Compile Data Set for Download or QSAR
Report error Found 110 Enz. Inhib. hit(s) with all data for entry = 12198
TargetGTPase KRas [G12V](Human)
University of Texas

US Patent
LigandPNGBDBM685775(US12043602, Compound NY0335 | (R)-N-(1-(4-methoxyp...)
Affinity DataIC50: 20nMAssay Description:Table 1: Potency and efficacy of K-RAS inhibition and toxicity of batch1 and 2 compounds. MDCK cells co-expressing GFP-K-RASG12V and mCherry-CAAX wer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/4/2024
Entry Details
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TargetGTPase KRas [G12V](Human)
University of Texas

US Patent
LigandPNGBDBM685826(US12043602, Compound PW323)
Affinity DataIC50: 50nMAssay Description:Table 7: Potency and efficacy of K-RAS inhibition and toxicity ofbatch 5 compounds. MDCK cells co-expressing GFP-K-RASG12V andmCherry-CAAX were grown...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/4/2024
Entry Details
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TargetGTPase KRas [G12V](Human)
University of Texas

US Patent
LigandPNGBDBM685762(US12043602, Compound NY0244 | (R)-N-(1-(4-methoxyp...)
Affinity DataIC50: 100nMAssay Description:Table 1: Potency and efficacy of K-RAS inhibition and toxicity of batch1 and 2 compounds. MDCK cells co-expressing GFP-K-RASG12V and mCherry-CAAX wer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/4/2024
Entry Details
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TargetGTPase KRas [G12V](Human)
University of Texas

US Patent
LigandPNGBDBM685762(US12043602, Compound NY0244 | (R)-N-(1-(4-methoxyp...)
Affinity DataIC50: 100nMAssay Description:Table 1: Potency and efficacy of K-RAS inhibition and toxicity of batch1 and 2 compounds. MDCK cells co-expressing GFP-K-RASG12V and mCherry-CAAX wer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/4/2024
Entry Details
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TargetGTPase KRas [G12V](Human)
University of Texas

US Patent
LigandPNGBDBM685764(US12043602, Compound 12f | US12043602, Compound NY...)
Affinity DataIC50: 100nMAssay Description:Table 9: IC50: 50% inhibitory concentration for KRASG12V mislocalization. Values were calculated from at least eight data points. In general, at leas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/4/2024
Entry Details
Go to US Patent

TargetGTPase KRas [G12V](Human)
University of Texas

US Patent
LigandPNGBDBM685764(US12043602, Compound 12f | US12043602, Compound NY...)
Affinity DataIC50: 100nMAssay Description:Table 10: IC50: 50% inhibitory concentration for KRASG12V mislocalization. Values were calculated from at least eight data points. In general, at lea...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/4/2024
Entry Details
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TargetGTPase KRas [G12V](Human)
University of Texas

US Patent
LigandPNGBDBM685753(US12043602, Compound NY022602 | (1R,2S)-N-(3,3-dip...)
Affinity DataIC50: 160nMAssay Description:Table 1: Potency and efficacy of K-RAS inhibition and toxicity of batch1 and 2 compounds. MDCK cells co-expressing GFP-K-RASG12V and mCherry-CAAX wer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/4/2024
Entry Details
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TargetGTPase KRas [G12V](Human)
University of Texas

US Patent
LigandPNGBDBM685743(US12043602, Compound AVA72 | US20150344407, Compou...)
Affinity DataIC50: 170nMAssay Description:Table 1: Potency and efficacy of K-RAS inhibition and toxicity of batch1 and 2 compounds. MDCK cells co-expressing GFP-K-RASG12V and mCherry-CAAX wer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/4/2024
Entry Details
Go to US Patent

