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Report error Found 32 Enz. Inhib. hit(s) with all data for entry = 11985
TargetD(2) dopamine receptor(Human)
Shanghaitech University

US Patent
LigandPNGBDBM668316(US20240124456, Compound I-8 | 7-(3-(4,6,6a,7,9,10-...)
Affinity DataKi:  0.490nMAssay Description:The affinity of the compounds of the present invention for the dopamine D2 receptors was determined by the method of radioligand competition experime...More data for this Ligand-Target Pair
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Date in BDB:
7/9/2024
Entry Details
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TargetD(2) dopamine receptor(Human)
Shanghaitech University

US Patent
LigandPNGBDBM668310(US20240124456, Compound (-)-I-2)
Affinity DataKi:  1.75nMAssay Description:The affinity of the compounds of the present invention for the dopamine D2 receptors was determined by the method of radioligand competition experime...More data for this Ligand-Target Pair
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Date in BDB:
7/9/2024
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TargetD(2) dopamine receptor(Human)
Shanghaitech University

US Patent
LigandPNGBDBM50130293(7-{4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butoxy}...)
Affinity DataKi:  5.95nMAssay Description:The affinity of the compounds of the present invention for the dopamine D2 receptors was determined by the method of radioligand competition experime...More data for this Ligand-Target Pair
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Date in BDB:
7/9/2024
Entry Details
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TargetD(2) dopamine receptor(Human)
Shanghaitech University

US Patent
LigandPNGBDBM668309(US20240124456, Compound (+)-I-2)
Affinity DataKi:  8.87nMAssay Description:The affinity of the compounds of the present invention for the dopamine D2 receptors was determined by the method of radioligand competition experime...More data for this Ligand-Target Pair
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Date in BDB:
7/9/2024
Entry Details
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TargetD(2) dopamine receptor(Human)
Shanghaitech University

US Patent
LigandPNGBDBM668308(US20240124456, Compound I-2 | 7-(4(4,6,6a,7,9,10-h...)
Affinity DataKi:  9.03nMAssay Description:The affinity of the compounds of the present invention for the dopamine D2 receptors was determined by the method of radioligand competition experime...More data for this Ligand-Target Pair
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Date in BDB:
7/9/2024
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TargetD(2) dopamine receptor(Human)
Shanghaitech University

US Patent
LigandPNGBDBM668335(US20240124456, Compound I-25 | 1-(4-fluorobenzene)...)
Affinity DataKi:  10.8nMAssay Description:The affinity of the compounds of the present invention for the dopamine D2 receptors was determined by the method of radioligand competition experime...More data for this Ligand-Target Pair
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Date in BDB:
7/9/2024
Entry Details
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TargetD(2) dopamine receptor(Human)
Shanghaitech University

US Patent
LigandPNGBDBM668323(US20240124456, Compound I-13 | N-(4-(2-(4,6,6a,7,9...)
Affinity DataKi:  16.3nMAssay Description:The affinity of the compounds of the present invention for the dopamine D2 receptors was determined by the method of radioligand competition experime...More data for this Ligand-Target Pair
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Date in BDB:
7/9/2024
Entry Details
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TargetD(2) dopamine receptor(Human)
Shanghaitech University

US Patent
LigandPNGBDBM668321(US20240124456, Compound I-11 | N-(4-(2-(4,6,6a,7,9...)
Affinity DataKi:  22.2nMAssay Description:The affinity of the compounds of the present invention for the dopamine D2 receptors was determined by the method of radioligand competition experime...More data for this Ligand-Target Pair
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Date in BDB:
7/9/2024
Entry Details
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TargetD(2) dopamine receptor(Human)
Shanghaitech University

US Patent
LigandPNGBDBM668319(US20240124456, Compound (-)-I-10)
Affinity DataKi:  22.4nMAssay Description:The affinity of the compounds of the present invention for the dopamine D2 receptors was determined by the method of radioligand competition experime...More data for this Ligand-Target Pair
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Date in BDB:
7/9/2024
Entry Details
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TargetD(2) dopamine receptor(Human)
Shanghaitech University

US Patent
LigandPNGBDBM668322(US20240124456, Compound I-12 | N-(4-(2-(4,6,6a,7,9...)
Affinity DataKi:  27.1nMAssay Description:The affinity of the compounds of the present invention for the dopamine D2 receptors was determined by the method of radioligand competition experime...More data for this Ligand-Target Pair
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Date in BDB:
7/9/2024
Entry Details
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TargetD(2) dopamine receptor(Human)
Shanghaitech University

US Patent
LigandPNGBDBM668312(US20240124456, Compound I-4 | 5-(4-(4,6,6a,7,9,10-...)
Affinity DataKi:  30.3nMAssay Description:The affinity of the compounds of the present invention for the dopamine D2 receptors was determined by the method of radioligand competition experime...More data for this Ligand-Target Pair
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Date in BDB:
7/9/2024
Entry Details
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TargetD(2) dopamine receptor(Human)
Shanghaitech University

