Compile Data Set for Download or QSAR
Report error Found 314 Enz. Inhib. hit(s) with all data for entry = 12531
TargetPeptidyl-prolyl cis-trans isomerase A(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM707923(US20240417410, Example A122)
Affinity DataKd:  30nMAssay Description:All SPR experiments were conducted on a Biacore 8K+ instrument (Cytiva). Recombinant biotinylated CYPA protein with a C-terminal AVI tag was purified...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/1/2025
Entry Details
Go to US Patent

TargetPeptidyl-prolyl cis-trans isomerase A(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM707838((1r,2R,3S)-N-[(7S,13S)-(20M)-20-[2-[(1S)-1-methoxy...)
Affinity DataKd:  13nMAssay Description:All SPR experiments were conducted on a Biacore 8K+ instrument (Cytiva). Recombinant biotinylated CYPA protein with a C-terminal AVI tag was purified...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/1/2025
Entry Details
Go to US Patent

LigandPNGBDBM707830((1S,5R,6r)-N-[(7S,13S)-(20M)-20-[2-[(1S)-1-methoxy...)
Affinity DataIC50: 1.5nMAssay Description:In this example, TR-FRET was also used to measure the compound or compound-CYPA dependent disruption of the KRAS G12C-BRAF complex. This protocol was...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/1/2025
Entry Details
Go to US Patent

LigandPNGBDBM707908((1r,2R,3S)-N-[(7S,13S)-(20M)-20-[5-(4-ethylpiperaz...)
Affinity DataIC50: 4.30nMAssay Description:In this example, TR-FRET was also used to measure the compound or compound-CYPA dependent disruption of the KRAS G12C-BRAF complex. This protocol was...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/1/2025
Entry Details
Go to US Patent

LigandPNGBDBM707852((1S,5R)-3,3-difluoro-N-[(7S,13S)-(20M)-20-[2-[(1S)...)
Affinity DataIC50: 4.40nMAssay Description:In this example, TR-FRET was also used to measure the compound or compound-CYPA dependent disruption of the KRAS G12C-BRAF complex. This protocol was...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/1/2025
Entry Details
Go to US Patent

LigandPNGBDBM707903((1r,2R,3S)-N-[(7S,13S)-(20M)-20-[2-[(1S)-1-methoxy...)
Affinity DataIC50: 4.60nMAssay Description:In this example, TR-FRET was also used to measure the compound or compound-CYPA dependent disruption of the KRAS G12C-BRAF complex. This protocol was...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/1/2025
Entry Details
Go to US Patent

LigandPNGBDBM707906((1r,2R,3S)-N-[(7S,13S)-(20M)-20-[5-[4-(3-hydroxypr...)
Affinity DataIC50: 4.70nMAssay Description:In this example, TR-FRET was also used to measure the compound or compound-CYPA dependent disruption of the KRAS G12C-BRAF complex. This protocol was...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/1/2025
Entry Details
Go to US Patent

LigandPNGBDBM707905((1r,2R,3S)-N-[(7S,13S)-(20M)-20-[5-[4-(2-fluoroeth...)
Affinity DataIC50: 4.90nMAssay Description:In this example, TR-FRET was also used to measure the compound or compound-CYPA dependent disruption of the KRAS G12C-BRAF complex. This protocol was...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/1/2025
Entry Details
Go to US Patent

LigandPNGBDBM707896((1r,2S,3R)-N-[(7S,13S)-(20M)-20-[5-[(9αR)-1,3,4,6,...)
Affinity DataIC50: 5.40nMAssay Description:In this example, TR-FRET was also used to measure the compound or compound-CYPA dependent disruption of the KRAS G12C-BRAF complex. This protocol was...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/1/2025
Entry Details
Go to US Patent

LigandPNGBDBM707827((1S,5R,6r)-N-[(7S,13S)-(20M)-20-[2-[(1S)-1-methoxy...)
Affinity DataIC50: 5.90nMAssay Description:In this example, TR-FRET was also used to measure the compound or compound-CYPA dependent disruption of the KRAS G12C-BRAF complex. This protocol was...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/1/2025
Entry Details
Go to US Patent