TargetGTPase KRas [G12V](Human)
University of Texas

US Patent
LigandPNGBDBM685743(US12043602, Compound AVA72 | US20150344407, Compou...)
Affinity DataIC50: 170nMAssay Description:Table 1: Potency and efficacy of K-RAS inhibition and toxicity of batch1 and 2 compounds. MDCK cells co-expressing GFP-K-RASG12V and mCherry-CAAX wer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/4/2024
Entry Details
Go to US Patent

TargetGTPase KRas [G12V](Human)
University of Texas

US Patent
LigandPNGBDBM685763(US12043602, Compound 15a | US12043602, Compound NY...)
Affinity DataIC50: 190nMAssay Description:Table 1: Potency and efficacy of K-RAS inhibition and toxicity of batch1 and 2 compounds. MDCK cells co-expressing GFP-K-RASG12V and mCherry-CAAX wer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/4/2024
Entry Details
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TargetGTPase KRas [G12V](Human)
University of Texas

US Patent
LigandPNGBDBM685761(US12043602, Compound NY0241 | (R)-2-((3,3-diphenyl...)
Affinity DataIC50: 200nMAssay Description:Table 1: Potency and efficacy of K-RAS inhibition and toxicity of batch1 and 2 compounds. MDCK cells co-expressing GFP-K-RASG12V and mCherry-CAAX wer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/4/2024
Entry Details
Go to US Patent

TargetGTPase KRas [G12V](Human)
University of Texas

US Patent
LigandPNGBDBM685792(US12043602, Compound NY040402 | N-(3,3-diphenylall...)
Affinity DataIC50: 200nMAssay Description:Table 3: Potency and efficacy K-RAS inhibition and toxicity of batch 3 compounds. MDCK cells co-expressing GFP-K-RASG12V and mCherry-CAAX were grown ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/4/2024
Entry Details
Go to US Patent

TargetGTPase KRas [G12V](Human)
University of Texas

US Patent
LigandPNGBDBM685748(US12043602, Compound NY0222 | (R)-N-(3,3-diphenyla...)
Affinity DataIC50: 250nMAssay Description:Table 1: Potency and efficacy of K-RAS inhibition and toxicity of batch1 and 2 compounds. MDCK cells co-expressing GFP-K-RASG12V and mCherry-CAAX wer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/4/2024
Entry Details
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TargetGTPase KRas [G12V](Human)
University of Texas

US Patent
LigandPNGBDBM685793(US12043602, Compound NY0428 | (R)-3-tert-butyl-1-(...)
Affinity DataIC50: 290nMAssay Description:Table 3: Potency and efficacy K-RAS inhibition and toxicity of batch 3 compounds. MDCK cells co-expressing GFP-K-RASG12V and mCherry-CAAX were grown ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/4/2024
Entry Details
Go to US Patent

TargetGTPase KRas [G12V](Human)
University of Texas

US Patent
LigandPNGBDBM685774(US12043602, Compound NY0331 | (R)-N-(1-(4-methoxyp...)
Affinity DataIC50: 300nMAssay Description:Table 1: Potency and efficacy of K-RAS inhibition and toxicity of batch1 and 2 compounds. MDCK cells co-expressing GFP-K-RASG12V and mCherry-CAAX wer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/4/2024
Entry Details
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TargetGTPase KRas [G12V](Human)
University of Texas

US Patent
LigandPNGBDBM685832(US12043602, Compound PW454)
Affinity DataIC50: 319nMAssay Description:Table 7: Potency and efficacy of K-RAS inhibition and toxicity ofbatch 5 compounds. MDCK cells co-expressing GFP-K-RASG12V andmCherry-CAAX were grown...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/4/2024
Entry Details
Go to US Patent

TargetGTPase KRas [G12V](Human)
University of Texas

US Patent
LigandPNGBDBM685776(US12043602, Compound NY0345 | (R)-tert-butyl 4-(2-...)
Affinity DataIC50: 329nMAssay Description:Table 1: Potency and efficacy of K-RAS inhibition and toxicity of batch1 and 2 compounds. MDCK cells co-expressing GFP-K-RASG12V and mCherry-CAAX wer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/4/2024
Entry Details
Go to US Patent

