Compile Data Set for Download or QSAR
Report error Found 24 Enz. Inhib. hit(s) with all data for entry = 12071
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Janssen Biotech, Inc.

US Patent
LigandPNGBDBM674344(US20240166622, Example 7 | (S*)-1-(2-(2-Chloro-6-f...)
Affinity DataIC50: 0.256nMAssay Description:To detect DHODH enzyme activities, dichloroindophenol (DCIP) is added as the final electron acceptor in the assay. DCIP can accept electrons from the...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2024
Entry Details
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TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Janssen Biotech, Inc.

US Patent
LigandPNGBDBM674349(US20240166622, Example 11 | 7-(4-Ethyl-3-(hydroxym...)
Affinity DataIC50: 0.303nMAssay Description:To detect DHODH enzyme activities, dichloroindophenol (DCIP) is added as the final electron acceptor in the assay. DCIP can accept electrons from the...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2024
Entry Details
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TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Janssen Biotech, Inc.

US Patent
LigandPNGBDBM674343(US20240166622, Example 6 | 1-(2-(2-Chloro-6-fluoro...)
Affinity DataIC50: 0.504nMAssay Description:To detect DHODH enzyme activities, dichloroindophenol (DCIP) is added as the final electron acceptor in the assay. DCIP can accept electrons from the...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2024
Entry Details
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TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Janssen Biotech, Inc.

US Patent
LigandPNGBDBM676203(US20240166622, Example 20 | Racemic 4-Ethyl-2-(6-f...)
Affinity DataIC50: 0.607nMAssay Description:To detect DHODH enzyme activities, dichloroindophenol (DCIP) is added as the final electron acceptor in the assay. DCIP can accept electrons from the...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2024
Entry Details
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TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Janssen Biotech, Inc.

US Patent
LigandPNGBDBM676164(US20240166622, Example 16 | 4-Ethyl-2-((3R*,4R*)-6...)
Affinity DataIC50: 2.24nMAssay Description:To detect DHODH enzyme activities, dichloroindophenol (DCIP) is added as the final electron acceptor in the assay. DCIP can accept electrons from the...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2024
Entry Details
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TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Janssen Biotech, Inc.

US Patent
LigandPNGBDBM674341(US20240166622, Example 4 | 2-(2-(2-Chloro-6-fluoro...)
Affinity DataIC50: 2.42nMAssay Description:To detect DHODH enzyme activities, dichloroindophenol (DCIP) is added as the final electron acceptor in the assay. DCIP can accept electrons from the...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2024
Entry Details
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TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Janssen Biotech, Inc.

US Patent
LigandPNGBDBM676204(US20240166622, Example 21 | 4-Ethyl-2-(6-fluoro-1-...)
Affinity DataIC50: 3.71nMAssay Description:To detect DHODH enzyme activities, dichloroindophenol (DCIP) is added as the final electron acceptor in the assay. DCIP can accept electrons from the...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2024
Entry Details
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TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Janssen Biotech, Inc.

US Patent
LigandPNGBDBM674345(US20240166622, Example 8 | (R*)-1-(2-(2-Chloro-6-f...)
Affinity DataIC50: 5.5nMAssay Description:To detect DHODH enzyme activities, dichloroindophenol (DCIP) is added as the final electron acceptor in the assay. DCIP can accept electrons from the...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2024
Entry Details
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TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Janssen Biotech, Inc.

US Patent
LigandPNGBDBM674374(US20240166622, Example 14 | Racemic 4-Ethyl-2-(6-f...)
Affinity DataIC50: 5.62nMAssay Description:To detect DHODH enzyme activities, dichloroindophenol (DCIP) is added as the final electron acceptor in the assay. DCIP can accept electrons from the...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2024
Entry Details
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TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Janssen Biotech, Inc.

US Patent
LigandPNGBDBM676201(US20240166622, Example 18 | 4-Ethyl-2-((3R*,4S*)-6...)
Affinity DataIC50: 6.91nMAssay Description:To detect DHODH enzyme activities, dichloroindophenol (DCIP) is added as the final electron acceptor in the assay. DCIP can accept electrons from the...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2024
Entry Details
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TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Janssen Biotech, Inc.

US Patent
LigandPNGBDBM676202(US20240166622, Example 19 | Racemic 7-(4-Ethyl-3-(...)
Affinity DataIC50: 7.06nMAssay Description:To detect DHODH enzyme activities, dichloroindophenol (DCIP) is added as the final electron acceptor in the assay. DCIP can accept electrons from the...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2024
Entry Details
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TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Janssen Biotech, Inc.

US Patent
LigandPNGBDBM674347(US20240166622, Example 10 | 7-(4-Ethyl-3-(hydroxym...)
Affinity DataIC50: 7.59nMAssay Description:To detect DHODH enzyme activities, dichloroindophenol (DCIP) is added as the final electron acceptor in the assay. DCIP can accept electrons from the...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2024
Entry Details
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PDB3D3D Structure (crystal)
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Janssen Biotech, Inc.