LigandPNGBDBM707884((1S,2S)-N-[(7S,13S)-(20M)-20-[2-[(1S)-1-methoxyeth...)
Affinity DataIC50: 6nMAssay Description:In this example, TR-FRET was also used to measure the compound or compound-CYPA dependent disruption of the KRAS G12C-BRAF complex. This protocol was...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/1/2025
Entry Details
Go to US Patent

LigandPNGBDBM707898((1S,2S)-N-[(7S,13S)-(20M)-20-[5-[(9αR)-1,3,4,6,7,8...)
Affinity DataIC50: 6nMAssay Description:In this example, TR-FRET was also used to measure the compound or compound-CYPA dependent disruption of the KRAS G12C-BRAF complex. This protocol was...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/1/2025
Entry Details
Go to US Patent

LigandPNGBDBM707904((1r,2R,3S)-N-[(7S,13S)-20-[5-[4-(2,2-difluoroethyl...)
Affinity DataIC50: 6nMAssay Description:In this example, TR-FRET was also used to measure the compound or compound-CYPA dependent disruption of the KRAS G12C-BRAF complex. This protocol was...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/1/2025
Entry Details
Go to US Patent

LigandPNGBDBM707837((1S,2S)-N-[(7S,13S)-(20M)-20-[2-[(1S)-1-methoxyeth...)
Affinity DataIC50: 6.40nMAssay Description:In this example, TR-FRET was also used to measure the compound or compound-CYPA dependent disruption of the KRAS G12C-BRAF complex. This protocol was...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/1/2025
Entry Details
Go to US Patent

LigandPNGBDBM707885((1S,2S)-N-[(7S,13S)-(20M)-20-[2-[(1S)-1-methoxyeth...)
Affinity DataIC50: 6.40nMAssay Description:In this example, TR-FRET was also used to measure the compound or compound-CYPA dependent disruption of the KRAS G12C-BRAF complex. This protocol was...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/1/2025
Entry Details
Go to US Patent

LigandPNGBDBM707897((1S,2S)-N-[(7S,13S)-(20M)-20-[5-[(9αR)-1,3,4,6,7,8...)
Affinity DataIC50: 6.5nMAssay Description:In this example, TR-FRET was also used to measure the compound or compound-CYPA dependent disruption of the KRAS G12C-BRAF complex. This protocol was...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/1/2025
Entry Details
Go to US Patent

LigandPNGBDBM707889((1S,2S)-N-[(7S,13S)-(20M)-20-[2-[(1S)-1-methoxyeth...)
Affinity DataIC50: 6.90nMAssay Description:In this example, TR-FRET was also used to measure the compound or compound-CYPA dependent disruption of the KRAS G12C-BRAF complex. This protocol was...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/1/2025
Entry Details
Go to US Patent

LigandPNGBDBM707861((1S,2S)-N-[(7S,13S)-(20M)-20-[2-[(1S)-1-methoxyeth...)
Affinity DataIC50: 8nMAssay Description:In this example, TR-FRET was also used to measure the compound or compound-CYPA dependent disruption of the KRAS G12C-BRAF complex. This protocol was...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/1/2025
Entry Details
Go to US Patent

LigandPNGBDBM707886((1S,2S)-N-[(7S,13S)-23,23-difluoro-(20M)-20-[2-[(1...)
Affinity DataIC50: 8.10nMAssay Description:In this example, TR-FRET was also used to measure the compound or compound-CYPA dependent disruption of the KRAS G12C-BRAF complex. This protocol was...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/1/2025
Entry Details
Go to US Patent

