Compile Data Set for Download or QSAR
Report error Found 86 Enz. Inhib. hit(s) with all data for entry = 11721
TargetTyrosine-protein kinase JAK2(Human)
Artivila (Shenzhen) Innovation Center

US Patent
LigandPNGBDBM50021656(LY-3009104 | INCB-028050 | BARICITINIB | US1011290...)
Affinity DataIC50: 9nMAssay Description:The inhibitory activity (IC50) of the amide compound for JAK1 and JAK2 under 1 mM ATP was measured by a mobility shift assay method. JAK1 was purchas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2024
Entry Details
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TargetTyrosine-protein kinase JAK1(Human)
Artivila (Shenzhen) Innovation Center

US Patent
LigandPNGBDBM50021656(LY-3009104 | INCB-028050 | BARICITINIB | US1011290...)
Affinity DataIC50: 9.30nMAssay Description:The inhibitory activity (IC50) of the amide compound for JAK1 and JAK2 under 1 mM ATP was measured by a mobility shift assay method. JAK1 was purchas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2024
Entry Details
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TargetTyrosine-protein kinase JAK1(Human)
Artivila (Shenzhen) Innovation Center

US Patent
LigandPNGBDBM642606(US20230416237, Example 33 | (2R,3'R)-4,4-difluoro-...)
Affinity DataIC50: 26nMAssay Description:The inhibitory activity (IC50) of the amide compound for JAK1 and JAK2 under 1 mM ATP was measured by a mobility shift assay method. JAK1 was purchas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2024
Entry Details
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TargetTyrosine-protein kinase JAK1(Human)
Artivila (Shenzhen) Innovation Center

US Patent
LigandPNGBDBM642588((R)-N-(3-(5-chloro- 2-((3-methoxy- 1-methyl-1H-pyr...)
Affinity DataIC50: 27nMAssay Description:The inhibitory activity (IC50) of the amide compound for JAK1 and JAK2 under 1 mM ATP was measured by a mobility shift assay method. JAK1 was purchas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2024
Entry Details
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TargetTyrosine-protein kinase JAK1(Human)
Artivila (Shenzhen) Innovation Center

US Patent
LigandPNGBDBM642604(US20230416237, Example 31 | (2R,3'R,4S)-4-fluoro-N...)
Affinity DataIC50: 33nMAssay Description:The inhibitory activity (IC50) of the amide compound for JAK1 and JAK2 under 1 mM ATP was measured by a mobility shift assay method. JAK1 was purchas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2024
Entry Details
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TargetTyrosine-protein kinase JAK1(Human)
Artivila (Shenzhen) Innovation Center

US Patent
LigandPNGBDBM642612((2R,3'R,4S)-4-fluoro-N- (3-(5-fluoro-2-((3-meth- o...)
Affinity DataIC50: 34nMAssay Description:The inhibitory activity (IC50) of the amide compound for JAK1 and JAK2 under 1 mM ATP was measured by a mobility shift assay method. JAK1 was purchas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2024
Entry Details
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TargetTyrosine-protein kinase JAK1(Human)
Artivila (Shenzhen) Innovation Center

US Patent
LigandPNGBDBM642606(US20230416237, Example 33 | (2R,3'R)-4,4-difluoro-...)
Affinity DataIC50: 39nMAssay Description:The inhibitory activity (IC50) of the amide compound for JAK1 and JAK2 under 1 mM ATP was measured by a mobility shift assay method. JAK1 was purchas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2024
Entry Details
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TargetTyrosine-protein kinase JAK1(Human)
Artivila (Shenzhen) Innovation Center

US Patent
LigandPNGBDBM642597(US20230416237, Example 25 | (2R,3'R)-N-(3-(5-fluor...)
Affinity DataIC50: 40nMAssay Description:The inhibitory activity (IC50) of the amide compound for JAK1 and JAK2 under 1 mM ATP was measured by a mobility shift assay method. JAK1 was purchas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2024
Entry Details
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TargetTyrosine-protein kinase JAK1(Human)
Artivila (Shenzhen) Innovation Center

US Patent
LigandPNGBDBM642589((R)-4,4-difluoro- N-(3-(2-((3-meth- oxy-1-methyl-1...)
Affinity DataIC50: 40nMAssay Description:The inhibitory activity (IC50) of the amide compound for JAK1 and JAK2 under 1 mM ATP was measured by a mobility shift assay method. JAK1 was purchas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2024
Entry Details
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TargetTyrosine-protein kinase JAK1(Human)
Artivila (Shenzhen) Innovation Center

