Compile Data Set for Download or QSAR
Report error Found 36 Enz. Inhib. hit(s) with all data for entry = 12739
TargetDNA polymerase theta [1792-2590](Homo sapiens (Human))
Shanghai Apeiron Therapeutics Company

US Patent
LigandPNGBDBM724554((S)-N-(3-chloro-2,4-difluorophenyl)-3-(7,7-difluor...)
Affinity DataIC50: 50nMAssay Description:The ability of compounds to inhibit Pol 0 polymerase activity was determined by the PicoGreen method in vitro.The His-TEV-SUMO-tagged Polθ protein (a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/30/2025
Entry Details
Go to US Patent

TargetDNA polymerase theta [1792-2590](Homo sapiens (Human))
Shanghai Apeiron Therapeutics Company

US Patent
LigandPNGBDBM724565((S)—N-(3-chloro-2,4-difluorophenyl)-N-methyl-2-oxo...)
Affinity DataIC50: 50nMAssay Description:The ability of compounds to inhibit Pol 0 polymerase activity was determined by the PicoGreen method in vitro.The His-TEV-SUMO-tagged Polθ protein (a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/30/2025
Entry Details
Go to US Patent

TargetDNA polymerase theta [1792-2590](Homo sapiens (Human))
Shanghai Apeiron Therapeutics Company

US Patent
LigandPNGBDBM724564((S)—N-(3-chloro-2,4-difluorophenyl)-N-methyl-2-oxo...)
Affinity DataIC50: 50nMAssay Description:The ability of compounds to inhibit Pol 0 polymerase activity was determined by the PicoGreen method in vitro.The His-TEV-SUMO-tagged Polθ protein (a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/30/2025
Entry Details
Go to US Patent

TargetDNA polymerase theta [1792-2590](Homo sapiens (Human))
Shanghai Apeiron Therapeutics Company

US Patent
LigandPNGBDBM724563((S)—N-(3-chloro-2,4-difluorophenyl)-N-methyl-2-oxo...)
Affinity DataIC50: 50nMAssay Description:The ability of compounds to inhibit Pol 0 polymerase activity was determined by the PicoGreen method in vitro.The His-TEV-SUMO-tagged Polθ protein (a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/30/2025
Entry Details
Go to US Patent

TargetDNA polymerase theta [1792-2590](Homo sapiens (Human))
Shanghai Apeiron Therapeutics Company

US Patent
LigandPNGBDBM724566((S)—N-(3-chloro-2,4-difluorophenyl)-N-methyl-2-oxo...)
Affinity DataIC50: 50nMAssay Description:The ability of compounds to inhibit Pol 0 polymerase activity was determined by the PicoGreen method in vitro.The His-TEV-SUMO-tagged Polθ protein (a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/30/2025
Entry Details
Go to US Patent

TargetDNA polymerase theta [1792-2590](Homo sapiens (Human))
Shanghai Apeiron Therapeutics Company

US Patent
LigandPNGBDBM724561((2S,3S,4S)—N-(5-chloro-2,4-difluorophenyl)-3,4-dih...)
Affinity DataIC50: 50nMAssay Description:The ability of compounds to inhibit Pol 0 polymerase activity was determined by the PicoGreen method in vitro.The His-TEV-SUMO-tagged Polθ protein (a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/30/2025
Entry Details
Go to US Patent

TargetDNA polymerase theta [1792-2590](Homo sapiens (Human))
Shanghai Apeiron Therapeutics Company

US Patent
LigandPNGBDBM724542(Synthesis of (S)—N-(3-chloro-2,4-difluorophenyl)-N...)
Affinity DataIC50: 50nMAssay Description:The ability of compounds to inhibit Pol 0 polymerase activity was determined by the PicoGreen method in vitro.The His-TEV-SUMO-tagged Polθ protein (a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/30/2025
Entry Details
Go to US Patent

TargetDNA polymerase theta [1792-2590](Homo sapiens (Human))
Shanghai Apeiron Therapeutics Company

US Patent
LigandPNGBDBM724567((2S,3S,4S)—N-(5-chloro-2,4-difluorophenyl)-3,4-dih...)
Affinity DataIC50: 50nMAssay Description:The ability of compounds to inhibit Pol 0 polymerase activity was determined by the PicoGreen method in vitro.The His-TEV-SUMO-tagged Polθ protein (a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/30/2025
Entry Details
Go to US Patent

TargetDNA polymerase theta [1792-2590](Homo sapiens (Human))
Shanghai Apeiron Therapeutics Company

US Patent
LigandPNGBDBM724558((2S,3S,4S)—N-(5-chloro-2,4-difluorophenyl)-3,4-dih...)
Affinity DataIC50: 50nMAssay Description:The ability of compounds to inhibit Pol 0 polymerase activity was determined by the PicoGreen method in vitro.The His-TEV-SUMO-tagged Polθ protein (a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/30/2025
Entry Details
Go to US Patent