LigandPNGBDBM707874((1r,2S,3R)-N-[(7S,13S)-(20M)-20-[2-[(1S)-1-methoxy...)
Affinity DataIC50: 8.90nMAssay Description:In this example, TR-FRET was also used to measure the compound or compound-CYPA dependent disruption of the KRAS G12C-BRAF complex. This protocol was...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/1/2025
Entry Details
Go to US Patent

LigandPNGBDBM707909((1R,2R)-N-[(7S,13S)-(20M)-20-[2-[(1S)-1-methoxyeth...)
Affinity DataIC50: 8.90nMAssay Description:In this example, TR-FRET was also used to measure the compound or compound-CYPA dependent disruption of the KRAS G12C-BRAF complex. This protocol was...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/1/2025
Entry Details
Go to US Patent

LigandPNGBDBM707876((1r,2S,3R)-N-[(7S,13S)-23,23-difluoro-(20M)-20-[2-...)
Affinity DataIC50: 9.10nMAssay Description:In this example, TR-FRET was also used to measure the compound or compound-CYPA dependent disruption of the KRAS G12C-BRAF complex. This protocol was...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/1/2025
Entry Details
Go to US Patent

LigandPNGBDBM707914((1r,2S,3R)-N-[(7S,13S)-(20M)-20-[2-[(1S)-1-methoxy...)
Affinity DataIC50: 9.30nMAssay Description:In this example, TR-FRET was also used to measure the compound or compound-CYPA dependent disruption of the KRAS G12C-BRAF complex. This protocol was...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/1/2025
Entry Details
Go to US Patent

LigandPNGBDBM707824((1S,5R,6r)-N-[(7S,13S)-(20M)-20-[2-[(1S)-1-methoxy...)
Affinity DataIC50: 9.40nMAssay Description:In this example, TR-FRET was also used to measure the compound or compound-CYPA dependent disruption of the KRAS G12C-BRAF complex. This protocol was...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/1/2025
Entry Details
Go to US Patent

LigandPNGBDBM707891((1S,2S)-N-[(7S,13S)-(20M)-20-[2-[(1S)-1-methoxyeth...)
Affinity DataIC50: 9.40nMAssay Description:In this example, TR-FRET was also used to measure the compound or compound-CYPA dependent disruption of the KRAS G12C-BRAF complex. This protocol was...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/1/2025
Entry Details
Go to US Patent

LigandPNGBDBM707838((1r,2R,3S)-N-[(7S,13S)-(20M)-20-[2-[(1S)-1-methoxy...)
Affinity DataIC50: 9.70nMAssay Description:In this example, TR-FRET was also used to measure the compound or compound-CYPA dependent disruption of the KRAS G12C-BRAF complex. This protocol was...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/1/2025
Entry Details
Go to US Patent

LigandPNGBDBM707883((1S,2S)-N-[(7S,13S)-(20M)-20-[2-[(1S)-1-methoxyeth...)
Affinity DataIC50: 9.70nMAssay Description:In this example, TR-FRET was also used to measure the compound or compound-CYPA dependent disruption of the KRAS G12C-BRAF complex. This protocol was...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/1/2025
Entry Details
Go to US Patent

LigandPNGBDBM707899((1S,2S)-N-[(7S,13S)-(20M)-20-[5-[(9αS)-3,4,6,7,9,9...)
Affinity DataIC50: 9.80nMAssay Description:In this example, TR-FRET was also used to measure the compound or compound-CYPA dependent disruption of the KRAS G12C-BRAF complex. This protocol was...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/1/2025
Entry Details
Go to US Patent

LigandPNGBDBM707833((1R,2S)-2-cyclopropyl-N-[(7S,13S)-(20M)-20-[2-[(1S...)
Affinity DataIC50: 10.2nMAssay Description:In this example, TR-FRET was also used to measure the compound or compound-CYPA dependent disruption of the KRAS G12C-BRAF complex. This protocol was...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/1/2025
Entry Details
Go to US Patent