US Patent
LigandPNGBDBM668334(US20240124456, Compound I-24 | 1-(4-fluorobenzene)...)
Affinity DataKi:  32.4nMAssay Description:The affinity of the compounds of the present invention for the dopamine D2 receptors was determined by the method of radioligand competition experime...More data for this Ligand-Target Pair
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Date in BDB:
7/9/2024
Entry Details
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TargetD(2) dopamine receptor(Human)
Shanghaitech University

US Patent
LigandPNGBDBM668331(US20240124456, Compound I-21 | (E)-74(4-(4,6,6a,7,...)
Affinity DataKi:  33.2nMAssay Description:The affinity of the compounds of the present invention for the dopamine D2 receptors was determined by the method of radioligand competition experime...More data for this Ligand-Target Pair
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Date in BDB:
7/9/2024
Entry Details
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TargetD(2) dopamine receptor(Human)
Shanghaitech University

US Patent
LigandPNGBDBM668307(US20240124456, Compound I-1 | 7-(4(4,6,6a,7,9,10-h...)
Affinity DataKi:  33.6nMAssay Description:The affinity of the compounds of the present invention for the dopamine D2 receptors was determined by the method of radioligand competition experime...More data for this Ligand-Target Pair
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Date in BDB:
7/9/2024
Entry Details
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TargetD(2) dopamine receptor(Human)
Shanghaitech University

US Patent
LigandPNGBDBM668313(US20240124456, Compound I-5 | 6-(4-(4,6,6a,7,9,10-...)
Affinity DataKi:  37.1nMAssay Description:The affinity of the compounds of the present invention for the dopamine D2 receptors was determined by the method of radioligand competition experime...More data for this Ligand-Target Pair
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Date in BDB:
7/9/2024
Entry Details
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TargetD(2) dopamine receptor(Human)
Shanghaitech University

US Patent
LigandPNGBDBM668324(US20240124456, Compound I-14 | N-(4-(2-(4,6,6a,7,9...)
Affinity DataKi:  40.7nMAssay Description:The affinity of the compounds of the present invention for the dopamine D2 receptors was determined by the method of radioligand competition experime...More data for this Ligand-Target Pair
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Date in BDB:
7/9/2024
Entry Details
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TargetD(2) dopamine receptor(Human)
Shanghaitech University

US Patent
LigandPNGBDBM668311(US20240124456, Compound I-3 | 5-(4-(4,6,6a,7,9,10-...)
Affinity DataKi:  49.6nMAssay Description:The affinity of the compounds of the present invention for the dopamine D2 receptors was determined by the method of radioligand competition experime...More data for this Ligand-Target Pair
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Date in BDB:
7/9/2024
Entry Details
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TargetD(2) dopamine receptor(Human)
Shanghaitech University

US Patent
LigandPNGBDBM668318(US20240124456, Compound I-10 | 3-(4-(2-(4,6,6a,7,9...)
Affinity DataKi:  50.6nMAssay Description:The affinity of the compounds of the present invention for the dopamine D2 receptors was determined by the method of radioligand competition experime...More data for this Ligand-Target Pair
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Date in BDB:
7/9/2024
Entry Details
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TargetD(2) dopamine receptor(Human)
Shanghaitech University

US Patent
LigandPNGBDBM668314(US20240124456, Compound I-6)
Affinity DataKi:  51.6nMAssay Description:The affinity of the compounds of the present invention for the dopamine D2 receptors was determined by the method of radioligand competition experime...More data for this Ligand-Target Pair
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Date in BDB:
7/9/2024
Entry Details
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TargetD(2) dopamine receptor(Human)
Shanghaitech University

US Patent
LigandPNGBDBM668329(US20240124456, Compound I-19 | 1,1-dimethyl-3-(4-(...)
Affinity DataKi:  52.7nMAssay Description:The affinity of the compounds of the present invention for the dopamine D2 receptors was determined by the method of radioligand competition experime...More data for this Ligand-Target Pair
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Date in BDB:
7/9/2024
Entry Details
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TargetD(2) dopamine receptor(Human)
Shanghaitech University

US Patent
LigandPNGBDBM668327(US20240124456, Compound I-17 | 3-(2-(4,6,6a,7,9,10...)
Affinity DataKi:  55.8nMAssay Description:The affinity of the compounds of the present invention for the dopamine D2 receptors was determined by the method of radioligand competition experime...More data for this Ligand-Target Pair
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Date in BDB:
7/9/2024
Entry Details
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TargetD(2) dopamine receptor(Human)
Shanghaitech University

