Compile Data Set for Download or QSAR
Report error Found 332 Enz. Inhib. hit(s) with all data for entry = 12833
TargetEstrogen receptor(Human)
Genentech

US Patent
LigandPNGBDBM50542086(CHEMBL4649161 | US20250114338, Example 101)
Affinity DataEC50:  0.0490nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2025
Entry Details
Go to US Patent

TargetEstrogen receptor(Human)
Genentech

US Patent
LigandPNGBDBM50503111(CHEMBL4528514 | US11672785, Goodacre Compound 102 ...)
Affinity DataEC50:  0.0140nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2025
Entry Details
Go to US Patent
PDB3D3D Structure (crystal)
TargetEstrogen receptor(Human)
Genentech

US Patent
LigandPNGBDBM731608(1-((1R,3R)-1-(2,6- difluoro-4-(2-(3- (fluoromethyl...)
Affinity DataEC50:  0.110nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/22/2025
Entry Details
Go to US Patent

TargetEstrogen receptor(Human)
Genentech

US Patent
LigandPNGBDBM731609(1-((1R,3R)-1-(2,6- difluoro-4-(2-(3- (fluoromethyl...)
Affinity DataEC50:  0.0430nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/22/2025
Entry Details
Go to US Patent

TargetEstrogen receptor(Human)
Genentech

US Patent
LigandPNGBDBM50542084(CHEMBL4648503 | US20250114338, Example 128)
Affinity DataEC50:  0.0270nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2025
Entry Details
Go to US Patent

TargetEstrogen receptor(Human)
Genentech

US Patent
LigandPNGBDBM50542090(CHEMBL4641732 | US20250114338, Example 129)
Affinity DataEC50:  0.142nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2025
Entry Details
Go to US Patent

TargetEstrogen receptor(Human)
Genentech

US Patent
LigandPNGBDBM50542087(CHEMBL4635493 | US11672785, Goodacre Compound 107 ...)
Affinity DataEC50:  0.0240nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2025
Entry Details
Go to US Patent

TargetEstrogen receptor(Human)
Genentech

US Patent
LigandPNGBDBM50542082(CHEMBL4645364 | US20250114338, Example 108)
Affinity DataEC50:  0.110nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2025
Entry Details
Go to US Patent

TargetEstrogen receptor(Human)
Genentech

US Patent
LigandPNGBDBM50542081(CHEMBL4644486 | US20250114338, Example 109)
Affinity DataEC50:  0.0500nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2025
Entry Details
Go to US Patent

TargetEstrogen receptor(Human)
Genentech

US Patent
LigandPNGBDBM50572812(CHEMBL4852984 | US20250114338, Example 111)
Affinity DataEC50:  0.898nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2025
Entry Details
Go to US Patent

TargetEstrogen receptor(Human)
Genentech

US Patent
LigandPNGBDBM50572811(CHEMBL4869612 | US20250114338, Example 112)
Affinity DataEC50:  0.0920nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2025
Entry Details
Go to US Patent

TargetEstrogen receptor(Human)
Genentech

US Patent
LigandPNGBDBM731660((1R,3R)-2- (cyclobutylmethyl)-1- (2,6-difluoro-4-(...)
Affinity DataEC50:  6.18nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/22/2025
Entry Details
Go to US Patent

TargetEstrogen receptor(Human)
Genentech

US Patent
LigandPNGBDBM50572814(CHEMBL4867106 | US20250114338, Example 114)
Affinity DataEC50:  0.715nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2025
Entry Details
Go to US Patent

TargetEstrogen receptor(Human)
Genentech

US Patent
LigandPNGBDBM731662((1R,3R)-1-(2,6-difluoro- 4-(2-(3- (fluoromethyl)az...)
Affinity DataEC50:  23.1nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/22/2025
Entry Details
Go to US Patent

TargetEstrogen receptor(Human)
Genentech

US Patent
LigandPNGBDBM731663((1R,3R)-1-(2,6-difluoro- 4-(2-(3- (fluoromethyl)az...)
Affinity DataEC50:  41.4nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/22/2025
Entry Details
Go to US Patent

TargetEstrogen receptor(Human)
Genentech

US Patent
LigandPNGBDBM650922(US20240043442, Example 6 | US20250114338, Example ...)
Affinity DataEC50:  0.171nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2025
Entry Details
Go to US Patent

TargetEstrogen receptor(Human)
Genentech

US Patent
LigandPNGBDBM650923(US20240043442, Example 7 | US20250114338, Example ...)
Affinity DataEC50:  0.488nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2025
Entry Details
Go to US Patent

