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Report error Found 611 Enz. Inhib. hit(s) with all data for entry = 12874
TargetTyrosine-protein kinase JAK3(Human)
Pfizer

US Patent
LigandPNGBDBM316515(US9617258, Example 3 | US11111242, Example 3 | US2...)
Affinity DataIC50: 0.100nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2025
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK3(Human)
Pfizer

US Patent
LigandPNGBDBM316711(5-{2-[(1-acryloylpiperidin-4-yl)amino]-5H-pyrrolo[...)
Affinity DataIC50: 0.100nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2025
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK3(Human)
Pfizer

US Patent
LigandPNGBDBM316739(2-[(1-acryloylpiperidin-4-yl)amino]-N-(3,3-difluor...)
Affinity DataIC50: 0.100nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2025
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK3(Human)
Pfizer

US Patent
LigandPNGBDBM316743(2-[(1-acryloylpiperidin-4-yl)amino]-N-(4,4,4-trifl...)
Affinity DataIC50: 0.100nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2025
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK3(Human)
Pfizer

US Patent
LigandPNGBDBM316745(2-[(1-acryloylpiperidin-4-yl)amino]-N-(3-cyanoprop...)
Affinity DataIC50: 0.100nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2025
Entry Details
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TargetTyrosine-protein kinase JAK3(Human)
Pfizer

US Patent
LigandPNGBDBM316746(2-[(1-acryloylpiperidin-4-yl)amino]-N-(3-fluorocyc...)
Affinity DataIC50: 0.100nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2025
Entry Details
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TargetTyrosine-protein kinase JAK3(Human)
Pfizer

US Patent
LigandPNGBDBM316774(2-[(1-acryloylpiperidin-4-yl)amino]-N-(cyclopentyl...)
Affinity DataIC50: 0.100nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2025
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK3(Human)
Pfizer

US Patent
LigandPNGBDBM316840(US9617258, Example 343 | US11111242, Example 343 |...)
Affinity DataIC50: 0.100nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2025
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK3(Human)
Pfizer

US Patent
LigandPNGBDBM316513(US9617258, Example 1 | US11111242, Example 1 | US2...)
Affinity DataIC50: 0.200nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2025
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK3(Human)
Pfizer

US Patent
LigandPNGBDBM316514(US9617258, Example 2 | US11111242, Example 2 | US2...)
Affinity DataIC50: 0.200nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2025
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK3(Human)
Pfizer

US Patent
LigandPNGBDBM736434(US20250134869, Example 18)
Affinity DataIC50: 0.200nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
9/2/2025
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK3(Human)
Pfizer

US Patent
LigandPNGBDBM316673(2-[(1-acryloylpiperidin-4-yl)amino]-N-(propan-2-yl...)
Affinity DataIC50: 0.200nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2025
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK3(Human)
Pfizer

US Patent
LigandPNGBDBM316714(1-{4-[(7-phenyl-5H-pyrrolo[2,3-b]pyrazin-2-yl)amin...)
Affinity DataIC50: 0.200nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2025
Entry Details
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TargetTyrosine-protein kinase JAK3(Human)
Pfizer

US Patent
LigandPNGBDBM316716(1-(4-{[7-(2-fluoropyridin-4-yl)-5H-pyrrolo[2,3-b]p...)
Affinity DataIC50: 0.200nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2025
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK3(Human)
Pfizer

US Patent
LigandPNGBDBM736640(2-[(1-acryloylpiperidin-4-yl)amino]-N- | US2025013...)
Affinity DataIC50: 0.200nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
9/2/2025
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK3(Human)
Pfizer

US Patent
LigandPNGBDBM316740(2-[(1-acryloylpiperidin-4-yl)amino]-N-[(1R,2R)-2-f...)
Affinity DataIC50: 0.200nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2025
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK3(Human)
Pfizer

US Patent
LigandPNGBDBM316741(2-[(1-acryloylpiperidin-4-yl)amino]-N-[(3,3-difluo...)
Affinity DataIC50: 0.200nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2025
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK3(Human)
Pfizer

US Patent
LigandPNGBDBM316744(2-[(1-acryloylpiperidin-4-yl)amino]-N-[(2R)-4,4,4-...)
Affinity DataIC50: 0.200nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2025
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK3(Human)
Pfizer

US Patent
LigandPNGBDBM316747(2-[(1-acryloylpiperidin-4-yl)amino]-N-[(1S,3R)-3-f...)
Affinity DataIC50: 0.200nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2025
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK3(Human)
Pfizer

US Patent
LigandPNGBDBM316748(2-[(1-acryloylpiperidin-4-yl)amino]-N-(3,3-difluor...)
Affinity DataIC50: 0.200nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2025
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK3(Human)
Pfizer

US Patent
LigandPNGBDBM316750(2-[(1-acryloylpiperidin-4-yl)amino]-N-[(1S,3S)-3-f...)
Affinity DataIC50: 0.200nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2025
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK3(Human)
Pfizer

US Patent
LigandPNGBDBM316754(2-[(1-acryloylpiperidin-4-yl)amino]-N-[(1R,2S)-2-f...)
Affinity DataIC50: 0.200nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2025
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK3(Human)
Pfizer

US Patent
LigandPNGBDBM316758(2-[(1-acryloylpiperidin-4-yl)amino]-N-(4,4,4-trifl...)
Affinity DataIC50: 0.200nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2025
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK3(Human)
Pfizer

US Patent
LigandPNGBDBM316761(2-[(1-acryloylpiperidin-4-yl)amino]-N-(2,2-difluor...)
Affinity DataIC50: 0.200nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2025
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK3(Human)
Pfizer