TargetDNA polymerase theta [1792-2590](Homo sapiens (Human))
Shanghai Apeiron Therapeutics Company

US Patent
LigandPNGBDBM724568((S)—N-(3-chloro-2,4-difluorophenyl)-N-methyl-2-oxo...)
Affinity DataIC50: 50nMAssay Description:The ability of compounds to inhibit Pol 0 polymerase activity was determined by the PicoGreen method in vitro.The His-TEV-SUMO-tagged Polθ protein (a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/30/2025
Entry Details
Go to US Patent

TargetDNA polymerase theta [1792-2590](Homo sapiens (Human))
Shanghai Apeiron Therapeutics Company

US Patent
LigandPNGBDBM724556((S)—N-(3-chloro-2,4-difluorophenyl)-N-methyl-2-oxo...)
Affinity DataIC50: 50nMAssay Description:The ability of compounds to inhibit Pol 0 polymerase activity was determined by the PicoGreen method in vitro.The His-TEV-SUMO-tagged Polθ protein (a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/30/2025
Entry Details
Go to US Patent

TargetDNA polymerase theta [1792-2590](Homo sapiens (Human))
Shanghai Apeiron Therapeutics Company

US Patent
LigandPNGBDBM724555((S)—N-(3-chloro-2,4-difluorophenyl)-N-methyl-2-oxo...)
Affinity DataIC50: 50nMAssay Description:The ability of compounds to inhibit Pol 0 polymerase activity was determined by the PicoGreen method in vitro.The His-TEV-SUMO-tagged Polθ protein (a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/30/2025
Entry Details
Go to US Patent

TargetDNA polymerase theta [1792-2590](Homo sapiens (Human))
Shanghai Apeiron Therapeutics Company

US Patent
LigandPNGBDBM724569((R)-4-(1-(3-chloro-4-fluorophenyl)-4-fluoro-1H-imi...)
Affinity DataIC50: 50nMAssay Description:The ability of compounds to inhibit Pol 0 polymerase activity was determined by the PicoGreen method in vitro.The His-TEV-SUMO-tagged Polθ protein (a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/30/2025
Entry Details
Go to US Patent

TargetDNA polymerase theta [1792-2590](Homo sapiens (Human))
Shanghai Apeiron Therapeutics Company

US Patent
LigandPNGBDBM724570([(4S)-3-(7-cyclopropyl (1,3-thiazolo[4,5-e]pyridin...)
Affinity DataIC50: 50nMAssay Description:The ability of compounds to inhibit Pol 0 polymerase activity was determined by the PicoGreen method in vitro.The His-TEV-SUMO-tagged Polθ protein (a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/30/2025
Entry Details
Go to US Patent

TargetDNA polymerase theta [1792-2590](Homo sapiens (Human))
Shanghai Apeiron Therapeutics Company

US Patent
LigandPNGBDBM724551(US20250066368, Compound 9b)
Affinity DataIC50: 50nMAssay Description:The ability of compounds to inhibit Pol 0 polymerase activity was determined by the PicoGreen method in vitro.The His-TEV-SUMO-tagged Polθ protein (a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/30/2025
Entry Details
Go to US Patent

TargetDNA polymerase theta [1792-2590](Homo sapiens (Human))
Shanghai Apeiron Therapeutics Company

US Patent
LigandPNGBDBM724550(US20250066368, Compound 9a)
Affinity DataIC50: 50nMAssay Description:The ability of compounds to inhibit Pol 0 polymerase activity was determined by the PicoGreen method in vitro.The His-TEV-SUMO-tagged Polθ protein (a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/30/2025
Entry Details
Go to US Patent

TargetDNA polymerase theta [1792-2590](Homo sapiens (Human))
Shanghai Apeiron Therapeutics Company

US Patent
LigandPNGBDBM724571((S)—N-(3-chloro-2,4-difluorophenyl)-N-methyl-2-oxo...)
Affinity DataIC50: 50nMAssay Description:The ability of compounds to inhibit Pol 0 polymerase activity was determined by the PicoGreen method in vitro.The His-TEV-SUMO-tagged Polθ protein (a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/30/2025
Entry Details
Go to US Patent

TargetDNA polymerase theta [1792-2590](Homo sapiens (Human))
Shanghai Apeiron Therapeutics Company

US Patent
LigandPNGBDBM724548(Synthesis of (2S,3S,4S)—N-(5-chloro-2,4-difluoroph...)
Affinity DataIC50: 50nMAssay Description:The ability of compounds to inhibit Pol 0 polymerase activity was determined by the PicoGreen method in vitro.The His-TEV-SUMO-tagged Polθ protein (a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/30/2025
Entry Details
Go to US Patent