LigandPNGBDBM707860((1S,2S)-N-[(7S,13S)-(20M)-20-[2-[(1S)-1-methoxyeth...)
Affinity DataIC50: 10.3nMAssay Description:In this example, TR-FRET was also used to measure the compound or compound-CYPA dependent disruption of the KRAS G12C-BRAF complex. This protocol was...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/1/2025
Entry Details
Go to US Patent

LigandPNGBDBM707879((1r,2S,3R)-N-[(7S,13S)-23,23-difluoro-(20M)-20-[2-...)
Affinity DataIC50: 10.3nMAssay Description:In this example, TR-FRET was also used to measure the compound or compound-CYPA dependent disruption of the KRAS G12C-BRAF complex. This protocol was...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/1/2025
Entry Details
Go to US Patent

LigandPNGBDBM707907((1R,2R)-N-[(7S,13S)-(20M)-20-[2-[(1S)-1-methoxyeth...)
Affinity DataIC50: 10.4nMAssay Description:In this example, TR-FRET was also used to measure the compound or compound-CYPA dependent disruption of the KRAS G12C-BRAF complex. This protocol was...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/1/2025
Entry Details
Go to US Patent

LigandPNGBDBM707901((1r,2R,3S)-N-[(7S,13S)-(20M)-20-[5-(4-cyclopropylp...)
Affinity DataIC50: 10.8nMAssay Description:In this example, TR-FRET was also used to measure the compound or compound-CYPA dependent disruption of the KRAS G12C-BRAF complex. This protocol was...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/1/2025
Entry Details
Go to US Patent

LigandPNGBDBM707823((1S,2S)-2-(difluoromethyl)-N-[(7S,13S)-(20M)-20-[2...)
Affinity DataIC50: 11.1nMAssay Description:In this example, TR-FRET was also used to measure the compound or compound-CYPA dependent disruption of the KRAS G12C-BRAF complex. This protocol was...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/1/2025
Entry Details
Go to US Patent

LigandPNGBDBM707893((1S,2S)-N-[(7S,13S)-(20M)-20-[2-[(1S)-1-methoxyeth...)
Affinity DataIC50: 11.1nMAssay Description:In this example, TR-FRET was also used to measure the compound or compound-CYPA dependent disruption of the KRAS G12C-BRAF complex. This protocol was...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/1/2025
Entry Details
Go to US Patent

LigandPNGBDBM707832((1S,5R,6r)-N-[(7S,13S)-(20M)-20-[2-[(1S)-1-methoxy...)
Affinity DataIC50: 11.9nMAssay Description:In this example, TR-FRET was also used to measure the compound or compound-CYPA dependent disruption of the KRAS G12C-BRAF complex. This protocol was...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/1/2025
Entry Details
Go to US Patent

LigandPNGBDBM707829((1S,5R,6r)-N-[(7S,13S)-(20M)-20-[2-[(1S)-1-methoxy...)
Affinity DataIC50: 12nMAssay Description:In this example, TR-FRET was also used to measure the compound or compound-CYPA dependent disruption of the KRAS G12C-BRAF complex. This protocol was...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/1/2025
Entry Details
Go to US Patent

LigandPNGBDBM707828((1S,2S)-2-(difluoromethyl)-N-[(7S,13S)-(20M)-20-[2...)
Affinity DataIC50: 12.4nMAssay Description:In this example, TR-FRET was also used to measure the compound or compound-CYPA dependent disruption of the KRAS G12C-BRAF complex. This protocol was...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/1/2025
Entry Details
Go to US Patent

LigandPNGBDBM707894((1S,2S)-N-[(7S,13S)-(20M)-20-[2-[(1S)-1-methoxyeth...)
Affinity DataIC50: 12.6nMAssay Description:In this example, TR-FRET was also used to measure the compound or compound-CYPA dependent disruption of the KRAS G12C-BRAF complex. This protocol was...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/1/2025
Entry Details
Go to US Patent

LigandPNGBDBM707841(US20240417410, Example 29)
Affinity DataIC50: 12.7nMAssay Description:In this example, TR-FRET was also used to measure the compound or compound-CYPA dependent disruption of the KRAS G12C-BRAF complex. This protocol was...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/1/2025
Entry Details
Go to US Patent

