Compile Data Set for Download or QSAR
Report error Found 25 Enz. Inhib. hit(s) with all data for entry = 11953
TargetDipeptidyl peptidase 4(Human)
THE SCRIPPS RESEARCH INSTITUTE

US Patent
LigandPNGBDBM50228403(8-[(3R)-3-Aminopiperidin-1-yl]-7-but-2-yn-1-yl-3-m...)
Affinity DataIC50: 0.200nMAssay Description:Human DPP4 activity assay data were obtained using a DPP4 Activity Assay Kit (Sigma-Aldrich, MAK088) according to the manufacturer's instructions...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/29/2024
Entry Details
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TargetDipeptidyl peptidase 4(Human)
THE SCRIPPS RESEARCH INSTITUTE

US Patent
LigandPNGBDBM50344779((R)-4-((R)-3-amino-4-(2,4,5-trifluorophenyl)butano...)
Affinity DataIC50: 0.300nMAssay Description:Human DPP4 activity assay data were obtained using a DPP4 Activity Assay Kit (Sigma-Aldrich, MAK088) according to the manufacturer's instructions...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/29/2024
Entry Details
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PDB3D3D Structure (crystal)
TargetDipeptidyl peptidase 4(Human)
THE SCRIPPS RESEARCH INSTITUTE

US Patent
LigandPNGBDBM664705(methyl (R)-7-(3-amino-4-(2,4,5- trifluorophenyl)bu...)
Affinity DataIC50: 0.600nMAssay Description:Human DPP4 activity assay data were obtained using a DPP4 Activity Assay Kit (Sigma-Aldrich, MAK088) according to the manufacturer's instructions...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/29/2024
Entry Details
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TargetDipeptidyl peptidase 4(Human)
THE SCRIPPS RESEARCH INSTITUTE

US Patent
LigandPNGBDBM50335784(2-[6-(3-Aminopiperidin-1-yl)-3-methyl-2,4-dioxo-3,...)
Affinity DataIC50: 0.700nMAssay Description:Human DPP4 activity assay data were obtained using a DPP4 Activity Assay Kit (Sigma-Aldrich, MAK088) according to the manufacturer's instructions...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/29/2024
Entry Details
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PDB3D3D Structure (crystal)
TargetDipeptidyl peptidase 4(Human)
THE SCRIPPS RESEARCH INSTITUTE

US Patent
LigandPNGBDBM664724((R)-7-(3-amino-4-(2,4,5-trifluorophenyl)butanoyl)-...)
Affinity DataIC50: 0.800nMAssay Description:Human DPP4 activity assay data were obtained using a DPP4 Activity Assay Kit (Sigma-Aldrich, MAK088) according to the manufacturer's instructions...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/29/2024
Entry Details
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TargetDipeptidyl peptidase 4(Human)
THE SCRIPPS RESEARCH INSTITUTE

US Patent
LigandPNGBDBM50003020(MK-3102 | OMARIGLIPTIN | US10155775, Omarigliptin ...)
Affinity DataIC50: 0.800nMAssay Description:Human DPP4 activity assay data were obtained using a DPP4 Activity Assay Kit (Sigma-Aldrich, MAK088) according to the manufacturer's instructions...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/29/2024
Entry Details
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TargetDipeptidyl peptidase 4(Human)
THE SCRIPPS RESEARCH INSTITUTE

US Patent
LigandPNGBDBM50391565(CHEMBL2147777 | US20240115577, Compound 8)
Affinity DataIC50: 0.800nMAssay Description:Human DPP4 activity assay data were obtained using a DPP4 Activity Assay Kit (Sigma-Aldrich, MAK088) according to the manufacturer's instructions...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/29/2024
Entry Details
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TargetDipeptidyl peptidase 4(Human)
THE SCRIPPS RESEARCH INSTITUTE

US Patent
LigandPNGBDBM16285(2-({6-[(3R)-3-aminopiperidin-1-yl]-3-methyl-2,4-di...)
Affinity DataIC50: 0.900nMAssay Description:Human DPP4 activity assay data were obtained using a DPP4 Activity Assay Kit (Sigma-Aldrich, MAK088) according to the manufacturer's instructions...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/29/2024
Entry Details
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TargetDipeptidyl peptidase 4(Human)
THE SCRIPPS RESEARCH INSTITUTE

