Compile Data Set for Download or QSAR
Report error Found 71 Enz. Inhib. hit(s) with all data for entry = 11624
TargetSon of sevenless homolog 1/GTPase KRas [G12C](Human)
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US Patent
LigandPNGBDBM634093(US20230357239, Example 61 | 4-acetyl-1-[2-methyl-4...)
Affinity DataIC50: 2.53nMAssay Description:The assay buffer containes 5 mM HEPES pH 7.4 (Applichem), 150 mM NaCl (Sigma), 10 mM EDTA (Promega), 1 mM DTT (Thermofisher), 0.05% BSA Fraction V, p...More data for this Ligand-Target Pair
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Date in BDB:
1/4/2024
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TargetSon of sevenless homolog 1/GTPase KRas [G12C](Human)
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US Patent
LigandPNGBDBM634078(US20230357239, Example 46 | 1-{4-[4-({(1R)-1-[3-(1...)
Affinity DataIC50: 2.70nMAssay Description:The assay buffer containes 5 mM HEPES pH 7.4 (Applichem), 150 mM NaCl (Sigma), 10 mM EDTA (Promega), 1 mM DTT (Thermofisher), 0.05% BSA Fraction V, p...More data for this Ligand-Target Pair
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Date in BDB:
1/4/2024
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TargetSon of sevenless homolog 1/GTPase KRas [G12C](Human)
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US Patent
LigandPNGBDBM634056(US20230357239, Example 24 | 1-{6-[4-({(1R)-1-[3-(1...)
Affinity DataIC50: 2.80nMAssay Description:The assay buffer containes 5 mM HEPES pH 7.4 (Applichem), 150 mM NaCl (Sigma), 10 mM EDTA (Promega), 1 mM DTT (Thermofisher), 0.05% BSA Fraction V, p...More data for this Ligand-Target Pair
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Date in BDB:
1/4/2024
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TargetSon of sevenless homolog 1/GTPase KRas [G12C](Human)
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US Patent
LigandPNGBDBM634100(US20230357239, Example 68 | 4-acetyl-1-[2,7-dimeth...)
Affinity DataIC50: 2.93nMAssay Description:The assay buffer containes 5 mM HEPES pH 7.4 (Applichem), 150 mM NaCl (Sigma), 10 mM EDTA (Promega), 1 mM DTT (Thermofisher), 0.05% BSA Fraction V, p...More data for this Ligand-Target Pair
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Date in BDB:
1/4/2024
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TargetSon of sevenless homolog 1/GTPase KRas [G12C](Human)
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US Patent
LigandPNGBDBM634082(US20230357239, Example 50 | 1-{(1 S,4S)-5-[4-({(1R...)
Affinity DataIC50: 2.93nMAssay Description:The assay buffer containes 5 mM HEPES pH 7.4 (Applichem), 150 mM NaCl (Sigma), 10 mM EDTA (Promega), 1 mM DTT (Thermofisher), 0.05% BSA Fraction V, p...More data for this Ligand-Target Pair
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Date in BDB:
1/4/2024
Entry Details
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TargetSon of sevenless homolog 1/GTPase KRas [G12C](Human)
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LigandPNGBDBM634098(US20230357239, Example 66 | 1-{4-[4-({(1R)-1-[3-(1...)
Affinity DataIC50: 3.18nMAssay Description:The assay buffer containes 5 mM HEPES pH 7.4 (Applichem), 150 mM NaCl (Sigma), 10 mM EDTA (Promega), 1 mM DTT (Thermofisher), 0.05% BSA Fraction V, p...More data for this Ligand-Target Pair
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Date in BDB:
1/4/2024
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TargetSon of sevenless homolog 1/GTPase KRas [G12C](Human)
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LigandPNGBDBM634081(US20230357239, Example 49 | 1-{3-[4-({(1R)-1-[3-(1...)
Affinity DataIC50: 3.31nMAssay Description:The assay buffer containes 5 mM HEPES pH 7.4 (Applichem), 150 mM NaCl (Sigma), 10 mM EDTA (Promega), 1 mM DTT (Thermofisher), 0.05% BSA Fraction V, p...More data for this Ligand-Target Pair
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Date in BDB:
1/4/2024
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TargetSon of sevenless homolog 1/GTPase KRas [G12C](Human)
