Compile Data Set for Download or QSAR
Report error Found 30 Enz. Inhib. hit(s) with all data for entry = 12455
LigandPNGBDBM704036(2-((8-Amino-6-(5-amino-4-methylpyridin-3- yl)cinno...)
Affinity DataKi:  0.0980nMAssay Description:HPK-FL enzyme phosphorylates Biotin-SLP-76 substrate in the presence of ATP at 1 mM and varying concentrations of test compound. Product is detected ...More data for this Ligand-Target Pair
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Date in BDB:
3/14/2025
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LigandPNGBDBM704029((1R,2R)-N-(8-Amino-6-(5-amino-4- | US20240368170, ...)
Affinity DataKi:  0.700nMAssay Description:For the binding assay, 4 μL 2×HPK1 and Eu-anti-GST antibody were added to each well of the assay plate using a Multidrop reagent dispenser. The solut...More data for this Ligand-Target Pair
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Date in BDB:
3/14/2025
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LigandPNGBDBM50598500(CHEMBL5196939 | US20240368170, Compound 25)
Affinity DataKi:  1.90nMAssay Description:For the binding assay, 4 μL 2×HPK1 and Eu-anti-GST antibody were added to each well of the assay plate using a Multidrop reagent dispenser. The solut...More data for this Ligand-Target Pair
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Date in BDB:
3/14/2025
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LigandPNGBDBM704021(cis-N-[8-Amino-6-(4-methylisothiazol-5- yl)cinnoli...)
Affinity DataKi:  3nMAssay Description:For the binding assay, 4 μL 2×HPK1 and Eu-anti-GST antibody were added to each well of the assay plate using a Multidrop reagent dispenser. The solut...More data for this Ligand-Target Pair
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Date in BDB:
3/14/2025
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LigandPNGBDBM704027(cis-N-(8-Amino-6-(4-ethylpyridin-3- yl)cinnolin-3-...)
Affinity DataKi:  4nMAssay Description:For the binding assay, 4 μL 2×HPK1 and Eu-anti-GST antibody were added to each well of the assay plate using a Multidrop reagent dispenser. The solut...More data for this Ligand-Target Pair
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Date in BDB:
3/14/2025
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LigandPNGBDBM704030(methylpyridin-3-yl)cinnolin-3-yl)-2- | US202403681...)
Affinity DataKi:  4nMAssay Description:For the binding assay, 4 μL 2×HPK1 and Eu-anti-GST antibody were added to each well of the assay plate using a Multidrop reagent dispenser. The solut...More data for this Ligand-Target Pair
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Date in BDB:
3/14/2025
Entry Details
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LigandPNGBDBM704017(1-[8-Amino-6-(4-ethyl-3-pyridyl)cinnolin-3-yl]- 3-...)
Affinity DataKi:  8nMAssay Description:For the binding assay, 4 μL 2×HPK1 and Eu-anti-GST antibody were added to each well of the assay plate using a Multidrop reagent dispenser. The solut...More data for this Ligand-Target Pair
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Date in BDB:
3/14/2025
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LigandPNGBDBM704018(1-[8-Amino-6-(4-ethyl-3-pyridyl)cinnolin-3-yl]- 3-...)
Affinity DataKi:  11nMAssay Description:For the binding assay, 4 μL 2×HPK1 and Eu-anti-GST antibody were added to each well of the assay plate using a Multidrop reagent dispenser. The solut...More data for this Ligand-Target Pair
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Date in BDB:
3/14/2025
Entry Details
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LigandPNGBDBM704026(trans-8-Amino-6-(4-ethylpyridin-3-yl)cinnolin- 3-y...)
Affinity DataKi:  13nMAssay Description:For the binding assay, 4 μL 2×HPK1 and Eu-anti-GST antibody were added to each well of the assay plate using a Multidrop reagent dispenser. The solut...More data for this Ligand-Target Pair
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Date in BDB:
3/14/2025
Entry Details
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LigandPNGBDBM704025(trans-N-(8-Amino-6-(1-methyl-1H-pyrazol-4- yl)cinn...)