US Patent
LigandPNGBDBM642602((2R,3'R)-N-(3-(2-((3-meth- oxy-1-methyl-1H-py- raz...)
Affinity DataIC50: 40nMAssay Description:The inhibitory activity (IC50) of the amide compound for JAK1 and JAK2 under 1 mM ATP was measured by a mobility shift assay method. JAK1 was purchas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2024
Entry Details
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TargetTyrosine-protein kinase JAK1(Human)
Artivila (Shenzhen) Innovation Center

US Patent
LigandPNGBDBM642587((2R,4S)-4-fluoro- N-(3-(2-((3-meth- oxy-1-methyl-1...)
Affinity DataIC50: 41nMAssay Description:The inhibitory activity (IC50) of the amide compound for JAK1 and JAK2 under 1 mM ATP was measured by a mobility shift assay method. JAK1 was purchas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2024
Entry Details
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TargetTyrosine-protein kinase JAK1(Human)
Artivila (Shenzhen) Innovation Center

US Patent
LigandPNGBDBM642595((2R,3'R)-N-(3-(5-fluoro- 2-((3-methoxy-1-meth- yl-...)
Affinity DataIC50: 46nMAssay Description:The inhibitory activity (IC50) of the amide compound for JAK1 and JAK2 under 1 mM ATP was measured by a mobility shift assay method. JAK1 was purchas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2024
Entry Details
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TargetTyrosine-protein kinase JAK1(Human)
Artivila (Shenzhen) Innovation Center

US Patent
LigandPNGBDBM642599((2R,3'R)-4,4-difluoro-N- (3-(5-fluoro-2-((3-meth- ...)
Affinity DataIC50: 48nMAssay Description:The inhibitory activity (IC50) of the amide compound for JAK1 and JAK2 under 1 mM ATP was measured by a mobility shift assay method. JAK1 was purchas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2024
Entry Details
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TargetTyrosine-protein kinase JAK1(Human)
Artivila (Shenzhen) Innovation Center

US Patent
LigandPNGBDBM642616(US20230416237, Example abrocitinib)
Affinity DataIC50: 49nMAssay Description:The inhibitory activity (IC50) of the amide compound for JAK1 and JAK2 under 1 mM ATP was measured by a mobility shift assay method. JAK1 was purchas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2024
Entry Details
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TargetTyrosine-protein kinase JAK1(Human)
Artivila (Shenzhen) Innovation Center

US Patent
LigandPNGBDBM642613((2R,3'S,4S)-4-fluoro-N- (3-(5-fluoro-2-((3-meth- o...)
Affinity DataIC50: 50nMAssay Description:The inhibitory activity (IC50) of the amide compound for JAK1 and JAK2 under 1 mM ATP was measured by a mobility shift assay method. JAK1 was purchas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2024
Entry Details
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TargetTyrosine-protein kinase JAK1(Human)
Artivila (Shenzhen) Innovation Center

US Patent
LigandPNGBDBM642582((2R,4S)-N-(3-(5- fluoro-2-((3-meth- oxy-1-methyl-1...)
Affinity DataIC50: 51nMAssay Description:The inhibitory activity (IC50) of the amide compound for JAK1 and JAK2 under 1 mM ATP was measured by a mobility shift assay method. JAK1 was purchas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2024
Entry Details
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TargetTyrosine-protein kinase JAK1(Human)
Artivila (Shenzhen) Innovation Center

US Patent
LigandPNGBDBM642577((S)-N-(3-(5-chloro- 2-((3-methoxy-1-meth- yl-1H-py...)
Affinity DataIC50: 53nMAssay Description:The inhibitory activity (IC50) of the amide compound for JAK1 and JAK2 under 1 mM ATP was measured by a mobility shift assay method. JAK1 was purchas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2024
Entry Details
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TargetTyrosine-protein kinase JAK1(Human)
Artivila (Shenzhen) Innovation Center

US Patent
LigandPNGBDBM642578((R)—N-(3-(5-fluoro-2-((3-methoxy-1-methyl-1H-...)
Affinity DataIC50: 55nMAssay Description:The inhibitory activity (IC50) of the amide compound for JAK1 and JAK2 under 1 mM ATP was measured by a mobility shift assay method. JAK1 was purchas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2024
Entry Details
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TargetTyrosine-protein kinase JAK1(Human)
Artivila (Shenzhen) Innovation Center

US Patent
LigandPNGBDBM264212((2R)-N-(3-{2-[(3- methoxy-1-methyl- 1H-pyrazol-4-y...)
Affinity DataIC50: 56nMAssay Description:The inhibitory activity (IC50) of the amide compound for JAK1 and JAK2 under 1 mM ATP was measured by a mobility shift assay method. JAK1 was purchas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2024
Entry Details
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TargetTyrosine-protein kinase JAK1(Human)
Artivila (Shenzhen) Innovation Center