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LigandPNGBDBM634085(US20230357239, Example 53 | 1-{4-[4-({(1R)-1-[3-(1...)
Affinity DataIC50: 3.34nMAssay Description:The assay buffer containes 5 mM HEPES pH 7.4 (Applichem), 150 mM NaCl (Sigma), 10 mM EDTA (Promega), 1 mM DTT (Thermofisher), 0.05% BSA Fraction V, p...More data for this Ligand-Target Pair
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Date in BDB:
1/4/2024
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TargetSon of sevenless homolog 1/GTPase KRas [G12C](Human)
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LigandPNGBDBM634086(US20230357239, Example 54 | 1-{6-[4-({(1R)-1-[3-(1...)
Affinity DataIC50: 3.52nMAssay Description:The assay buffer containes 5 mM HEPES pH 7.4 (Applichem), 150 mM NaCl (Sigma), 10 mM EDTA (Promega), 1 mM DTT (Thermofisher), 0.05% BSA Fraction V, p...More data for this Ligand-Target Pair
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Date in BDB:
1/4/2024
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TargetSon of sevenless homolog 1/GTPase KRas [G12C](Human)
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LigandPNGBDBM634042(US20230357239, Example 10 | 1-{4-[4-({(1R)-1-[2-me...)
Affinity DataIC50: 3.55nMAssay Description:The assay buffer containes 5 mM HEPES pH 7.4 (Applichem), 150 mM NaCl (Sigma), 10 mM EDTA (Promega), 1 mM DTT (Thermofisher), 0.05% BSA Fraction V, p...More data for this Ligand-Target Pair
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Date in BDB:
1/4/2024
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TargetSon of sevenless homolog 1/GTPase KRas [G12C](Human)
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LigandPNGBDBM634049(US20230357239, Example 17 | 1-{4-[2-methyl-4-({(1R...)
Affinity DataIC50: 3.56nMAssay Description:The assay buffer containes 5 mM HEPES pH 7.4 (Applichem), 150 mM NaCl (Sigma), 10 mM EDTA (Promega), 1 mM DTT (Thermofisher), 0.05% BSA Fraction V, p...More data for this Ligand-Target Pair
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Date in BDB:
1/4/2024
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TargetSon of sevenless homolog 1/GTPase KRas [G12C](Human)
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LigandPNGBDBM634079(US20230357239, Example 47 | 1-{4-[4-({(1R)-1-[3-(1...)
Affinity DataIC50: 4nMAssay Description:The assay buffer containes 5 mM HEPES pH 7.4 (Applichem), 150 mM NaCl (Sigma), 10 mM EDTA (Promega), 1 mM DTT (Thermofisher), 0.05% BSA Fraction V, p...More data for this Ligand-Target Pair
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Date in BDB:
1/4/2024
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TargetSon of sevenless homolog 1/GTPase KRas [G12C](Human)
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LigandPNGBDBM634044(US20230357239, Example 12 | 1-{4-[4-({(1R)-1-[2-me...)
Affinity DataIC50: 4.06nMAssay Description:The assay buffer containes 5 mM HEPES pH 7.4 (Applichem), 150 mM NaCl (Sigma), 10 mM EDTA (Promega), 1 mM DTT (Thermofisher), 0.05% BSA Fraction V, p...More data for this Ligand-Target Pair
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Date in BDB:
1/4/2024
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TargetSon of sevenless homolog 1/GTPase KRas [G12C](Human)
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LigandPNGBDBM634037(US20230357239, Example 5 | 1-{4-[4-({(1R)-1-[3-(tr...)
Affinity DataIC50: 4.24nMAssay Description:The assay buffer containes 5 mM HEPES pH 7.4 (Applichem), 150 mM NaCl (Sigma), 10 mM EDTA (Promega), 1 mM DTT (Thermofisher), 0.05% BSA Fraction V, p...More data for this Ligand-Target Pair
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Date in BDB:
1/4/2024
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TargetSon of sevenless homolog 1/GTPase KRas [G12C](Human)
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LigandPNGBDBM634096(US20230357239, Example 64 | 1-{(1 S,4S)-5-[4-({(1R...)
Affinity DataIC50: 4.35nMAssay Description:The assay buffer containes 5 mM HEPES pH 7.4 (Applichem), 150 mM NaCl (Sigma), 10 mM EDTA (Promega), 1 mM DTT (Thermofisher), 0.05% BSA Fraction V, p...More data for this Ligand-Target Pair