TargetGTPase KRas [G12V](Human)
University of Texas

US Patent
LigandPNGBDBM685752(US12043602, Compound NY022601 | (1R,2S)-N,N-bis(3,...)
Affinity DataIC50: 420nMAssay Description:Table 1: Potency and efficacy of K-RAS inhibition and toxicity of batch1 and 2 compounds. MDCK cells co-expressing GFP-K-RASG12V and mCherry-CAAX wer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/4/2024
Entry Details
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TargetGTPase KRas [G12V](Human)
University of Texas

US Patent
LigandPNGBDBM685751(US12043602, Compound NY0225 | (R)-phenyl (3,3-diph...)
Affinity DataIC50: 430nMAssay Description:Table 1: Potency and efficacy of K-RAS inhibition and toxicity of batch1 and 2 compounds. MDCK cells co-expressing GFP-K-RASG12V and mCherry-CAAX wer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/4/2024
Entry Details
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TargetGTPase KRas [G12V](Human)
University of Texas

US Patent
LigandPNGBDBM685836(US12043602, Compound 7)
Affinity DataIC50: 500nMAssay Description:Table 9: IC50: 50% inhibitory concentration for KRASG12V mislocalization. Values were calculated from at least eight data points. In general, at leas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/4/2024
Entry Details
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TargetGTPase KRas [G12V](Human)
University of Texas

US Patent
LigandPNGBDBM685836(US12043602, Compound 7)
Affinity DataIC50: 500nMAssay Description:Table 10: IC50: 50% inhibitory concentration for KRASG12V mislocalization. Values were calculated from at least eight data points. In general, at lea...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/4/2024
Entry Details
Go to US Patent

TargetGTPase KRas [G12V](Human)
University of Texas

US Patent
LigandPNGBDBM685823(US12043602, Compound PW305 | (R)-N-(2-(4-(aminomet...)
Affinity DataIC50: 507nMAssay Description:Table 7: Potency and efficacy of K-RAS inhibition and toxicity ofbatch 5 compounds. MDCK cells co-expressing GFP-K-RASG12V andmCherry-CAAX were grown...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/4/2024
Entry Details
Go to US Patent

TargetGTPase KRas [G12V](Human)
University of Texas

US Patent
LigandPNGBDBM685806(US12043602, Compound PW124 | (R)-N-(3,3-diphenylal...)
Affinity DataIC50: 553nMAssay Description:Table 7: Potency and efficacy of K-RAS inhibition and toxicity ofbatch 5 compounds. MDCK cells co-expressing GFP-K-RASG12V andmCherry-CAAX were grown...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/4/2024
Entry Details
Go to US Patent

TargetGTPase KRas [G12V](Human)
University of Texas

US Patent
LigandPNGBDBM685773(US12043602, Compound NY0329 | (R)-N-(1-(4-methoxyp...)
Affinity DataIC50: 600nMAssay Description:Table 1: Potency and efficacy of K-RAS inhibition and toxicity of batch1 and 2 compounds. MDCK cells co-expressing GFP-K-RASG12V and mCherry-CAAX wer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/4/2024
Entry Details
Go to US Patent

TargetGTPase KRas [G12V](Human)
University of Texas

US Patent
LigandPNGBDBM685841(US12043602, Compound 15d)
Affinity DataIC50: 600nMAssay Description:Table 9: IC50: 50% inhibitory concentration for KRASG12V mislocalization. Values were calculated from at least eight data points. In general, at leas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/4/2024
Entry Details
Go to US Patent

TargetGTPase KRas [G12V](Human)
University of Texas

US Patent
LigandPNGBDBM685750(US12043602, Compound NY0224 | (R)-1-(3,3-diphenyla...)
Affinity DataIC50: 640nMAssay Description:Table 1: Potency and efficacy of K-RAS inhibition and toxicity of batch1 and 2 compounds. MDCK cells co-expressing GFP-K-RASG12V and mCherry-CAAX wer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/4/2024
Entry Details
Go to US Patent