US Patent
LigandPNGBDBM642595((2R,3'R)-N-(3-(5-fluoro- 2-((3-methoxy-1-meth- yl-...)
Affinity DataIC50: 59nMAssay Description:The inhibitory activity (IC50) of the amide compound for JAK1 and JAK2 under 1 mM ATP was measured by a mobility shift assay method. JAK1 was purchas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2024
Entry Details
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TargetTyrosine-protein kinase JAK1(Human)
Artivila (Shenzhen) Innovation Center

US Patent
LigandPNGBDBM642600((2R,3'S)-4,4-difluoro-N- (3-(5-fluoro-2-((3-meth- ...)
Affinity DataIC50: 60nMAssay Description:The inhibitory activity (IC50) of the amide compound for JAK1 and JAK2 under 1 mM ATP was measured by a mobility shift assay method. JAK1 was purchas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2024
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK1(Human)
Artivila (Shenzhen) Innovation Center

US Patent
LigandPNGBDBM642602((2R,3'R)-N-(3-(2-((3-meth- oxy-1-methyl-1H-py- raz...)
Affinity DataIC50: 67nMAssay Description:The inhibitory activity (IC50) of the amide compound for JAK1 and JAK2 under 1 mM ATP was measured by a mobility shift assay method. JAK1 was purchas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2024
Entry Details
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TargetTyrosine-protein kinase JAK1(Human)
Artivila (Shenzhen) Innovation Center

US Patent
LigandPNGBDBM642579((2R,4S)-4-fluoro- N-(3-(5-fluoro-2- ((3-methoxy-1-...)
Affinity DataIC50: 68nMAssay Description:The inhibitory activity (IC50) of the amide compound for JAK1 and JAK2 under 1 mM ATP was measured by a mobility shift assay method. JAK1 was purchas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2024
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK1(Human)
Artivila (Shenzhen) Innovation Center

US Patent
LigandPNGBDBM642597(US20230416237, Example 25 | (2R,3'R)-N-(3-(5-fluor...)
Affinity DataIC50: 68nMAssay Description:The inhibitory activity (IC50) of the amide compound for JAK1 and JAK2 under 1 mM ATP was measured by a mobility shift assay method. JAK1 was purchas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2024
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK1(Human)
Artivila (Shenzhen) Innovation Center

US Patent
LigandPNGBDBM642584((R)-N-(3-(2-((3- methoxy-1-meth- yl-1H-pyrazol-4- ...)
Affinity DataIC50: 69nMAssay Description:The inhibitory activity (IC50) of the amide compound for JAK1 and JAK2 under 1 mM ATP was measured by a mobility shift assay method. JAK1 was purchas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2024
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK1(Human)
Artivila (Shenzhen) Innovation Center

US Patent
LigandPNGBDBM642545((S)-N-(3-(2-((3-meth- oxy-1-methyl-1H- pyrazol-4-y...)
Affinity DataIC50: 70nMAssay Description:The inhibitory activity (IC50) of the amide compound for JAK1 and JAK2 under 1 mM ATP was measured by a mobility shift assay method. JAK1 was purchas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2024
Entry Details
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TargetTyrosine-protein kinase JAK1(Human)
Artivila (Shenzhen) Innovation Center

US Patent
LigandPNGBDBM642535((S)—N-(3-(5-fluoro-2-((3-methoxy-1-methyl-1H-...)
Affinity DataIC50: 73nMAssay Description:The inhibitory activity (IC50) of the amide compound for JAK1 and JAK2 under 1 mM ATP was measured by a mobility shift assay method. JAK1 was purchas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2024
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK1(Human)
Artivila (Shenzhen) Innovation Center

US Patent
LigandPNGBDBM642610((2R,3'R)-4,4-difluoro-N- (3-(2-((3-methoxy-1- meth...)
Affinity DataIC50: 91nMAssay Description:The inhibitory activity (IC50) of the amide compound for JAK1 and JAK2 under 1 mM ATP was measured by a mobility shift assay method. JAK1 was purchas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2024
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK1(Human)
Artivila (Shenzhen) Innovation Center

US Patent
LigandPNGBDBM642604(US20230416237, Example 31 | (2R,3'R,4S)-4-fluoro-N...)
Affinity DataIC50: 92nMAssay Description:The inhibitory activity (IC50) of the amide compound for JAK1 and JAK2 under 1 mM ATP was measured by a mobility shift assay method. JAK1 was purchas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2024
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK1(Human)
Artivila (Shenzhen) Innovation Center