US Patent
LigandPNGBDBM664715(methyl 4-((2-((2S,4S)-2-cyano-4-fluoropyrrolidin-1...)
Affinity DataIC50: 1nMAssay Description:Human DPP4 activity assay data were obtained using a DPP4 Activity Assay Kit (Sigma-Aldrich, MAK088) according to the manufacturer's instructions...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/29/2024
Entry Details
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TargetDipeptidyl peptidase 4(Human)
THE SCRIPPS RESEARCH INSTITUTE

US Patent
LigandPNGBDBM664714(4-((2-((2S,4S)-2-cyano-4-fluoropyrrolidin-1-yl)-2-...)
Affinity DataIC50: 1.20nMAssay Description:Human DPP4 activity assay data were obtained using a DPP4 Activity Assay Kit (Sigma-Aldrich, MAK088) according to the manufacturer's instructions...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/29/2024
Entry Details
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TargetDipeptidyl peptidase 4(Human)
THE SCRIPPS RESEARCH INSTITUTE

US Patent
LigandPNGBDBM664701(ethyl 4-((2-((2S,4S)-2-cyano-4-fluoropyrrolidin-1-...)
Affinity DataIC50: 2.20nMAssay Description:Human DPP4 activity assay data were obtained using a DPP4 Activity Assay Kit (Sigma-Aldrich, MAK088) according to the manufacturer's instructions...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/29/2024
Entry Details
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TargetDipeptidyl peptidase 4(Human)
THE SCRIPPS RESEARCH INSTITUTE

US Patent
LigandPNGBDBM50516918(CHEMBL4446618 | US20240115577, Compound 22)
Affinity DataIC50: 3nMAssay Description:Human DPP4 activity assay data were obtained using a DPP4 Activity Assay Kit (Sigma-Aldrich, MAK088) according to the manufacturer's instructions...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/29/2024
Entry Details
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TargetDipeptidyl peptidase 4(Human)
THE SCRIPPS RESEARCH INSTITUTE

US Patent
LigandPNGBDBM50440470(CHEMBL2425883 | US20240115577, Compound 24)
Affinity DataIC50: 3nMAssay Description:Human DPP4 activity assay data were obtained using a DPP4 Activity Assay Kit (Sigma-Aldrich, MAK088) according to the manufacturer's instructions...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/29/2024
Entry Details
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TargetDipeptidyl peptidase 4(Human)
THE SCRIPPS RESEARCH INSTITUTE

US Patent
LigandPNGBDBM50249549(cis-((2S,4S)-4-(4-(pyrimidin-2-yl)piperazin-1-yl)p...)
Affinity DataIC50: 3.30nMAssay Description:Human DPP4 activity assay data were obtained using a DPP4 Activity Assay Kit (Sigma-Aldrich, MAK088) according to the manufacturer's instructions...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/29/2024
Entry Details
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TargetDipeptidyl peptidase 4(Human)
THE SCRIPPS RESEARCH INSTITUTE

US Patent
LigandPNGBDBM50516930(CHEMBL4448186 | US20240115577, Compound 20)
Affinity DataIC50: 3.70nMAssay Description:Human DPP4 activity assay data were obtained using a DPP4 Activity Assay Kit (Sigma-Aldrich, MAK088) according to the manufacturer's instructions...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/29/2024
Entry Details
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TargetDipeptidyl peptidase 4(Human)
THE SCRIPPS RESEARCH INSTITUTE

US Patent
LigandPNGBDBM664710((S)-1-(2-amino-4-(2,4-bis(trifluoromethyl)-5,8- di...)
Affinity DataIC50: 4.10nMAssay Description:Human DPP4 activity assay data were obtained using a DPP4 Activity Assay Kit (Sigma-Aldrich, MAK088) according to the manufacturer's instructions...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/29/2024
Entry Details
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TargetDipeptidyl peptidase 4(Human)
THE SCRIPPS RESEARCH INSTITUTE