Affinity DataKi:  14nMAssay Description:For the binding assay, 4 μL 2×HPK1 and Eu-anti-GST antibody were added to each well of the assay plate using a Multidrop reagent dispenser. The solut...More data for this Ligand-Target Pair
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Date in BDB:
3/14/2025
Entry Details
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LigandPNGBDBM704011((1S,2S)-N-(8-Amino-6-(6-amino-4- | US20240368170, ...)
Affinity DataKi:  15nMAssay Description:For the binding assay, 4 μL 2×HPK1 and Eu-anti-GST antibody were added to each well of the assay plate using a Multidrop reagent dispenser. The solut...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/14/2025
Entry Details
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LigandPNGBDBM704024((1S,2S)-N-(8-Amino-6-(1-methyl-1H-pyrazol-4- | US2...)
Affinity DataKi:  15nMAssay Description:For the binding assay, 4 μL 2×HPK1 and Eu-anti-GST antibody were added to each well of the assay plate using a Multidrop reagent dispenser. The solut...More data for this Ligand-Target Pair
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Date in BDB:
3/14/2025
Entry Details
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LigandPNGBDBM704014(1-[8-Amino-6-(1-methylpyrazol-4-yl)cinnolin- 3-yl]...)
Affinity DataKi:  21nMAssay Description:For the binding assay, 4 μL 2×HPK1 and Eu-anti-GST antibody were added to each well of the assay plate using a Multidrop reagent dispenser. The solut...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/14/2025
Entry Details
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LigandPNGBDBM704020(1-[8-Amino-6-(4-ethyl-3-pyridyl)cinnolin-3-yl]- 3-...)
Affinity DataKi:  22nMAssay Description:For the binding assay, 4 μL 2×HPK1 and Eu-anti-GST antibody were added to each well of the assay plate using a Multidrop reagent dispenser. The solut...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/14/2025
Entry Details
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LigandPNGBDBM704015(Isopropyl N-[8-amino-6-(1-methylpyrazol-4- yl)cinn...)
Affinity DataKi:  28nMAssay Description:For the binding assay, 4 μL 2×HPK1 and Eu-anti-GST antibody were added to each well of the assay plate using a Multidrop reagent dispenser. The solut...More data for this Ligand-Target Pair
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Date in BDB:
3/14/2025
Entry Details
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LigandPNGBDBM704028(cis-N-(8-Amino-6-(4-cyclopropylpyridin-3- yl)cinno...)
Affinity DataKi:  31nMAssay Description:For the binding assay, 4 μL 2×HPK1 and Eu-anti-GST antibody were added to each well of the assay plate using a Multidrop reagent dispenser. The solut...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/14/2025
Entry Details
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LigandPNGBDBM704019(N-[8-Amino-6-(4-ethyl-3-pyridyl)cinnolin-3- yl]pyr...)
Affinity DataKi:  31nMAssay Description:For the binding assay, 4 μL 2×HPK1 and Eu-anti-GST antibody were added to each well of the assay plate using a Multidrop reagent dispenser. The solut...More data for this Ligand-Target Pair
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Date in BDB:
3/14/2025
Entry Details
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LigandPNGBDBM704035(2-((6-(5-Amino-4-methylpyridin-3-yl)cinnolin- 3-yl...)
Affinity DataKi:  40nMAssay Description:HPK-FL enzyme phosphorylates Biotin-SLP-76 substrate in the presence of ATP at 1 mM and varying concentrations of test compound. Product is detected ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/14/2025
Entry Details
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LigandPNGBDBM704023((1S,2S)-N-(8-Amino-6-(3-methylpyridin-4- | US20240...)
Affinity DataKi:  53nMAssay Description:For the binding assay, 4 μL 2×HPK1 and Eu-anti-GST antibody were added to each well of the assay plate using a Multidrop reagent dispenser. The solut...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/14/2025
Entry Details
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LigandPNGBDBM704008((1S,2S)-N-(8-Amino-6-(4-methoxypyridin-3- | US2024...)
Affinity DataKi:  58nMAssay Description:For the binding assay, 4 μL 2×HPK1 and Eu-anti-GST antibody were added to each well of the assay plate using a Multidrop reagent dispenser. The solut...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/14/2025
Entry Details
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LigandPNGBDBM704016(N-[8-Amino-6-(1-methylpyrazol-4-yl)cinnolin- 3-yl]...)