TargetGTPase KRas [G12V](Human)
University of Texas

US Patent
LigandPNGBDBM685747(US12043602, Compound NY0221 | 2-(3,3-diphenylallyl...)
Affinity DataIC50: 650nMAssay Description:Table 1: Potency and efficacy of K-RAS inhibition and toxicity of batch1 and 2 compounds. MDCK cells co-expressing GFP-K-RASG12V and mCherry-CAAX wer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/4/2024
Entry Details
Go to US Patent

TargetGTPase KRas [G12V](Human)
University of Texas

US Patent
LigandPNGBDBM685820(US12043602, Compound PW299 | (R)-N-(2-(3,5-dimethy...)
Affinity DataIC50: 654nMAssay Description:Table 7: Potency and efficacy of K-RAS inhibition and toxicity ofbatch 5 compounds. MDCK cells co-expressing GFP-K-RASG12V andmCherry-CAAX were grown...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/4/2024
Entry Details
Go to US Patent

TargetGTPase KRas [G12V](Human)
University of Texas

US Patent
LigandPNGBDBM685835(US12043602, Compound PW361 | (R,Z)-N-(1-(4-fluorop...)
Affinity DataIC50: 725nMAssay Description:Table 7: Potency and efficacy of K-RAS inhibition and toxicity ofbatch 5 compounds. MDCK cells co-expressing GFP-K-RASG12V andmCherry-CAAX were grown...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/4/2024
Entry Details
Go to US Patent

TargetGTPase KRas [G12V](Human)
University of Texas

US Patent
LigandPNGBDBM685801(US12043602, Compound NY0444 | N-(3,3-diphenylallyl...)
Affinity DataIC50: 730nMAssay Description:Table 3: Potency and efficacy K-RAS inhibition and toxicity of batch 3 compounds. MDCK cells co-expressing GFP-K-RASG12V and mCherry-CAAX were grown ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/4/2024
Entry Details
Go to US Patent

TargetGTPase KRas [G12V](Human)
University of Texas

US Patent
LigandPNGBDBM685800(US12043602, Compound NY0443 | N-(3,3-diphenylallyl...)
Affinity DataIC50: 910nMAssay Description:Table 3: Potency and efficacy K-RAS inhibition and toxicity of batch 3 compounds. MDCK cells co-expressing GFP-K-RASG12V and mCherry-CAAX were grown ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/4/2024
Entry Details
Go to US Patent

TargetGTPase KRas [G12V](Human)
University of Texas

US Patent
LigandPNGBDBM685830(US12043602, Compound PW358)
Affinity DataIC50: 1.02E+3nMAssay Description:Table 7: Potency and efficacy of K-RAS inhibition and toxicity ofbatch 5 compounds. MDCK cells co-expressing GFP-K-RASG12V andmCherry-CAAX were grown...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/4/2024
Entry Details
Go to US Patent

TargetGTPase KRas [G12V](Human)
University of Texas

US Patent
LigandPNGBDBM685756(US12043602, Compound NY0232 | (R)-2-((3,3-diphenyl...)
Affinity DataIC50: 1.10E+3nMAssay Description:Table 1: Potency and efficacy of K-RAS inhibition and toxicity of batch1 and 2 compounds. MDCK cells co-expressing GFP-K-RASG12V and mCherry-CAAX wer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/4/2024
Entry Details
Go to US Patent

TargetGTPase KRas [G12V](Human)
University of Texas

US Patent
LigandPNGBDBM685781(US12043602, Compound NY0351 | (R)-N-(1-(4-methoxyp...)
Affinity DataIC50: 1.11E+3nMAssay Description:Table 1: Potency and efficacy of K-RAS inhibition and toxicity of batch1 and 2 compounds. MDCK cells co-expressing GFP-K-RASG12V and mCherry-CAAX wer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/4/2024
Entry Details
Go to US Patent