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Date in BDB:
1/4/2024
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TargetSon of sevenless homolog 1/GTPase KRas [G12C](Human)
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LigandPNGBDBM634087(US20230357239, Example 55 | N-{(3R)-1-[4-({(1R)-1-...)
Affinity DataIC50: 4.46nMAssay Description:The assay buffer containes 5 mM HEPES pH 7.4 (Applichem), 150 mM NaCl (Sigma), 10 mM EDTA (Promega), 1 mM DTT (Thermofisher), 0.05% BSA Fraction V, p...More data for this Ligand-Target Pair
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Date in BDB:
1/4/2024
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TargetSon of sevenless homolog 1/GTPase KRas [G12C](Human)
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LigandPNGBDBM634084(US20230357239, Example 52 | 1,1-difluoro-1-{2-fluo...)
Affinity DataIC50: 4.48nMAssay Description:The assay buffer containes 5 mM HEPES pH 7.4 (Applichem), 150 mM NaCl (Sigma), 10 mM EDTA (Promega), 1 mM DTT (Thermofisher), 0.05% BSA Fraction V, p...More data for this Ligand-Target Pair
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Date in BDB:
1/4/2024
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TargetSon of sevenless homolog 1/GTPase KRas [G12C](Human)
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LigandPNGBDBM634046(US20230357239, Example 14 | 1-{(1S,4S)-5-[2-methyl...)
Affinity DataIC50: 5.15nMAssay Description:The assay buffer containes 5 mM HEPES pH 7.4 (Applichem), 150 mM NaCl (Sigma), 10 mM EDTA (Promega), 1 mM DTT (Thermofisher), 0.05% BSA Fraction V, p...More data for this Ligand-Target Pair
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Date in BDB:
1/4/2024
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TargetSon of sevenless homolog 1/GTPase KRas [G12C](Human)
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LigandPNGBDBM634075(US20230357239, Example 43 | 1-{4-[4-({(1R)-1-[3-(d...)
Affinity DataIC50: 5.20nMAssay Description:The assay buffer containes 5 mM HEPES pH 7.4 (Applichem), 150 mM NaCl (Sigma), 10 mM EDTA (Promega), 1 mM DTT (Thermofisher), 0.05% BSA Fraction V, p...More data for this Ligand-Target Pair
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Date in BDB:
1/4/2024
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TargetSon of sevenless homolog 1/GTPase KRas [G12C](Human)
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LigandPNGBDBM634102(US20230357239, Example 70 | 1-{6-[4-({(1R)-1-[3-(1...)
Affinity DataIC50: 5.47nMAssay Description:The assay buffer containes 5 mM HEPES pH 7.4 (Applichem), 150 mM NaCl (Sigma), 10 mM EDTA (Promega), 1 mM DTT (Thermofisher), 0.05% BSA Fraction V, p...More data for this Ligand-Target Pair
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Date in BDB:
1/4/2024
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TargetSon of sevenless homolog 1/GTPase KRas [G12C](Human)
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US Patent
LigandPNGBDBM634097(US20230357239, Example 65 | 1-{4-[4-({(1R)-1-[3-(1...)
Affinity DataIC50: 5.72nMAssay Description:The assay buffer containes 5 mM HEPES pH 7.4 (Applichem), 150 mM NaCl (Sigma), 10 mM EDTA (Promega), 1 mM DTT (Thermofisher), 0.05% BSA Fraction V, p...More data for this Ligand-Target Pair
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Date in BDB:
1/4/2024
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TargetSon of sevenless homolog 1/GTPase KRas [G12C](Human)
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US Patent
LigandPNGBDBM634050(US20230357239, Example 18 | N-{(3R)-1-[2,7-dimethy...)
Affinity DataIC50: 5.74nMAssay Description:The assay buffer containes 5 mM HEPES pH 7.4 (Applichem), 150 mM NaCl (Sigma), 10 mM EDTA (Promega), 1 mM DTT (Thermofisher), 0.05% BSA Fraction V, p...More data for this Ligand-Target Pair
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Date in BDB:
1/4/2024
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TargetSon of sevenless homolog 1/GTPase KRas [G12C](Human)
Bayer Aktiengesellschaft

