Compile Data Set for Download or QSAR
Report error Found 99 Enz. Inhib. hit(s) with all data for entry = 12277
LigandPNGBDBM50001765(Halcion | CHEMBL646 | 8-chloro-6-(2-chlorophenyl)-...)
Affinity DataKi:  1.5nMAssay Description:Radioligand binding assays were carried out in a volume of 200 μL (96-well plates) which contained 100 μL of cell membranes, [3H]RO7239181 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2024
Entry Details
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LigandPNGBDBM692584(US20240270744, Example 5 | (7S)-11-chloro-9-(2,6-d...)
Affinity DataKi:  1.70nMAssay Description:Radioligand binding assays were carried out in a volume of 200 μL (96-well plates) which contained 100 μL of cell membranes, [3H]RO7239181 ...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/3/2024
Entry Details
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LigandPNGBDBM692541(US20240270744, Example 1 | (7S)-11,12-dichloro-9-(...)
Affinity DataKi:  2.40nMAssay Description:Radioligand binding assays were carried out in a volume of 200 μL (96-well plates) which contained 100 μL of cell membranes, [3H]RO7239181 ...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/3/2024
Entry Details
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LigandPNGBDBM692587(US20240270744, Example 8 | [(7S)-11-chloro-9-(2,6-...)
Affinity DataKi:  2.5nMAssay Description:Radioligand binding assays were carried out in a volume of 200 μL (96-well plates) which contained 100 μL of cell membranes, [3H]RO7239181 ...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/3/2024
Entry Details
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LigandPNGBDBM692594(US20240270744, Example 15 | (7S)-11-chloro-9-(2,6-...)
Affinity DataKi:  2.60nMAssay Description:Radioligand binding assays were carried out in a volume of 200 μL (96-well plates) which contained 100 μL of cell membranes, [3H]RO7239181 ...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/3/2024
Entry Details
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LigandPNGBDBM692603(US20240270744, Example 24 | (7S)-11-chloro-9-(2,6-...)
Affinity DataKi:  2.80nMAssay Description:Radioligand binding assays were carried out in a volume of 200 μL (96-well plates) which contained 100 μL of cell membranes, [3H]RO7239181 ...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/3/2024
Entry Details
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LigandPNGBDBM692589(US20240270744, Example 10 | [(7S)-11-chloro-9-(2,6...)
Affinity DataKi:  3nMAssay Description:Radioligand binding assays were carried out in a volume of 200 μL (96-well plates) which contained 100 μL of cell membranes, [3H]RO7239181 ...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/3/2024
Entry Details
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LigandPNGBDBM692592(US20240270744, Example 13 | 1-[(7S)-11-chloro-9-(2...)
Affinity DataKi:  3.10nMAssay Description:Radioligand binding assays were carried out in a volume of 200 μL (96-well plates) which contained 100 μL of cell membranes, [3H]RO7239181 ...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/3/2024
Entry Details
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LigandPNGBDBM692586(US20240270744, Example 7 | [(7S)-11-chloro-9-(2,6-...)
Affinity DataKi:  3.5nMAssay Description:Radioligand binding assays were carried out in a volume of 200 μL (96-well plates) which contained 100 μL of cell membranes, [3H]RO7239181 ...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/3/2024
Entry Details
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LigandPNGBDBM692593(US20240270744, Example 14 | (7S)-11-chloro-9-(2,6-...)
Affinity DataKi:  3.70nMAssay Description:Radioligand binding assays were carried out in a volume of 200 μL (96-well plates) which contained 100 μL of cell membranes, [3H]RO7239181 ...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/3/2024
Entry Details
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LigandPNGBDBM692596(US20240270744, Example 17 | (7S)-11-chloro-9-(2-ch...)
Affinity DataKi:  3.80nMAssay Description:Radioligand binding assays were carried out in a volume of 200 μL (96-well plates) which contained 100 μL of cell membranes, [3H]RO7239181 ...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/3/2024
Entry Details
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LigandPNGBDBM692598(US20240270744, Example 19 | (7S)-11-chloro-9-(2,6-...)
Affinity DataKi:  3.80nMAssay Description:Radioligand binding assays were carried out in a volume of 200 μL (96-well plates) which contained 100 μL of cell membranes, [3H]RO7239181 ...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/3/2024
Entry Details
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LigandPNGBDBM692595(US20240270744, Example 16 | (7S)-11-chloro-9-(2,6-...)