LigandPNGBDBM707847((1S,5R,6r)-N-[(7S,13S)-(20M)-20-[5-[(9αS)-3,4,6,7,...)
Affinity DataIC50: 13nMAssay Description:In this example, TR-FRET was also used to measure the compound or compound-CYPA dependent disruption of the KRAS G12C-BRAF complex. This protocol was...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/1/2025
Entry Details
Go to US Patent

LigandPNGBDBM707916((1r,2R,3S)-N-[(7S,13S)-(20M)-20-[2-[(1S)-1-methoxy...)
Affinity DataIC50: 13nMAssay Description:In this example, TR-FRET was also used to measure the compound or compound-CYPA dependent disruption of the KRAS G12C-BRAF complex. This protocol was...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/1/2025
Entry Details
Go to US Patent

LigandPNGBDBM707900((1S,2S)-N-[(7S,13S)-(20M)-20-[5-[(9αS)-3,4,6,7,9,9...)
Affinity DataIC50: 13.3nMAssay Description:In this example, TR-FRET was also used to measure the compound or compound-CYPA dependent disruption of the KRAS G12C-BRAF complex. This protocol was...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/1/2025
Entry Details
Go to US Patent

LigandPNGBDBM707913((1r,2R,3S)-N-[(7S,13S)-(20M)-20-[2-[(1S)-1-methoxy...)
Affinity DataIC50: 13.5nMAssay Description:In this example, TR-FRET was also used to measure the compound or compound-CYPA dependent disruption of the KRAS G12C-BRAF complex. This protocol was...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/1/2025
Entry Details
Go to US Patent

LigandPNGBDBM707890((1S,2S)-N-[(7S,13S)-23,23-difluoro-(20M)-20-[2-[(1...)
Affinity DataIC50: 13.7nMAssay Description:In this example, TR-FRET was also used to measure the compound or compound-CYPA dependent disruption of the KRAS G12C-BRAF complex. This protocol was...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/1/2025
Entry Details
Go to US Patent

LigandPNGBDBM707918((1r,2R,3S)-N-[(7S,13S)-(20M)-20-[2-[(1S)-1-methoxy...)
Affinity DataIC50: 13.7nMAssay Description:In this example, TR-FRET was also used to measure the compound or compound-CYPA dependent disruption of the KRAS G12C-BRAF complex. This protocol was...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/1/2025
Entry Details
Go to US Patent

LigandPNGBDBM707862(US20240417410, Example 58)
Affinity DataIC50: 14nMAssay Description:In this example, TR-FRET was also used to measure the compound or compound-CYPA dependent disruption of the KRAS G12C-BRAF complex. This protocol was...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/1/2025
Entry Details
Go to US Patent

LigandPNGBDBM707850(US20240417410, Example 45)
Affinity DataIC50: 14.1nMAssay Description:In this example, TR-FRET was also used to measure the compound or compound-CYPA dependent disruption of the KRAS G12C-BRAF complex. This protocol was...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/1/2025
Entry Details
Go to US Patent

LigandPNGBDBM707892((1S,2S)-N-[(7S,13S)-(20M)-20-[2-[(1S)-1-methoxyeth...)
Affinity DataIC50: 14.4nMAssay Description:In this example, TR-FRET was also used to measure the compound or compound-CYPA dependent disruption of the KRAS G12C-BRAF complex. This protocol was...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/1/2025
Entry Details
Go to US Patent

LigandPNGBDBM707845((1S,5R,6r)-N-[(7S,13S)-(20M)-20-[2-[(1S)-1-methoxy...)
Affinity DataIC50: 14.5nMAssay Description:In this example, TR-FRET was also used to measure the compound or compound-CYPA dependent disruption of the KRAS G12C-BRAF complex. This protocol was...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/1/2025
Entry Details
Go to US Patent

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