US Patent
LigandPNGBDBM634057(US20230357239, Example 25 | US20230357239, Example...)
Affinity DataIC50: 5.75nMAssay Description:The assay buffer containes 5 mM HEPES pH 7.4 (Applichem), 150 mM NaCl (Sigma), 10 mM EDTA (Promega), 1 mM DTT (Thermofisher), 0.05% BSA Fraction V, p...More data for this Ligand-Target Pair
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Date in BDB:
1/4/2024
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TargetSon of sevenless homolog 1/GTPase KRas [G12C](Human)
Bayer Aktiengesellschaft

US Patent
LigandPNGBDBM634057(US20230357239, Example 25 | US20230357239, Example...)
Affinity DataIC50: 5.78nMAssay Description:The assay buffer containes 5 mM HEPES pH 7.4 (Applichem), 150 mM NaCl (Sigma), 10 mM EDTA (Promega), 1 mM DTT (Thermofisher), 0.05% BSA Fraction V, p...More data for this Ligand-Target Pair
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Date in BDB:
1/4/2024
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TargetSon of sevenless homolog 1/GTPase KRas [G12C](Human)
Bayer Aktiengesellschaft

US Patent
LigandPNGBDBM634103(US20230357239, Example 71 | 1-{6-[2-methyl-4-({(1R...)
Affinity DataIC50: 5.78nMAssay Description:The assay buffer containes 5 mM HEPES pH 7.4 (Applichem), 150 mM NaCl (Sigma), 10 mM EDTA (Promega), 1 mM DTT (Thermofisher), 0.05% BSA Fraction V, p...More data for this Ligand-Target Pair
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Date in BDB:
1/4/2024
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TargetSon of sevenless homolog 1/GTPase KRas [G12C](Human)
Bayer Aktiengesellschaft

US Patent
LigandPNGBDBM634099(US20230357239, Example 67 | 1-{4-[4-({(1R)-1-[3-(1...)
Affinity DataIC50: 6.23nMAssay Description:The assay buffer containes 5 mM HEPES pH 7.4 (Applichem), 150 mM NaCl (Sigma), 10 mM EDTA (Promega), 1 mM DTT (Thermofisher), 0.05% BSA Fraction V, p...More data for this Ligand-Target Pair
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Date in BDB:
1/4/2024
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TargetSon of sevenless homolog 1/GTPase KRas [G12C](Human)
Bayer Aktiengesellschaft

US Patent
LigandPNGBDBM634040(US20230357239, Example 8 | 1-{6-[2-methyl-4-({(1R)...)
Affinity DataIC50: 6.35nMAssay Description:The assay buffer containes 5 mM HEPES pH 7.4 (Applichem), 150 mM NaCl (Sigma), 10 mM EDTA (Promega), 1 mM DTT (Thermofisher), 0.05% BSA Fraction V, p...More data for this Ligand-Target Pair
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Date in BDB:
1/4/2024
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TargetSon of sevenless homolog 1/GTPase KRas [G12C](Human)
Bayer Aktiengesellschaft

US Patent
LigandPNGBDBM634068(US20230357239, Example 36 | 1-{4-[2-methyl-4-({(1R...)
Affinity DataIC50: 6.46nMAssay Description:The assay buffer containes 5 mM HEPES pH 7.4 (Applichem), 150 mM NaCl (Sigma), 10 mM EDTA (Promega), 1 mM DTT (Thermofisher), 0.05% BSA Fraction V, p...More data for this Ligand-Target Pair
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Date in BDB:
1/4/2024
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TargetSon of sevenless homolog 1/GTPase KRas [G12C](Human)
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US Patent
LigandPNGBDBM634091(US20230357239, Example 59 | 2-[4-({(1R)-1-[3-(1,1-...)
Affinity DataIC50: 7.23nMAssay Description:The assay buffer containes 5 mM HEPES pH 7.4 (Applichem), 150 mM NaCl (Sigma), 10 mM EDTA (Promega), 1 mM DTT (Thermofisher), 0.05% BSA Fraction V, p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2024
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TargetSon of sevenless homolog 1/GTPase KRas [G12C](Human)
Bayer Aktiengesellschaft

