Compile Data Set for Download or QSAR
Report error Found 5 Enz. Inhib. hit(s) with all data for entry = 12477
TargetProtein Rev(Human immunodeficiency virus type 1)
Karyopharm Therapeutics

US Patent
LigandPNGBDBM705292((Z)-3-(3-(3,5- bis(trifluoromethyl)phenyl)-1H-1,2,...)
Affinity DataIC50: 1.00E+3nMAssay Description:The ability of exemplary compounds of the invention to inhibit CRM1-mediated nuclear export was assessed in a RevGFP assay. Rev is a protein from hum...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/20/2025
Entry Details
Go to US Patent

TargetProtein Rev(Human immunodeficiency virus type 1)
Karyopharm Therapeutics

US Patent
LigandPNGBDBM705293((E)-3-(3-(3,5- bis(trifluoromethyl)phenyl)-1H-1,2,...)
Affinity DataIC50: 1.00E+3nMAssay Description:The ability of exemplary compounds of the invention to inhibit CRM1-mediated nuclear export was assessed in a RevGFP assay. Rev is a protein from hum...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/20/2025
Entry Details
Go to US Patent

TargetProtein Rev(Human immunodeficiency virus type 1)
Karyopharm Therapeutics

US Patent
LigandPNGBDBM705294((Z)-N-(3-azabicyclo[3.1.0]hexan-6-yl)- 3-(3-(3,5-b...)
Affinity DataIC50: 1.00E+3nMAssay Description:The ability of exemplary compounds of the invention to inhibit CRM1-mediated nuclear export was assessed in a RevGFP assay. Rev is a protein from hum...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/20/2025
Entry Details
Go to US Patent

TargetProtein Rev(Human immunodeficiency virus type 1)
Karyopharm Therapeutics

US Patent
LigandPNGBDBM50527778(KPT-330 | Selinexor | Xpovio | US20240376114, Comp...)
Affinity DataIC50: 1.00E+3nMAssay Description:The ability of exemplary compounds of the invention to inhibit CRM1-mediated nuclear export was assessed in a RevGFP assay. Rev is a protein from hum...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2025
Entry Details
Go to US Patent

TargetProtein Rev(Human immunodeficiency virus type 1)
Karyopharm Therapeutics

US Patent
LigandPNGBDBM705296(US20240376114, Compound 71)
Affinity DataIC50: 1.00E+3nMAssay Description:The ability of exemplary compounds of the invention to inhibit CRM1-mediated nuclear export was assessed in a RevGFP assay. Rev is a protein from hum...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/20/2025
Entry Details
Go to US Patent