TargetGTPase KRas [G12V](Human)
University of Texas

US Patent
LigandPNGBDBM685771(US12043602, Compound NY0356 | US12043602, Compound...)
Affinity DataIC50: 1.15E+3nMAssay Description:Table 3: Potency and efficacy K-RAS inhibition and toxicity of batch 3 compounds. MDCK cells co-expressing GFP-K-RASG12V and mCherry-CAAX were grown ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/4/2024
Entry Details
Go to US Patent

TargetGTPase KRas [G12V](Human)
University of Texas

US Patent
LigandPNGBDBM685763(US12043602, Compound 15a | US12043602, Compound NY...)
Affinity DataIC50: 1.20E+3nMAssay Description:Table 9: IC50: 50% inhibitory concentration for KRASG12V mislocalization. Values were calculated from at least eight data points. In general, at leas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/4/2024
Entry Details
Go to US Patent

TargetGTPase KRas [G12V](Human)
University of Texas

US Patent
LigandPNGBDBM685759(US12043602, Compound NY0235 | (R)-N-(3,3-diphenyla...)
Affinity DataIC50: 1.21E+3nMAssay Description:Table 1: Potency and efficacy of K-RAS inhibition and toxicity of batch1 and 2 compounds. MDCK cells co-expressing GFP-K-RASG12V and mCherry-CAAX wer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/4/2024
Entry Details
Go to US Patent

TargetGTPase KRas [G12V](Human)
University of Texas

US Patent
LigandPNGBDBM685763(US12043602, Compound 15a | US12043602, Compound NY...)
Affinity DataIC50: 1.24E+3nMAssay Description:Table 3: Potency and efficacy K-RAS inhibition and toxicity of batch 3 compounds. MDCK cells co-expressing GFP-K-RASG12V and mCherry-CAAX were grown ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/4/2024
Entry Details
Go to US Patent

TargetGTPase KRas [G12V](Human)
University of Texas

US Patent
LigandPNGBDBM685778(US12043602, Compound NY0347 | (R)-N-(1-(4-methoxyp...)
Affinity DataIC50: 1.30E+3nMAssay Description:Table 1: Potency and efficacy of K-RAS inhibition and toxicity of batch1 and 2 compounds. MDCK cells co-expressing GFP-K-RASG12V and mCherry-CAAX wer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/4/2024
Entry Details
Go to US Patent

TargetGTPase KRas [G12V](Human)
University of Texas

US Patent
LigandPNGBDBM685791(US12043602, Compound NY040401 | N,N-bis(3,3-diphen...)
Affinity DataIC50: 1.46E+3nMAssay Description:Table 3: Potency and efficacy K-RAS inhibition and toxicity of batch 3 compounds. MDCK cells co-expressing GFP-K-RASG12V and mCherry-CAAX were grown ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/4/2024
Entry Details
Go to US Patent

TargetGTPase KRas [G12V](Human)
University of Texas

US Patent
LigandPNGBDBM685842(US12043602, Compound 15e)
Affinity DataIC50: 1.50E+3nMAssay Description:Table 9: IC50: 50% inhibitory concentration for KRASG12V mislocalization. Values were calculated from at least eight data points. In general, at leas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/4/2024
Entry Details
Go to US Patent

TargetGTPase KRas [G12V](Human)
University of Texas

US Patent
LigandPNGBDBM685782(US12043602, Compound NY0352 | (R)-4-(2-((3,3-diphe...)
Affinity DataIC50: 1.68E+3nMAssay Description:Table 1: Potency and efficacy of K-RAS inhibition and toxicity of batch1 and 2 compounds. MDCK cells co-expressing GFP-K-RASG12V and mCherry-CAAX wer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/4/2024
Entry Details
Go to US Patent