US Patent
LigandPNGBDBM642586((2R,4S)-4-methoxy- N-(3-(2-((3-meth- oxy-1-methyl-...)
Affinity DataIC50: 101nMAssay Description:The inhibitory activity (IC50) of the amide compound for JAK1 and JAK2 under 1 mM ATP was measured by a mobility shift assay method. JAK1 was purchas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2024
Entry Details
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TargetTyrosine-protein kinase JAK1(Human)
Artivila (Shenzhen) Innovation Center

US Patent
LigandPNGBDBM642585((2R,4S)-4-ethoxy- N-(3-(2-((3-meth- oxy-1-methyl-1...)
Affinity DataIC50: 103nMAssay Description:The inhibitory activity (IC50) of the amide compound for JAK1 and JAK2 under 1 mM ATP was measured by a mobility shift assay method. JAK1 was purchas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2024
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK1(Human)
Artivila (Shenzhen) Innovation Center

US Patent
LigandPNGBDBM642583((R)-N-(3-(5-fluoro- 2-((3-methoxy- 1-methyl-1H-pyr...)
Affinity DataIC50: 104nMAssay Description:The inhibitory activity (IC50) of the amide compound for JAK1 and JAK2 under 1 mM ATP was measured by a mobility shift assay method. JAK1 was purchas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2024
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK1(Human)
Artivila (Shenzhen) Innovation Center

US Patent
LigandPNGBDBM642591(US20230416237, Example 18)
Affinity DataIC50: 108nMAssay Description:The inhibitory activity (IC50) of the amide compound for JAK1 and JAK2 under 1 mM ATP was measured by a mobility shift assay method. JAK1 was purchas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2024
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK1(Human)
Artivila (Shenzhen) Innovation Center

US Patent
LigandPNGBDBM642608(US20230416237, Example 35 | (R)-4,4-difluoro-N-(3-...)
Affinity DataIC50: 115nMAssay Description:The inhibitory activity (IC50) of the amide compound for JAK1 and JAK2 under 1 mM ATP was measured by a mobility shift assay method. JAK1 was purchas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2024
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK1(Human)
Artivila (Shenzhen) Innovation Center

US Patent
LigandPNGBDBM642593(US20230416237, Example 20)
Affinity DataIC50: 120nMAssay Description:The inhibitory activity (IC50) of the amide compound for JAK1 and JAK2 under 1 mM ATP was measured by a mobility shift assay method. JAK1 was purchas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2024
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK1(Human)
Artivila (Shenzhen) Innovation Center

US Patent
LigandPNGBDBM642544((S)-N-(3-(5-fluoro- 2-((3-methoxy-1-meth- yl-1H-py...)
Affinity DataIC50: 137nMAssay Description:The inhibitory activity (IC50) of the amide compound for JAK1 and JAK2 under 1 mM ATP was measured by a mobility shift assay method. JAK1 was purchas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2024
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK1(Human)
Artivila (Shenzhen) Innovation Center

US Patent
LigandPNGBDBM642580((2R,4R)-4-fluoro- N-(3-(5-fluoro-2- ((3-methoxy-1-...)
Affinity DataIC50: 152nMAssay Description:The inhibitory activity (IC50) of the amide compound for JAK1 and JAK2 under 1 mM ATP was measured by a mobility shift assay method. JAK1 was purchas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2024
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK1(Human)
Artivila (Shenzhen) Innovation Center

US Patent
LigandPNGBDBM642608(US20230416237, Example 35 | (R)-4,4-difluoro-N-(3-...)
Affinity DataIC50: 161nMAssay Description:The inhibitory activity (IC50) of the amide compound for JAK1 and JAK2 under 1 mM ATP was measured by a mobility shift assay method. JAK1 was purchas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2024
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK1(Human)
Artivila (Shenzhen) Innovation Center

US Patent
LigandPNGBDBM642590((R)-4,4-difluoro- N-(3-(2-((3-meth- oxy-1-methyl-1...)
Affinity DataIC50: 216nMAssay Description:The inhibitory activity (IC50) of the amide compound for JAK1 and JAK2 under 1 mM ATP was measured by a mobility shift assay method. JAK1 was purchas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2024
Entry Details
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TargetTyrosine-protein kinase JAK1(Human)
Artivila (Shenzhen) Innovation Center

US Patent
LigandPNGBDBM642611((2R,3'S)-4,4-difluoro-N- (3-(2-((3-methoxy-1- meth...)
Affinity DataIC50: 216nMAssay Description:The inhibitory activity (IC50) of the amide compound for JAK1 and JAK2 under 1 mM ATP was measured by a mobility shift assay method. JAK1 was purchas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2024
Entry Details
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TargetTyrosine-protein kinase JAK1(Human)
Artivila (Shenzhen) Innovation Center