TargetEstrogen receptor(Human)
Genentech

US Patent
LigandPNGBDBM731666((1-(2-(3,5-difluoro-4- ((1R,3R)-2-(2-fluoro-2- met...)
Affinity DataEC50:  1.98nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/22/2025
Entry Details
Go to US Patent

TargetEstrogen receptor(Human)
Genentech

US Patent
LigandPNGBDBM731667((1R,3R)-2-(2-fluoro-2- methylpropyl)-1-(2- fluoro-...)
Affinity DataEC50:  0.0560nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/22/2025
Entry Details
Go to US Patent

TargetEstrogen receptor(Human)
Genentech

US Patent
LigandPNGBDBM731668(1-((1R,3R)-1-(2,6- difluoro-4-(2-(3- (fluoromethyl...)
Affinity DataEC50:  8nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/22/2025
Entry Details
Go to US Patent

TargetEstrogen receptor(Human)
Genentech

US Patent
LigandPNGBDBM731669(1-((1R,3R)-1-(2,6- difluoro-4-(2-(3- (fluoromethyl...)
Affinity DataEC50:  1.40nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/22/2025
Entry Details
Go to US Patent

TargetEstrogen receptor(Human)
Genentech

US Patent
LigandPNGBDBM731670((R)-3-((1R,3R)-1-(2,6- difluoro-4-(2-(3- (fluorome...)
Affinity DataEC50:  1.04nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/22/2025
Entry Details
Go to US Patent

TargetEstrogen receptor(Human)
Genentech

US Patent
LigandPNGBDBM731671(((1R,3R)-1-(2,6-difluoro- 4-(2-(3- (fluoromethyl)a...)
Affinity DataEC50:  135nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/22/2025
Entry Details
Go to US Patent

TargetEstrogen receptor(Human)
Genentech

US Patent
LigandPNGBDBM731672(1-(1-(2,6-difluoro-4-(2- (3-(fluoromethyl)azetidin...)
Affinity DataEC50:  74.4nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/22/2025
Entry Details
Go to US Patent

TargetEstrogen receptor(Human)
Genentech

US Patent
LigandPNGBDBM50567217(CHEMBL4851830 | US20250114338, Example 126)
Affinity DataEC50:  0.469nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2025
Entry Details
Go to US Patent

TargetEstrogen receptor(Human)
Genentech

US Patent
LigandPNGBDBM731674(1-[(1R,3R)-1-[2,6-difluoro-4- [2-[3-(fluoromethyl)...)
Affinity DataEC50:  0.641nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/22/2025
Entry Details
Go to US Patent

TargetEstrogen receptor(Human)
Genentech

US Patent
LigandPNGBDBM50542084(CHEMBL4648503 | US20250114338, Example 128)
Affinity DataEC50:  0.0640nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2025
Entry Details
Go to US Patent

TargetEstrogen receptor(Human)
Genentech

US Patent
LigandPNGBDBM50542090(CHEMBL4641732 | US20250114338, Example 129)
Affinity DataEC50:  0.170nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2025
Entry Details
Go to US Patent

TargetEstrogen receptor(Human)
Genentech

US Patent
LigandPNGBDBM50542087(CHEMBL4635493 | US11672785, Goodacre Compound 107 ...)
Affinity DataEC50:  0.0500nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2025
Entry Details
Go to US Patent

TargetEstrogen receptor(Human)
Genentech

US Patent
LigandPNGBDBM731678(((1S,3R)-1-(2,6-difluoro-4-(2- (3-(fluoromethyl)az...)
Affinity DataEC50:  0.146nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/22/2025
Entry Details
Go to US Patent

TargetEstrogen receptor(Human)
Genentech

US Patent
LigandPNGBDBM731679((1R,3R)-1-[4-(azetidin-3- yloxy)-2,6-difluoro-phen...)
Affinity DataEC50:  0.310nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/22/2025
Entry Details
Go to US Patent

TargetEstrogen receptor(Human)
Genentech

US Patent
LigandPNGBDBM731681((1R,3R)-2-(2-fluoro-2- methylpropyl)-1-(2-fluoro-4...)
Affinity DataEC50:  0.0560nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/22/2025
Entry Details
Go to US Patent

TargetEstrogen receptor(Human)
Genentech

US Patent
LigandPNGBDBM731682((1R,3R)-2-cyclobutyl-1-[2,6- difluoro-4-[2-[3- (fl...)
Affinity DataEC50:  0.542nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/22/2025
Entry Details
Go to US Patent

TargetEstrogen receptor(Human)
Genentech

US Patent
LigandPNGBDBM731683((1R,3S)-1-[2,6-difluoro-4-[2- [3-(fluoromethyl)aze...)
Affinity DataEC50:  0.0970nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/22/2025
Entry Details
Go to US Patent