US Patent
LigandPNGBDBM634067(US20230357239, Example 35 | 1-{4-[2-methyl-4-({(1R...)
Affinity DataIC50: 7.71nMAssay Description:The assay buffer containes 5 mM HEPES pH 7.4 (Applichem), 150 mM NaCl (Sigma), 10 mM EDTA (Promega), 1 mM DTT (Thermofisher), 0.05% BSA Fraction V, p...More data for this Ligand-Target Pair
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Date in BDB:
1/4/2024
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TargetSon of sevenless homolog 1/GTPase KRas [G12C](Human)
Bayer Aktiengesellschaft

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LigandPNGBDBM634059(US20230357239, Example 27 | 1-{7-[2-methyl-4-({(1R...)
Affinity DataIC50: 7.96nMAssay Description:The assay buffer containes 5 mM HEPES pH 7.4 (Applichem), 150 mM NaCl (Sigma), 10 mM EDTA (Promega), 1 mM DTT (Thermofisher), 0.05% BSA Fraction V, p...More data for this Ligand-Target Pair
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Date in BDB:
1/4/2024
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TargetSon of sevenless homolog 1/GTPase KRas [G12C](Human)
Bayer Aktiengesellschaft

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LigandPNGBDBM634051(US20230357239, Example 19 | 1-{4-[2,7-dimethyl-4-(...)
Affinity DataIC50: 8.25nMAssay Description:The assay buffer containes 5 mM HEPES pH 7.4 (Applichem), 150 mM NaCl (Sigma), 10 mM EDTA (Promega), 1 mM DTT (Thermofisher), 0.05% BSA Fraction V, p...More data for this Ligand-Target Pair
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Date in BDB:
1/4/2024
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TargetSon of sevenless homolog 1/GTPase KRas [G12C](Human)
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LigandPNGBDBM634076(US20230357239, Example 44 | 1-{4-[4-({(1R)-1-[3-(d...)
Affinity DataIC50: 8.43nMAssay Description:The assay buffer containes 5 mM HEPES pH 7.4 (Applichem), 150 mM NaCl (Sigma), 10 mM EDTA (Promega), 1 mM DTT (Thermofisher), 0.05% BSA Fraction V, p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2024
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TargetSon of sevenless homolog 1/GTPase KRas [G12C](Human)
Bayer Aktiengesellschaft

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LigandPNGBDBM634069(US20230357239, Example 37 | 1-{6-[4-({(1R)-1-[3-(d...)
Affinity DataIC50: 8.47nMAssay Description:The assay buffer containes 5 mM HEPES pH 7.4 (Applichem), 150 mM NaCl (Sigma), 10 mM EDTA (Promega), 1 mM DTT (Thermofisher), 0.05% BSA Fraction V, p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2024
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TargetSon of sevenless homolog 1/GTPase KRas [G12C](Human)
Bayer Aktiengesellschaft

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LigandPNGBDBM634095(US20230357239, Example 63 | 1-{6-[2,7-dimethyl-4-(...)
Affinity DataIC50: 8.66nMAssay Description:The assay buffer containes 5 mM HEPES pH 7.4 (Applichem), 150 mM NaCl (Sigma), 10 mM EDTA (Promega), 1 mM DTT (Thermofisher), 0.05% BSA Fraction V, p...More data for this Ligand-Target Pair
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Date in BDB:
1/4/2024
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TargetSon of sevenless homolog 1/GTPase KRas [G12C](Human)
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LigandPNGBDBM634060(US20230357239, Example 28 | 1-{7-[2-methyl-4-({(1R...)
Affinity DataIC50: 9.40nMAssay Description:The assay buffer containes 5 mM HEPES pH 7.4 (Applichem), 150 mM NaCl (Sigma), 10 mM EDTA (Promega), 1 mM DTT (Thermofisher), 0.05% BSA Fraction V, p...More data for this Ligand-Target Pair
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Date in BDB:
1/4/2024
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TargetSon of sevenless homolog 1/GTPase KRas [G12C](Human)
Bayer Aktiengesellschaft