US Patent
LigandPNGBDBM316764(2-[(1-acryloylpiperidin-4-yl)amino]-N-(3,3-difluor...)
Affinity DataIC50: 0.200nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2025
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK3(Human)
Pfizer

US Patent
LigandPNGBDBM316765(2-[(1-acryloylpiperidin-4-yl)amino]-N-(8-cyanoocty...)
Affinity DataIC50: 0.200nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2025
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK3(Human)
Pfizer

US Patent
LigandPNGBDBM316766(2-[(1-acryloylpiperidin-4-yl)amino]-N-(2-cyanoethy...)
Affinity DataIC50: 0.200nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2025
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK3(Human)
Pfizer

US Patent
LigandPNGBDBM316767(2-[(1-acryloylpiperidin-4-yl)amino]-N-[(1S,3S)-3-(...)
Affinity DataIC50: 0.200nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2025
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK3(Human)
Pfizer

US Patent
LigandPNGBDBM316768(2-[(1-acryloylpiperidin-4-yl)amino]-N-[(2R)-1 -cya...)
Affinity DataIC50: 0.200nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2025
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK3(Human)
Pfizer

US Patent
LigandPNGBDBM316773(2-[(1-acryloylpiperidin-4-yl)amino]-N-butyl-5H-pyr...)
Affinity DataIC50: 0.200nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2025
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK3(Human)
Pfizer

US Patent
LigandPNGBDBM316776(2-[(1-acryloylpiperidin-4-yl)amino]-N-(2-methylpro...)
Affinity DataIC50: 0.200nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2025
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK3(Human)
Pfizer

US Patent
LigandPNGBDBM316778(2-[(1-acryloylpiperidin-4-yl)amino]-N-[(2R)-pentan...)
Affinity DataIC50: 0.200nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2025
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK3(Human)
Pfizer

US Patent
LigandPNGBDBM316782(2-[(1-acryloylpiperidin-4-yl)amino]-N-cyclohexyl-5...)
Affinity DataIC50: 0.200nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2025
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK3(Human)
Pfizer

US Patent
LigandPNGBDBM316784(2-[(1-acryloylpiperidin-4-yl)amino]-N-cyclobutyl-5...)
Affinity DataIC50: 0.200nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2025
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK3(Human)
Pfizer

US Patent
LigandPNGBDBM316786(2-[(1-acryloylpiperidin-4-yl)amino]-N-(2,2-difluor...)
Affinity DataIC50: 0.200nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2025
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK3(Human)
Pfizer

US Patent
LigandPNGBDBM316792(2-[(1-acryloylpiperidin-4-yl)amino]-N-(1-cycloprop...)
Affinity DataIC50: 0.200nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2025
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK3(Human)
Pfizer

US Patent
LigandPNGBDBM316794(2-{[(3R,4R)-1-acryloyl-3-fluoropiperidin-4-yl]amin...)
Affinity DataIC50: 0.200nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2025
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK3(Human)
Pfizer

US Patent
LigandPNGBDBM316836(US9617258, Example 339 | US11111242, Example 339 |...)
Affinity DataIC50: 0.200nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2025
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK3(Human)
Pfizer

US Patent
LigandPNGBDBM209866(PF-06651600 | US9617258, Example 5 | US11111242, E...)
Affinity DataIC50: 0.300nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2025
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK3(Human)
Pfizer

US Patent
LigandPNGBDBM316518(US9617258, Example 6 | US11111242, Example 6 | US2...)
Affinity DataIC50: 0.300nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2025
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK3(Human)
Pfizer

US Patent
LigandPNGBDBM316666(US9617258, Example 161 | US20250134869, Example 16...)
Affinity DataIC50: 0.300nMMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
9/2/2025
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK3(Human)
Pfizer

US Patent
LigandPNGBDBM316556(1-{(3R)-3-[(5-ethyl-7H-pyrrolo[2,3-d]pyrimidin-4-y...)
Affinity DataIC50: 0.300nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2025
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK3(Human)
Pfizer

US Patent
LigandPNGBDBM316646(US9617258, Example 137 | US11111242, Example 137 |...)
Affinity DataIC50: 0.300nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2025
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK3(Human)
Pfizer

US Patent
LigandPNGBDBM316666(US9617258, Example 161 | US20250134869, Example 16...)
Affinity DataIC50: 0.300nMMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
9/2/2025
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK3(Human)
Pfizer

US Patent
LigandPNGBDBM316693(2-[(1-acryloylazetidin-3-yl)amino]-N-(propan-2-yl)...)
Affinity DataIC50: 0.300nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2025
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK3(Human)
Pfizer

US Patent
LigandPNGBDBM316701(2-{[(3R,4R)-1-acryloyl-3-hydroxypiperidin-4-yl]ami...)
Affinity DataIC50: 0.300nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2025
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK3(Human)
Pfizer

US Patent
LigandPNGBDBM316712(1-(4-{[7-(6-fluoropyridin-3-yl)-5H-pyrrolo[2,3-b]p...)
Affinity DataIC50: 0.300nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2025
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK3(Human)
Pfizer

US Patent
LigandPNGBDBM316717(1-(4-{[7-(5-fluoropyridin-3-yl)-5H-pyrrolo[2,3-b]p...)
Affinity DataIC50: 0.300nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2025
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK3(Human)
Pfizer

US Patent
LigandPNGBDBM316735(2-[(1-acryloylpiperidin-4-yl)amino]-N-[(1-hydroxyc...)
Affinity DataIC50: 0.300nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2025
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK3(Human)
Pfizer

US Patent
LigandPNGBDBM316737(2-[(1-acryloylpiperidin-4-yl)amino]-N-(2,2-difluor...)
Affinity DataIC50: 0.300nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2025
Entry Details
Go to US Patent

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