US Patent
LigandPNGBDBM668328(US20240124456, Compound I-18 | 7-(4-(4-methyl-4,6,...)
Affinity DataKi:  61nMAssay Description:The affinity of the compounds of the present invention for the dopamine D2 receptors was determined by the method of radioligand competition experime...More data for this Ligand-Target Pair
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Date in BDB:
7/9/2024
Entry Details
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TargetD(2) dopamine receptor(Human)
Shanghaitech University

US Patent
LigandPNGBDBM668330(US20240124456, Compound I-20 | (E)-7-(4-(4,6,6a,7,...)
Affinity DataKi:  70.9nMAssay Description:The affinity of the compounds of the present invention for the dopamine D2 receptors was determined by the method of radioligand competition experime...More data for this Ligand-Target Pair
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Date in BDB:
7/9/2024
Entry Details
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TargetD(2) dopamine receptor(Human)
Shanghaitech University

US Patent
LigandPNGBDBM668325(US20240124456, Compound I-15 | N-(4-(2-(4,6,6a,7,9...)
Affinity DataKi:  77.5nMAssay Description:The affinity of the compounds of the present invention for the dopamine D2 receptors was determined by the method of radioligand competition experime...More data for this Ligand-Target Pair
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Date in BDB:
7/9/2024
Entry Details
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TargetD(2) dopamine receptor(Human)
Shanghaitech University

US Patent
LigandPNGBDBM668333(US20240124456, Compound I-23 | (E)-7-((4-(4-methyl...)
Affinity DataKi:  100nMAssay Description:The affinity of the compounds of the present invention for the dopamine D2 receptors was determined by the method of radioligand competition experime...More data for this Ligand-Target Pair
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Date in BDB:
7/9/2024
Entry Details
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TargetD(2) dopamine receptor(Human)
Shanghaitech University

US Patent
LigandPNGBDBM668332(US20240124456, Compound I-22 | (E)-7-((4-(4-methyl...)
Affinity DataKi:  176nMAssay Description:The affinity of the compounds of the present invention for the dopamine D2 receptors was determined by the method of radioligand competition experime...More data for this Ligand-Target Pair
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Date in BDB:
7/9/2024
Entry Details
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TargetD(2) dopamine receptor(Human)
Shanghaitech University

US Patent
LigandPNGBDBM668337(US20240124456, Compound I-27 | 1-(4-fluorobenzene)...)
Affinity DataKi:  383nMAssay Description:The affinity of the compounds of the present invention for the dopamine D2 receptors was determined by the method of radioligand competition experime...More data for this Ligand-Target Pair
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Date in BDB:
7/9/2024
Entry Details
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TargetD(2) dopamine receptor(Human)
Shanghaitech University

US Patent
LigandPNGBDBM668315(US20240124456, Compound I-7 | 7-(3-(4,6,6a,7,9,10-...)
Affinity DataKi:  403nMAssay Description:The affinity of the compounds of the present invention for the dopamine D2 receptors was determined by the method of radioligand competition experime...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/9/2024
Entry Details
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TargetD(2) dopamine receptor(Human)
Shanghaitech University

US Patent
LigandPNGBDBM668317(US20240124456, Compound I-9 | 8-(3-(benzo[d][1,3]d...)
Affinity DataKi:  752nMAssay Description:The affinity of the compounds of the present invention for the dopamine D2 receptors was determined by the method of radioligand competition experime...More data for this Ligand-Target Pair
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Date in BDB:
7/9/2024
Entry Details
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TargetD(2) dopamine receptor(Human)
Shanghaitech University

US Patent
LigandPNGBDBM668320(US20240124456, Compound (+)-I-10)
Affinity DataKi:  1.14E+3nMAssay Description:The affinity of the compounds of the present invention for the dopamine D2 receptors was determined by the method of radioligand competition experime...More data for this Ligand-Target Pair
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Date in BDB:
7/9/2024
Entry Details
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TargetD(2) dopamine receptor(Human)
Shanghaitech University

US Patent
LigandPNGBDBM668336(US20240124456, Compound I-26 | 1-(4-fluorobenzene)...)
Affinity DataKi:  1.35E+3nMAssay Description:The affinity of the compounds of the present invention for the dopamine D2 receptors was determined by the method of radioligand competition experime...More data for this Ligand-Target Pair
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Date in BDB:
7/9/2024
Entry Details
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TargetD(2) dopamine receptor(Human)
Shanghaitech University

US Patent
LigandPNGBDBM668326(US20240124456, Compound I-16 | 3-(4-04,6,6a,7,9,10...)
Affinity DataKi:  1.99E+3nMAssay Description:The affinity of the compounds of the present invention for the dopamine D2 receptors was determined by the method of radioligand competition experime...More data for this Ligand-Target Pair
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Date in BDB:
7/9/2024
Entry Details
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