TargetDNA polymerase theta [1792-2590](Homo sapiens (Human))
Shanghai Apeiron Therapeutics Company

US Patent
LigandPNGBDBM724572({(2S,3S,4S)-1-[7,7-difluoro-4-(trifluoromethyl)(5,...)
Affinity DataIC50: 50nMAssay Description:The ability of compounds to inhibit Pol 0 polymerase activity was determined by the PicoGreen method in vitro.The His-TEV-SUMO-tagged Polθ protein (a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/30/2025
Entry Details
Go to US Patent

TargetDNA polymerase theta [1792-2590](Homo sapiens (Human))
Shanghai Apeiron Therapeutics Company

US Patent
LigandPNGBDBM724576((2S,3S,4S)—N-(5-chloro-2,4-difluorophenyl)-3,4-dih...)
Affinity DataIC50: 50nMAssay Description:The ability of compounds to inhibit Pol 0 polymerase activity was determined by the PicoGreen method in vitro.The His-TEV-SUMO-tagged Polθ protein (a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/30/2025
Entry Details
Go to US Patent

TargetDNA polymerase theta [1792-2590](Homo sapiens (Human))
Shanghai Apeiron Therapeutics Company

US Patent
LigandPNGBDBM724577((2S,3S,4S)—N-(5-chloro-2,4-difluorophenyl)-3,4-dih...)
Affinity DataIC50: 50nMAssay Description:The ability of compounds to inhibit Pol 0 polymerase activity was determined by the PicoGreen method in vitro.The His-TEV-SUMO-tagged Polθ protein (a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/30/2025
Entry Details
Go to US Patent

TargetDNA polymerase theta [1792-2590](Homo sapiens (Human))
Shanghai Apeiron Therapeutics Company

US Patent
LigandPNGBDBM724560((S)—N-(3-chloro-2,4-difluorophenyl)-N-methyl-3-(1-...)
Affinity DataIC50: 275nMAssay Description:The ability of compounds to inhibit Pol 0 polymerase activity was determined by the PicoGreen method in vitro.The His-TEV-SUMO-tagged Polθ protein (a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/30/2025
Entry Details
Go to US Patent

TargetDNA polymerase theta [1792-2590](Homo sapiens (Human))
Shanghai Apeiron Therapeutics Company

US Patent
LigandPNGBDBM724574((S)—N-(3-chloro-2,4-difluorophenyl)-N-methyl-3-(7-...)
Affinity DataIC50: 275nMAssay Description:The ability of compounds to inhibit Pol 0 polymerase activity was determined by the PicoGreen method in vitro.The His-TEV-SUMO-tagged Polθ protein (a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/30/2025
Entry Details
Go to US Patent

TargetDNA polymerase theta [1792-2590](Homo sapiens (Human))
Shanghai Apeiron Therapeutics Company

US Patent
LigandPNGBDBM724575((S)—N-(3-chloro-2,4-difluorophenyl)-N-methyl-2-oxo...)
Affinity DataIC50: 275nMAssay Description:The ability of compounds to inhibit Pol 0 polymerase activity was determined by the PicoGreen method in vitro.The His-TEV-SUMO-tagged Polθ protein (a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/30/2025
Entry Details
Go to US Patent

TargetDNA polymerase theta [1792-2590](Homo sapiens (Human))
Shanghai Apeiron Therapeutics Company

US Patent
LigandPNGBDBM724562((S)—N-(3-chloro-2,4-difluorophenyl)-N-methyl-2-oxo...)
Affinity DataIC50: 275nMAssay Description:The ability of compounds to inhibit Pol 0 polymerase activity was determined by the PicoGreen method in vitro.The His-TEV-SUMO-tagged Polθ protein (a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/30/2025
Entry Details
Go to US Patent

TargetDNA polymerase theta [1792-2590](Homo sapiens (Human))
Shanghai Apeiron Therapeutics Company

US Patent
LigandPNGBDBM724559((S)—N-(3-chloro-2,4-difluorophenyl)-N-methyl-2-oxo...)
Affinity DataIC50: 275nMAssay Description:The ability of compounds to inhibit Pol 0 polymerase activity was determined by the PicoGreen method in vitro.The His-TEV-SUMO-tagged Polθ protein (a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/30/2025
Entry Details
Go to US Patent

TargetDNA polymerase theta [1792-2590](Homo sapiens (Human))
Shanghai Apeiron Therapeutics Company

US Patent
LigandPNGBDBM724557((S)—N-(3-chloro-2,4-difluorophenyl)-N-methyl-2-oxo...)
Affinity DataIC50: 275nMAssay Description:The ability of compounds to inhibit Pol 0 polymerase activity was determined by the PicoGreen method in vitro.The His-TEV-SUMO-tagged Polθ protein (a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/30/2025
Entry Details
Go to US Patent