US Patent
LigandPNGBDBM642614((2R,4S)-4-fluoro-N-(3-(2-((3-methoxy-1-methyl-1H-p...)
Affinity DataIC50: 259nMAssay Description:The inhibitory activity (IC50) of the amide compound for JAK1 and JAK2 under 1 mM ATP was measured by a mobility shift assay method. JAK1 was purchas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2024
Entry Details
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TargetTyrosine-protein kinase JAK1(Human)
Artivila (Shenzhen) Innovation Center

US Patent
LigandPNGBDBM642594(US20230416237, Example 21)
Affinity DataIC50: 262nMAssay Description:The inhibitory activity (IC50) of the amide compound for JAK1 and JAK2 under 1 mM ATP was measured by a mobility shift assay method. JAK1 was purchas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2024
Entry Details
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TargetTyrosine-protein kinase JAK1(Human)
Artivila (Shenzhen) Innovation Center

US Patent
LigandPNGBDBM642592(US20230416237, Example 19)
Affinity DataIC50: 368nMAssay Description:The inhibitory activity (IC50) of the amide compound for JAK1 and JAK2 under 1 mM ATP was measured by a mobility shift assay method. JAK1 was purchas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2024
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK2(Human)
Artivila (Shenzhen) Innovation Center

US Patent
LigandPNGBDBM642577((S)-N-(3-(5-chloro- 2-((3-methoxy-1-meth- yl-1H-py...)
Affinity DataIC50: 652nMAssay Description:The inhibitory activity (IC50) of the amide compound for JAK1 and JAK2 under 1 mM ATP was measured by a mobility shift assay method. JAK1 was purchas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2024
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK2(Human)
Artivila (Shenzhen) Innovation Center

US Patent
LigandPNGBDBM642616(US20230416237, Example abrocitinib)
Affinity DataIC50: 873nMAssay Description:The inhibitory activity (IC50) of the amide compound for JAK1 and JAK2 under 1 mM ATP was measured by a mobility shift assay method. JAK1 was purchas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2024
Entry Details
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TargetTyrosine-protein kinase JAK1(Human)
Artivila (Shenzhen) Innovation Center

US Patent
LigandPNGBDBM642581((2R,4R)-N-(3-(5- fluoro-2-((3-meth- oxy-1-methyl-1...)
Affinity DataIC50: 1.17E+3nMAssay Description:The inhibitory activity (IC50) of the amide compound for JAK1 and JAK2 under 1 mM ATP was measured by a mobility shift assay method. JAK1 was purchas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2024
Entry Details
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TargetTyrosine-protein kinase JAK2(Human)
Artivila (Shenzhen) Innovation Center

US Patent
LigandPNGBDBM642544((S)-N-(3-(5-fluoro- 2-((3-methoxy-1-meth- yl-1H-py...)
Affinity DataIC50: 1.85E+3nMAssay Description:The inhibitory activity (IC50) of the amide compound for JAK1 and JAK2 under 1 mM ATP was measured by a mobility shift assay method. JAK1 was purchas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2024
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK2(Human)
Artivila (Shenzhen) Innovation Center

US Patent
LigandPNGBDBM642608(US20230416237, Example 35 | (R)-4,4-difluoro-N-(3-...)
Affinity DataIC50: 1.89E+3nMAssay Description:The inhibitory activity (IC50) of the amide compound for JAK1 and JAK2 under 1 mM ATP was measured by a mobility shift assay method. JAK1 was purchas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2024
Entry Details
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TargetTyrosine-protein kinase JAK2(Human)
Artivila (Shenzhen) Innovation Center

US Patent
LigandPNGBDBM642545((S)-N-(3-(2-((3-meth- oxy-1-methyl-1H- pyrazol-4-y...)
Affinity DataIC50: 2.21E+3nMAssay Description:The inhibitory activity (IC50) of the amide compound for JAK1 and JAK2 under 1 mM ATP was measured by a mobility shift assay method. JAK1 was purchas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2024
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK2(Human)
Artivila (Shenzhen) Innovation Center

US Patent
LigandPNGBDBM642608(US20230416237, Example 35 | (R)-4,4-difluoro-N-(3-...)
Affinity DataIC50: 2.51E+3nMAssay Description:The inhibitory activity (IC50) of the amide compound for JAK1 and JAK2 under 1 mM ATP was measured by a mobility shift assay method. JAK1 was purchas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2024
Entry Details
Go to US Patent

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