US Patent
LigandPNGBDBM676128(US20240166622, Example 15 | 4-Ethyl-2-((3S*,4S*)-6...)
Affinity DataIC50: 7.90nMAssay Description:To detect DHODH enzyme activities, dichloroindophenol (DCIP) is added as the final electron acceptor in the assay. DCIP can accept electrons from the...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2024
Entry Details
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TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Janssen Biotech, Inc.

US Patent
LigandPNGBDBM674350(US20240166622, Example 12 | 3-(2-Chloro-6-fluoroph...)
Affinity DataIC50: 20nMAssay Description:To detect DHODH enzyme activities, dichloroindophenol (DCIP) is added as the final electron acceptor in the assay. DCIP can accept electrons from the...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2024
Entry Details
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TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Janssen Biotech, Inc.

US Patent
LigandPNGBDBM674342(US20240166622, Example 5 | 2-(2-Chloro-6-fluorophe...)
Affinity DataIC50: 42.3nMAssay Description:To detect DHODH enzyme activities, dichloroindophenol (DCIP) is added as the final electron acceptor in the assay. DCIP can accept electrons from the...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2024
Entry Details
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TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Janssen Biotech, Inc.

US Patent
LigandPNGBDBM676206(US20240166622, Example 23 | 4-Ethyl-2-((2R*,4S*)-7...)
Affinity DataIC50: 49.2nMAssay Description:To detect DHODH enzyme activities, dichloroindophenol (DCIP) is added as the final electron acceptor in the assay. DCIP can accept electrons from the...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2024
Entry Details
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TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Janssen Biotech, Inc.

US Patent
LigandPNGBDBM674372(US20240166622, Example 13 | Racemic 4-Ethyl-2-(7-f...)
Affinity DataIC50: 51.7nMAssay Description:To detect DHODH enzyme activities, dichloroindophenol (DCIP) is added as the final electron acceptor in the assay. DCIP can accept electrons from the...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2024
Entry Details
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TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Janssen Biotech, Inc.

US Patent
LigandPNGBDBM674346(US20240166622, Example 9 | 7-(4-Ethyl-3-(hydroxyme...)
Affinity DataIC50: 58.2nMAssay Description:To detect DHODH enzyme activities, dichloroindophenol (DCIP) is added as the final electron acceptor in the assay. DCIP can accept electrons from the...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2024
Entry Details
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TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Janssen Biotech, Inc.

US Patent
LigandPNGBDBM676205(US20240166622, Example 22 | 4-Ethyl-2-((2R*,4S*)-7...)
Affinity DataIC50: 113nMAssay Description:To detect DHODH enzyme activities, dichloroindophenol (DCIP) is added as the final electron acceptor in the assay. DCIP can accept electrons from the...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2024
Entry Details
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TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Janssen Biotech, Inc.

US Patent
LigandPNGBDBM676196(US20240166622, Example 17 | 4-Ethyl-2-((3S*,4R*)-6...)
Affinity DataIC50: 173nMAssay Description:To detect DHODH enzyme activities, dichloroindophenol (DCIP) is added as the final electron acceptor in the assay. DCIP can accept electrons from the...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2024
Entry Details
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TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Janssen Biotech, Inc.

US Patent
LigandPNGBDBM674340(US20240166622, Example 3 | 3-(2-Chloro-6-fluorophe...)
Affinity DataIC50: 293nMAssay Description:To detect DHODH enzyme activities, dichloroindophenol (DCIP) is added as the final electron acceptor in the assay. DCIP can accept electrons from the...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2024
Entry Details
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TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Janssen Biotech, Inc.

US Patent
LigandPNGBDBM674337(US20240166622, Example 1 | 7-(4-Ethyl-3-(hydroxyme...)
Affinity DataIC50: 528nMAssay Description:To detect DHODH enzyme activities, dichloroindophenol (DCIP) is added as the final electron acceptor in the assay. DCIP can accept electrons from the...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2024
Entry Details
Go to US Patent

TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Janssen Biotech, Inc.

US Patent
LigandPNGBDBM674339(US20240166622, Example 2 | 7-(4-Ethyl-3-(hydroxyme...)
Affinity DataIC50: 588nMAssay Description:To detect DHODH enzyme activities, dichloroindophenol (DCIP) is added as the final electron acceptor in the assay. DCIP can accept electrons from the...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2024
Entry Details
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TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Janssen Biotech, Inc.

US Patent
LigandPNGBDBM676207(US20240166622, Example 24 | 1-(1-Acetyl-7-fluoro-4...)
Affinity DataIC50: 5.53E+3nMAssay Description:To detect DHODH enzyme activities, dichloroindophenol (DCIP) is added as the final electron acceptor in the assay. DCIP can accept electrons from the...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2024
Entry Details
Go to US Patent