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LigandPNGBDBM634083(US20230357239, Example 51 | 1-{(1 R,4R)-5-[4-({(1R...)
Affinity DataIC50: 9.79nMAssay Description:The assay buffer containes 5 mM HEPES pH 7.4 (Applichem), 150 mM NaCl (Sigma), 10 mM EDTA (Promega), 1 mM DTT (Thermofisher), 0.05% BSA Fraction V, p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2024
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TargetSon of sevenless homolog 1/GTPase KRas [G12C](Human)
Bayer Aktiengesellschaft

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LigandPNGBDBM634089(US20230357239, Example 57 | 1-{4-[4-({(1R)-1-[3-(d...)
Affinity DataIC50: 9.81nMAssay Description:The assay buffer containes 5 mM HEPES pH 7.4 (Applichem), 150 mM NaCl (Sigma), 10 mM EDTA (Promega), 1 mM DTT (Thermofisher), 0.05% BSA Fraction V, p...More data for this Ligand-Target Pair
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Date in BDB:
1/4/2024
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TargetSon of sevenless homolog 1/GTPase KRas [G12C](Human)
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LigandPNGBDBM634080(US20230357239, Example 48 | 6-[2-methyl-4-({(1R)-1...)
Affinity DataIC50: 9.95nMAssay Description:The assay buffer containes 5 mM HEPES pH 7.4 (Applichem), 150 mM NaCl (Sigma), 10 mM EDTA (Promega), 1 mM DTT (Thermofisher), 0.05% BSA Fraction V, p...More data for this Ligand-Target Pair
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Date in BDB:
1/4/2024
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TargetSon of sevenless homolog 1/GTPase KRas [G12C](Human)
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LigandPNGBDBM634047(US20230357239, Example 15 | 2-methyl-6-(4-methylpi...)
Affinity DataIC50: 10.6nMAssay Description:The assay buffer containes 5 mM HEPES pH 7.4 (Applichem), 150 mM NaCl (Sigma), 10 mM EDTA (Promega), 1 mM DTT (Thermofisher), 0.05% BSA Fraction V, p...More data for this Ligand-Target Pair
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Date in BDB:
1/4/2024
Entry Details
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TargetSon of sevenless homolog 1/GTPase KRas [G12C](Human)
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LigandPNGBDBM634063(US20230357239, Example 31 | 1-{(3RS)-3-[2-methyl-4...)
Affinity DataIC50: 11.9nMAssay Description:The assay buffer containes 5 mM HEPES pH 7.4 (Applichem), 150 mM NaCl (Sigma), 10 mM EDTA (Promega), 1 mM DTT (Thermofisher), 0.05% BSA Fraction V, p...More data for this Ligand-Target Pair
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Date in BDB:
1/4/2024
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TargetSon of sevenless homolog 1/GTPase KRas [G12C](Human)
Bayer Aktiengesellschaft

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LigandPNGBDBM634066(US20230357239, Example 34 | 2-[2-methyl-4-({(1R)-1...)
Affinity DataIC50: 13nMAssay Description:The assay buffer containes 5 mM HEPES pH 7.4 (Applichem), 150 mM NaCl (Sigma), 10 mM EDTA (Promega), 1 mM DTT (Thermofisher), 0.05% BSA Fraction V, p...More data for this Ligand-Target Pair
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Date in BDB:
1/4/2024
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TargetSon of sevenless homolog 1/GTPase KRas [G12C](Human)
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LigandPNGBDBM634035(US20230357239, Example 3 | 6-(4-methylpiperazin-1-...)
Affinity DataIC50: 13.9nMAssay Description:The assay buffer containes 5 mM HEPES pH 7.4 (Applichem), 150 mM NaCl (Sigma), 10 mM EDTA (Promega), 1 mM DTT (Thermofisher), 0.05% BSA Fraction V, p...More data for this Ligand-Target Pair
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Date in BDB:
1/4/2024
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TargetSon of sevenless homolog 1/GTPase KRas [G12C](Human)
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US Patent
LigandPNGBDBM634088(US20230357239, Example 56 | 1-{4-[4-({(1R)-1-[3-(d...)
Affinity DataIC50: 14.1nMAssay Description:The assay buffer containes 5 mM HEPES pH 7.4 (Applichem), 150 mM NaCl (Sigma), 10 mM EDTA (Promega), 1 mM DTT (Thermofisher), 0.05% BSA Fraction V, p...More data for this Ligand-Target Pair
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Date in BDB:
1/4/2024
Entry Details
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TargetSon of sevenless homolog 1/GTPase KRas [G12C](Human)
Bayer Aktiengesellschaft

