Compile Data Set for Download or QSAR
Report error Found 39 Enz. Inhib. hit(s) with all data for entry = 12488
TargetCannabinoid receptor 2(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM693150(2-Fluoroethyl 2-{[6-(cyclopropylmethoxy)-5-(3-meth...)
Affinity DataKi:  2nMAssay Description:The affinity of the compounds of the invention for cannabinoid CB1 receptors was determined using recommended amounts of membrane preparations (Perki...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
4/11/2025
Entry Details
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TargetCannabinoid receptor 2(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM693148(Fluoromethyl 2-{[6-(cyclopropylmethoxy)-5-(3-metho...)
Affinity DataKi:  2nMAssay Description:The affinity of the compounds of the invention for cannabinoid CB1 receptors was determined using recommended amounts of membrane preparations (Perki...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
4/11/2025
Entry Details
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TargetCannabinoid receptor 2(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM693158(Fluoromethyl 2-{[6-(cyclopropylmethoxy)-5-(pyrroli...)
Affinity DataKi:  2nMAssay Description:The affinity of the compounds of the invention for cannabinoid CB1 receptors was determined using recommended amounts of membrane preparations (Perki...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
4/11/2025
Entry Details
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TargetCannabinoid receptor 2(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM693159(2-Fluoroethyl 2-{[6-(cyclopropylmethoxy)-5-(pyrrol...)
Affinity DataKi:  3nMAssay Description:The affinity of the compounds of the invention for cannabinoid CB1 receptors was determined using recommended amounts of membrane preparations (Perki...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
4/11/2025
Entry Details
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TargetCannabinoid receptor 2(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM693156(3-Fluoropropyl 2-{[6-(cyclopropylmethoxy)-5-(pyrro...)
Affinity DataKi:  5nMAssay Description:The affinity of the compounds of the invention for cannabinoid CB1 receptors was determined using recommended amounts of membrane preparations (Perki...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
4/11/2025
Entry Details
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TargetCannabinoid receptor 2(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM693152(3-Fluoropropyl 2-{[6-(cyclopropylmethoxy)-5-(3-met...)
Affinity DataKi:  6nMAssay Description:The affinity of the compounds of the invention for cannabinoid CB1 receptors was determined using recommended amounts of membrane preparations (Perki...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
4/11/2025
Entry Details
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TargetCannabinoid receptor 2(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM693153(Fluoromethyl 2-{[6-(cyclopropylmethoxy)-5-(3,3-dif...)
Affinity DataKi:  6nMAssay Description:The affinity of the compounds of the invention for cannabinoid CB1 receptors was determined using recommended amounts of membrane preparations (Perki...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
4/11/2025
Entry Details
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TargetCannabinoid receptor 2(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM693154(2-Fluoroethyl 2-{[6-(cyclopropylmethoxy)-5-(3,3-di...)
Affinity DataKi:  7nMAssay Description:The affinity of the compounds of the invention for cannabinoid CB1 receptors was determined using recommended amounts of membrane preparations (Perki...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
4/11/2025
Entry Details
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TargetCannabinoid receptor 2(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM693166(6-(Cyclopropylmethoxy)-N-[(2S)-1-(fluoromethoxy)-4...)
Affinity DataKi:  8nMAssay Description:The affinity of the compounds of the invention for cannabinoid CB1 receptors was determined using recommended amounts of membrane preparations (Perki...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
4/11/2025
Entry Details
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TargetCannabinoid receptor 2(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM693167(6-(Cyclopropylmethoxy)-N-[(2S)-1-(2-fluoroethoxy)-...)
Affinity DataKi:  10nMAssay Description:The affinity of the compounds of the invention for cannabinoid CB1 receptors was determined using recommended amounts of membrane preparations (Perki...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
4/11/2025
Entry Details
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TargetCannabinoid receptor 2(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM693175(6-(Cyclopropylmethoxy)-N-[(2S)-1-(fluoromethoxy)-4...)
Affinity DataKi:  14nMAssay Description:The affinity of the compounds of the invention for cannabinoid CB1 receptors was determined using recommended amounts of membrane preparations (Perki...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
4/11/2025
Entry Details
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TargetCannabinoid receptor 2(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM693164(2-Fluoroethyl N-[6-(cyclopropylmethoxy)-5-(pyrroli...)
Affinity DataKi:  15nMAssay Description:The affinity of the compounds of the invention for cannabinoid CB1 receptors was determined using recommended amounts of membrane preparations (Perki...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
4/11/2025
Entry Details
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TargetCannabinoid receptor 2(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM693161(2-Fluoroethyl N-[6-(cyclopropylmethoxy)-5-(3-metho...)