Affinity DataKi:  4.10nMAssay Description:Radioligand binding assays were carried out in a volume of 200 μL (96-well plates) which contained 100 μL of cell membranes, [3H]RO7239181 ...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/3/2024
Entry Details
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LigandPNGBDBM692590(US20240270744, Example 11 | [(7S)-11-chloro-9-(2,6...)
Affinity DataKi:  4.60nMAssay Description:Radioligand binding assays were carried out in a volume of 200 μL (96-well plates) which contained 100 μL of cell membranes, [3H]RO7239181 ...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/3/2024
Entry Details
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LigandPNGBDBM692582(US20240270744, Example 3 | (7S)-11-chloro-9-(2,6-d...)
Affinity DataKi:  4.70nMAssay Description:Radioligand binding assays were carried out in a volume of 200 μL (96-well plates) which contained 100 μL of cell membranes, [3H]RO7239181 ...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/3/2024
Entry Details
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LigandPNGBDBM692583(US20240270744, Example 4 | (7S)-11-chloro-9-(2,6-d...)
Affinity DataKi:  4.90nMAssay Description:Radioligand binding assays were carried out in a volume of 200 μL (96-well plates) which contained 100 μL of cell membranes, [3H]RO7239181 ...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/3/2024
Entry Details
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LigandPNGBDBM692599(US20240270744, Example 20 | (10S)-6-chloro-8-(2,6-...)
Affinity DataKi:  4.90nMAssay Description:Radioligand binding assays were carried out in a volume of 200 μL (96-well plates) which contained 100 μL of cell membranes, [3H]RO7239181 ...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/3/2024
Entry Details
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LigandPNGBDBM21363(12-chloro-9-(2-fluorophenyl)-3-methyl-2,4,8-triaza...)
Affinity DataKi:  5nMAssay Description:Radioligand binding assays were carried out in a volume of 200 μL (96-well plates) which contained 100 μL of cell membranes, [3H]RO7239181 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2024
Entry Details
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LigandPNGBDBM692591(US20240270744, Example 12 | N-[(7S)-11-chloro-9-(2...)
Affinity DataKi:  5.20nMAssay Description:Radioligand binding assays were carried out in a volume of 200 μL (96-well plates) which contained 100 μL of cell membranes, [3H]RO7239181 ...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/3/2024
Entry Details
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LigandPNGBDBM692597(US20240270744, Example 18 | (7S)-11-chloro-9-(2,6-...)
Affinity DataKi:  5.90nMAssay Description:Radioligand binding assays were carried out in a volume of 200 μL (96-well plates) which contained 100 μL of cell membranes, [3H]RO7239181 ...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/3/2024
Entry Details
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LigandPNGBDBM692601(US20240270744, Example 22 | (7S)-11-chloro-9-(2,6-...)
Affinity DataKi:  6.40nMAssay Description:Radioligand binding assays were carried out in a volume of 200 μL (96-well plates) which contained 100 μL of cell membranes, [3H]RO7239181 ...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/3/2024
Entry Details
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LigandPNGBDBM692588(US20240270744, Example 9 | [(7S)-11-chloro-9-(2,6-...)
Affinity DataKi:  7.10nMAssay Description:Radioligand binding assays were carried out in a volume of 200 μL (96-well plates) which contained 100 μL of cell membranes, [3H]RO7239181 ...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/3/2024
Entry Details
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LigandPNGBDBM692590(US20240270744, Example 11 | [(7S)-11-chloro-9-(2,6...)
Affinity DataKi:  9.60nMAssay Description:Radioligand binding assays were carried out in a volume of 200 μL (96-well plates) which contained 100 μL of cell membranes, [3H]RO7239181 ...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/3/2024
Entry Details
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LigandPNGBDBM692602(US20240270744, Example 23 | (7S)-11-chloro-9-(2,6-...)
Affinity DataKi:  9.70nMAssay Description:Radioligand binding assays were carried out in a volume of 200 μL (96-well plates) which contained 100 μL of cell membranes, [3H]RO7239181 ...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/3/2024
Entry Details
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LigandPNGBDBM692600(US20240270744, Example 21 | (7S)-11-chloro-9-(2,6-...)
Affinity DataKi:  10.7nMAssay Description:Radioligand binding assays were carried out in a volume of 200 μL (96-well plates) which contained 100 μL of cell membranes, [3H]RO7239181 ...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/3/2024
Entry Details
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LigandPNGBDBM692585(US20240270744, Example 6 | azetidin-1-yl-[(7S)-11-...)