TargetGTPase KRas [G12V](Human)
University of Texas

US Patent
LigandPNGBDBM685769(US12043602, Compound NY0314 | N-(3,3-diphenylallyl...)
Affinity DataIC50: 1.69E+3nMAssay Description:Table 1: Potency and efficacy of K-RAS inhibition and toxicity of batch1 and 2 compounds. MDCK cells co-expressing GFP-K-RASG12V and mCherry-CAAX wer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/4/2024
Entry Details
Go to US Patent

TargetGTPase KRas [G12V](Human)
University of Texas

US Patent
LigandPNGBDBM685764(US12043602, Compound 12f | US12043602, Compound NY...)
Affinity DataIC50: 1.76E+3nMAssay Description:Table 1: Potency and efficacy of K-RAS inhibition and toxicity of batch1 and 2 compounds. MDCK cells co-expressing GFP-K-RASG12V and mCherry-CAAX wer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/4/2024
Entry Details
Go to US Patent

TargetGTPase KRas [G12V](Human)
University of Texas

US Patent
LigandPNGBDBM685833(US12043602, Compound PW455)
Affinity DataIC50: 1.86E+3nMAssay Description:Table 7: Potency and efficacy of K-RAS inhibition and toxicity ofbatch 5 compounds. MDCK cells co-expressing GFP-K-RASG12V andmCherry-CAAX were grown...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/4/2024
Entry Details
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TargetGTPase KRas [G12V](Human)
University of Texas

US Patent
LigandPNGBDBM685802(US12043602, Compound NY0445 | (R)-4-((3,3-diphenyl...)
Affinity DataIC50: 2.02E+3nMAssay Description:Table 3: Potency and efficacy K-RAS inhibition and toxicity of batch 3 compounds. MDCK cells co-expressing GFP-K-RASG12V and mCherry-CAAX were grown ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/4/2024
Entry Details
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TargetGTPase KRas [G12V](Human)
University of Texas

US Patent
LigandPNGBDBM685834(US12043602, Compound PW460 | (R,Z)-N-(1-(4-fluorop...)
Affinity DataIC50: 2.02E+3nMAssay Description:Table 7: Potency and efficacy of K-RAS inhibition and toxicity ofbatch 5 compounds. MDCK cells co-expressing GFP-K-RASG12V andmCherry-CAAX were grown...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/4/2024
Entry Details
Go to US Patent

TargetGTPase KRas [G12V](Human)
University of Texas

US Patent
LigandPNGBDBM685808(US12043602, Compound PW126 | (R)-N-(3,3-diphenylal...)
Affinity DataIC50: 2.19E+3nMAssay Description:Table 7: Potency and efficacy of K-RAS inhibition and toxicity ofbatch 5 compounds. MDCK cells co-expressing GFP-K-RASG12V andmCherry-CAAX were grown...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/4/2024
Entry Details
Go to US Patent

TargetGTPase KRas [G12V](Human)
University of Texas

US Patent
LigandPNGBDBM685819(US12043602, Compound PW297 | (R)-N-(2-(1H-pyrrolo[...)
Affinity DataIC50: 2.27E+3nMAssay Description:Table 7: Potency and efficacy of K-RAS inhibition and toxicity ofbatch 5 compounds. MDCK cells co-expressing GFP-K-RASG12V andmCherry-CAAX were grown...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/4/2024
Entry Details
Go to US Patent

TargetGTPase KRas [G12V](Human)
University of Texas

US Patent
LigandPNGBDBM685765(US12043602, Compound NY0293 | 1-(3,3-diphenylallyl...)
Affinity DataIC50: 2.30E+3nMAssay Description:Table 1: Potency and efficacy of K-RAS inhibition and toxicity of batch1 and 2 compounds. MDCK cells co-expressing GFP-K-RASG12V and mCherry-CAAX wer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/4/2024
Entry Details
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