Affinity DataKi:  15nMAssay Description:The affinity of the compounds of the invention for cannabinoid CB1 receptors was determined using recommended amounts of membrane preparations (Perki...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
4/11/2025
Entry Details
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TargetCannabinoid receptor 2(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM693177(6-(Cyclopropylmethoxy)-N-[(2S)-1-(2-fluoroethoxy)-...)
Affinity DataKi:  18nMAssay Description:The affinity of the compounds of the invention for cannabinoid CB1 receptors was determined using recommended amounts of membrane preparations (Perki...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
4/11/2025
Entry Details
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TargetCannabinoid receptor 2(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM693155(3-Fluoropropyl 2-{[6-(cyclopropylmethoxy)-5-(3,3-d...)
Affinity DataKi:  19nMAssay Description:The affinity of the compounds of the invention for cannabinoid CB1 receptors was determined using recommended amounts of membrane preparations (Perki...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
4/11/2025
Entry Details
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TargetCannabinoid receptor 2(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM693176(6-(Cyclopropylmethoxy)-5-(3,3-difluoroazetidin-1-y...)
Affinity DataKi:  24nMAssay Description:The affinity of the compounds of the invention for cannabinoid CB1 receptors was determined using recommended amounts of membrane preparations (Perki...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
4/11/2025
Entry Details
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TargetCannabinoid receptor 2(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM693178(6-(Cyclopropylmethoxy)-N-[(2S)-1-(3-fluoropropoxy)...)
Affinity DataKi:  31nMAssay Description:The affinity of the compounds of the invention for cannabinoid CB1 receptors was determined using recommended amounts of membrane preparations (Perki...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
4/11/2025
Entry Details
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TargetCannabinoid receptor 2(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM693185(6-(Cyclopropylmethoxy)-N-{3-[(fluoromethoxy)methyl...)
Affinity DataKi:  33nMAssay Description:The affinity of the compounds of the invention for cannabinoid CB1 receptors was determined using recommended amounts of membrane preparations (Perki...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
4/11/2025
Entry Details
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TargetCannabinoid receptor 2(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM693165(3-Fluoropropyl N-[6-(cyclopropylmethoxy)-5-(pyrrol...)
Affinity DataKi:  40nMAssay Description:The affinity of the compounds of the invention for cannabinoid CB1 receptors was determined using recommended amounts of membrane preparations (Perki...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
4/11/2025
Entry Details
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TargetCannabinoid receptor 2(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM693168(6-(Cyclopropylmethoxy)-N-[(2S)-1-(3-fluoropropoxy)...)
Affinity DataKi:  40nMAssay Description:The affinity of the compounds of the invention for cannabinoid CB1 receptors was determined using recommended amounts of membrane preparations (Perki...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
4/11/2025
Entry Details
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TargetCannabinoid receptor 2(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM693162(3-Fluoropropyl N-[6-(cyclopropylmethoxy)-5-(3-meth...)
Affinity DataKi:  46nMAssay Description:The affinity of the compounds of the invention for cannabinoid CB1 receptors was determined using recommended amounts of membrane preparations (Perki...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
4/11/2025
Entry Details
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TargetCannabinoid receptor 2(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM693170(6-(Cyclopropylmethoxy)-N-[(2S)-1-(2-fluoroethoxy)-...)
Affinity DataKi:  60nMAssay Description:The affinity of the compounds of the invention for cannabinoid CB1 receptors was determined using recommended amounts of membrane preparations (Perki...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
4/11/2025
Entry Details
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TargetCannabinoid receptor 2(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM693186(6-(Cyclopropylmethoxy)-N-{3-[(2-fluoroethoxy)methy...)
Affinity DataKi:  62nMAssay Description:The affinity of the compounds of the invention for cannabinoid CB1 receptors was determined using recommended amounts of membrane preparations (Perki...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
4/11/2025
Entry Details
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TargetCannabinoid receptor 2(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM693163(Fluoromethyl N-[6-(cyclopropylmethoxy)-5-(pyrrolid...)
Affinity DataKi:  63nMAssay Description:The affinity of the compounds of the invention for cannabinoid CB1 receptors was determined using recommended amounts of membrane preparations (Perki...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
4/11/2025
Entry Details
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TargetCannabinoid receptor 2(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM693187(6-(Cyclopropylmethoxy)-N-{3-[(3-fluoropropoxy)meth...)
Affinity DataKi:  68nMAssay Description:The affinity of the compounds of the invention for cannabinoid CB1 receptors was determined using recommended amounts of membrane preparations (Perki...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
4/11/2025
Entry Details
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TargetCannabinoid receptor 2(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM693169(6-(Cylopropylmethoxy)-N-[(2S)-1-(fluoromethoxy)-3-...)
Affinity DataKi:  70nMAssay Description:The affinity of the compounds of the invention for cannabinoid CB1 receptors was determined using recommended amounts of membrane preparations (Perki...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
4/11/2025
Entry Details
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TargetCannabinoid receptor 2(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM693171(6-(Cyclopropylmethoxy)-N-[(2S)-1-(3-fluoropropoxy)...)