Affinity DataKi:  11.6nMAssay Description:Radioligand binding assays were carried out in a volume of 200 μL (96-well plates) which contained 100 μL of cell membranes, [3H]RO7239181 ...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/3/2024
Entry Details
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LigandPNGBDBM692599(US20240270744, Example 20 | (10S)-6-chloro-8-(2,6-...)
Affinity DataKi:  11.8nMAssay Description:Radioligand binding assays were carried out in a volume of 200 μL (96-well plates) which contained 100 μL of cell membranes, [3H]RO7239181 ...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/3/2024
Entry Details
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LigandPNGBDBM692581(US20240270744, Example 2 | (7S)-11-chloro-12-cyclo...)
Affinity DataKi:  12.6nMAssay Description:Radioligand binding assays were carried out in a volume of 200 μL (96-well plates) which contained 100 μL of cell membranes, [3H]RO7239181 ...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/3/2024
Entry Details
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LigandPNGBDBM692589(US20240270744, Example 10 | [(7S)-11-chloro-9-(2,6...)
Affinity DataKi:  14.3nMAssay Description:Radioligand binding assays were carried out in a volume of 200 μL (96-well plates) which contained 100 μL of cell membranes, [3H]RO7239181 ...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/3/2024
Entry Details
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LigandPNGBDBM692589(US20240270744, Example 10 | [(7S)-11-chloro-9-(2,6...)
Affinity DataKi:  14.3nMAssay Description:Radioligand binding assays were carried out in a volume of 200 μL (96-well plates) which contained 100 μL of cell membranes, [3H]RO7239181 ...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/3/2024
Entry Details
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LigandPNGBDBM692587(US20240270744, Example 8 | [(7S)-11-chloro-9-(2,6-...)
Affinity DataKi:  14.6nMAssay Description:Radioligand binding assays were carried out in a volume of 200 μL (96-well plates) which contained 100 μL of cell membranes, [3H]RO7239181 ...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/3/2024
Entry Details
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LigandPNGBDBM50001728(CHEMBL661 | 8-chloro-1-methyl-6-phenyl-4H-[1,2,4]t...)
Affinity DataKi:  19.6nMAssay Description:Radioligand binding assays were carried out in a volume of 200 μL (96-well plates) which contained 100 μL of cell membranes, [3H]RO7239181 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2024
Entry Details
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LigandPNGBDBM692588(US20240270744, Example 9 | [(7S)-11-chloro-9-(2,6-...)
Affinity DataKi:  19.9nMAssay Description:Radioligand binding assays were carried out in a volume of 200 μL (96-well plates) which contained 100 μL of cell membranes, [3H]RO7239181 ...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/3/2024
Entry Details
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LigandPNGBDBM692586(US20240270744, Example 7 | [(7S)-11-chloro-9-(2,6-...)
Affinity DataKi:  20.2nMAssay Description:Radioligand binding assays were carried out in a volume of 200 μL (96-well plates) which contained 100 μL of cell membranes, [3H]RO7239181 ...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/3/2024
Entry Details
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LigandPNGBDBM692598(US20240270744, Example 19 | (7S)-11-chloro-9-(2,6-...)
Affinity DataKi:  21.2nMAssay Description:Radioligand binding assays were carried out in a volume of 200 μL (96-well plates) which contained 100 μL of cell membranes, [3H]RO7239181 ...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/3/2024
Entry Details
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LigandPNGBDBM692596(US20240270744, Example 17 | (7S)-11-chloro-9-(2-ch...)
Affinity DataKi:  22.6nMAssay Description:Radioligand binding assays were carried out in a volume of 200 μL (96-well plates) which contained 100 μL of cell membranes, [3H]RO7239181 ...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/3/2024
Entry Details
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LigandPNGBDBM692541(US20240270744, Example 1 | (7S)-11,12-dichloro-9-(...)
Affinity DataKi:  31.7nMAssay Description:Radioligand binding assays were carried out in a volume of 200 μL (96-well plates) which contained 100 μL of cell membranes, [3H]RO7239181 ...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/3/2024
Entry Details
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LigandPNGBDBM692592(US20240270744, Example 13 | 1-[(7S)-11-chloro-9-(2...)