TargetDNA polymerase theta [1792-2590](Homo sapiens (Human))
Shanghai Apeiron Therapeutics Company

US Patent
LigandPNGBDBM724553((S)—N-(3-chloro-2,4-difluorophenyl)-3-(5,5-difluor...)
Affinity DataIC50: 275nMAssay Description:The ability of compounds to inhibit Pol 0 polymerase activity was determined by the PicoGreen method in vitro.The His-TEV-SUMO-tagged Polθ protein (a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/30/2025
Entry Details
Go to US Patent

TargetDNA polymerase theta [1792-2590](Homo sapiens (Human))
Shanghai Apeiron Therapeutics Company

US Patent
LigandPNGBDBM724545(Synthesis of (S)—N-(3-chloro-2,4-difluorophenyl)-N...)
Affinity DataIC50: 275nMAssay Description:The ability of compounds to inhibit Pol 0 polymerase activity was determined by the PicoGreen method in vitro.The His-TEV-SUMO-tagged Polθ protein (a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/30/2025
Entry Details
Go to US Patent

TargetDNA polymerase theta [1792-2590](Homo sapiens (Human))
Shanghai Apeiron Therapeutics Company

US Patent
LigandPNGBDBM724549(US20250066368, Compound 8a)
Affinity DataIC50: 3.00E+3nMAssay Description:The ability of compounds to inhibit Pol 0 polymerase activity was determined by the PicoGreen method in vitro.The His-TEV-SUMO-tagged Polθ protein (a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/30/2025
Entry Details
Go to US Patent

TargetDNA polymerase theta [1792-2590](Homo sapiens (Human))
Shanghai Apeiron Therapeutics Company

US Patent
LigandPNGBDBM724547(US20250066368, Compound 6a)
Affinity DataIC50: 3.00E+3nMAssay Description:The ability of compounds to inhibit Pol 0 polymerase activity was determined by the PicoGreen method in vitro.The His-TEV-SUMO-tagged Polθ protein (a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/30/2025
Entry Details
Go to US Patent

TargetDNA polymerase theta [1792-2590](Homo sapiens (Human))
Shanghai Apeiron Therapeutics Company

US Patent
LigandPNGBDBM724546((S)-N-(3-chloro-2,4-difluorophenyl)-N-methyl-2-oxo...)
Affinity DataIC50: 3.00E+3nMAssay Description:The ability of compounds to inhibit Pol 0 polymerase activity was determined by the PicoGreen method in vitro.The His-TEV-SUMO-tagged Polθ protein (a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/30/2025
Entry Details
Go to US Patent

TargetDNA polymerase theta [1792-2590](Homo sapiens (Human))
Shanghai Apeiron Therapeutics Company

US Patent
LigandPNGBDBM724543(Synthesis of (S)—N-(3-chloro-2,4-difluorophenyl)-3...)
Affinity DataIC50: 3.00E+3nMAssay Description:The ability of compounds to inhibit Pol 0 polymerase activity was determined by the PicoGreen method in vitro.The His-TEV-SUMO-tagged Polθ protein (a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/30/2025
Entry Details
Go to US Patent

TargetDNA polymerase theta [1792-2590](Homo sapiens (Human))
Shanghai Apeiron Therapeutics Company

US Patent
LigandPNGBDBM724552(Synthesis of (S)—N-(3-chloro-2,4-difluorophenyl)-N...)
Affinity DataIC50: 5.00E+3nMAssay Description:The ability of compounds to inhibit Pol 0 polymerase activity was determined by the PicoGreen method in vitro.The His-TEV-SUMO-tagged Polθ protein (a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/30/2025
Entry Details
Go to US Patent

TargetDNA polymerase theta [1792-2590](Homo sapiens (Human))
Shanghai Apeiron Therapeutics Company

US Patent
LigandPNGBDBM724573((S)—N-(3-chloro-2,4-difluorophenyl)-3-(imidazo[1,2...)
Affinity DataIC50: 5.00E+3nMAssay Description:The ability of compounds to inhibit Pol 0 polymerase activity was determined by the PicoGreen method in vitro.The His-TEV-SUMO-tagged Polθ protein (a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/30/2025
Entry Details
Go to US Patent

TargetDNA polymerase theta [1792-2590](Homo sapiens (Human))
Shanghai Apeiron Therapeutics Company

US Patent
LigandPNGBDBM724544(Synthesis of (S)—N-(3-chloro-2,4-difluorophenyl)-N...)
Affinity DataIC50: 5.00E+3nMAssay Description:The ability of compounds to inhibit Pol 0 polymerase activity was determined by the PicoGreen method in vitro.The His-TEV-SUMO-tagged Polθ protein (a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/30/2025
Entry Details
Go to US Patent