Affinity DataKi:  156nMAssay Description:The affinity of the compounds of the invention for cannabinoid CB1 receptors was determined using recommended amounts of membrane preparations (Perki...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
4/11/2025
Entry Details
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TargetCannabinoid receptor 2(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM693180(6-(Cyclopropylmethoxy)-N-[(2S)-1-(2-fluoroethoxy)-...)
Affinity DataKi:  165nMAssay Description:The affinity of the compounds of the invention for cannabinoid CB1 receptors was determined using recommended amounts of membrane preparations (Perki...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
4/11/2025
Entry Details
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TargetCannabinoid receptor 2(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM693181(6-(Cyclopropylmethoxy)-N-[(2S)-1-(3-fluoropropoxy)...)
Affinity DataKi:  247nMAssay Description:The affinity of the compounds of the invention for cannabinoid CB1 receptors was determined using recommended amounts of membrane preparations (Perki...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
4/11/2025
Entry Details
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TargetCannabinoid receptor 2(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM693179(6-(Cyclopropylmethoxy)-N-[(2S)-1-(fluoromethoxy)-3...)
Affinity DataKi:  269nMAssay Description:The affinity of the compounds of the invention for cannabinoid CB1 receptors was determined using recommended amounts of membrane preparations (Perki...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
4/11/2025
Entry Details
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TargetCannabinoid receptor 2(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM693188(6-(Cyclopropylmethoxy)-N-[(2R)-1-(2-fluoroethoxy)-...)
Affinity DataKi:  288nMAssay Description:The affinity of the compounds of the invention for cannabinoid CB1 receptors was determined using recommended amounts of membrane preparations (Perki...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
4/11/2025
Entry Details
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TargetCannabinoid receptor 2(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM693160(Fluoromethyl N-[6-(cyclopropylmethoxy)-5-(3-methox...)
Affinity DataKi:  336nMAssay Description:The affinity of the compounds of the invention for cannabinoid CB1 receptors was determined using recommended amounts of membrane preparations (Perki...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
4/11/2025
Entry Details
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TargetCannabinoid receptor 2(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM693173(6-(Cyclopropylmethoxy)-N-[(2S)-1-(2-fluoroethoxy)p...)
Affinity DataKi:  490nMAssay Description:The affinity of the compounds of the invention for cannabinoid CB1 receptors was determined using recommended amounts of membrane preparations (Perki...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
4/11/2025
Entry Details
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TargetCannabinoid receptor 2(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM706180(6-(Cyclopropylmethoxy)-5-(3-fluoro-3-methylazetidi...)
Affinity DataKi:  524nMAssay Description:The affinity of the compounds of the invention for cannabinoid CB1 receptors was determined using recommended amounts of membrane preparations (Perki...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
4/11/2025
Entry Details
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TargetCannabinoid receptor 2(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM693174(6-(Cyclopropylmethoxy)-N-[(2S)-1-(3-fluoropropoxy)...)
Affinity DataKi:  671nMAssay Description:The affinity of the compounds of the invention for cannabinoid CB1 receptors was determined using recommended amounts of membrane preparations (Perki...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
4/11/2025
Entry Details
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TargetCannabinoid receptor 2(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM693172(6-(Cyclopropylmethoxy)-N-[(2S)-1-(fluoromethoxy)pr...)
Affinity DataKi:  787nMAssay Description:The affinity of the compounds of the invention for cannabinoid CB1 receptors was determined using recommended amounts of membrane preparations (Perki...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
4/11/2025
Entry Details
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TargetCannabinoid receptor 2(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM693189(6-(Cyclopropylmethoxy)-N-[(2R)-1-(2-fluoroethoxy)-...)
Affinity DataKi:  1.30E+3nMAssay Description:The affinity of the compounds of the invention for cannabinoid CB1 receptors was determined using recommended amounts of membrane preparations (Perki...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
4/11/2025
Entry Details
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TargetCannabinoid receptor 2(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM693184(6-(Cyclopropylmethoxy)-N-[(2S)-1-(3-fluoropropoxy)...)
Affinity DataKi:  2.81E+3nMAssay Description:The affinity of the compounds of the invention for cannabinoid CB1 receptors was determined using recommended amounts of membrane preparations (Perki...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
4/11/2025
Entry Details
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TargetCannabinoid receptor 2(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM693183(6-(Cyclopropylmethoxy)-N-[(2S)-1-(2-fluoroethoxy)p...)
Affinity DataKi:  3.12E+3nMAssay Description:The affinity of the compounds of the invention for cannabinoid CB1 receptors was determined using recommended amounts of membrane preparations (Perki...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
4/11/2025
Entry Details
Go to US Patent