Affinity DataKi:  32nMAssay Description:Radioligand binding assays were carried out in a volume of 200 μL (96-well plates) which contained 100 μL of cell membranes, [3H]RO7239181 ...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/3/2024
Entry Details
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LigandPNGBDBM692596(US20240270744, Example 17 | (7S)-11-chloro-9-(2-ch...)
Affinity DataKi:  34.4nMAssay Description:Radioligand binding assays were carried out in a volume of 200 μL (96-well plates) which contained 100 μL of cell membranes, [3H]RO7239181 ...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/3/2024
Entry Details
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LigandPNGBDBM692594(US20240270744, Example 15 | (7S)-11-chloro-9-(2,6-...)
Affinity DataKi:  34.5nMAssay Description:Radioligand binding assays were carried out in a volume of 200 μL (96-well plates) which contained 100 μL of cell membranes, [3H]RO7239181 ...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/3/2024
Entry Details
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LigandPNGBDBM692595(US20240270744, Example 16 | (7S)-11-chloro-9-(2,6-...)
Affinity DataKi:  39.8nMAssay Description:Radioligand binding assays were carried out in a volume of 200 μL (96-well plates) which contained 100 μL of cell membranes, [3H]RO7239181 ...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/3/2024
Entry Details
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LigandPNGBDBM692584(US20240270744, Example 5 | (7S)-11-chloro-9-(2,6-d...)
Affinity DataKi:  40nMAssay Description:Radioligand binding assays were carried out in a volume of 200 μL (96-well plates) which contained 100 μL of cell membranes, [3H]RO7239181 ...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/3/2024
Entry Details
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LigandPNGBDBM692601(US20240270744, Example 22 | (7S)-11-chloro-9-(2,6-...)
Affinity DataKi:  43.2nMAssay Description:Radioligand binding assays were carried out in a volume of 200 μL (96-well plates) which contained 100 μL of cell membranes, [3H]RO7239181 ...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/3/2024
Entry Details
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LigandPNGBDBM50001765(Halcion | CHEMBL646 | 8-chloro-6-(2-chlorophenyl)-...)
Affinity DataKi:  44.2nMAssay Description:Radioligand binding assays were carried out in a volume of 200 μL (96-well plates) which contained 100 μL of cell membranes, [3H]RO7239181 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2024
Entry Details
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LigandPNGBDBM692585(US20240270744, Example 6 | azetidin-1-yl-[(7S)-11-...)
Affinity DataKi:  45.2nMAssay Description:Radioligand binding assays were carried out in a volume of 200 μL (96-well plates) which contained 100 μL of cell membranes, [3H]RO7239181 ...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/3/2024
Entry Details
Go to US Patent

LigandPNGBDBM692588(US20240270744, Example 9 | [(7S)-11-chloro-9-(2,6-...)
Affinity DataKi:  45.8nMAssay Description:Radioligand binding assays were carried out in a volume of 200 μL (96-well plates) which contained 100 μL of cell membranes, [3H]RO7239181 ...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/3/2024
Entry Details
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LigandPNGBDBM692590(US20240270744, Example 11 | [(7S)-11-chloro-9-(2,6...)
Affinity DataKi:  45.8nMAssay Description:Radioligand binding assays were carried out in a volume of 200 μL (96-well plates) which contained 100 μL of cell membranes, [3H]RO7239181 ...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/3/2024
Entry Details
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LigandPNGBDBM692593(US20240270744, Example 14 | (7S)-11-chloro-9-(2,6-...)
Affinity DataKi:  46nMAssay Description:Radioligand binding assays were carried out in a volume of 200 μL (96-well plates) which contained 100 μL of cell membranes, [3H]RO7239181 ...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/3/2024
Entry Details
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LigandPNGBDBM50001765(Halcion | CHEMBL646 | 8-chloro-6-(2-chlorophenyl)-...)
Affinity DataKi:  46.2nMAssay Description:Radioligand binding assays were carried out in a volume of 200 μL (96-well plates) which contained 100 μL of cell membranes, [3H]RO7239181 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2024
Entry Details
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LigandPNGBDBM692587(US20240270744, Example 8 | [(7S)-11-chloro-9-(2,6-...)
Affinity DataKi:  48.8nMAssay Description:Radioligand binding assays were carried out in a volume of 200 μL (96-well plates) which contained 100 μL of cell membranes, [3H]RO7239181 ...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/3/2024
Entry Details
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