Affinity DataKi:  65nMAssay Description:For the binding assay, 4 μL 2×HPK1 and Eu-anti-GST antibody were added to each well of the assay plate using a Multidrop reagent dispenser. The solut...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/14/2025
Entry Details
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LigandPNGBDBM704007((1S,2S)-N-(8-Amino-6-(1-ethyl-1H-pyrazol-4- | US20...)
Affinity DataKi:  84nMAssay Description:For the binding assay, 4 μL 2×HPK1 and Eu-anti-GST antibody were added to each well of the assay plate using a Multidrop reagent dispenser. The solut...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/14/2025
Entry Details
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LigandPNGBDBM704031(N-(8-Methyl-6-(4-methylpyridin-3-yl)cinnolin- 3-yl...)
Affinity DataKi:  260nMAssay Description:For the binding assay, 4 μL 2×HPK1 and Eu-anti-GST antibody were added to each well of the assay plate using a Multidrop reagent dispenser. The solut...More data for this Ligand-Target Pair
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Date in BDB:
3/14/2025
Entry Details
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LigandPNGBDBM704022(6-(4-Ethyl-3-pyridyl)-N3-isopropyl-cinnoline- 3,8-...)
Affinity DataKi:  400nMAssay Description:For the binding assay, 4 μL 2×HPK1 and Eu-anti-GST antibody were added to each well of the assay plate using a Multidrop reagent dispenser. The solut...More data for this Ligand-Target Pair
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Date in BDB:
3/14/2025
Entry Details
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LigandPNGBDBM704012((1S,2S)-N-(8-Amino-6-ethylcinnolin-3-yl)-2- | US20...)
Affinity DataKi:  440nMAssay Description:For the binding assay, 4 μL 2×HPK1 and Eu-anti-GST antibody were added to each well of the assay plate using a Multidrop reagent dispenser. The solut...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/14/2025
Entry Details
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LigandPNGBDBM50598499(CHEMBL5199200 | US20240368170, Compound 27)
Affinity DataKi:  510nMAssay Description:For the binding assay, 4 μL 2×HPK1 and Eu-anti-GST antibody were added to each well of the assay plate using a Multidrop reagent dispenser. The solut...More data for this Ligand-Target Pair
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Date in BDB:
3/14/2025
Entry Details
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LigandPNGBDBM704013(cis-N-(8-Amino-6-cyclopropylcinnolin-3-yl)-2- fluo...)
Affinity DataKi:  600nMAssay Description:For the binding assay, 4 μL 2×HPK1 and Eu-anti-GST antibody were added to each well of the assay plate using a Multidrop reagent dispenser. The solut...More data for this Ligand-Target Pair
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Date in BDB:
3/14/2025
Entry Details
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LigandPNGBDBM704010(cis-N-(8-Amino-6-(4-cyanopyridin-3- yl)cinnolin-3-...)
Affinity DataKi:  600nMAssay Description:For the binding assay, 4 μL 2×HPK1 and Eu-anti-GST antibody were added to each well of the assay plate using a Multidrop reagent dispenser. The solut...More data for this Ligand-Target Pair
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Date in BDB:
3/14/2025
Entry Details
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LigandPNGBDBM704033(N-(8-Chloro-6-(4-methylpyridin-3-yl)cinnolin- 3-yl...)
Affinity DataKi: >1.00E+3nMAssay Description:For the binding assay, 4 μL 2×HPK1 and Eu-anti-GST antibody were added to each well of the assay plate using a Multidrop reagent dispenser. The solut...More data for this Ligand-Target Pair
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Date in BDB:
3/14/2025
Entry Details
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LigandPNGBDBM704009(6-(4-Ethylpyridin-3-yl)-N3-(tetrahydrofuran-3- yl)...)
Affinity DataKi:  2.60E+3nMAssay Description:For the binding assay, 4 μL 2×HPK1 and Eu-anti-GST antibody were added to each well of the assay plate using a Multidrop reagent dispenser. The solut...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/14/2025
Entry Details
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