radioligand dose displacement assays used 0.4-0.8 nM [3H]-U69,593 (NEN; 40 Ci/mmole) with 10-20 μg membrane protein (recombinant kappa opioid rece...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/5/2013
Entry Details
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TargetMu-type opioid receptor(Human)
Purdue Pharma

US Patent
LigandPNGBDBM97710(US8476271, 16 | US9145408, 362)
Affinity DataKi:  1.63E+3nM ΔG°:  -33.0kJ/molepH: 7.4 T: 2°CAssay Description:Radioligand dose displacement assays used 0.4-0.8 nM [3H]-U69,593 (NEN; 40 Ci/mmole) with 10-20 μg membrane protein (recombinant kappa opioid rece...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/5/2013
Entry Details
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TargetKappa-type opioid receptor(Human)
Purdue Pharma

US Patent
LigandPNGBDBM97710(US8476271, 16 | US9145408, 362)
Affinity DataKi:  2.28E+3nM ΔG°:  -32.2kJ/molepH: 7.4 T: 2°CAssay Description:Radioligand dose-displacement binding assays for μ-opioid receptors used 0.2 nM[3H]-diprenorphine (NEN, Boston, Mass.), with 5-20 mg membrane prot...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/5/2013
Entry Details
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TargetKappa-type opioid receptor(Human)
Purdue Pharma

US Patent
LigandPNGBDBM97716(US8476271, 97)
Affinity DataKi:  2.69E+3nM ΔG°:  -31.8kJ/molepH: 7.4 T: 2°CAssay Description:Radioligand dose-displacement binding assays for μ-opioid receptors used 0.2 nM[3H]-diprenorphine (NEN, Boston, Mass.), with 5-20 mg membrane prot...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/5/2013
Entry Details
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TargetMu-type opioid receptor(Human)
Purdue Pharma

US Patent
LigandPNGBDBM97716(US8476271, 97)
Affinity DataKi:  3.83E+3nM ΔG°:  -30.9kJ/molepH: 7.4 T: 2°CAssay Description:Radioligand dose displacement assays used 0.4-0.8 nM [3H]-U69,593 (NEN; 40 Ci/mmole) with 10-20 μg membrane protein (recombinant kappa opioid rece...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/5/2013
Entry Details
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TargetMu-type opioid receptor(Human)
Purdue Pharma

US Patent
LigandPNGBDBM97713(US8846929, 222 | US8476271, 19)
Affinity DataKi:  4.03E+3nM ΔG°:  -30.8kJ/molepH: 7.4 T: 2°CAssay Description:Radioligand dose displacement assays used 0.4-0.8 nM [3H]-U69,593 (NEN; 40 Ci/mmole) with 10-20 μg membrane protein (recombinant kappa opioid rece...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/5/2013
Entry Details
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TargetMu-type opioid receptor(Human)
Purdue Pharma

US Patent
LigandPNGBDBM97711(US8846929, 361 | US8846929, 360 | US8476271, 17 | ...)
Affinity DataKi:  4.45E+3nM ΔG°:  -30.5kJ/molepH: 7.4 T: 2°CAssay Description:Radioligand dose displacement assays used 0.4-0.8 nM [3H]-U69,593 (NEN; 40 Ci/mmole) with 10-20 μg membrane protein (recombinant kappa opioid rece...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/5/2013
Entry Details
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TargetKappa-type opioid receptor(Human)
Purdue Pharma

US Patent
LigandPNGBDBM97710(US8476271, 16 | US9145408, 362)
Affinity DataKi:  4.76E+3nM ΔG°:  -30.4kJ/molepH: 7.4 T: 2°CAssay Description:Radioligand dose-displacement binding assays for μ-opioid receptors used 0.2 nM[3H]-diprenorphine (NEN, Boston, Mass.), with 5-20 mg membrane prot...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/5/2013
Entry Details
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TargetKappa-type opioid receptor(Human)
Purdue Pharma

US Patent
LigandPNGBDBM97713(US8846929, 222 | US8476271, 19)
Affinity DataKi:  5.35E+3nM ΔG°:  -30.1kJ/molepH: 7.4 T: 2°CAssay Description:Radioligand dose-displacement binding assays for μ-opioid receptors used 0.2 nM[3H]-diprenorphine (NEN, Boston, Mass.), with 5-20 mg membrane prot...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/5/2013
Entry Details
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TargetKappa-type opioid receptor(Human)
Purdue Pharma

US Patent
LigandPNGBDBM97711(US8846929, 361 | US8846929, 360 | US8476271, 17 | ...)
Affinity DataKi:  6.14E+3nM ΔG°:  -29.7kJ/molepH: 7.4 T: 2°CAssay Description:Radioligand dose-displacement binding assays for μ-opioid receptors used 0.2 nM[3H]-diprenorphine (NEN, Boston, Mass.), with 5-20 mg membrane prot...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/5/2013
Entry Details
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TargetKappa-type opioid receptor(Human)
Purdue Pharma

US Patent
LigandPNGBDBM97712(US8846929, 358 | US8476271, 18 | US9145408, 358)
Affinity DataKi:  8.90E+3nM ΔG°:  -28.8kJ/molepH: 7.4 T: 2°CAssay Description:Radioligand dose-displacement binding assays for μ-opioid receptors used 0.2 nM[3H]-diprenorphine (NEN, Boston, Mass.), with 5-20 mg membrane prot...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/5/2013
Entry Details
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TargetKappa-type opioid receptor(Human)
Purdue Pharma

US Patent
LigandPNGBDBM97715(US8846929, 356 | US8476271, 96 | US9145408, 356)
Affinity DataKi:  1.82E+4nM ΔG°:  -27.1kJ/molepH: 7.4 T: 2°CAssay Description:Radioligand dose-displacement binding assays for μ-opioid receptors used 0.2 nM[3H]-diprenorphine (NEN, Boston, Mass.), with 5-20 mg membrane prot...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/5/2013
Entry Details
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TargetKappa-type opioid receptor(Human)
Purdue Pharma

US Patent
LigandPNGBDBM97711(US8846929, 361 | US8846929, 360 | US8476271, 17 | ...)
Affinity DataKi: >2.00E+4nM ΔG°: >-26.8kJ/molepH: 7.4 T: 2°CAssay Description:Radioligand dose-displacement binding assays for μ-opioid receptors used 0.2 nM[3H]-diprenorphine (NEN, Boston, Mass.), with 5-20 mg membrane prot...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/5/2013
Entry Details
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TargetKappa-type opioid receptor(Human)
Purdue Pharma

US Patent
LigandPNGBDBM97716(US8476271, 97)
Affinity DataKi: >2.00E+4nM ΔG°: >-26.8kJ/molepH: 7.4 T: 2°CAssay Description:Radioligand dose-displacement binding assays for μ-opioid receptors used 0.2 nM[3H]-diprenorphine (NEN, Boston, Mass.), with 5-20 mg membrane prot...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/5/2013
Entry Details
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TargetKappa-type opioid receptor(Human)
Purdue Pharma

US Patent
LigandPNGBDBM97713(US8846929, 222 | US8476271, 19)
Affinity DataKi: >2.00E+4nM ΔG°: >-26.8kJ/molepH: 7.4 T: 2°CAssay Description:Radioligand dose-displacement binding assays for μ-opioid receptors used 0.2 nM[3H]-diprenorphine (NEN, Boston, Mass.), with 5-20 mg membrane prot...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/5/2013
Entry Details
Go to US Patent