Compile Data Set for Download or QSAR
Report error Found 12 Enz. Inhib. hit(s) with all data for entry = 12379
TargetGTPase KRas [G12D](Human)
Jiangsu Hengrui Pharmaceuticals

US Patent
LigandPNGBDBM699302(5-Ethyl-4-((5aS,6S,9R)-12-(((2R,7aS)-2- fluorotetr...)
Affinity DataKd:  0.400nMAssay Description:Biotinylated Avi-KRAS-WT or Avi-KRAS-G12D was diluted to 20 μg/mL with 1x HBS-P+(Cat. #BR1006-71) buffer containing 100 mM MgCl2, and then flowe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/3/2025
Entry Details
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TargetGTPase KRas(Human)
Jiangsu Hengrui Pharmaceuticals

US Patent
LigandPNGBDBM699302(5-Ethyl-4-((5aS,6S,9R)-12-(((2R,7aS)-2- fluorotetr...)
Affinity DataKd:  32.4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/3/2025
Entry Details
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TargetGTPase KRas [G12D](Human)
Jiangsu Hengrui Pharmaceuticals

US Patent
LigandPNGBDBM647778(US20240025919, Compound 5 | US20240327434, Compoun...)
Affinity DataKd:  0.140nMAssay Description:Biotinylated Avi-KRAS-WT or Avi-KRAS-G12D was diluted to 20 μg/mL with 1x HBS-P+(Cat. #BR1006-71) buffer containing 100 mM MgCl2, and then flowe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/3/2025
Entry Details
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TargetGTPase KRas(Human)
Jiangsu Hengrui Pharmaceuticals

US Patent
LigandPNGBDBM647778(US20240025919, Compound 5 | US20240327434, Compoun...)
Affinity DataKd:  3.40nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/3/2025
Entry Details
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TargetGTPase KRas [G12D](Human)
Jiangsu Hengrui Pharmaceuticals

US Patent
LigandPNGBDBM699304(3-Chloro-4-cyclopropyl-5-((5aS,6S,9R)-1-fluoro- 12...)
Affinity DataKd:  0.100nMAssay Description:Biotinylated Avi-KRAS-WT or Avi-KRAS-G12D was diluted to 20 μg/mL with 1x HBS-P+(Cat. #BR1006-71) buffer containing 100 mM MgCl2, and then flowe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/3/2025
Entry Details
Go to US Patent

TargetGTPase KRas(Human)
Jiangsu Hengrui Pharmaceuticals

US Patent
LigandPNGBDBM699304(3-Chloro-4-cyclopropyl-5-((5aS,6S,9R)-1-fluoro- 12...)
In Depth
Date in BDB:
2/3/2025
Entry Details
Go to US Patent

TargetGTPase KRas [G12D](Human)
Jiangsu Hengrui Pharmaceuticals

US Patent
LigandPNGBDBM629321(US20230339981, Example 1 | US20240327434, Compound...)
Affinity DataKd:  0.100nMAssay Description:Biotinylated Avi-KRAS-WT or Avi-KRAS-G12D was diluted to 20 μg/mL with 1x HBS-P+(Cat. #BR1006-71) buffer containing 100 mM MgCl2, and then flowe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/3/2025
Entry Details
Go to US Patent

TargetGTPase KRas(Human)
Jiangsu Hengrui Pharmaceuticals

US Patent
LigandPNGBDBM629321(US20230339981, Example 1 | US20240327434, Compound...)
Affinity DataKd:  3.80nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/3/2025
Entry Details
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TargetGTPase KRas [G12D](Human)
Jiangsu Hengrui Pharmaceuticals

US Patent
LigandPNGBDBM50628058(US20240327434, Compound 9-p1 | CHEMBL5439556)
Affinity DataKd:  0.0300nMAssay Description:Biotinylated Avi-KRAS-WT or Avi-KRAS-G12D was diluted to 20 μg/mL with 1x HBS-P+(Cat. #BR1006-71) buffer containing 100 mM MgCl2, and then flowe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/3/2025
Entry Details
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TargetGTPase KRas(Human)
Jiangsu Hengrui Pharmaceuticals

US Patent
LigandPNGBDBM50628058(US20240327434, Compound 9-p1 | CHEMBL5439556)
Affinity DataKd:  1.54nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/3/2025
Entry Details
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TargetGTPase KRas [G12D](Human)
Jiangsu Hengrui Pharmaceuticals

US Patent
LigandPNGBDBM699307(5-Ethyl-4-((5aR,6S,9R)-1-fluoro-12-(((2R,7aS)- 2-f...)
Affinity DataKd:  0.300nMAssay Description:Biotinylated Avi-KRAS-WT or Avi-KRAS-G12D was diluted to 20 μg/mL with 1x HBS-P+(Cat. #BR1006-71) buffer containing 100 mM MgCl2, and then flowe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/3/2025
Entry Details
Go to US Patent

TargetGTPase KRas(Human)
Jiangsu Hengrui Pharmaceuticals

US Patent
LigandPNGBDBM699307(5-Ethyl-4-((5aR,6S,9R)-1-fluoro-12-(((2R,7aS)- 2-f...)
Affinity DataKd:  7.60nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/3/2025
Entry Details
Go to US Patent