US Patent
LigandPNGBDBM634094(US20230357239, Example 62 | 1-{4-[4-({(1R)-1-[3-(1...)
Affinity DataIC50: 14.5nMAssay Description:The assay buffer containes 5 mM HEPES pH 7.4 (Applichem), 150 mM NaCl (Sigma), 10 mM EDTA (Promega), 1 mM DTT (Thermofisher), 0.05% BSA Fraction V, p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2024
Entry Details
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TargetSon of sevenless homolog 1/GTPase KRas [G12C](Human)
Bayer Aktiengesellschaft

US Patent
LigandPNGBDBM634040(US20230357239, Example 8 | 1-{6-[2-methyl-4-({(1R)...)
Affinity DataIC50: 15.7nMAssay Description:The assay buffer containes 5 mM HEPES pH 7.4 (Applichem), 150 mM NaCl (Sigma), 10 mM EDTA (Promega), 1 mM DTT (Thermofisher), 0.05% BSA Fraction V, p...More data for this Ligand-Target Pair
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Date in BDB:
1/4/2024
Entry Details
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TargetSon of sevenless homolog 1/GTPase KRas [G12C](Human)
Bayer Aktiengesellschaft

US Patent
LigandPNGBDBM634090(US20230357239, Example 58 | 2-[2,7-dimethyl-4-({(1...)
Affinity DataIC50: 15.9nMAssay Description:The assay buffer containes 5 mM HEPES pH 7.4 (Applichem), 150 mM NaCl (Sigma), 10 mM EDTA (Promega), 1 mM DTT (Thermofisher), 0.05% BSA Fraction V, p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2024
Entry Details
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TargetSon of sevenless homolog 1/GTPase KRas [G12C](Human)
Bayer Aktiengesellschaft

US Patent
LigandPNGBDBM634072(US20230357239, Example 40 | 1-{3-[2-methyl-4-({(1R...)
Affinity DataIC50: 16.1nMAssay Description:The assay buffer containes 5 mM HEPES pH 7.4 (Applichem), 150 mM NaCl (Sigma), 10 mM EDTA (Promega), 1 mM DTT (Thermofisher), 0.05% BSA Fraction V, p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2024
Entry Details
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TargetSon of sevenless homolog 1/GTPase KRas [G12C](Human)
Bayer Aktiengesellschaft

US Patent
LigandPNGBDBM634071(US20230357239, Example 39 | 2-[4-({(1R)-1-[3-(difl...)
Affinity DataIC50: 16.2nMAssay Description:The assay buffer containes 5 mM HEPES pH 7.4 (Applichem), 150 mM NaCl (Sigma), 10 mM EDTA (Promega), 1 mM DTT (Thermofisher), 0.05% BSA Fraction V, p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2024
Entry Details
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TargetSon of sevenless homolog 1/GTPase KRas [G12C](Human)
Bayer Aktiengesellschaft

US Patent
LigandPNGBDBM634036(US20230357239, Example 4 | 1-{4-[4-({(1R)-1-[3-(tr...)
Affinity DataIC50: 16.3nMAssay Description:The assay buffer containes 5 mM HEPES pH 7.4 (Applichem), 150 mM NaCl (Sigma), 10 mM EDTA (Promega), 1 mM DTT (Thermofisher), 0.05% BSA Fraction V, p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2024
Entry Details
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