US Patent
LigandPNGBDBM664702((2S)-1-(((1S,3R,5S)-3-hydroxyadamantan-1- yl)glycy...)
Affinity DataIC50: 4.80nMAssay Description:Human DPP4 activity assay data were obtained using a DPP4 Activity Assay Kit (Sigma-Aldrich, MAK088) according to the manufacturer's instructions...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/29/2024
Entry Details
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TargetDipeptidyl peptidase 4(Human)
THE SCRIPPS RESEARCH INSTITUTE

US Patent
LigandPNGBDBM664703((1S,3S,5S)-2-((2S)-2-amino-2-((1S,3R,5S)-3- hydrox...)
Affinity DataIC50: 6nMAssay Description:Human DPP4 activity assay data were obtained using a DPP4 Activity Assay Kit (Sigma-Aldrich, MAK088) according to the manufacturer's instructions...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/29/2024
Entry Details
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TargetDipeptidyl peptidase 4(Human)
THE SCRIPPS RESEARCH INSTITUTE

US Patent
LigandPNGBDBM664723(methyl (R)-3-((4-(3-aminopiperidin-1-yl)-3-(but-2-...)
Affinity DataIC50: 6nMAssay Description:Human DPP4 activity assay data were obtained using a DPP4 Activity Assay Kit (Sigma-Aldrich, MAK088) according to the manufacturer's instructions...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/29/2024
Entry Details
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TargetDipeptidyl peptidase 4(Human)
THE SCRIPPS RESEARCH INSTITUTE

US Patent
LigandPNGBDBM50359366(CHEMBL1929387 | CHEMBL1929396 | US20240115577, Com...)
Affinity DataIC50: 11.4nMAssay Description:Human DPP4 activity assay data were obtained using a DPP4 Activity Assay Kit (Sigma-Aldrich, MAK088) according to the manufacturer's instructions...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/29/2024
Entry Details
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PDB3D3D Structure (crystal)
TargetDipeptidyl peptidase 4(Human)
THE SCRIPPS RESEARCH INSTITUTE

US Patent
LigandPNGBDBM664717((2S)-1-(((1r,3R,5S)-adamantan-1- yl)glycyl)pyrroli...)
Affinity DataIC50: 15nMAssay Description:Human DPP4 activity assay data were obtained using a DPP4 Activity Assay Kit (Sigma-Aldrich, MAK088) according to the manufacturer's instructions...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/29/2024
Entry Details
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TargetDipeptidyl peptidase 4(Human)
THE SCRIPPS RESEARCH INSTITUTE

US Patent
LigandPNGBDBM50516929(CHEMBL4567320 | US20240115577, Compound 21)
Affinity DataIC50: 31nMAssay Description:Human DPP4 activity assay data were obtained using a DPP4 Activity Assay Kit (Sigma-Aldrich, MAK088) according to the manufacturer's instructions...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/29/2024
Entry Details
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TargetDipeptidyl peptidase 4(Human)
THE SCRIPPS RESEARCH INSTITUTE

US Patent
LigandPNGBDBM664716((2S)-1-(((1S,3R,5R)-3-aminoadamantan-1- yl)glycyl)...)
Affinity DataIC50: 38nMAssay Description:Human DPP4 activity assay data were obtained using a DPP4 Activity Assay Kit (Sigma-Aldrich, MAK088) according to the manufacturer's instructions...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/29/2024
Entry Details
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TargetDipeptidyl peptidase 4(Human)
THE SCRIPPS RESEARCH INSTITUTE

US Patent
LigandPNGBDBM664721(methyl (R)-2-((4-(3-aminopiperidin-1-yl)-3-(but-2-...)
Affinity DataIC50: 74nMAssay Description:Human DPP4 activity assay data were obtained using a DPP4 Activity Assay Kit (Sigma-Aldrich, MAK088) according to the manufacturer's instructions...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/29/2024
Entry Details
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TargetDipeptidyl peptidase 4(Human)
THE SCRIPPS RESEARCH INSTITUTE

US Patent
LigandPNGBDBM50589214(DUTOGLIPTIN | Dutogliptin | Phx1149 | PHX1149 | US...)
Affinity DataIC50: 122nMAssay Description:Human DPP4 activity assay data were obtained using a DPP4 Activity Assay Kit (Sigma-Aldrich, MAK088) according to the manufacturer's instructions...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/29/2024
Entry Details
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