Compile Data Set for Download or QSAR
Report error Found 18 Enz. Inhib. hit(s) with all data for entry = 11672
TargetEstrogen receptor(Human)
Nuvation Bio

US Patent
LigandPNGBDBM638391(US11834458, Example 2 | Synthesis of (S)-4,11-diet...)
Affinity DataIC50: 10nMAssay Description:ERα binding was assessed using the LanthaScreen TR-FRET ER Alpha Competitive Binding kit from ThermoFisherScientific. In this assay, a terbium-l...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2024
Entry Details
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TargetAndrogen receptor(Human)
Nuvation Bio

US Patent
LigandPNGBDBM638392(US11834458, Example 3 | Synthesis of (S)-4,11-diet...)
Affinity DataIC50: 10nMAssay Description:To assess AR binding, test compound (top dose 10 μM, 4 fold serial dilution, 8 point dose response) and control (progesterone) were transferred ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2024
Entry Details
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TargetGlucocorticoid receptor(Human)
Nuvation Bio

US Patent
LigandPNGBDBM638392(US11834458, Example 3 | Synthesis of (S)-4,11-diet...)
Affinity DataIC50: 10nMAssay Description:To assess GR binding, test compound (top dose 1 μM, 4 fold serial dilution, 8 point dose response) and control (dexamethasone) were transferred ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2024
Entry Details
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TargetEstrogen receptor(Human)
Nuvation Bio

US Patent
LigandPNGBDBM638390(US11834458, Example 1 | Synthesis of (S)-4,11-diet...)
Affinity DataIC50: 10nMAssay Description:ERα binding was assessed using the LanthaScreen TR-FRET ER Alpha Competitive Binding kit from ThermoFisherScientific. In this assay, a terbium-l...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2024
Entry Details
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TargetGlucocorticoid receptor(Human)
Nuvation Bio

US Patent
LigandPNGBDBM638393(US11834458, Example 5 | Synthesis of (S)-10-((dime...)
Affinity DataIC50: 10nMAssay Description:To assess GR binding, test compound (top dose 1 μM, 4 fold serial dilution, 8 point dose response) and control (dexamethasone) were transferred ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2024
Entry Details
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TargetAndrogen receptor(Human)
Nuvation Bio

US Patent
LigandPNGBDBM638405(US11834458, Example 21 | Preparation of 2-(((5S,8R...)
Affinity DataIC50: 255nMAssay Description:To assess AR binding, test compound (top dose 10 μM, 4 fold serial dilution, 8 point dose response) and control (progesterone) were transferred ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2024
Entry Details
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TargetAndrogen receptor(Human)
Nuvation Bio

US Patent
LigandPNGBDBM638404(US11834458, Example 20 | Preparation of (S)-10-((D...)
Affinity DataIC50: 255nMAssay Description:To assess AR binding, test compound (top dose 10 μM, 4 fold serial dilution, 8 point dose response) and control (progesterone) were transferred ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2024
Entry Details
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TargetAndrogen receptor(Human)
Nuvation Bio

US Patent
LigandPNGBDBM638403(US11834458, Example 18 | Preparation of 2-(((5S,8R...)
Affinity DataIC50: 255nMAssay Description:To assess AR binding, test compound (top dose 10 μM, 4 fold serial dilution, 8 point dose response) and control (progesterone) were transferred ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2024
Entry Details
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TargetAndrogen receptor(Human)
Nuvation Bio

US Patent
LigandPNGBDBM638402(US11834458, Example 14 | Preparation of N-((1r,4r)...)
Affinity DataIC50: 255nMAssay Description:To assess AR binding, test compound (top dose 10 μM, 4 fold serial dilution, 8 point dose response) and control (progesterone) were transferred ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2024
Entry Details
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TargetEstrogen receptor(Human)
Nuvation Bio

US Patent
LigandPNGBDBM638401(US11834458, Example 13 | Preparation of (S)-10-((D...)
Affinity DataIC50: 255nMAssay Description:ERα binding was assessed using the LanthaScreen TR-FRET ER Alpha Competitive Binding kit from ThermoFisherScientific. In this assay, a terbium-l...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2024
Entry Details
Go to US Patent

TargetAndrogen receptor(Human)
Nuvation Bio

US Patent
LigandPNGBDBM638399(US11834458, Example 11 | Preparation of N-((1r,4r)...)
Affinity DataIC50: 255nMAssay Description:To assess AR binding, test compound (top dose 10 μM, 4 fold serial dilution, 8 point dose response) and control (progesterone) were transferred ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2024
Entry Details
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TargetAndrogen receptor(Human)
Nuvation Bio

US Patent
LigandPNGBDBM638398(US11834458, Example 10 | Preparation of (11R,13S,1...)
Affinity DataIC50: 255nMAssay Description:To assess AR binding, test compound (top dose 10 μM, 4 fold serial dilution, 8 point dose response) and control (progesterone) were transferred ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2024
Entry Details
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TargetAndrogen receptor(Human)
Nuvation Bio

US Patent
LigandPNGBDBM638397(US11834458, Example 9 | Preparation of (11R,13S,17...)
Affinity DataIC50: 255nMAssay Description:To assess AR binding, test compound (top dose 10 μM, 4 fold serial dilution, 8 point dose response) and control (progesterone) were transferred ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2024
Entry Details
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TargetAndrogen receptor(Human)
Nuvation Bio

US Patent
LigandPNGBDBM638396(US11834458, Example 8 | Preparation of (S)-10-((Di...)
Affinity DataIC50: 255nMAssay Description:To assess AR binding, test compound (top dose 10 μM, 4 fold serial dilution, 8 point dose response) and control (progesterone) were transferred ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2024
Entry Details
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TargetAndrogen receptor(Human)
Nuvation Bio

US Patent
LigandPNGBDBM638394(US11834458, Example 6 | Preparation of (S)-10-((Di...)
Affinity DataIC50: 255nMAssay Description:To assess AR binding, test compound (top dose 10 μM, 4 fold serial dilution, 8 point dose response) and control (progesterone) were transferred ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2024
Entry Details
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TargetAndrogen receptor(Human)
Nuvation Bio

US Patent
LigandPNGBDBM638393(US11834458, Example 5 | Synthesis of (S)-10-((dime...)
Affinity DataIC50: 255nMAssay Description:To assess AR binding, test compound (top dose 10 μM, 4 fold serial dilution, 8 point dose response) and control (progesterone) were transferred ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2024
Entry Details
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TargetAndrogen receptor(Human)
Nuvation Bio

US Patent
LigandPNGBDBM638400(US11834458, Example 12 | Preparation of N-((1r,4r)...)
Affinity DataIC50: 1.00E+3nMAssay Description:To assess AR binding, test compound (top dose 10 μM, 4 fold serial dilution, 8 point dose response) and control (progesterone) were transferred ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2024
Entry Details
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TargetAndrogen receptor(Human)
Nuvation Bio

US Patent
LigandPNGBDBM638395(US11834458, Example 7 | Preparation of N-((1r,4r)-...)
Affinity DataIC50: 1.00E+3nMAssay Description:To assess AR binding, test compound (top dose 10 μM, 4 fold serial dilution, 8 point dose response) and control (progesterone) were transferred ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2024
Entry Details
Go to US Patent