TargetEstrogen receptor(Human)
Genentech

US Patent
LigandPNGBDBM50572813(CHEMBL4862431 | US20250114338, Example 136)
Affinity DataEC50:  0.114nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2025
Entry Details
Go to US Patent

TargetEstrogen receptor(Human)
Genentech

US Patent
LigandPNGBDBM731685(cyclohexyl((1R,3R)-1-(2,6- difluoro-4-(2-(3- (fluo...)
Affinity DataEC50:  28nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/22/2025
Entry Details
Go to US Patent

TargetEstrogen receptor(Human)
Genentech

US Patent
LigandPNGBDBM731686(1-[(1R,3R)-1-[2,6-difluoro-4- [2-[3-(fluoromethyl)...)
Affinity DataEC50:  0.491nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/22/2025
Entry Details
Go to US Patent

TargetEstrogen receptor(Human)
Genentech

US Patent
LigandPNGBDBM731687(cyclopropyl((1R,3R)-1-(2,6- difluoro-4-(2-(3- (flu...)
Affinity DataEC50:  2.48nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/22/2025
Entry Details
Go to US Patent

TargetEstrogen receptor(Human)
Genentech

US Patent
LigandPNGBDBM50542083(CHEMBL4633886 | US20250114338, Example 140)
Affinity DataEC50:  0.130nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2025
Entry Details
Go to US Patent

TargetEstrogen receptor(Human)
Genentech

US Patent
LigandPNGBDBM731689((1R,3R)-1-(2,6-difluoro-4-(2- ((R)-3-methylpyrroli...)
Affinity DataEC50:  0.151nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/22/2025
Entry Details
Go to US Patent

TargetEstrogen receptor(Human)
Genentech

US Patent
LigandPNGBDBM731690((1R,3R)-1-[2,6-difluoro-4- [(2S)-2-pyrrolidin-1- y...)
Affinity DataEC50:  0.0900nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/22/2025
Entry Details
Go to US Patent

TargetEstrogen receptor(Human)
Genentech

US Patent
LigandPNGBDBM731693((1R,3R)-1-[2,6-difluoro-4-[3- [3-(fluoromethyl)aze...)
Affinity DataEC50:  0.0780nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/22/2025
Entry Details
Go to US Patent

TargetEstrogen receptor(Human)
Genentech

US Patent
LigandPNGBDBM731698((1R,3R)-1-[2,6-difluoro-4- [(E)-3-[3- (fluoromethy...)
Affinity DataEC50:  0.144nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/22/2025
Entry Details
Go to US Patent

TargetEstrogen receptor(Human)
Genentech

US Patent
LigandPNGBDBM731699(N-(3,5-difluoro-4-((1R,3R)-2- (2-fluoro-2-methylpr...)
Affinity DataEC50:  0.0960nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/22/2025
Entry Details
Go to US Patent

TargetEstrogen receptor(Human)
Genentech

US Patent
LigandPNGBDBM731701((1R,3R)-2-[(3,3- difluorocyclobutyl)methyl]-1- [2,...)
Affinity DataEC50:  10nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/22/2025
Entry Details
Go to US Patent

TargetEstrogen receptor(Human)
Genentech

US Patent
LigandPNGBDBM731702((1R,3R)-1-[2,6-difluoro-4-[2- [3-(fluoromethyl)aze...)
Affinity DataEC50:  0.698nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/22/2025
Entry Details
Go to US Patent

TargetEstrogen receptor(Human)
Genentech

US Patent
LigandPNGBDBM731705(cyclobutyl-[(1R,3R)-1-[2,6- difluoro-4-[2-[3- (flu...)
Affinity DataEC50:  1.47nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/22/2025
Entry Details
Go to US Patent

TargetEstrogen receptor(Human)
Genentech

US Patent
LigandPNGBDBM731716(cyclopentyl-[(1R,3R)-1-[2,6- difluoro-4-[2-[3- (fl...)
Affinity DataEC50:  2.16nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/22/2025
Entry Details
Go to US Patent

TargetEstrogen receptor(Human)
Genentech

US Patent
LigandPNGBDBM731717((1R,3R)-1-[2,6-difluoro-4-[2- [(3S)-3-methylpyrrol...)
Affinity DataEC50:  0.483nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/22/2025
Entry Details
Go to US Patent

TargetEstrogen receptor(Human)
Genentech

US Patent
LigandPNGBDBM731720((1R,3R)-1-[2,6-difluoro-4- [(2R)-2-pyrrolidin-1- y...)
Affinity DataEC50:  0.156nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/22/2025
Entry Details
Go to US Patent

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